ライフサイエンスコーパス: chemical modification

1 molecular analysis due to fragmentation and chemical modification.

2 ition of Cu(2+) without the need for further chemical modification.

3 was dependent on the kind of starch and its chemical modification.

4 a low immunogenicity and finally an ease of chemical modification.

5 cluding internalization, hydrophobicity, and chemical modification.

6 he part of the antigen that is stabilized by chemical modification.

7 er state (MLCT) energetics are tuned through chemical modification.

8 eractions without any protein engineering or chemical modification.

9 es, such as small size, low cost, and facile chemical modification.

10 ic structures of starch were altered through chemical modification.

11 protein- or medium engineering as well as by chemical modification.

12 ffold for nonribosomal peptide extension and chemical modification.

13 As are naturally decorated with a variety of chemical modifications.

14 ng of their structure and how it responds to chemical modifications.

15 egrity by eliminating nucleobases with small chemical modifications.

16 RNA contains over 150 types of chemical modifications.

17 us glycoconjugates with most sugar types and chemical modifications.

18 Nucleic acids undergo naturally occurring chemical modifications.

19 etic short interfering RNAs (siRNAs) require chemical modifications.

20 pairs of GSLs could be achieved with offline chemical modifications.

21 eoxy-2'-fluoro and 2'-O-methyl pentofuranose chemical modifications.

22 l) pentacene (TIPS-Pn), without the need for chemical modifications.

23 ed mainly through irreversible structural or chemical modifications.

24 ribosomal effect can also be reduced through chemical modifications.

25 ich the 3 and 3' positions are available for chemical modifications.

26 s, their detailed chemical interactions, and chemical modifications.

27 short and frequently mutated by post-mortem chemical modifications.

28 main stable against denaturation without any chemical modifications.

29 tion of the hydroxyl groups or harbor subtle chemical modifications.

30 it from uncovering sub-microscale sources of chemical modifications.

31 ance and stoichiometry of post-translational chemical modifications across temporal and steady-state

32 lf-stimulation in rats to understand how the chemical modifications affect abuse liability.

33 Our results provide the basis for further chemical modifications aimed at identifying novel antitr

34 his report, we investigated the hexopyranose chemical modification Altriol Nucleic Acid (ANA) within

35 -nucleic acid targets, ease of synthesis and chemical modification, amenability to be interfaced with

36 of the PG, however, encompasses a variety of chemical modifications among different bacterial species

37 peak shifts affirm the changes with surface chemical modification and biomolecular assembly.

38 dicinal chemists have identified a number of chemical modification and conjugation strategies which c

39 a more reproducible bioorthogonal method of chemical modification and facile expression in bacteria,

40 By comparing the voltage dependences of chemical modification and gating charge displacement, he

41 Chemical modification and mutational analyses of the lon

42 After separate chemical modification and pooling, mixed-modified librar

43 properties and is an excellent candidate for chemical modification and reconfiguration.

44 applications, with an emphasis on biopolymer chemical modifications and cross-linking methods.

45 s, given numerous advancements made to their chemical modifications and delivery methods.

46 y of this class of molecules, largely due to chemical modifications and delivery strategies that impr

47 cleic acid binding domains for ASO depend on chemical modifications and further demonstrate how ASO-p

48 t the 5'-position provides limited space for chemical modifications and identify 6ha as a potent wate

49 l potential of RNA requires understanding of chemical modifications and non-canonical bases; this in

50 epicistrome incorporates tissue-specific DNA chemical modifications and TF-specific chemical sensitiv

51 hylation (2'-O-Me) is the most abundant rRNA chemical modification, and displays a complex pattern in

52 Through de novo sequencing MS, chemical modification, and mutagenesis, we have pinpoint

53 directed evolution, saturation mutagenesis, chemical modification, and rational drug design to obtai

54 Hand-to-hand computational evaluation, chemical modifications, and cell viability testing were

55 We review techniques such as mutagenesis, chemical modifications, and optogenetics that have been

56 eresting hit was taken as starting point for chemical modification applying a ligand-based approach.

57 r movement, raising the question of how such chemical modifications are balanced in these essential s

58 he Elongator-dependent modification pathway, chemical modifications are introduced at the wobble urid

59 on, transfer into artificial environments or chemical modifications are therefore essential to analyz

60 d substitutions can yet be confused with the chemical modifications, arising from protein alkylation

61 However, structural and/or chemical modifications as a result of taphonomic and dia

62 We aim to encourage researchers to adopt chemical modifications as part of their work in DNA nano

63 s highlight the power of "post-translational chemical modification" as a tool to study biological mol

64 d conductivity, mechanical softness, ease of chemical modification, as well as moderate biocompatibil

65 including reduced, oxidative, TET-assisted, chemical-modification assisted, and methylase-assisted b

66 r sodium; ion passage is blocked by specific chemical modification at the pore entrance.

67 Carbohydrates can have various chemical modifications at different positions, making th

68 Cas9 activity in vitro tolerated most chemical modifications at predicted 2'-hydroxyl contact

69 diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA

70 A number of BVM analogs were synthesized by chemical modifications at the C-28 position to improve i

71 This is due to the broad diversity of chemical modifications available for the enone structura

72 orms, focusing on key approaches - including chemical modification, bioconjugation and the use of nan

73 Eukaryotic mRNA undergoes chemical modification both at the 5' cap and internally.

74 These minimal chemical modifications bring about two key structural ch

75 al properties of molecules, not only through chemical modifications but also by coupling molecules st

76 dentified sites on PAN either protected from chemical modification by protein binding or characterize

77 the most powerful expressions of how minute chemical modifications can affect electronic devices.

78 Chemical modifications can affect protein binding and un

79 Extrahelical structures and chemical modifications can be inserted at user-defined s

80 ring protein binding of ASOs using different chemical modifications can improve therapeutic performan

81 Chemical modifications can potentially change monoclonal

82 ADP-ribosylation is a reversible chemical modification catalysed by ADP-ribosyltransferas

83 Certain chemical modifications confer increased stability and lo

84 nality the endodermal cell wall has specific chemical modifications consisting of lignin bands (Caspa

85 as well as additional post-translational and chemical modifications could also be simultaneously dete

86 as those changes induced by drug binding or chemical modifications, directly in living human cells,

87 strated by recent findings that altering ASO chemical modifications dramatically improves therapeutic

88 This chemical modification drastically reduces the enzymatic

89 DNA constantly undergoes chemical modification due to endogenous and exogenous mu

90 ee of structural complexity and are prone to chemical modifications during production, processing, an

91 ifications, e.g., (extrusion/annealing); two chemical modifications, e.g., (succinylation/cross-linki

92 many chemical and biological processes, and chemical modification enables control and modulation of

93 Chemical modification experiments demonstrate that posit

94 ts demonstrate that stabilization of iChS by chemical modifications favors anion channeling at the ex

95 ng from the native RNA structure necessitate chemical modification for drug development.

96 ior in biological environments and a general chemical modification for rhodamines that optimizes long

97 ts, and open up new possibilities of further chemical modification for the growing class of potent pl

98 without having to alter their structure with chemical modifications for conjugation of radiochelators

99 fication (PS) is one of the most widely used chemical modifications for enhancing the drug-like prope

100 g activity, and we develop an optimal set of chemical modifications for in vivo applications.

101 One small chemical modification found frequently among pneumococca

102 switch these distortions on and off through chemical modification fundamentally expands the toolbox

103 ication of glycosylation types, sugar types, chemical modifications, glycosidic linkages, and anomeri

104 Although judicious use of chemical modifications has contributed to the success of

105 The tolerance of the gRNA and donor DNA to chemical modifications has the potential to enable new s

106 Over 100 types of chemical modifications have been identified in cellular

107 Various chemical modifications have been identified that enhance

108 Chemical modifications have myriad advantages over other

109 The multitude of possible chemical modifications highlights the necessity to obtai

110 of some analytes either due to extraction or chemical modification (i.e., polar metabolites).

111 The biochemical principles of chemical modification identified here will guide CRISPR-

112 Ile-16 is significantly less protected from chemical modification in G221E than in wild-type HABP2,

113 Ultrafast perfusion enabled us to perform chemical modification in less than 10 ms, reporting move

114 of the tagged metabolite and its subsequent chemical modification in living culture can be achieved.

115 ative structure of the pore by site-specific chemical modification in single-channel electrical recor

116 ification of multiple post-translational and chemical modifications in a single peptide mapping liqui

117 ion are known to be among the most prevalent chemical modifications in long-lived human proteins and

118 These treatments result in chemical modifications in milk proteins, mainly generate

119 tructure of Ago2 is relatively unaffected by chemical modifications in the bound siRNA.

120 l for complex glycan structures with various chemical modifications in the PDB.

121 ns than did RT-qPCR, suggesting that certain chemical modifications in the RNA were not detected by t

122 r characterization of post-translational and chemical modifications in therapeutic proteins.

123 thermore, stabilization of wild-type SOD1 by chemical modification including cisplatination, inhibits

124 oved and now identifies most sugar types and chemical modifications (including various glycolipids) i

125 d by synthetic and hydrolytic enzymes and by chemical modifications, including O-acetylation of MurNA

126 RNAs besides tRNA and rRNA contain chemical modifications, including the recently described

127 Despite the chemical modification increasing the density of the bead

128 roNaV2 allows for the assessment of chemical modification induced in fluorescence microscopy

129 calation chemistry of anatase TiO(2) and how chemical modifications influence the accommodation of Al

130 ASO length and chemical modification influenced the efficacy of these r

131 Furthermore, we show that chemical modifications, instrumentation advances and nan

132 fication system that transforms nucleic acid chemical modification into organismal innate immunity.

133 specific sequences, tertiary structures, and chemical modifications into lambda-DNA remains technical

134 The deposition of chemical modifications into RNA is a crucial regulator o

135 l factors, as well as methods to incorporate chemical modifications into sequences, in order to descr

136 Incorporation of chemical modifications into small interfering RNAs (siRN

137 nglet fission (SF) is affected by systematic chemical modifications introduced into phenazinothiadiaz

138 Ps with target-antigens by genetic fusion or chemical modification is time-consuming and often leads

139 biological contributions of these different chemical modifications is beginning to take shape, but i

140 eting PGC-1alpha acetylation in the liver, a chemical modification known to inhibit hepatic gluconeog

141 ion, sulfenic acid rapidly undergoes further chemical modification, leading to irreversible protein m

142 Herein, extensive chemical modifications led to the development of a new a

143 view aims to present a brief overview of key chemical modifications, mechanisms of action and routes

144 Chemical modification of a unique cysteine residue is am

145 These ligands are commonly generated through chemical modification of accessible lysine residues, whi

146 t the VidaL system as a tool for the precise chemical modification of cellular proteins with spatial

147 Chemical modification of DNA is a commonly used strategy

148 wever, functionality can be obtained through chemical modification of DNA nanostructures and the oppo

149 This work demonstrates that chemical modification of dynamic interactions can be use

150 adenosine (m(6)A) is a prevalent, reversible chemical modification of functional RNAs and is importan

151 Therefore, chemical modification of gluten can be mainly conducted

152 .2%), hematopoietic development (29.7%), and chemical modification of histones (48.6%).

153 Here, we combined chemical modification of lysines and multiple-reaction m

154 fy a facile and straightforward approach for chemical modification of membrane proteins with bioortho

155 methyladenosine (m(6)A) is the most abundant chemical modification of mRNA, yet the role of m(6)A mod

156 emonstrate its utility for the site-specific chemical modification of nanobodies and an antibody Fc f

157 Methods for direct chemical modification of native RNA would provide an att

158 Chemical modification of nucleotide bases in DNA provide

159 Chemical modification of PAI-1 confirmed an essential re

160 Targeted chemical modification of peptides and proteins by laser

161 his chemistry to bacteriophage allows facile chemical modification of phage libraries, which greatly

162 including osmotic disruption of the BBB and chemical modification of prodrugs.

163 Chemical modification of proteins and peptides represent

164 The field of chemical modification of proteins has been dominated by

165 The chemical modification of proteins in a site-selective ma

166 Chemical modification of proteins is essential for a var

167 s are privileged molecular scaffolds for the chemical modification of proteins.

168 denosine (m(6)A) is a widespread, reversible chemical modification of RNA molecules, implicated in ma

169 tionally, most of these methods involved the chemical modification of RNA structure using solid-state

170 Small nucleolar RNAs (SnoRNAs) direct chemical modification of RNA substrates to fine-tune spl

171 he FFPE process results in fragmentation and chemical modification of RNA, rendering it less suitable

172 r RNA therapeutics have shown that judicious chemical modification of RNAs can improve therapeutic ef

173 e detection that, in many instances, involve chemical modification of samples prior to analysis.

174 The chemical modification of structurally complex fermentati

175 monomethyl ester is described involving the chemical modification of the commercially available glut

176 Inspired by the potential for chemical modification of the D(3) preferential agonists

177 ssible to minimize such a reaction through a chemical modification of the electrodes, and this enable

178 eract across very long distances without any chemical modification of the environment.

179 Conclusion: Chemical modification of the FAPI framework enabled enha

180 time also allow for resynthesis and adaptive chemical modification of the glycocalyx.

181 s, without the need for added surfactants or chemical modification of the graphene.

182 Chemical modification of the gRNA and donor DNA has grea

183 Therefore, chemical modification of the guide RNA can be used to ch

184 ial for permanent porosity and postsynthetic chemical modification of the inorganic and organic compo

185 MA inhibitor variants showed that systematic chemical modification of the linker has a significant im

186 These area modifications induced by the chemical modification of the membrane upon oxidation wer

187 In many cases, this process depends on the chemical modification of the O antigen's nonreducing ter

188 Here, through chemical modification of the primary amines to aromatic

189 hout the need for any base, pretreatment, or chemical modification of the underlying surface.

190 Substitution or chemical modification of this residue abolishes photolab

191 Chemical modification of TMDCs is expected to be key in

192 Chemical modification of transcripts with 5' caps occurs

193 Here, we have used the chemical modification of Trp9, site-directed mutagenesis

194 The optimized chemical modifications of adenine base editor mRNA and g

195 tive for imaging FFPE tissues because of the chemical modifications of analytes, including complex cr

196 Here, we show how chemical modifications of apramycin and geneticin, consi

197 imise oligonucleotide chemistries as well as chemical modifications of ASOs.

198 imise oligonucleotide chemistries as well as chemical modifications of ASOs.

199 Specific chemical modifications of biological molecules are an ef

200 Covalent chemical modifications of cellular RNAs directly impact

201 These programs are carried out through chemical modifications of DNA and proteins such as histo

202 genetic and environmental effects as stable chemical modifications of DNA.

203 resolution genomic maps of the many types of chemical modifications of DNA.

204 Chemical modifications of histones and nucleic acids con

205 Chemical modifications of histones can mediate diverse D

206 tant for pan opioid receptor activity, using chemical modifications of key pharmacophoric groups.

207 rstanding of pore formation, and evidence of chemical modifications of membrane lipids and functional

208 mtosecond laser pulses to produce controlled chemical modifications of non-photosensitive peptides an

209 Small nucleolar RNAs (snoRNAs) guide chemical modifications of ribosomal and small nuclear RN

210 Chemical modifications of RNA allow rapid cellular respo

211 Chemical modifications of RNAs have emerged as a new lay

212 Chemical modifications of RNAs have long been establishe

213 Systematic chemical modifications of synthetic receptors that are a

214 omplement proteins, but the effects of small chemical modifications of the capsule on its function ha

215 neralization exhibit distinct and observable chemical modifications of the collagen prior to the onse

216 On the basis of these findings, specific chemical modifications of the ligand could be shown to y

217 For oligonucleotide therapeutics, chemical modifications of the sugar-phosphate backbone a

218 dge about the structural, morphological, and chemical modifications of these solids, either caused du

219 ate that the 'tubulin code' - the pattern of chemical modifications of tubulin along a microtubule -

220 Hence, screening of chemical modifications on DNA can be used to provide inf

221 Chemical modifications on DNA molecules, such as 5-methy

222 Moreover, we show that chemical modifications on fungal oxyluciferin can affect

223 In the present study, the time-dependent chemical modifications on GSH and GSSG in the presence o

224 s simulations to identify the time-dependent chemical modifications on GSH and GSSG that are caused b

225 tools that are currently available to detect chemical modifications on linear peptides are not applic

226 is known about the functional importance of chemical modifications on other nucleobases in the brain

227 Chemical modifications on protein biopharmaceuticals int

228 ule acceptors (SMAs) are realized via subtle chemical modifications on strong electron-withdrawing en

229 to assess the conformational impact of these chemical modifications on the backbone structure and the

230 to investigate the effects of metabolic and chemical modifications on the estrogenicity of AOH.

231 dyes of this family are centered around the chemical modifications on the polymethine chain.

232 Typically, this is achieved by either chemical modification or by controlling the hierarchical

233 bPNA+ enabled this readout without covalent chemical modification or introduction of new structural

234 eveloped complex repair networks that remove chemical modifications or aberrant base arrangements and

235 alignment of nanofibrils, without additional chemical modifications or additives.

236 (siRNAs), of the same sequence but different chemical modification pattern and metabolic stability, c

237 Spontaneous chemical modifications play an important role in human d

238 Pseudouridine (Psi) is the most common chemical modification present in RNA.

239 tumor suppressor protein p53 by mutagenesis, chemical modification, protein-protein interaction, or a

240 s spectrometry, CD spectroscopy, and protein chemical modification reactions (protein footprinting).

241 , as well as for the optimization of protein chemical modification reactions.

242 DNA chemical modifications regulate genomic function.

243 The chemical modifications result in favorable changes to th

244 Previous work using limited proteolysis and chemical modification revealed that Redbeta consists of

245 This chemical modification scheme spontaneously forms phospho

246 gents interact with various proteins and how chemical modifications, sequence, and structure influenc

247 Proteolytic stabilization of the peptide by chemical modification significantly enhanced the in vivo

248 Using a combination of methods including chemical modification, site-directed mutagenesis, and fl

249 ic systems provide an excellent diversity of chemical modifications, stability, controlled release, h

250 izing proteins typically require physical or chemical modification steps or cannot be used to examine

251 of a mAb and identified correlations between chemical modification, structure, and function of the th

252 Chemical modification studies confirm the requirement fo

253 Moreover, chemical modifications such as glycation and carbamylati

254 saccharides that were subjected to selective chemical modifications such as regioselective O- and N-s

255 essing the encased DNA strands difficult, or chemical modification, such as covalent crosslinking of

256 tRNA are post-transcriptionally modified by chemical modifications that affect all aspects of tRNA b

257 Here, we report chemical modifications that allow site-specific and mult

258 terest, preserving cell- and tissue-specific chemical modifications that are known to affect TF bindi

259 the vast diversity of post-translational and chemical modifications that are unaccounted in a typical

260 Herein, we report chemical modifications that can be used to impart resist

261 Here, we discuss the rationale behind the chemical modifications that have been utilized and sugge

262 lerene acceptors, highlighting the important chemical modifications that have led to progress in the

263 ld be enhanced through the identification of chemical modifications that strengthen its physical stab

264 Here, we show how a small chemical modification, the oxidation of two cysteine thi

265 Although an apparently simple chemical modification, the presence of the 2'OH in RNA h

266 field that are shaping our understanding of chemical modifications, their impact on development and

267 sidues can propagate the molecular impact of chemical modifications throughout a protein and influenc

268 Presented here is a facile chemical modification to attenuate solvent-dependent mec

269 we use a combinatorial approach for covalent chemical modification to generate a large library of var

270 Coupling of structure-specific in vivo chemical modification to next-generation sequencing is t

271 t the high reactivity of EDT causes a severe chemical modification to the active layer that deteriora

272 In this study, we explored the effects of chemical modifications to a natural product macrocycle u

273 very of conjugated siRNAs requires extensive chemical modifications to achieve stability in vivo.

274 , we used peptide design to perform targeted chemical modifications to Ang II to generate conformatio

275 dulate domain communication, suggesting that chemical modifications to carrier proteins during NRPS s

276 ons is also essential for designing specific chemical modifications to develop new reagents and thera

277 Natural RNAs utilize extensive chemical modifications to diversify their structures and

278 Chemical modifications to DNA and histone proteins are i

279 ion of gene expression by noncoding RNAs and chemical modifications to DNA or DNA-associated proteins

280 The results suggest that chemical modifications to membranes that decrease the pr

281 Chemical modifications to messenger RNA are increasingly

282 unctions of enhancer RNAs, circular RNAs and chemical modifications to RNA in cellular processes.

283 gation into the interfacial effects of small chemical modifications to substrate surfaces.

284 Here, we introduce chemical modifications to the sugar-phosphate backbone o

285 d scalable fabrication, high flux, efficient chemical modification, tunable channel size, etc.

286 he structural and functional impact of these chemical modifications underlie these arguments.

287 The dominant strategy for detecting in vivo chemical modifications uses reverse transcriptase trunca

288 es include simple self-assembly or involving chemical modifications via coupling drugs together or co

289 The behavior of peptides after this chemical modification was simulated at the pH range used

290 Chemical modification was used to quantitatively determi

291 with a computer-aided method, different new chemical modifications were designed and carried out, wi

292 Although many of these chemical modifications were discovered several decades a

293 abrupt modulation with increasing degrees of chemical modification, which decreases at first and then

294 We discuss strategies for the pores' chemical modification with lipid anchors to enable them

295 Chemical modification with octenyl succinic anhydride (O

296 Subsequent chemical modification with silanes, followed by the immo

297 ine), which combines structure probing using chemical modifications with direct long-read RNA sequenc

298 as an alternative to either encapsulation or chemical modifications with polymers.

299 creens suggest they are a starting point for chemical modifications with potential for future antibac

300 impact on mAb attributes induced by specific chemical modifications within the CDR, hydrogen-deuteriu