ライフサイエンスコーパス: chemist

1 owing superior performance to a well-trained chemist.

2 been the domain of the expert computational chemist.

3 al of techniques available to the modern day chemist.

4 s has much to offer to the synthetic organic chemist.

5 , is well suited to the sensibilities of the chemist.

6 y depend on whether you ask a physicist or a chemist.

7 ent significant challenges for any synthetic chemist.

8 worked at du Pont for 42 years as a research chemist.

9 challenging goal for the synthetic inorganic chemist.

10 are a constant source of inspiration to the chemist.

11 paper reveals the human side of this eminent chemist.

12 ng to the Association of Official Analytical Chemists.

13 be a little less familiar to organometallic chemists.

14 reactor engineers and colloidal nanomaterial chemists.

15 ions and an unsolved challenge for synthetic chemists.

16 characterization tool for surface analytical chemists.

17 proteins should be of interest to biological chemists.

18 versatile tools in the repertoire of organic chemists.

19 zonolysis continues to challenge atmospheric chemists.

20 kage presents a great challenge to synthetic chemists.

21 in Nature, they remain elusive to synthetic chemists.

22 reactions remains a challenge for synthetic chemists.

23 al interest for both medicinal and synthetic chemists.

24 quire time and effort investment from expert chemists.

25 tractive targets for synthetic and medicinal chemists.

26 ty of medicinal, agricultural, and materials chemists.

27 poses an exceptional challenge to analytical chemists.

28 l knowledge of energetic science new to most chemists.

29 to becoming a mainstream tool for medicinal chemists.

30 cognosists, natural products, and ecological chemists.

31 th ease, it remains a difficult task for the chemists.

32 have attracted the interest of many organic chemists.

33 synthetic value for academic and industrial chemists.

34 ns have become an important tool for organic chemists.

35 y applied to problems of interest to organic chemists.

36 e-containing chemical entities for medicinal chemists.

37 le targets for pharmaceutical and analytical chemists.

38 tension between computational and medicinal chemists.

39 t but challenging targets for supramolecular chemists.

40 ignificantly enrich the toolbox of synthetic chemists.

41 ed compounds is an aspirational goal for all chemists.

42 of significant interest among supramolecular chemists.

43 rt C-H bonds, which is a major challenge for chemists.

44 of the former that are favored by medicinal chemists.

45 mains a long-standing challenge to synthetic chemists.

46 a chemical template for inspiring medicinal chemists.

47 articular challenge to analysis for forensic chemists.

48 a challenge and an opportunity for synthetic chemists.

49 view of this important toolbox for medicinal chemists.

50 in nature and is often used by (bio-)organic chemists(7), enables a predetermined and site-selective

51 , this versatile reactivity offers medicinal chemists a general strategy to rapidly prepare and funct

52 ed drug design approaches can help medicinal chemists a long way toward discovering better drugs.

53 s, and radiometals offer radiopharmaceutical chemists a tremendous range of options with which to acc

54 dvancements in organic chemistry depend upon chemists' ability to interpret NMR spectra, though resea

55 ysis and chemo-catalysis increasingly offers chemists access to more diverse chemical architectures.

56 veloped in our laboratory broadens synthetic chemists' access to classes of photochemical cycloadditi

57 Many chemists acquire and utilize skills that are well beyond

58 dings will inform clinicians and therapeutic chemists alike as they strive to develop novel therapies

59 red the interest of synthetic and biological chemists alike.

60 erspective of computational and experimental chemists alike.

61 The synthetic chemists always look for developing new catalysts, susta

62 xes: these two words jump to the mind of the chemist and are directly associated with their utility i

63 te to re-examine the life of this remarkable chemist and his legacy to heterocyclic chemistry.

64 This Review should be of interest for chemists and also physicists working in the fields of mo

65 cel, a familiar, easily accessed program for chemists and biologists.

66 ointly discuss the efforts of supramolecular chemists and biotechnologists who previously worked inde

67 this area as well as to encourage synthetic chemists and chemical engineers to address the challenge

68 orizations of cascade reactions by synthetic chemists and delineate the common underlying chemistry,

69 more comprehensible, both for synthetic POM chemists and for scientists with different backgrounds i

70 ke the subject more comprehensible, both for chemists and for scientists with different materials sci

71 The goal is to inspire chemists and materials scientists and to give them hope

72 s critical review addresses the community of chemists and materials scientists to share with it a cri

73 ules are of particular interest to medicinal chemists and materials scientists.

74 mote a closer interaction between analytical chemists and modellers to identify models for biochemica

75 Chemists and non-allopathic practitioners do not treat w

76 ent applications will be useful to medicinal chemists and other investigators interested in the lates

77 ce is an important objective that challenges chemists and physicists in order to access an entirely n

78 of this review article is to help materials chemists and physicists, particularly students, in selec

79 on science (QIS) currently being explored by chemists and physicists.

80 enormous amount of attention from synthetic chemists and played an important role in the development

81 lementation details are determined by expert chemists and recorded in reusable recipe files, which ar

82 ction of N(2) have been a major challenge to chemists and the focus since now has mostly been on the

83 Environmental chemists and toxicologists have moved beyond detecting a

84 source for medicinal chemists, computational chemists, and DMPK scientists working in drug design to

85 ors, including public and private providers, chemists, and non-allopathic practitioners.

86 clinicians, microbiologists, natural product chemists, and pharmacologists together with pharmaceutic

87 iew will serve to help materials scientists, chemists, and physicists, particularly students and youn

88 the origin of life in a manner accessible to chemists, and summarizes experiments suggesting several

89 quire strategic alignments among clinicians, chemists, and toxicologists.

90 his Review will be useful to a wide range of chemists, and will spur further research in this promisi

91 method of Association of Official Analytical Chemists (AOAC).

92 Likewise, synthetic chemists are able to make ever more complex electrocatal

93 Organic chemists are able to synthesize molecules in greater num

94 Medicinal chemists are accountable for embedding the appropriate d

95 Inspired by the properties of graphene, chemists are also designing graphene-like molecules in w

96 ing what is becoming an environmental issue, chemists are currently developing solutions to add value

97 o optimize drug candidates, modern medicinal chemists are increasingly turning to an unconventional s

98 enzymes have evolved to approach perfection, chemists are interested to know the minimal active site

99 Medicinal chemists are often guided by the physicochemical propert

100 The biocatalytic transformations used by chemists are often restricted to simple functional-group

101 ries of unexplored chemical space, medicinal chemists are routinely turning to unusual strained biois

102 Chemists are still far from achieving the most obvious a

103 ange in large pharma including how medicinal chemists are trained.

104 Chemists are visual creatures who are adept at discernin

105 Crystallization is widely used by synthetic chemists as a purification technique because it usually

106 to stimuli have been developed by synthetic chemists as building blocks for molecular machines.

107 f this emerging field to organic and polymer chemists as well as materials scientists.

108 attempt to provide guidance to the synthetic chemist, as well as a perspective on both the challenges

109 duate and postgraduate training of medicinal chemists at GSK is also briefly described.

110 This raises a question: should medicinal chemists avoid making sulfonamide-containing compounds i

111 portance, such that biologists and synthetic chemists avoid pursuing phantom chemical entities.

112 gle-electron reductants available to organic chemists because it is effective in reducing and couplin

113 phisticated catalysts are rarely employed by chemists, because the substrate scope, selectivity and r

114 review will be important and informative for chemists, biochemists, physicists, materials scientists,

115 Chemists, biologists and clinicians, among other scienti

116 ussion on what might lie ahead for medicinal chemists, biologists, and physicians as they try to impr

117 , which should bring valuable information to chemists, biologists, pharmacologists and toxicologists.

118 ules will be discussed - providing synthetic chemists both with the understanding and the tools requi

119 ll-known to enzymologists and bio(inorganic) chemists but may be a little less familiar to organometa

120 f broad interest to materials scientists and chemists but remains a formidable challenge.

121 emistry is the ease with which the synthetic chemist can effect a wide range of transformations throu

122 addition, the needs of the synthetic organic chemist can often be met by flow cells operating with re

123 up a multitude of new possibilities for how chemists can modulate cellular function and behaviour an

124 Microbes are nature's chemists, capable of producing and metabolizing a divers

125 laboration between synthetic and theoretical chemists (cf. the cerocene problem).

126 Chemists classify molecules according to characteristics

127 -PK should serve as a resource for medicinal chemists, computational chemists, and DMPK scientists wo

128 IUPAC (International Union of Pure & Applied Chemist)-condensed inputs to render Symbol Nomenclature

129 e "best practice" guidelines which will give chemists confidence in reported DSC results and the conc

130 n the focal point of interest of solid-state chemists, crystal engineers, and crystallographers from

131 useful and valuable tool for those medicinal chemists dealing with research programs focused on NS4B

132 : on the one hand, synthetic and biophysical chemists develop new fluorescent labels and isomorphic n

133 stic behavior, and profoundly change the way chemists discover and optimize reactions.

134 Medicinal chemists do not yet completely understand the nuances of

135 tracted significant attention from synthetic chemists due primarily to the historically synthetically

136 ted the attention of synthetic and medicinal chemists due to boron's ability to modulate enzyme funct

137 works, which have attracted the attention of chemists due to their natural product-like structures.

138 BCPs) have sparked the interest of medicinal chemists due to their recent discovery as bioisosteres o

139 Utilizing the Artificial Chemist, eleven precision-tailored QD synthesis composit

140 atalyzed alkyne-azide cycloaddition, peptide chemists embraced transition metal catalysis as a powerf

141 rface between computational and experimental chemists, emphasizing the need for computation to predic

142 l nomenclature systems inorganic and organic chemists employ to describe these phenomena.

143 This has brought together biologists, chemists, engineers, physicists, and mathematicians to s

144 o help NMR spectroscopists and computational chemists estimate the ranges of the NMR shifts for an un

145 ure and medicinal chemistry, have fascinated chemists ever since their discovery.

146 o be of particular interest to the medicinal chemist for other reasons.

147 Iron-nitrosyls have fascinated chemists for a long time due to the noninnocent nature o

148 d porphyrins have attracted the attention of chemists for a long time in view of their diverse applic

149 These features have inspired chemists for decades to seek artificial mimetics of prot

150 sought-after anticancer targets, has eluded chemists for decades until an irreversible covalent stra

151 zed cross-coupling of nitroarenes has eluded chemists for decades.

152 s, known as cyclo[n]carbons, have fascinated chemists for many years, but until now they could not be

153 been studied and exploited by supramolecular chemists for many years, most of this work has been cond

154 c alkynes and cyclic allenes, have intrigued chemists for more than a century with their unusual stru

155 erature, solvent, additives, etc., dissuades chemists from employing light-initiated reactions as a r

156 paradigm of chemical synthesis that relieves chemists from routine tasks, combining artificial intell

157 de, it has become increasingly recognized by chemists from various fields of synthetic chemistry such

158 hat this minireview will help more synthetic chemists gain insight into the design of CDC reactions a

159 the present day, a major challenge faced by chemists has been the separation of RE elements, which h

160 Synthetic organic chemists have a long-standing appreciation for transitio

161 Here, we will discuss how chemists have been able to harmonize the opposing functi

162 Inspired by nature, chemists have been interested in developing synthetic cy

163 Chemists have been interested in the N-alkylation of a p

164 Fortunately, chemists have bridged this experimental gap through the

165 Chemists have created molecular machines and switches wi

166 n both biological and material settings, and chemists have developed an ever-increasing vernacular to

167 such bionanodevices, in the past few decades chemists have developed artificial prototypes of molecul

168 ently catalyze a variety of transformations, chemists have developed large numbers of dinuclear trans

169 Chemists have developed mechanistic insight into numerou

170 tivity of these Cu-dependent metalloenzymes, chemists have developed synthetic protocols to functiona

171 Synthetic chemists have devoted tremendous effort towards the prod

172 s Perspective is to illustrate how medicinal chemists have elegantly employed the gem-dimethyl group

173 n cited in the sentence that starts "Polymer chemists have employed strategies such as single monomer

174 However, chemists have exploited the unique properties of fluorin

175 More recently, chemists have explored how NP analogues alter the retros

176 Synthetic chemists have focused on preparing such model compounds,

177 Chemists have had a long-standing interest in reactive i

178 ails of the synthesis process, we found that chemists have had preferences in the selection of substr

179 Over the past two decades, medicinal chemists have identified a number of chemical modificati

180 Chemists have long sought the ability to modify molecule

181 d by the normally harsh reaction conditions, chemists have long sought to develop catalytic variants

182 most productive, medicinal and computational chemists have made significant progress in delivering ne

183 The technology is easy to handle, and many chemists have managed to train themselves in its impleme

184 So far, chemists have only been able to synthesize monomer seque

185 nistic steps during biological N2 reduction, chemists have prepared iron complexes that mimic various

186 Biologists and chemists have put forth a lot of effort toward understan

187 eactions stored in the Reaxys database, that chemists have reported new compounds in an exponential f

188 Chemists have spent over a hundred years trying to make

189 e to have a profound impact on human health, chemists have succeeded in generating semisynthetic anal

190 Recently, chemists have turned their attention to the development

191 spired by this time-tested moiety, medicinal chemists have widely explored its use in developing bioa

192 rvations is intended to assist the synthetic chemist in the design of new catalysts and the developme

193 omputational models can assist the medicinal chemist in this endeavour.

194 ce for both FBDD practitioners and medicinal chemists in general.

195 the authors of this review as computational chemists in pharma.

196 so highlight the opportunities for medicinal chemists in radiotracer development for bacterial infect

197 complexity, are a source of inspiration for chemists in the field of total synthesis for the develop

198 g adequate credit to the great creativity of chemists in the field.

199 al chemistry knowledge potentially useful to chemists in the pursuit of synthesizing metabolically st

200 unities that have been under-investigated by chemists in the selective probe and sensor field.

201 n seeking to extend the lexicon of synthetic chemists in this regard, we have developed an expedient

202 s and thereby serve as an efficient tool for chemists, including those interested in synthesis.

203 In order to guide medicinal chemists into making more selective and potent Mcl-1 inh

204 generated from these studies, the Artificial Chemist is pre-trained to use a new batch of precursors

205 In response, an Artificial Chemist is presented: the integration of machine-learnin

206 The training of new medicinal chemists is vital to the future of the field, and as gra

207 Chemists live off them." Thus, the detailed image analys

208 ous choices are now available to a synthetic chemist looking to utilize a Minisci-type reaction.

209 With the self-driving Artificial Chemist, made-to-measure inorganic perovskite quantum do

210 ith better potency: selection by a medicinal chemist, manual modeling, docking followed by manual fil

211 5th anniversary of the birth of the physical chemist Michael Polanyi, as well as the 40th of his deat

212 r, having been studied almost exclusively by chemists, molecular crystals still lack the appropriate

213 nterest for structural biologists, medicinal chemists, molecular modellers and teachers.

214 Chemists must play and active role in this effort.

215 Prebiotic chemists often study how modern biopolymers, e.g., pepti

216 e and up-to-date reference for the medicinal chemist on the structure-activity-toxicity of this impor

217 s that often present themselves to medicinal chemists optimizing their compounds for candidate select

218 Whether chemists or biologists, researchers dealing with metabol

219 The Soai reaction has profoundly impacted chemists' perspective of autocatalysis, chiral symmetry

220 1%, as a result of synergistic efforts among chemists, physicists, and engineers.

221 These developments will benefit biologists, chemists, physicists, and materials scientists alike.

222 To the experienced molecular chemist, predicting the geometries and reactivities of a

223 , is a valuable transformation for medicinal chemists, providing a modular disconnection for the rapi

224 Chemists rely on organocatalysts or transition metal cat

225 Correction for 'The medicinal chemist's toolbox for late stage functionalization of dr

226 sidered as a routine part of every medicinal chemist's toolbox.

227 d on unraveling the content of the medicinal chemist's toolbox.

228 panding synthetic methodologies, a medicinal chemist's toolkit continues to swell.

229 t atomic resolution is a crucial tool in the chemist's toolset.

230 n constant use over the last half century by chemists seeking to functionalize heterocycles in a rapi

231 importance in both areas: mainstream organic chemists should feel comfortable taking this fork in the

232 red with non-sulfonamides and that medicinal chemists should not avoid use of the sulfonamide group.

233 this fork in the road, just as carbohydrate chemists should traveling in the opposite direction.

234 avier group 14 multiple bonds have intrigued chemists since more than a century.

235 Morphine has been a target for synthetic chemists since Robinson proposed its correct structure i

236 ural products have captured the attention of chemists since the isolation of the first members of the

237 to the conventional titration (American Oil Chemists' Society) and UV-Vis spectroscopic methods.

238 nd serves as a navigation tool for medicinal chemists, structural and cell biologists exploring ubiqu

239 onal, in order to provide inspiration to our chemists, suggest next steps in their work, and automate

240 o solids from the viewpoint of a solid-state chemist, summarizes techniques for growing single crysta

241 Clandestine chemists synthesize novel stimulant drugs by exploiting

242 bright future is ahead of the organometallic chemist, thanks to these novel technologies.

243 g on recent cases in order to give medicinal chemists the full scope of this strategy which has great

244 This strategy gives chemists the tools to design and refine vast libraries,

245 We hope to offer chemists the tools to have a good grasp of this singular

246 From the perspective of the medicinal chemist, the GRI is also important as a generalized mode

247 For MOF chemists, the chemical design space is a combination of

248 bond-containing products and may impact how chemists think of multistep synthetic sequences in the f

249 hoped that this Perspective will inspire the chemist to utilize quaternary carbon stereocenters to en

250 s a valuable synthetic roadmap for medicinal chemists to access a range of fluorinated therapeutic ca

251 esign and development challenge to medicinal chemists to achieve acceptable oral pharmacokinetics.

252 their work in DNA nanotechnology and inspire chemists to address current challenges and opportunities

253 ases, it will become increasingly useful for chemists to adopt the knot terminology employed by other

254 nalization chemistries has enabled medicinal chemists to consider a synthetic strategy, late stage fu

255 irect and feasible way for synthetic organic chemists to construct complicated molecules.

256 new transformation is presented that enables chemists to couple simple alkyl carboxylic acids with ar

257 ve-mentioned disorders and to help medicinal chemists to design novel dynamin ligands, which could be

258 of these enzymes have inspired bioinorganic chemists to design synthetic models to mimic their abili

259 into the design of network motifs, enabling chemists to develop "molecular software" to create funct

260 bs) in particular have stimulated analytical chemists to develop new methods and strategies for their

261 heterocyclic scaffolds has inspired organic chemists to discover several methodologies over recent y

262 polysubstituted cyclopropanes nowadays allow chemists to easily access these strained rings with high

263 us available stimuli, as tools for synthetic chemists to exploit.

264 thetic disconnection offer opportunities for chemists to explore and select more efficient syntheses/

265 egradation processes, and will stimulate the chemists to explore new chemical strategies to design sa

266 e machine learning algorithms can assist the chemists to faster search for the optimal reaction param

267 essential properties has inspired synthetic chemists to mimic these properties in artificial one-dim

268 ibition of single SCs has driven clandestine chemists to produce analogues of increasing structural d

269 , stimulated a furious worldwide effort from chemists to provide a solution for its preparation throu

270 is widely used by biologists, linguists and chemists to quantify similarity between pairs of phyloge

271 hts some of the strategies used by medicinal chemists to reduce DILI risk during the optimization of

272 tics is also due to the attempt of medicinal chemists to stabilize candidates toward cytochrome P450

273 The analytical toolbox available for chemists to study atmospheric organic components has exp

274 an attractive proposition because it allows chemists to synthetically tweak various kinetic and ther

275 inspired a new generation of natural product chemists to tackle powerful undeveloped scaffolds.

276 s an excellent tool for experimental organic chemists to understand, even to predict, the chemical or

277 C-H activation reactions enable chemists to unveil new retrosynthetic disconnections and

278 lization of C-H bonds will ultimately afford chemists transformative tools for editing and constructi

279 ed with unfamiliar reaction space, synthetic chemists typically apply the reported conditions (reagen

280 cus is on the strategies that supramolecular chemists use to emulate the efficiency of biological pro

281 Private healthcare providers including chemists were the first point of contact for the majorit

282 garded as benign and often used by medicinal chemists when attempting to avoid bioactivation.

283 within the binding site, directing medicinal chemists where to grow the molecule and alerting them to

284 his performance sets very high standards for chemists who aim at designing synthetic electrocatalysts

285 Here, we write to introduce analytical chemists who are new to the open-source movement to best

286 The intended audience is both quantum chemists who seek to learn more about quantum computing

287 pect that should be considered by analytical chemists who use MCR methods.

288 to molecular masterpieces devised by expert chemists whose properties are now being exploited far be

289 This Perspective provides the medicinal chemist with background and advice on the art and proces

290 self to his students, colleagues, and fellow chemists with an aura of nobility and romanticism.

291 its druglike properties, providing medicinal chemists with an unconventional strategy for replacing a

292 ester structural motif continues to intrigue chemists with its electrophilic and nucleophilic sites.

293 mistry principles and provide supramolecular chemists with meaningful understanding for tuning hydrog

294 vated photoredox catalysts provide synthetic chemists with the unprecedented capability to harness re

295 Flow equipment provides chemists with unique control over reaction parameters en

296 e single-electron redox events have provided chemists with useful tools for solving synthetic problem

297 More recently, however, supramolecular chemists - with their expertise in macrocyclic synthesis

298 lecule is of great interest to computational chemists, with applications in in silico materials desig

299 of which could arguably be designed by human chemists within minutes, without the help of a computer.

300 fundamental challenges for the bioanalytical chemist working in living tissue samples as well as best