ライフサイエンスコーパス: chemical synthesis

1 lkylamines provides a continual challenge to chemical synthesis.

2 nologies, and advances in library design and chemical synthesis.

3 catalyst and it applications attractive for chemical synthesis.

4 try in contrast with classical approaches of chemical synthesis.

5 tile route to free radical intermediates for chemical synthesis.

6 and tunability that can dramatically improve chemical synthesis.

7 natural sources, recombinant expression, or chemical synthesis.

8 hK polypeptide chains were prepared by total chemical synthesis.

9 ower of rhodium carbene chemistry in organic chemical synthesis.

10 the scope of aerobic oxidation chemistry in chemical synthesis.

11 e knot topologies have been realized through chemical synthesis.

12 s to achieve different product outcomes from chemical synthesis.

13 r the evolution (and at times revolution) in chemical synthesis.

14 le either through biosynthetic precursors or chemical synthesis.

15 oligonucleotide at a fraction of the cost of chemical synthesis.

16 etic materials produced by stereo-controlled chemical synthesis.

17 and catalytic membrane reactors for greener chemical synthesis.

18 rfect example of the intersection of art and chemical synthesis.

19 t, its low reactivity has limited its use in chemical synthesis.

20 poised to realize the potential of solar-to-chemical synthesis.

21 ysts with enormous potential for sustainable chemical synthesis.

22 aximize atom- and step-economy, and simplify chemical synthesis.

23 l main group solid catalysts for sustainable chemical synthesis.

24 ide the inspiration for critical advances in chemical synthesis.

25 new types of one-pot biotransformations for chemical synthesis.

26 oselectivity is of fundamental importance in chemical synthesis.

27 ative fashion is an important goal in modern chemical synthesis.

28 ystems is of utmost importance in nature and chemical synthesis.

29 nm) of natural collagen are recalcitrant to chemical synthesis.

30 izations of alkenes are highly desirable for chemical synthesis.

31 out homogeneous counterparts for sustainable chemical synthesis.

32 but becomes a disadvantage and challenge in chemical synthesis.

33 alysts are critically needed for sustainable chemical synthesis.

34 er reaction has proven a great challenge for chemical synthesis.

35 aditionally avoided reactive intermediate in chemical synthesis.

36 halides are important C-C bond formations in chemical synthesis.

37 s and allenes, opening new opportunities for chemical synthesis.

38 novel approaches to challenging problems in chemical synthesis.

39 ill provide scalability and availability, is chemical synthesis.

40 lizations known, providing a unique tool for chemical synthesis.

41 organoboron species with great potential in chemical synthesis.

42 carbon-heteroatom bond-forming reactions in chemical synthesis.

43 ound them suggested promising candidates for chemical synthesis.

44 d organic building blocks in the large-scale chemical synthesis.

45 r of opportunities in the field of selective chemical synthesis.

46 ly, they present a substantial challenge for chemical synthesis.

47 cules, and they are useful intermediates for chemical synthesis.

48 n product species not directly accessible by chemical synthesis.

49 retical prediction can be tested directly by chemical synthesis.

50 hape-selective catalysis plays a key role in chemical synthesis.

51 age motif of AlbD with substrates derived by chemical synthesis.

52 h electrochemistry for energy conversion and chemical synthesis.

53 olate-type donor substrates and their use in chemical synthesis.

54 ng molecules is a long-standing challenge in chemical synthesis.

55 tro isotopic labelling of this cluster using chemical synthesis.

56 formation are of great importance in modern chemical synthesis.

57 mplemented by protein semisynthesis or total chemical synthesis.

58 control stereochemistry are prized tools in chemical synthesis.

59 cient photocatalysis are highly desirable in chemical synthesis.

60 strategy for initiating radical reactions in chemical synthesis.

61 ydrates remains a long-standing challenge in chemical synthesis.

62 atalyst is expected to bring new insights in chemical synthesis.

63 h photoluminescence quantum yield and facile chemical synthesis.

64 her study of strained alkynes and allenes in chemical synthesis.

65 proach for installing amide functionality in chemical synthesis.

66 atform based on oligosaccharides obtained by chemical synthesis.

67 ecules and provide the foundation for modern chemical synthesis.

68 remain key building blocks in bulk and fine chemical synthesis.

69 e, and mass production compatibility through chemical synthesis.

70 eir structural complexity, which limits bulk chemical synthesis.

71 topologies present an unusual challenge for chemical synthesis and an opportunity for innovation.

72 nfluenza A virus subtype H1N1, and extensive chemical synthesis and analysis of the structure-activit

73 For miniaturization and integration of chemical synthesis and analytics on small length scales,

74 vity relationships, which was facilitated by chemical synthesis and biochemical activity analysis, in

75 Here we report the structure-guided design, chemical synthesis and biological investigations of biva

76 This review focuses on the chemical synthesis and biology of anticancer nucleoside,

77 ucts were unambiguously assigned both by the chemical synthesis and by X-ray structure analysis.

78 Herein, we describe the chemical synthesis and characterization of two series of

79 We first carried out a chemical synthesis and complete spectroscopic structure

80 We describe here a new program for virtual chemical synthesis and computational assessment, ChemGen

81 We established efficient chemical synthesis and de novo sequencing procedures and

82 ectrides offer physical properties useful in chemical synthesis and electronics.

83 The powerful synergy of chemical synthesis and ENGase-mediated biocatalysis enab

84 While chemical synthesis and gel or chromatographic purificati

85 cular machines may have significant roles in chemical synthesis and molecular manufacturing.

86 describe the close connection between novel chemical synthesis and optimized light emission by collo

87 NTES-PF4 heterodimer (termed OPRAH) by total chemical synthesis and oxime ligation, with an accelerat

88 ructurally simpler, making it attractive for chemical synthesis and potential applications in biology

89 emselves valuable chiral building blocks for chemical synthesis and precursors to numerous important

90 This Article outlines the optimized chemical synthesis and preliminary biochemical character

91 Recent developments in the area of chemical synthesis and semisynthesis of proteins offer g

92 molecular dynamics simulation program before chemical synthesis and spectral characterizations viz.,

93 Further chemical synthesis and structure-activity relationship s

94 Here, we report the chemical synthesis and testing of Caulobacter ethensis-2

95 The simplicity in chemical synthesis and the fungal specific property make

96 of polymers have been used to revolutionize chemical synthesis and the selection of functional nucle

97 By integrating chemical synthesis and two types of O-sulfo transferases

98 contrast agents based on the synergy between chemical synthesis and ultrafast laser processing.

99 Here, we report the design, chemical synthesis, and biological profiling of natural

100 Here, we report the development, chemical synthesis, and biological screening of a compou

101 to date: in vivo strain manipulation, total chemical synthesis, and chemoenzymatic synthesis methods

102 cysteine makes the molecule more amenable to chemical synthesis, and coupled with its increased class

103 ations in single-cell biology, combinatorial chemical synthesis, and drug screening.

104 The high potency, low toxicity, facile chemical synthesis, and great opportunities for chemical

105 ticle, we use a combination of computations, chemical synthesis, and mechanistic analysis to develop

106 in LC-MS, biochemical ubiquitination assays, chemical synthesis, and protein crystallography to enabl

107 assignments of DHD1 and DHD3, their de novo chemical synthesis, and their production in systems in v

108 e designed CovCore proteins were prepared by chemical synthesis, and their structures were determined

109 Robotic systems for chemical synthesis are growing in popularity but can be

110 imple hydrocarbons, yet applications to fine chemical synthesis are rare.

111 es recent advances on use of vinyl azides in chemical synthesis as a radical acceptor and an enamine-

112 alyzed (NHC) transformations are valuable to chemical synthesis, as they can generate high enantiosel

113 pt, this Review is primarily focusing on the chemical synthesis aspects of the ADCs multidisciplinary

114 amongst which 15 peptides were selected for chemical synthesis based on their predicted ACE-I inhibi

115 Using a combination of chemical synthesis, biological evaluation, molecular dyn

116 r sequences and structures, biosynthesis and chemical synthesis, biological functions, and applicatio

117 free energy perturbation (FEP) calculations, chemical synthesis, biophysical mapping and X-ray crysta

118 pplications in the field of enzyme catalyzed chemical synthesis but also enzyme based fuel cells.

119 -metal catalysis has become indispensable to chemical synthesis, but homogeneous high-valent transiti

120 ies, including 2D nanomaterials in colloidal chemical synthesis, but it is still highly challenging t

121 elopment of large-scale solar fuel and solar chemical synthesis, but the poor photovoltages often rep

122 onalization of C(sp(3) )-H bonds streamlines chemical synthesis by allowing the use of simple molecul

123 This review focuses on advances in fine chemical synthesis by titanium-catalyzed reactions featu

124 f natural products, here we demonstrate that chemical synthesis can provide important insights into b

125 e combination of rational design and modular chemical synthesis can revitalize classes of antibiotics

126 metal-mediated hydride transfer reactions in chemical synthesis, catalysis, and biology has inspired

127 The bacteria require no chemical synthesis, come in variable sizes and shapes, d

128 ophysical characterization against tractable chemical synthesis: Complexity-building nitro-Mannich/la

129 Chemical synthesis confirms hinokiflavone is the active

130 ,9-EET in this COX pathway were confirmed by chemical synthesis: ct-8,9-epoxy-11-hydroxy-eicosatrieno

131 alkaloid has remained an elusive target for chemical synthesis due to insurmountable issues of react

132 products represent useful intermediates for chemical synthesis due to the versatility of the C-B bon

133 We have used chemical synthesis, electron paramagnetic resonance (EPR

134 Chemical synthesis enabled identification of isocyanoter

135 Chemical synthesis from ribose and 2,6-dichloropurine pr

136 Computer design and chemical synthesis generated viable variants of poliovir

137 ation of potent, drug-like molecules through chemical synthesis has been challenging.

138 Despite efforts spanning 40 years, chemical synthesis has been unable to compete with these

139 Routes to their chemical synthesis have been developed over the past two

140 ophilic compounds originating from nature or chemical synthesis have profound effects on immune cells

141 Recent advances in chemical synthesis have yielded new nanoscale materials

142 ing potentially valuable building blocks for chemical synthesis, have each been prepared from cyclope

143 recently intensified, thanks to advances in chemical synthesis, improved understanding of charged st

144 ructures of polymers and address the use for chemical synthesis in general.

145 il our efforts to prepare these molecules by chemical synthesis, including a photochemical approach,

146 promising approach to tackle this problem is chemical synthesis inside nanocapsules, although enzyme-

147 The chemical synthesis intermediate 3,4-dichloronitrobenzene

148 entified one hit, which was expanded through chemical synthesis into a small panel of potent compound

149 ilico discovered hits have been optimized by chemical synthesis into selective nanomolar compounds, t

150 re l-sugar building blocks through efficient chemical synthesis is a crucial step toward the synthesi

151 Although any chemical synthesis is broadly useful for its versatility

152 This strategy for computer-augmented chemical synthesis is demonstrated for 15 drug or drug-l

153 Chemical synthesis is the most creative and critical asp

154 Chemical synthesis led to further compound collections t

155 tilization of carbon dioxide as feedstock in chemical synthesis, low-energy-barrier CO2 activation is

156 veral other classes of enzymes, but a simple chemical synthesis may have created the first peptides a

157 Here, we report a cost-effective chemical synthesis method to produce antimicrobial cockt

158 The development of chemical synthesis methods allowing for the precise cont

159 DNA is stifled by the continued reliance on chemical synthesis methods.

160 dation, H(2) evolution, CO(2) reduction, and chemical synthesis more broadly.

161 rides in peptoid monomer model systems using chemical synthesis, NMR spectroscopy, and X-ray crystall

162 We herein report the chemical synthesis of (+)-brevianamide A (seven steps, 7

163 Here we report a chemical synthesis of (+)-perseanol, which proceeds in 1

164 Herein we report the first chemical synthesis of (+)-pseudoanisatin from the abunda

165 Here, we report a short chemical synthesis of (+)-ryanodol that proceeds in only

166 tiomer-specific activity and straightforward chemical synthesis of (unnatural) ent-(+)-verticilide pr

167 ffect of such modification, we report here a chemical synthesis of 3F(ax)-Neu5Ac-alpha2,6-Gal as a bu

168 In silico docking and screening, followed by chemical synthesis of a library of quinazolinones, led t

169 to the complex peptide substrate, relying on chemical synthesis of a modified C-terminal fragment and

170 Recently, chemical synthesis of a range of large nanographene mole

171 It is based on the chemical synthesis of a tetra-antennary glycan that has

172 Chemical synthesis of a uniformly (13)C-labeled octasacc

173 based design efforts in combination with the chemical synthesis of additional molecular entities are

174 Herein, we report a total chemical synthesis of all-l- and all-d-amino acid biotin

175 Despite advances in the chemical synthesis of alpha-syn and other proteins, the

176 based self-assembled nanoparticles, from the chemical synthesis of AMPDs, through nanoparticle prepar

177 Chemical synthesis of an analog library combined with in

178 To overcome such limitation, the catalyzed chemical synthesis of bacterial PHAs has been developed,

179 A chemical synthesis of bilobalide should facilitate the i

180 masked form of selenocysteine (Sec) for the chemical synthesis of challenging proteins.

181 difficult for cost-effective production, and chemical synthesis of complex isoprenoids is impractical

182 has long served as a starting point for the chemical synthesis of complex natural products, includin

183 Chemical synthesis of conjugate vaccines, consisting of

184 The first chemical synthesis of ECA-derived oligosaccharides for t

185 instructed specific living neurons to guide chemical synthesis of electrically functional (conductiv

186 Chemical synthesis of elemental selenium nanoparticles i

187 de nucleic acids (PNA), we herein report the chemical synthesis of fluorinated PNA monomers and bioph

188 Herein, we report the total chemical synthesis of four candidate Ts3 toxin protein m

189 The method includes the chemical synthesis of glycan oxazolines with varied numb

190 Chemical synthesis of HS and DS is required to generate

191 Here, we report a new method for the total chemical synthesis of IGF-1 analogs, which entails the s

192 We report a concise chemical synthesis of kalihinol C via a possible biosynt

193 structure-activity relationships enabled the chemical synthesis of LCL204, with enhanced inhibitory p

194 In this work, we describe the wet-chemical synthesis of monodisperse nanohelices based on

195 protocol consists of four major stages: (i) chemical synthesis of MPNs, (ii) conjugation with DNA an

196 The incorporation of impurities during the chemical synthesis of nanomaterials is usually uncontrol

197 The wet chemical synthesis of nanostructures has many crucial ad

198 Chemical synthesis of nearly 30 derivatives has resulted

199 ase peptide synthesis as demonstrated in the chemical synthesis of NEDD8 protein, without the use of

200 mounts of free-volume are based primarily on chemical synthesis of new polymers.

201 onstrate the utility of this approach by the chemical synthesis of nine different protein chains that

202 nventional methods for natural extraction or chemical synthesis of O-PS are technically demanding, in

203 The chemical synthesis of oligonucleotides and their enzyme-

204 cosylation remains the main challenge in the chemical synthesis of oligosaccharides.

205 General strategies for the chemical synthesis of organic compounds, especially of a

206 Meanwhile, the chemical synthesis of organized 3D structures with a per

207 Chemical synthesis of PAR is an attractive alternative t

208 owever, the utility of this functionality in chemical synthesis of peptides and proteins remains unex

209 unctionalized silica resin to facilitate the chemical synthesis of peptides in organic solvent as wel

210 he first example of the use of non-enzymatic chemical synthesis of phospholipids to prepare proteolip

211 The chemical synthesis of phosphoramidite derivatives of all

212 Chemical synthesis of platinum-rare earth metal (Pt-RE)

213 The chemical synthesis of poly(gamma-butyrolactone) (PgammaB

214 hemical definition and solubility, while the chemical synthesis of polysaccharides is challenging wit

215 This involves (i) chemical synthesis of precursor N-acetyl-D-galactosamine

216 Here, we use total chemical synthesis of proteins to generate highly homoge

217 We applied the total chemical synthesis of proteins to prepare H2AY57p effici

218 tion of sulfonated-PCBs was confirmed by the chemical synthesis of reference standards, obtained thro

219 The first chemical synthesis of SB is reported, which enables furt

220 r previous research in this area through the chemical synthesis of six site-specifically O-GlcNAcylat

221 The routes that have been taken for the chemical synthesis of such nucleoside derivatives are de

222 is a powerful synthetic methodology for the chemical synthesis of technologically important biodegra

223 It is then applied to the challenging chemical synthesis of the 97-residue co-chaperonin GroES

224 Here we describe the chemical synthesis of the ADP-ribose dimer, and we use t

225 A unified strategy for the chemical synthesis of the chivosazoles is described.

226 The first chemical synthesis of the complete protective O-antigen

227 This protocol covers the chemical synthesis of the fluorogenic amino acid Fmoc-Tr

228 Chemical synthesis of the L- and D-enantiomeric forms of

229 We also describe the HDDA-enabled chemical synthesis of the natural product alkaloids maha

230 Additionally, research toward chemical synthesis of the prodiginine alkaloids over the

231 The chemical synthesis of the repeating unit of S. aureus ca

232 at we validated through performing the first chemical synthesis of the two natural products Tasipepti

233 a promising green alternative to the current chemical synthesis of these esters of unquestionable nut

234 ix different research groups have reported a chemical synthesis of this compound, five of which used

235 Here, we describe the chemical synthesis of this intermediate, which was instr

236 Here, we report the chemical synthesis of two DPDPE analogues 7a (NOVA1) and

237 Here we report a new strategy for the chemical synthesis of ubiquitinated proteins to generate

238 Here, we report a one-pot wet-chemical synthesis of well-defined heterophase fcc-2H-fc

239 h-resolution mass spectrometry platform, and chemical synthesis of well-defined HS oligosaccharides f

240 ive update on the properties (structural and chemical), synthesis of sulfide solid-state electrolytes

241 tions including the destruction of hazardous chemicals, synthesis of organic compounds, and many othe

242 eotide, which is incorporated into RNA using chemical synthesis or biochemical techniques.

243 Unlike starting material obtained by chemical synthesis or direct isolation from natural sour

244 The INSL3 is typically prepared using chemical synthesis or overexpression in Escherichia coli

245 ging task due to the complexity in multistep chemical synthesis or the inability of the biosynthetic

246 ke features, and synthetic accessibility for chemical synthesis, out of 593 hits, 39 were left top hi

247 tensely investigated from both medicinal and chemical-synthesis perspectives for decades.

248 In chemical synthesis, protected or unprotected nucleosides

249 Here, we report a highly optimized chemical synthesis protocol for constructing multigram q

250 Chemical synthesis remains a preferred method for the pr

251 It is shown how wet-chemical synthesis results in an uncontrolled integratio

252 aulobacter crescentus through the process of chemical synthesis rewriting and studied the genetic inf

253 In sum, our results highlight the promise of chemical synthesis rewriting to decode fundamental genom

254 n, we report on a first direct aqueous-phase chemical synthesis route to NIR PLNPs and present their

255 nosheets are synthesized using a one-pot wet-chemical synthesis route with and without Re doping.

256 ched between two layers of graphene oxide by chemical synthesis route.

257 s play an important role such as fuel cells, chemical synthesis, self-assembly, catalysis and surface

258 Chemical synthesis served as an important tool in the st

259 Structural verification and modification by chemical synthesis showed that O4I1 and its derivatives

260 ily, was prepared for the first time through chemical synthesis starting from 2,3-dimethylbutadiene.

261 epared via two methods: (1) conventional wet chemical synthesis (strong electrostatic adsorption-SEA)

262 based on first-principles methods including chemical synthesis, structure elucidation and standard-a

263 Reduction of the cage window size by chemical synthesis switches the selectivity from Xe-sele

264 Here, we describe an advance in chemical synthesis that has established an enantiospecif

265 Here, we report a step toward a paradigm of chemical synthesis that relieves chemists from routine t

266 ediate to many potent Illicium terpenes make chemical synthesis the unquestionable method for accessi

267 amongst the most studied reactions in all of chemical synthesis, the number of reactions that apply t

268 ional groups, rarely does one consider using chemical synthesis to add molecular complexity to the na

269 tope labeling, tandem mass spectrometry, and chemical synthesis to deduce the structure of colibactin

270 an untargeted DNA adductomics approach with chemical synthesis to identify and characterize a covale

271 erent extraction approaches from tea shoots, chemical synthesis to microbial transformation have been

272 We used whole-genome design and complete chemical synthesis to minimize the 1079-kilobase pair sy

273 lies on bioinformatic algorithms followed by chemical synthesis to predict and then produce small mol

274 Use of chemical synthesis to prepare the monomers suggests broa

275 extensive modification by mutagenesis and/or chemical synthesis to prevent rapid in vivo degradation.

276 Overall, the study demonstrates the power of chemical synthesis to produce natural product variants w

277 to predict the output of a BGC and in vitro chemical synthesis to produce the predicted structure.

278 e M-MoS2 has not been previously prepared by chemical synthesis, to the best of our knowledge.

279 ctionalization is a powerful addition to the chemical synthesis toolkit.

280 Chemical synthesis typically relies on reactions that ge

281 t they present challenging issues of complex chemical synthesis, undesirable physical properties, and

282 lop a scalable, cost-effective and versatile chemical synthesis using a fired brick to control oxidat

283 x molecules highlight the power of iterative chemical synthesis using boronic esters.

284 Chemical synthesis using petrochemical-derived precursor

285 aries (DELs) link the powers of genetics and chemical synthesis via combinatorial optimization.

286 Microorganisms can be programmed to perform chemical synthesis via metabolic engineering.

287 Herein, we report total chemical synthesis, via native chemical ligation, and fu

288 Chemical synthesis was combined with endo-beta-N-acetylg

289 lengths and N- and O-sulfation patterns via chemical synthesis were systematically studied about the

290 iven to some of the recent advances in their chemical synthesis which allows not only the preparation

291 ptide, albopeptide, through NMR analysis and chemical synthesis, which contains two contiguous unsatu

292 esponsive materials offers simple design and chemical synthesis while enabling different stimuli to p

293 igomers and unnatural variants produced from chemical synthesis will allow for further detailed struc

294 e use of biocatalytic methods in the area of chemical synthesis with focused attention on retrosynthe

295 nt two important strategies for eco-friendly chemical synthesis with high atom efficiency and reduced

296 This approach combined the flexibility of chemical synthesis with the selectivity of enzyme-cataly

297 Here we combine the flexibility of chemical synthesis with the specificity of a programmabl

298 zyme activities that have been exploited for chemical synthesis, with an emphasis on reactions that d

299 This paper describes the chemical synthesis, X-ray crystallographic structure, an

300 Chemical synthesis yielded compound AZ-05, which bound t