ライフサイエンスコーパス: chicoric acid

1 atalysis in vitro, and cross-resistance to l-chicoric acid.

2 nge was sufficient to confer resistance to L-chicoric acid.

3 ed neutral, nonhydrolyzable analogues of the chicoric acids.

4 dertaken to examine structural features of L-chicoric acid (3) which are important for potency agains

5 llowed by luteolin (46.5-345.4 mg/100 g DW), chicoric acid (36.3-212.5 mg/100 g DW), coumarin (65.7-1

6 analogues, it was shown that enantiomeric D-chicoric acid (4) retains inhibitory potency against pur

7 All mutant HIVs were resistant to l-chicoric acid, a dicaffeoyltartaric acid IN inhibitor, b

8 In this study, 17 analogues of L-chicoric acid, a potent inhibitor of HIV integrase, were

9 structed from energy-minimized structures of chicoric acid and dicaffeoylquinic acid.

10 In CEM cells, for both the parent chicoric acid and selected analogues, antiviral activity

11 st HIV-1- and HIV-2-infected MT-4 cells, the chicoric acids and their tetraacetylated esters exhibite

12 fied acyltransferases, we have reconstituted chicoric acid biosynthesis in tobacco.

13 a species suggesting convergent evolution of chicoric acid biosynthesis.

14 potent compounds were D-chicoric acid, meso-chicoric acid, bis(3,4-dihydroxydihydrocinnamoyl)-L-tart

15 ications but no such differences observed in chicoric acid content or PAL activity.

16 The charged nature of the chicoric acids contributes to poor cellular uptake, and

17 y related IN inhibitor, the tetra-acetylated-chicoric acid derivative (2R,3R)-2,3-bis[[(2E)-3-[3,4-bi

18 , potent antiviral IN inhibitors such as the chicoric acids do not act upon the intended enzymatic ta

19 ted in target and cell-based assays that the chicoric acids do not significantly inhibit other target

20 e presence of increasing concentrations of L-chicoric acid, HIV-1 was completely resistant to the com

21 inacea, exemplified by the natural product d-chicoric acid (I1) is disclosed.

22 aftaric acid as its acyl acceptor to produce chicoric acid in vacuoles, which has evolved its acyl do

23 thoxyoxalyl-3,5-dicaffeoylquinic acid, and L-chicoric acid, inhibit HIV-1 integrase in biochemical as

24 previous biochemical studies showing that L-chicoric acid inhibits integrase and that the drug is li

25 L-Chicoric acid is an inhibitor of human immunodeficiency

26 Its major bioactive compound, chicoric acid, is reported to have various potential phy

27 ive compounds, including (-)-epicatechin and chicoric acid isomers, were identified in peels, while s

28 d derivates and one digalloylderivative of L-chicoric acid (L-CA) showed improved selectivity over L-

29 of the anti-HIV-1 integrase (IN) inhibitor L-chicoric acid (L-CA) were prepared.

30 cid was higher in S(Ca) and S(Mg) plants and chicoric acid levels were S(Mg) > S(Ca) > S(K).

31 The most potent compounds were D-chicoric acid, meso-chicoric acid, bis(3,4-dihydroxydihy

32 y correlated to TPC (r = 0.57) as well as to chicoric acid (r = 0.73).

33 A detailed evaluation of chicoric acid's mechanism of inhibition reveals that the

34 id change at position 140 into the native, L-chicoric acid-sensitive virus demonstrated that this cha

35 study also examined the reported ability of chicoric acid to exert cytoprotective effects in HIV-inf

36 verse phytochemical substances such as EGCG, chicoric acid, tomatidine, and others, all of which have