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1 could promote cancer mutations and expedite chemoresistance.
2 (hPXR) has been associated with induction of chemoresistance.
3 ibutes to their epigenetic reprogramming and chemoresistance.
4 RB signaling regulates leukemic survival and chemoresistance.
5 nt obstacles to successful OvCa treatment is chemoresistance.
6 ion of Snail1-dependent tumoral invasion and chemoresistance.
7 w poor efficacy due to intrinsic or acquired chemoresistance.
8 stem cell (CSC) expansion and CSC-associated chemoresistance.
9 tive stress responses, tumor progression and chemoresistance.
10 iated traits such as migration, invasion and chemoresistance.
11 o identify novel mechanisms involved in SCLC chemoresistance.
12 of high-risk neuroblastomas recur because of chemoresistance.
13 nown about the role of histone expression in chemoresistance.
14 ar fitness' that may be also associated with chemoresistance.
15 ited therapeutic efficacy is achieved due to chemoresistance.
16 al of leukemic cells and also tackling their chemoresistance.
17 SOX9/2/17 are involved in MRP3-mediated CCA chemoresistance.
18 inhibition of IL6-induced proliferation and chemoresistance.
19 contributing to tumor cell proliferation and chemoresistance.
20 rvival, and their potential as modulators of chemoresistance.
21 s alongside chemotherapy for overcoming PDAC chemoresistance.
22 lution, tumorigenesis, and the phenomenon of chemoresistance.
23 owth inhibition, apoptosis, G0/G1 arrest and chemoresistance.
24 sponsible for tumor relapse, metastasis, and chemoresistance.
25 carcinoma, contributing to poor survival and chemoresistance.
26 limited efficacy due to de novo or acquired chemoresistance.
27 stance differs from that underlying acquired chemoresistance.
28 r the development of MDR-based predictors of chemoresistance.
29 en a high metabolically active phenotype and chemoresistance.
30 nd mechanistically control colorectal cancer chemoresistance.
31 emosensitive but then relapses with acquired chemoresistance.
32 utations are linked to tumor progression and chemoresistance.
33 of self-renewal, cell cycle quiescence, and chemoresistance.
34 ch correlates with poor overall survival and chemoresistance.
35 crophages was found to reverse their natural chemoresistance.
36 ith active Notch signaling, known to mediate chemoresistance.
37 rstudied phenomenon known as hypoxia-induced chemoresistance.
38 on that contributes to tumor maintenance and chemoresistance.
39 (AML) patient samples, indicating a role in chemoresistance.
40 hey drive tumor progression, metastasis, and chemoresistance.
41 sidered responsible for tumor initiation and chemoresistance.
42 t, is limited by its severe side effects and chemoresistance.
43 nt EMT and CSC functions, thereby conferring chemoresistance.
44 y in general, plays an important role in AML chemoresistance.
45 cells, thereby supporting tumour growth and chemoresistance.
46 henotype, as well as the rare progression to chemoresistance.
47 auses uncontrolled lethality, in part due to chemoresistance.
48 ctor T cells: they abrogate stromal-mediated chemoresistance.
49 but instead acutely secrete IL-6, promoting chemoresistance.
50 ggesting a novel mechanism to overcome tumor chemoresistance.
51 but that loss of HMGA2 did not give rise to chemoresistance.
52 OCC spheroids, as well as cell migration and chemoresistance.
53 roliferation, migration, transformation, and chemoresistance.
54 r in breast cancer patients who had acquired chemoresistance.
55 dual disease, underscoring their role in AML chemoresistance.
56 racteristic of melanoma progression and also chemoresistance.
57 ported that karyopherins are associated with chemoresistance.
58 uncovering new opportunities for addressing chemoresistance.
59 agents whose efficacy is often attenuated by chemoresistance.
60 ltiple overlapping effects that characterize chemoresistance.
61 ther MYCN or MYCL also conferred a switch to chemoresistance.
62 assembly of stress granules, an indicator of chemoresistance.
63 h little susceptible to transporter-mediated chemoresistance.
64 fied to be the key mechanism of SOX9-induced chemoresistance.
65 hieve a synergistic effect and a decrease in chemoresistance.
66 permits expression of ARE mRNAs that promote chemoresistance.
67 to promote synthetic lethality and overcome chemoresistance.
68 butor in pancreatic cancer tumorigenesis and chemoresistance.
69 expression of ARE-bearing mRNAs that promote chemoresistance.
70 ffecting downstream pathways involved in AML chemoresistance.
71 ize hPXR agonist-induced gene expression and chemoresistance.
72 that BEL could suppress hPXR agonist-induced chemoresistance.
73 , little is known about their impact on OvCa chemoresistance.
74 that are implicated in cancer metastasis and chemoresistance.
75 r secreted AA as important mediators of OvCa chemoresistance.
76 SOX9/2/17 are involved in MRP3-mediated CCA chemoresistance.
77 at secreted lipids mediate adipocyte-induced chemoresistance.
78 eta signaling to drive tumor progression and chemoresistance.
79 geting sCLU via miR-378 may help disable the chemoresistance against cisplatin in lung adenocarcinoma
80 ed repeated chemotherapy and correlates with chemoresistance, aggressiveness and poor prognosis in NS
81 a major role for cancer stem cells (CSC) in chemoresistance, although their involvement in acquired
82 ffluxion from liver cancer cells, leading to chemoresistance and a diminished chemotherapeutic effect
83 ple-negative breast cancer (TNBC) are due to chemoresistance and aggressive metastases, with high pre
84 C regulator as a prognostic marker of cancer chemoresistance and as a potential drug target for CSC t
87 dothelial cell crosstalk signaling in cancer chemoresistance and demonstrate the improved efficacy of
88 apeutic target to prevent and treat acquired chemoresistance and disease recurrence in OC and enhance
90 , anchorage independence, cell survival, and chemoresistance and efficiently inhibited tumorigenesis
91 ed gene expression associated with stemness, chemoresistance and epithelial-mesenchymal transition an
92 all-molecule modulator of miR-34a to reverse chemoresistance and further enhance the therapeutic effi
93 le for DNMT3A(R882) mutations in driving AML chemoresistance and highlight the importance of chromati
94 acute need to decipher mechanisms underlying chemoresistance and identify new targets to improve pati
95 y be a highly effective approach to overcome chemoresistance and improve the outcome of advanced BC.
96 challenging due to diverse genetic make-up, chemoresistance and inefficient drug transport across th
97 e, we investigated the role of ASC in cancer chemoresistance and invasiveness, the attributes of tumo
100 tivation of growth factor receptors leads to chemoresistance and limits the clinical impact of sorafe
101 expression correlated strongly with acquired chemoresistance and malignant behavior of OC cells, expr
103 128-3p) is key to concomitant development of chemoresistance and metastasis in residual NSCLC cells h
106 tumor cells may yield insights into clinical chemoresistance and potentially improve therapeutic outc
107 lesions, particularly those associated with chemoresistance and progression to highly aggressive for
108 te the mechanistic features of KRAS-mediated chemoresistance and provide a rationale for exploiting m
109 gs show that MYCN overexpression drives SCLC chemoresistance and provide a therapeutic strategy to re
110 docrine marker expression is associated with chemoresistance and reducing MYC levels decreases gemcit
114 lammation has a crucial role in induction of chemoresistance and results, in part, from the induction
115 tion of most chemotherapeutic drugs develops chemoresistance and severe systemic toxicities, herein w
116 f the proinflammatory cytokine IL-6 promotes chemoresistance and show that the chemotherapeutic doxor
118 is critical for glioblastoma initiation and chemoresistance and that inhibition of ID1 enhances the
119 are poor and have remained stagnant owing to chemoresistance and the high propensity to form lung met
121 M3A promotes ovarian CSCs, proliferation and chemoresistance and thus, highlights the significance of
122 thereby providing a new strategy to overcome chemoresistance and to improve the treatment and surviva
123 ve been suggested as a mechanism for driving chemoresistance and tumor recurrence in human cancers in
125 This study explores the role of PKM2 in chemoresistance and whether inhibiting PKM2 augments the
127 by virtue of its Y5 receptor (Y5R)-mediated chemoresistance and Y2 receptor (Y2R)-mediated prolifera
128 ce causes increased lung cancer development, chemoresistance, and complete resistance to anti-PD-1 an
130 gressive with extensive tissue infiltration, chemoresistance, and expressed genes related to epitheli
131 CLX downregulation drives metastatic spread, chemoresistance, and expression of epithelial-to-mesench
132 he drug efflux pump ABCB1 is a key driver of chemoresistance, and high expression predicts treatment
133 detail mechanisms that drive metastasis and chemoresistance, and highlights dysregulation of signali
134 decreases their ability to promote invasion, chemoresistance, and in vivo tumor growth, indicating th
135 fectors that induce metabolic reprogramming, chemoresistance, and invasiveness of retrodifferentiated
137 known to promote proliferation, metastasis, chemoresistance, and suppression of cytotoxic lymphocyte
139 of TAMs as tumor drivers and as mediators of chemoresistance, and the potential effectiveness of targ
140 ll proliferation, stem cell differentiation, chemoresistance, and tissue organization, the ubiquitous
141 oid formation, ALDH expression and activity, chemoresistance, and tumorigenesis in subcutaneous and i
143 ent epithelial-to-mesenchymal transition and chemoresistance, arguing strongly against the use of dru
144 c translesion synthesis (TLS) contributes to chemoresistance as well as treatment-induced mutations,
145 cts, we also found SOX9 to mediate cisplatin chemoresistance associated with reduced disease-free sur
146 -transitioned prostate cancer, abrogated the chemoresistance both in cell culture and in animal model
148 requires neutralization of self-renewal and chemoresistance, but these phenotypes are often regulate
149 e may represent a unique model to understand chemoresistance, but to our knowledge, the phenotypic an
150 presses ovarian cancer apoptosis and confers chemoresistance by binding to its direct novel target, A
152 ler, lysyl oxidase (LOX) as a key inducer of chemoresistance by developing chemoresistant TNBC tumors
153 data propose a mechanism where CD82 promotes chemoresistance by increasing PKCalpha activation and do
154 y, therapy-induced senescence contributes to chemoresistance by inducing cancer stem-like cells (CSC)
155 o chemotherapy suppressed the acquisition of chemoresistance by perturbing the nuclear translocation
156 ibroblasts played the most important role in chemoresistance by upregulating C-X-C motif chemokine re
157 itaxel often fails due to the development of chemoresistance caused by downregulation of the tumor su
159 i combination to suppress stemness-dependent chemoresistance development in xenotransplantation model
161 self-renewal, tumorigenicity, pluripotency, chemoresistance, differentiation, invasive ability, and
162 suggests that the genetic basis for initial chemoresistance differs from that underlying acquired ch
163 MB (SHH-MB), but their repeated use develops chemoresistance due to mutations in smoothened (SMO).
164 found that loss of miR-424(322)/503 promotes chemoresistance due to the up-regulation of two of its t
167 xhibited elevated expression of stemness and chemoresistance genes and demonstrated increased clonoge
170 tanding of the driving mechanisms underlying chemoresistance hinders the development of effective the
172 ome profiling of multiple cellular models of chemoresistance identified unique sets of distal enhance
173 red metabolism, neoplasticity, invasiveness, chemoresistance, immune evasion, and ultimately to poor
175 a-catenin, which regulated ARC and augmented chemoresistance in AML cells; inhibition of beta-catenin
176 croenvironment and microenvironment-mediated chemoresistance in AML.Significance: The antiapoptotic p
184 h genomic instability, clonal evolution, and chemoresistance in chronic lymphocytic leukemia (CLL).
185 r and that its downregulation contributes to chemoresistance in esophageal cancer cells by targeting
189 gest that decreases in MAF1 protein underlie chemoresistance in HCC and perhaps other cancers and poi
191 autophagy plays a role in the development of chemoresistance in HNSCC and how autophagy is initiated
198 ore effective treatments that can circumvent chemoresistance in Multiple Myeloma (MM) is a priority.
199 , but its contributions to tumorigenesis and chemoresistance in nasopharyngeal carcinoma (NPC) are no
200 r SOX9 is an important regulator of acquired chemoresistance in non-small-cell lung cancer (NSCLC).
202 (EMT) has been linked to the development of chemoresistance in other cancers, yet little is known re
203 cancer-associated fibroblasts (CAFs) confer chemoresistance in ovarian cancer is poorly understood.
206 igated the contribution of gut microbiota to chemoresistance in patients with colorectal cancer.
207 factors and molecular mechanisms involved in chemoresistance in patients with esophageal squamous cel
210 with cisplatin and effectively reverses NAC-chemoresistance in PDXs from NAC-resistant breast cancer
211 long with chemotherapy substantially reduces chemoresistance in primary leukemic cells ex vivo and in
214 s with stromal cells increased autophagy and chemoresistance in the AML cells exposed to chemotherape
218 sphere-forming potential, cell motility, and chemoresistance in vitro, and was sufficient to attenuat
222 with colorectal cancer (CRC) proliferation, chemoresistance, inflammation, metastasis, and now DNA d
224 ism by which NF-kappaB and Akt contribute to chemoresistance involving a signaling pathway consisting
227 ently used chemotherapy for glioma; however, chemoresistance is a major problem limiting its effectiv
228 mall molecules that can overcome dox-induced chemoresistance is a promising strategy in cancer therap
229 lso demonstrate that this co-culture-induced chemoresistance is abrogated by inhibition of the CXCR4
237 in tumor initiation, growth, metastasis, and chemoresistance is well recognized and is encouraging th
241 vide insight into the MDSC exosomal-mediated chemoresistance mechanism, which will be useful for the
244 progress in understanding the niche-imposed chemoresistance mechanisms will likely contribute to the
247 cular mechanism of prostate cancer docetaxel chemoresistance mediated by the mammalian target of rapa
248 erium nucleatum as a previously unrecognized chemoresistance mediator in colorectal cancer, thereby e
249 n in children, could be repurposed to reduce chemoresistance, migration and invasion in paediatric ep
250 they might improve safety and delay onset of chemoresistance, no anti-ligand antibodies have been cli
253 ppression of EZH2 protein expression induced chemoresistance of AML cell lines and primary cells in v
254 de evidence that chemotherapy itself induces chemoresistance of bone metastases, mediated by osteobla
256 tigated the contribution of CSCs to acquired chemoresistance of breast cancer and the avenues for rev
260 luence of non-neoplastic cells and matrix on chemoresistance of GBM cells to three agents with differ
263 miR-128-3p potently reverses metastasis and chemoresistance of highly malignant NSCLC cells, which c
267 that TAM and myofibroblasts directly support chemoresistance of pancreatic cancer cells by secreting
269 in CD44 and CXCR4 expression, which mediate chemoresistance often observed after multicycle chemothe
271 or as these tumors often display generalized chemoresistance, particularly for carcinomas that derive
272 blem is compounded by near-universal primary chemoresistance; patients with advanced stage OCCC thus
274 udy was to identify analytical challenges in chemoresistance-predictor development and suggest ways t
276 espite thousands of publications on putative chemoresistance predictors, there are only about a dozen
280 s Nrf2 is strongly associated with aging and chemoresistance, these findings will provide a novel app
282 and functional interaction between PD-L1 and chemoresistance through the microRNA regulatory cascade.
283 aclitaxel to overcome the drug effluxion and chemoresistance thus, synergistically treating HCC.
285 hese findings suggest that ADAM12-L mediates chemoresistance to 5-FU and 5-FU-induced recurrence of B
288 linical use of a predictor of ovarian cancer chemoresistance to its frontline therapy is presented.
289 the PDK4 inhibitor dichloroacetate reversed chemoresistance to sorafenib or cisplatin in HCC stem ce
291 CXCR4) and hedgehog pathways cooperate in PC chemoresistance via bidirectional tumor-stromal crosstal
293 ent cells decreased leukemic cell growth and chemoresistance via downregulation of prosurvival factor
296 r MYCN amplification in SCLC progression and chemoresistance, we developed a genetically engineered m
297 anced cell invasion, PD-L1 upregulation, and chemoresistance, were sustained in the absence of contin
298 toration of miR-424(322) expression reverses chemoresistance, which is accompanied by blockage of the
299 fferentiation, metastatic dissemination, and chemoresistance, which is associated with elevated TGF-b
300 ING-less BRCA1 was shown to directly mediate chemoresistance, while maintaining some homologous recom