ライフサイエンスコーパス: chemoselectivity

1 yields with essentially complete regio- and chemoselectivity.

2 lymerization processes and the origin of the chemoselectivity.

3 with good efficiency and complete regio- and chemoselectivity.

4 l of regio-, stereo-, and, where applicable, chemoselectivity.

5 ium catalyst produces kinetically controlled chemoselectivity.

6 ssential in terms of reaction efficiency and chemoselectivity.

7 up to 99% enantiomeric excess) and excellent chemoselectivity.

8 sions, high preparative yields and excellent chemoselectivity.

9 splaying fast kinetics, high yield, and good chemoselectivity.

10 l reaction that proceeds with high yield and chemoselectivity.

11 The system shows moderate chemoselectivity.

12 lsulfoxide (DMSO) ligand in controlling this chemoselectivity.

13 yridines with exquisite site selectivity and chemoselectivity.

14 tep as well as obtain the correct regio- and chemoselectivity.

15 hanges in reaction conditions markedly alter chemoselectivity.

16 cts with high levels of stereo-, regio-, and chemoselectivity.

17 40-60% conversion with excellent tryptophan chemoselectivity.

18 ere labeled with OND electrophiles with high chemoselectivity.

19 -based catalyst systems displayed orthogonal chemoselectivity.

20 nto the controlling features of the observed chemoselectivity.

21 the corresponding aldehydes with remarkable chemoselectivity.

22 c coupling of the 2-naphthol with remarkable chemoselectivity.

23 inoalcohols had lower rate constants or less chemoselectivity.

24 TMS(2)NLi) displays highly solvent-dependent chemoselectivity.

25 group efficiency (OMe vs OPh) modulates the chemoselectivity.

26 up of ascorbic acid with complete regio- and chemoselectivity.

27 osed to play a role in the solvent-dependent chemoselectivity.

28 erically differentiated substrates with high chemoselectivity.

29 c amines were formed in excellent yields and chemoselectivity.

30 radicals which add to olefins with exclusive chemoselectivity.

31 roceeds with excellent stereospecificity and chemoselectivity.

32 scalable, offers broad substrate scope, high chemoselectivity.

33 lyaromatic N-heteroarenes exhibited uncommon chemoselectivity.

34 ding opportunities to increase both rate and chemoselectivity.

35 00 h(-1), a 99:1 enantiomeric ratio and 100% chemoselectivity.

36 substituents determine the overall reaction chemoselectivity.

37 vicinal diamines in a single step, with high chemoselectivity.

38 to the desired vicinal dichlorides with high chemoselectivity.

39 mechanism and the rationale for this unusual chemoselectivity.

40 carbon bonds under mild conditions with high chemoselectivity.

41 fice the high claim to stereoselectivity and chemoselectivity.

42 trate scope, operational simplicity and high chemoselectivity.

43 ons featuring increased regio-, stereo-, and chemoselectivities.

44 excellent enantio-, diastereo-, regio-, and chemoselectivities.

45 h moderate to excellent conversion rates and chemoselectivities.

46 h a process raises the problem of regio- and chemoselectivity, a challenging goal even more difficult

47 Investigations on scope, limitations, chemoselectivities and stereoselectivities regarding an

48 discovered cascade reaction showed excellent chemoselectivity and a wide substrate scope for both oxy

49 se under-utilized amino acids with excellent chemoselectivity and affords good-to-high yields using l

50 The reactions exhibit high levels of chemoselectivity and broad functional-group tolerance, a

51 quantitative chemical yield with remarkable chemoselectivity and diastereoselectivity.

52 nulation processes, in which aspects such as chemoselectivity and diversity generation at the ring-cl

53 ligand, solvent, and temperature on both the chemoselectivity and ee value were explored.

54 Significant advances in the chemoselectivity and enantioselectivity of [2+2] photocy

55 e catalyst, which controls regioselectivity, chemoselectivity and enantioselectivity, with a fluoroph

56 ylation that proceeds with broad reactivity, chemoselectivity and enantioselectivity.

57 he cathode and the anode was key to ensuring chemoselectivity and high deuterium incorporation under

58 ntaining peptides and proteins with complete chemoselectivity and high n/i regioselectivity.

59 s under ambient conditions exhibits complete chemoselectivity and high stereoselectivity, thus produc

60 on of allylic alcohols is effected with high chemoselectivity and is tolerant of a wide range of func

61 of the PCO/POC-isomers proceeds with a high chemoselectivity and leads to the formation of P(IV)-dio

62 However, the combination of high substrate chemoselectivity and low substrate stereoselectivity is

63 The chemoselectivity and mild nature of this platform is sho

64 wide array of substrates, demonstrating the chemoselectivity and mildness of this simple reaction.

65 list of ancillary considerations to mitigate chemoselectivity and oxidation state issues involving pr

66 s and drug molecules demonstrates remarkable chemoselectivity and predictable regioselectivity.

67 izations, which proceed with noteworthy high chemoselectivity and provide an overall access to struct

68 The observed chemoselectivity and regioselectivity are explained via

69 hat the prepared Pt(1)/N-C exhibits superior chemoselectivity and regioselectivity in hydrogenation.

70 th excellent functional group compatibility, chemoselectivity and regioselectivity.

71 ored in a mechanistic study to ascertain the chemoselectivity and stereospecificity.

72 The boron influences both the chemoselectivity and the regioselectivity of this reacti

73 ones generally in high yields with excellent chemoselectivity and very good functional group toleranc

74 d many other reactions that offer orthogonal chemoselectivity and/or regioselectivity patterns to pro

75 tion), the ratio of 3 to the sum of (4 + 5) (chemoselectivity), and the ratio of 4 to 5 (diastereosel

76 to commercial availability of reagents, high chemoselectivity, and a pressure on delivery.

77 nd styrenes with exclusive regioselectivity, chemoselectivity, and E-stereoselectivity.

78 applied to address challenges of reactivity, chemoselectivity, and enantioselectivity.

79 nzylic C-O bonds with high site selectivity, chemoselectivity, and functional-group tolerance using o

80 igh concentrations of ammonium ion, the high chemoselectivity, and the high enantioselectivity (99.5%

81 A primary reason for this imperfect chemoselectivity appears to be the slow chain extension

82 polyfunctional substrate, unique profiles in chemoselectivity are exhibited by the metal-free approac

83 is reaction is that it exhibits a remarkable chemoselectivity, as acid and ketone functionalities are

84 talytic Staudinger reduction exhibits a high chemoselectivity, as exemplified by reduction of azides

85 r, is essential for achieving the unexpected chemoselectivity between arene dearomatization and benzy

86 NaB(OAc)3H that not only achieves excellent chemoselectivity but also avoids formation of the undesi

87 tric constraint to iORC substrates, both the chemoselectivity (C7 vs N1 cyclization) and the stereose

88 f such stabilizing interactions, established chemoselectivities can be overthrown.

89 High chemoselectivity can be achieved with epichlorohydrin an

90 g reagent or method of addition of reagents, chemoselectivity can be controlled toward either oxazole

91 The chemoselectivity can be easily switched by the selection

92 This high chemoselectivity can be governed by the use of different

93 ty, including substrate, stereo-, regio- and chemoselectivity, can be markedly affected, and sometime

94 A fundamental chemoselectivity challenge that remains intrinsically un

95 ing genetically encoded catalysts to address chemoselectivity challenges.

96 The method allows good chemoselectivity control and shows good functional group

97 A chemoselectivity-controllable two-stage process enables

98 The broad substrates scope and high chemoselectivity could make this method attractive for s

99 The chemoselectivity could not be improved through kinetic c

100 Enzymatic chemoselectivity (Cys vs Ser cyclization rates) was asse

101 he mechanisms and origins of this switchable chemoselectivity, density functional theory (DFT) calcul

102 ond functionalization at a single site, with chemoselectivity derived from the properties of the cata

103 to an allyl group have been investigated for chemoselectivity, diastereoselectivity, and enantioselec

104 This chemoselectivity difference is explored by means of mole

105 observe a protecting group dependency in the chemoselectivity displayed by the dioxirane 1b.

106 Birch-type reductions suffer from a lack of chemoselectivity due to a reliance on alkali metals or h

107 erocyclic carbene ligands provide orthogonal chemoselectivity during the Pd-catalyzed Suzuki-Miyaura

108 This observed bimetallic chemoselectivity effect follows the same general trend a

109 ty, substrate selectivity, regioselectivity, chemoselectivity, enantioselectivity and catalysis at am

110 Catalytic antibodies have been shown to have chemoselectivity, enantioselectivity, large rate acceler

111 Common problems of regio- and chemoselectivity encountered in the kalihinol class are

112 The reaction demonstrates extraordinary chemoselectivity-even di- and trisubstituted alkenes suc

113 meric (exo/endo) photoproducts with complete chemoselectivity (exclusive [2 + 2] photoproduct).

114 Both reaction pathways proceed with high chemoselectivity, exhibit excellent functional group tol

115 e method was discovered by comparison of the chemoselectivities exhibited by complexes 1a, 1b, 2, and

116 Uniformly, the catalyst showcases high chemoselectivity favoring C-H bonds with lower bond diss

117 A tridentate pybox ligand governs the chemoselectivity favoring C-N bond formation, and overri

118 tuted aldehydes, giving high conversions and chemoselectivities for a wide variety of substrates.

119 The observed experimental chemoselectivity for ArCl was found to be inconsistent w

120 nantiomeric 3 degrees centers, displays high chemoselectivity for benzylic oxidation, and enables the

121 proved crucial for achieving high rates and chemoselectivity for C-C bond formation over beta-H elim

122 The chemoselectivity for C-H bond amination is greater than

123 unctionalities is displayed, with remarkable chemoselectivity for either group being possible in this

124 These reactions occur with chemoselectivity for insertion of the nitrene units into

125 The transformation exhibits unique chemoselectivity for isoindonlines.

126 ~52%, turnover numbers of 100, and improved chemoselectivity for monoborylated versus diborylated me

127 favor monoborylated products, it has a high chemoselectivity for monoborylation (CH(3) Bpin:CH(2) (B

128 The possibility of enhanced chemoselectivity for simultaneous separation of ephedrin

129 using aryl halides, strategies that provide chemoselectivity for systems bearing multiple carbon-hal

130 es a rapid and straightforward prediction of chemoselectivity for systems involved in halofunctionali

131 of these reactions have been limited by low chemoselectivity for the amination of C-H bonds over com

132 Pd(DMSO)2(TFA)2 is unique in its high chemoselectivity for the conversion of cyclohexanones to

133 cid serves as a key additive to achieve high chemoselectivity for the formal [4+2] annulation product

134 The chemoselectivity for the formation of carboxylic acid ra

135 enzylidene functionality, but there was poor chemoselectivity for the reduction of the thioacetal in

136 tion shows a broad substrate scope with high chemoselectivity for the synthesis of 8-benzyl quinoline

137 h acylation reactions display high and broad chemoselectivity for the target group.

138 nal propeptide of substrate 88mer, and (2) a chemoselectivity for thiazole over oxazole formation.

139 h the regioselectivity from C5 to C4 and the chemoselectivity from hydroxylation to chlorination.

140 This transformation represents different chemoselectivity from previous reports that demonstrated

141 mplex substrates and exhibits high levels of chemoselectivity (functional group tolerability), regios

142 This excellent chemoselectivity gives zinc- and magnesium-organometalli

143 ong acid/base-free reaction conditions, high chemoselectivity has also been observed.

144 A key role played by ammonium acetate in chemoselectivity has been examined.

145 Moreover, a very interesting chemoselectivity has been observed depending on the natu

146 in insight into the factors that control the chemoselectivity (i.e., acylation vs alpha-arylation rea

147 Computation has also revealed the origin of chemoselectivity in (5 + 2) cycloadditions with allene-y

148 ds quickly (k ~ 1 M(-1) s(-1)) and with high chemoselectivity in an aqueous environment.

149 The mediated system shows excellent chemoselectivity in bulk oxidations of 2-propanol and 1,

150 s a quantitative basis for understanding the chemoselectivity in competitive PCET activations of amid

151 ver, this methodology demonstrated excellent chemoselectivity in formation of only the corresponding

152 ionalized cyanoesters in excellent yield and chemoselectivity in good to excellent diastereoselectivi

153 owing achievement of complete control of the chemoselectivity in reactions of the beta-arylmethyl der

154 rium-mediated redistribution at silicon, and chemoselectivity in sigma-bond metathesis reactions, are

155 d spectroscopic analysis of alkyne-dependent chemoselectivity in the copper-catalyzed azide-alkyne cl

156 alcohol was required to provide the desired chemoselectivity in the elimination of HX.

157 A distinct chemoselectivity in the gold-catalyzed oxidative cycliza

158 An exploration into the origin of chemoselectivity in the NHC-catalyzed cross-benzoin reac

159 Additionally, the DCCP exhibits remarkable chemoselectivity in the presence of aryl chloride substr

160 ulfenate anion arylation exhibited excellent chemoselectivity in the presence of functional groups, s

161 intramolecularly, while displaying excellent chemoselectivity in the presence of pi functionality.

162 Additionally, the DCCP exhibits remarkable chemoselectivity in the presence of substrates that are

163 NH/HSi cross-dehydrocoupling, with excellent chemoselectivity in the reaction of (di)amines with (di)

164 ut to be important in order to ensure a high chemoselectivity in the reaction.

165 This process allows unprecedented chemoselectivity in the reduction of cyclic esters using

166 n state palladium chemistry, we examined the chemoselectivity in the reductive elimination of a dinuc

167 esented as a strategy to achieve nucleophile chemoselectivity in the Suzuki-Miyaura reaction.

168 iverse demonstration of synthetically useful chemoselectivity in the synthesis of di-, tri-, and tetr

169 Chemoselectivity in these reactions is thought to arise

170 sought to elucidate the factors that control chemoselectivity in these reactions.

171 selective manipulation of functional groups (chemoselectivity) in organic synthesis have historically

172 ant cells may be an example of gene deletion chemoselectivity, in which genetic deletions that occur

173 ligation/migratory insertion event allowing chemoselectivity independent of overall rate.

174 Chemoselectivity is a cornerstone of catalysis, permitti

175 Complete chemoselectivity is achievable.

176 Chemoselectivity is an important issue frequently encoun

177 The altered chemoselectivity is attributed to a prior enyne cyclizat

178 the ones obtained with heme enzymes, but the chemoselectivity is lesser affected by external perturba

179 controlled conditions reveal that this high chemoselectivity is not accompanied by a loss of catalyt

180 Catalyst-controlled chemoselectivity is observed for C(acyl)-O bond activati

181 Chemoselectivity is observed, whereby Zr(IV) and Hf(IV)

182 id, and lysine demonstrated that significant chemoselectivity is present in this reaction.

183 A mechanistic rationale for the observed chemoselectivity is provided.

184 The chemoselectivity is reversed for [4 + 2]-cycloadditions,

185 A critical requirement for the high chemoselectivity is the use of donor/acceptor-substitute

186 ic reaction, explaining also the stereo- and chemoselectivity, is provided by means of DFT calculatio

187 upport provides a mechanism to alleviate the chemoselectivity issues and provide products in high pur

188 on for the preparation of polyynes; however, chemoselectivity issues have precluded its widespread ut

189 alyst design approach was adopted to address chemoselectivity issues in the oxidative coupling of phe

190 Alkylidenecarbene insertion chemoselectivity issues were explored en route to the fi

191 material, mild reaction conditions, and high chemoselectivity), keeping the focus on molecules that w

192 selectivity, enantioselectivity, and product chemoselectivity make asymmetric C-H oxidation a general

193 The key problems are a lack of chemoselectivity-namely, the preponderance of side react

194 C-H bonds with the pi-bond would explain the chemoselectivity observed for cyclic substrates.

195 The high chemoselectivity observed is a result of greater electro

196 The reactivities and chemoselectivities of sodium diisopropylamide (NaDA) in

197 e reaction takes advantage of the pronounced chemoselectivity of a recently reported ruthenium-based

198 that produce a snapshot of the instantaneous chemoselectivity of a single catalyst for either a singl

199 tuning of reaction conditions to control the chemoselectivity of Ar-Ar' coupling.

200 of precise potential control to optimize the chemoselectivity of challenging substrates.

201 these reactions and provide insight into the chemoselectivity of cross-benzoin reactions.

202 The chemoselectivity of diazo and alkynyl groups enables dua

203 s have been reduced, highlighting the unique chemoselectivity of diimide as a reduction system.

204 By studying the regio- and chemoselectivity of fluoro-substituted thienothiophene a

205 By combining the high cysteine chemoselectivity of hypervalent iodine-based ethynylbenz

206 In addition, these studies shed light on the chemoselectivity of insertion, suggesting that the alken

207 In particular, the ability to control the chemoselectivity of intermolecular reactions in the pres

208 The chemoselectivity of molecular catalysts underpins much o

209 re carried out to understand the distinctive chemoselectivity of N-alkylation and C-alkylation of unp

210 lization and reductive amination secured the chemoselectivity of N-methylation, leading to pseudoakua

211 ble site-selectivity, stereoselectivity, and chemoselectivity of NzeB, we obtained high-resolution cr

212 plore the mechanism for the observed unusual chemoselectivity of pnGFP toward peroxynitrite over hydr

213 The practicality and chemoselectivity of radical reactions enable rapid acces

214 Another indication is obtained from the chemoselectivity of the catalyses.

215 hindrance of the enyne greatly affected the chemoselectivity of the cycloaddition of enynes and alde

216 tional analyses to provide insights into the chemoselectivity of the diazo group in 1,3-dipolar cyclo

217 OH) ratio, which is determined by the unique chemoselectivity of the La-X (X = OR, NR2, R) group.

218 atmospheric oxidants attack), and hence the chemoselectivity of the PAHs.

219 e ligands, have been selected to control the chemoselectivity of the process, allowing a 6-exo-carbop

220 The excellent chemoselectivity of the process, where only monoalkylati

221 The wide substrate scope highlights the chemoselectivity of the process.

222 These conditions retain the high chemoselectivity of the reaction and do not lead to a su

223 Exceptionally high chemoselectivity of the reactions (no side-formation of

224 eC bond and at the iminic carbon atom on the chemoselectivity of the reduction was studied.

225 (pLys)-containing peptides by employing the chemoselectivity of the Staudinger-phosphite reaction.

226 The chemoselectivity of these complicated transformations ca

227 Additives have a profound impact on the chemoselectivity of these reductive elimination reaction

228 Furthermore, the exceptional chemoselectivity of this catalyst system enables industr

229 The high chemoselectivity of this process was demonstrated and as

230 ds could be achieved, demonstrating the high chemoselectivity of this process.

231 The unique chemoselectivity of this reaction is attributed to the c

232 The regio- and chemoselectivity of this reaction is discussed and evide

233 The chemoselectivity of unsymmetrical diaryliodonium salts h

234 electivity, modification yield, and reaction chemoselectivity of vinyl sulfonamide 4 are good enough

235 The high reactivities and chemoselectivities often complement those of LDA-THF.

236 be performed on a gram scale without loss of chemoselectivity or enantioselectivity.

237 i then C-Si, or C-H then C-H auration); this chemoselectivity originates from differences in the prod

238 esis--including site-selectivity, regio- and chemoselectivity, orthogonal reactivity, coupling reacti

239 ith excellent functional-group tolerance and chemoselectivity over aryl and vinyl C-X bonds.

240 of cyclic alpha-diazocarbonyl compounds with chemoselectivity over beta-hydride elimination are descr

241 ted 3,4-dihydroisoquinolines (DHIQs) in high chemoselectivity over competing annulation processes, ex

242 with high to excellent yields and with good chemoselectivities (over N-alkylation).

243 ates under mild conditions with an excellent chemoselectivity profile and a divergent syn/anti select

244 arkable selectivity pattern and an excellent chemoselectivity profile using air-, moisture-insensitiv

245 arrangement shows a wide substrate scope and chemoselectivity profile while exhibiting an excellent [

246 high enantioselectivities and possess unique chemoselectivity profiles.

247 , exhibits a broad substrate scope with high chemoselectivity, providing effective access to valuable

248 The most studied solutions for switching the chemoselectivity rely on the catalyst, ligand, additive,

249 vity of catalytic reactions, but controlling chemoselectivity remains challenging.

250 Chemoselectivity, scalability, and recyclability of reag

251 ions revealed this unusual enzyme-controlled chemoselectivity stems from the restricted conformation

252 scussed, highlighting factors such as yield, chemoselectivity, stereoselectivity, or the importance o

253 xin substrate but displays distinct and dual chemoselectivity, suggesting this E. coli pertussis-like

254 -1,3-thiazine 7 with high chemical yield and chemoselectivity, suppressing the common byproduct of ox

255 ition reaction is characterized by excellent chemoselectivity, taking place only at conjugated and un

256 The reaction displays different chemoselectivity than conventional cross-coupling reacti

257 Streptomyces hygroscopicus, shows a broader chemoselectivity than the corresponding amide synthase p

258 his design yields QD platforms with distinct chemoselectivities that are greatly promising for use as

259 or Paterno-Buchi (PB) photoreaction, with a chemoselectivity that was clearly dependent on the natur

260 aliphatic C(sp(3))-H bonds while displaying chemoselectivity (that is, tolerance of more oxidizable

261 he reactants also end up in the product) and chemoselectivity (the use of reactions that take place o

262 itial steps in the catalytic cycle, reaction chemoselectivity, the nature of the active oxidant, and

263 In addition to excellent chemoselectivity, the reaction is stereospecific.

264 Because of high chemoselectivity, this approach is useful for the organi

265 fers precise redox control to achieve unique chemoselectivity, this approach often becomes challengin

266 High chemoselectivity through substrate directivity is demons

267 Now, this work reverses this conventional chemoselectivity to enable the first ring-opening polyme

268 suspensions proceed with high efficiency and chemoselectivity to generate 4,4'-dimethoxy-dicumene 2OM

269 finely tuned and quantitatively predictable chemoselectivity to host-guest chemistry in water.

270 ethod described is relatively mild, exhibits chemoselectivity to other electrophiles present, avoids

271 le for modifying their outer pores to impart chemoselectivity to the uptake of similarly sized guests

272 dehyde carbon-hydrogen (C-H) bonds with high chemoselectivity to trigger carbon-carbon (C-C) bond cle

273 Very high chemoselectivity toward addition of primary and secondar

274 e readily available Shvo catalyst, excellent chemoselectivity toward alpha- and beta-protons with res

275 (3) and with TMSI generally gave the highest chemoselectivity toward ArN(3) and ArI formation.

276 e catalytic method showed exceptionally high chemoselectivity toward the carbonyl reduction over alke

277 ganic transformations and offering excellent chemoselectivities under mild reaction conditions.

278 g force relationships jointly determine PCET chemoselectivity under a given set of conditions.

279 ols were obtained in 29-97% yields with high chemoselectivity under mild conditions.

280 o-quinone methide intermediates with precise chemoselectivity under mild, aqueous conditions.

281 th broad functional group tolerance and high chemoselectivity under milder reaction conditions.

282 tioselectivities (K(R)/K(S)) of up to 550:1, chemoselectivity up to 11,000:1, and sensitivities in th

283 lyst Mn(CF(3)-PDP) system that achieves such chemoselectivity via an unexpected synergy of catalyst d

284 The N-oxide exerted complete chemoselectivity via chelation in directing the Grignard

285 The amination chemoselectivity was examined using substrates featuring

286 zed for the polymerization of LA, remarkable chemoselectivity was observed.

287 In all cases, complete chemoselectivity was observed; only dihydropyrans where

288 Insight into the origin of chemoselectivity was obtained through a detailed mechani

289 a number of positive attributes such as good chemoselectivity, water compatibility, high-yield under

290 ures of this reaction related to stereo- and chemoselectivities were uncovered.

291 chanism and origins of stereospecificity and chemoselectivity were explored with density functional t

292 us metal catalysts, however, suffer from low chemoselectivity when one or more reducible groups are p

293 or-substituted carbenoids display remarkable chemoselectivity, which allows for highly regioselective

294 functionalities and displays a high level of chemoselectivity, which is not generally explained by th

295 1a exhibited excellent chemoselectivity with alcohols containing internal carbo

296 The chemoselectivity with bidentate phosphine ligands can be

297 achieved by combining kinetic or mechanistic chemoselectivity with click reactions between the monome

298 f sodium iodide to the reaction improved the chemoselectivity with the electron-deficient aryl bromid

299 O(2)-mediated reaction pathway features high chemoselectivity without poisoning the surface.

300 (DC) addresses the long-standing obstacle of chemoselectivity, yet it also expands the parameter set