ライフサイエンスコーパス: chimaera

1 cidia sequence is a basidiomycete/heterokont chimaera).

2 vices used in cardiac surgery (Mycobacterium chimaera).

3 ed species (such as M. intracellulare and M. chimaera).

4 rosslinking and activation of a CD69-CD3zeta chimaera.

5 al and histopathologic ocular findings of M. chimaera.

6 s against M tuberculosis, M abscessus, and M chimaera.

7 lt in new, targeted treatment regimens for M chimaera.

8 mean MIC of 2.22 muM (0.80 mug/mL) against M chimaera.

9 that inhibit the newly recognised pathogen M chimaera.

10 romycin, ethambutol, and rifabutin against M chimaera.

11 cell (ESC) inoculum contributes to the adult chimaera.

12 18% were M. intracellulare, and 28% were M. chimaera.

13 criteria for infection than patients with M. chimaera.

14 obacterium intracellulare, and Mycobacterium chimaera.

15 tracellulare and 4 (7.4%) were Mycobacterium chimaera.

16 e full development when combined together in chimaeras.

17 eage differentiation both in fetal and adult chimaeras.

18 how compromised development when combined in chimaeras.

19 cter, including multilineage contribution to chimaeras.

20 from a field population readily mix to form chimaeras.

21 ral T cells are present in all older FADD-/- chimaeras.

22 opulations were apparently normal in newborn chimaeras.

23 modules are described for the paired fins of chimaeras.

24 ation epiblast and efficiently contribute to chimaeras.

25 gase, followed by sequencing to identify the chimaeras.

26 ,041 chondrichthyan fishes-sharks, rays, and chimaeras.

27 uting to traditional germline and tetraploid chimaeras.

28 e competent for multilineage colonisation of chimaeras.

29 erentiated progeny to all foetal lineages of chimaeras.

30 tribute to somatic tissues and germ cells in chimaeras.

31 peutic approaches such as lysosome-targeting chimaeras(1,2) (LYTACs) and cytokine receptor-targeting

32 s with vesicular stomatitis virus/SARS-CoV-2 chimaeras(5), here we show that multiple neutralizing ep

33 st, 30 (73%) household water samples were M. chimaera, 8 (20%) were other MAC X species (i.e., isolat

34 th disseminated infection with Mycobacterium chimaera, a slow-growing nontuberculous mycobacterium (N

35 In the chimaeras, activation resembled that of mu1, fast inacti

36 nse, M. mucogenicum and M. phocaicum, and M. chimaera and M. intracellulare.

37 Mycobacterium chimaera and other pathogens were recovered from water a

38 ul in corroborating a diagnosis of ocular M. chimaera and particularly in evaluating patient response

39 (mean MIC 3.13 mug/mL) were active against M chimaera and that bedaquiline was the most potent compou

40 Many methods for generating both chimaeras and a range of markers for tracing their linea

41 Rs by the creation of retroviral bone marrow chimaeras and a TCR transgenic line revealed that microb

42 rtoire and utility of mammalian interspecies chimaeras and carved out new paths towards understanding

43 ter, these iPSC clones contributed poorly to chimaeras and failed to support the development of entir

44 They efficiently produced adult chimaeras and gave germline transmission.

45 Dlk1-Dio3 cluster contributed to high-grade chimaeras and generated viable all-iPSC mice.

46 paralogues, the potential for unidentifiable chimaeras and priming across taxa.

47 including abundant stem-group holocephalans (chimaeras and relatives).

48 lts were presented with stationary or moving chimaeras and reported perceived sound motion and conten

49 major cartilaginous subclasses, Holocephali (chimaeras) and Elasmobranchii (sharks, skates, and rays)

50 gynandromorph birds are genuine male:female chimaeras, and indicated that male and female avian soma

51 MIC) of MMV Pathogen Box compounds against M chimaera; and the MICs of a panel of 20 drugs commonly u

52 avium (AOR, 5.64; 95% CI, 1.51-21.10) and M. chimaera (AOR, 4.47; 95% CI, 1.08-18.53) were more likel

53 Chimaeras are both monsters of the ancient imagination a

54 In modern terms, chimaeras are composite animals consisting of geneticall

55 Using genetically mixed blastocyst and BM chimaeras as well as in vivo T cell transfer systems, we

56 nds and drug repurposing opportunities for M chimaera, as current therapeutic options often result in

57 roper and to the trophectoderm lineages in a chimaera assay.

58 Mutagenesis and chimaera assays demonstrate that an intrinsically disord

59 INTERPRETATION: HCU contamination with M chimaera at the LivaNova factory seems a likely source f

60 transfected with complementary DNAs encoding chimaeras bearing appropriate localization signals.

61 igher viral loads while variants such as the chimaeras bearing the B14 and B28 Envs grew less well.

62 First, we made aggregation chimaeras between transgenic Dct-lacZ and non-transgenic

63 cing more than their fair share of spores in chimaeras, but cooperating normally when clonal.

64 In the present report, we designed a peptide chimaera called Chim2, formed by a membrane-active modul

65 M chimaera can cause disseminated disease, osteomyelitis,

66 rived from mouse fibroblasts-can form viable chimaeras, can contribute to the germ line and can gener

67 inst intravenous or mucosal SHIV (an HIV/SIV chimaera) challenge and topically applied antibodies can

68 endent K+ channel, which we call the 'paddle-chimaera channel', in which the voltage-sensor paddle ha

69 he first case in the literature to report M. chimaera chorioretinitis with concomitant negative neuro

70 Sharks, rays, and chimaeras (Class Chondrichthyes; herein 'sharks') are th

71 vitro antimicrobial drug susceptibility of M chimaera compared with the antimicrobial drug susceptibi

72 Chimaera competition is therefore a sensitive, quantitat

73 Interestingly, an LMP1/ CD40 chimaera comprising of the N-terminus and transmembrane

74 Chimaera containing the S1-S6 transmembrane region of HE

75 Finally, in mouse bone marrow chimaeras containing both wild-type and Tp53(+/-) haemat

76 derably shorter than either authentic ARF or chimaeras containing the entire coding domain, both of w

77 tic nuclear clones, they are in fact genetic chimaeras, containing somatic cell-derived nuclear DNA b

78 ragment of a mouse IgG1 antibody to create a chimaera CR2-Ig containing the major ligand binding doma

79 Mouse lymphoid chimaeras deficient in XBP-1 possessed normal numbers of

80 Chimaeras define the N terminus, and a segment of the pr

81 Chimaeras derived from ES cells treated with EMS transmi

82 We found that juvenile male chimaeras develop a full tenaculum before tooth developm

83 Additionally, male chimaeras develop an articulated cartilaginous facial ap

84 ic valve or root infection, or both, with M. chimaera diagnosed by culture, gene sequencing, or both.

85 ell autonomous, because wild-type cells in a chimaera do not rescue development of the autophagy muta

86 The slow inactivation phenotype in the chimaeras (domains denoted by subscripts) mu1(1)hH1(2,3,

87 In mixed bone marrow chimaeras, EBI2-deficient B cells phenocopied germinal c

88 hree separate analyses argued that the adult chimaera endoskeleton has features of the embryonic litt

89 Bone marrow chimaera experiments show the involvement of SphK2 expre

90 Chimaeras, fanciful beasts that drew their force from be

91 rally assumed that PGCs do not contribute to chimaeras following injection into the early mouse embry

92 elopmental potential of STAP cells, shown by chimaera formation and in vitro cell conversion, indicat

93 Here we report that this chimaera forms alternate prion strains in vivo when init

94 evidence for the airborne transmission of M. chimaera from contaminated heater-cooler unit water tank

95 We created auditory chimaera from speech and noise stimuli and varied the nu

96 We were able also to culture M. chimaera from water circuits of heater-cooler units conn

97 dly out-competed in the bone marrow of mouse chimaeras generated with Gfi-1-/- embryonic stem cells.

98 Human:pig chimaeras generated with TP53-null human induced pluripo

99 technologies, and compared with published M chimaera genomes.

100 uencing of 250 isolates revealed two major M chimaera groups.

101 Such a chimaera has therapeutic potential as a complement inhib

102 Phosphomimetics and inter-species chimaeras have shown that negative charge in the RACK1 l

103 eletons of chondrichthyans (sharks, batoids, chimaeras) have often been assumed to reflect ancestral

104 unusual PVE pathogens, such as Mycobacterium chimaera, have presented major diagnostic and therapeuti

105 -alanine), in the form of a ligand-inducible chimaera HER-1/2, was co-transfected into HEK-293 fibrob

106 Chimaeras (Holocephali) are an understudied group of mos

107 Analysis with chimaeras, however, shows that Arkadia functions within

108 could be induced by a Jun-estrogen receptor chimaera in the absence of de novo protein biosynthesis.

109 ted FADD-/- embryonic stem cells and FADD-/- chimaeras in a background devoid of the recombination ac

110 pact of deep-sea mining on sharks, rays, and chimaeras in Areas Beyond National Jurisdiction (ABNJ) a

111 re reports of cultured cell contributions to chimaeras in golden hamster, rat and pig, definitive ES

112 ession of green fluorescent protein (GFP) GK chimaeras in MIN6 beta-cells to study the phenotype defe

113 en mouse and chick in generating mouse-chick chimaeras in ovo.

114 Using chimaeras in which premigratory chick neural crest had b

115 trast to the outcome for mammalian mixed-sex chimaeras, in chicken mixed-sex chimaeras the donor cell

116 ntified low but escalating risk of severe M. chimaera infection associated with heater-coolers with c

117 tinitis died of systemic complications of M. chimaera infection despite long-term targeted antimicrob

118 hed to assess risk of invasive Mycobacterium chimaera infection in cardiothoracic surgery and a possi

119 M. chimaera infection subsequent to cardiothoracic surgery

120 tion of cardiopulmonary bypass-associated M. chimaera infection through national laboratory and hospi

121 ases of cardiopulmonary bypass-associated M. chimaera infection were identified; all except one occur

122 urysm repair in 2017 complicated by known M. chimaera infection.

123 ebrum and brainstem thought to be foci of M. chimaera infection.

124 findings, of patients with a disseminated M. chimaera infection.

125 Recent studies have detailed Mycobacterium chimaera infections acquired during cardiac surgery; how

126 The global outbreak of Mycobacterium chimaera infections associated with heater-cooler device

127 for cardiothoracic surgery-related severe M chimaera infections diagnosed in Switzerland, Germany, t

128 ients with fatal, disseminated Mycobacterium chimaera infections following cardiac surgeries.

129 midst of a global outbreak of Mycobacterium chimaera infections related to a point source contaminat

130 Invasive Mycobacterium chimaera infections were diagnosed in 2012 in 2 heart su

131 Mycobacterium chimaera is a slowly growing non-tuberculous mycobacteri

132 We included 24 M chimaera isolates from 21 cardiac surgery-related patien

133 Germany, the Netherlands, and the UK, 218 M chimaera isolates from various types of HCUs in hospital

134 ed on archived histopathology samples and M. chimaera isolates since 2006, and the patient population

135 Unlike sharks, chimaeras lack scales and do not have serially replacing

136 M. chimaera ocular infection with no CNS M. chimaera lesions on brain magnetic resonance imaging (MR

137 Chorioretinal M. chimaera lesions should motivate high suspicion of CNS i

138 Chimaeras made entirely of these equatorially or oblique

139 Chimaeras made from a 1:1 mix of targeted and wild-type

140 By contrast, chimaeras made from four-cell stage blastomeres from ear

141 The developmental defects of chimaeras made from the most vegetal blastomeres that re

142 Human:pig chimaeras may facilitate the production of exogenic orga

143 x, a dextrin, and a biopolymer obtained from Chimaera monstrosa.

144 Organoids and human-rodent chimaeras more accurately mirror the diverse cellular ec

145 chimaera mostly clustered in the distinct clades separat

146 However, the chimaera mu1(1)hH1(2,3,4) was more like wild-type hH1, w

147 ,3,4) was more like wild-type hH1, while the chimaeras mu1(1,2)hH1(3,4) and mu1(1,2,3)hH1(4) were mor

148 chimaera) not known to cross-react, whole genome sequenc

149 Mycobacterium chimaera ocular infection is a rare disease that is link

150 Here we present a case of M. chimaera ocular infection with no CNS M. chimaera lesion

151 The fusion protein, a chimaera of glutathione S-transferase and BLT 801, has b

152 A chimaera of human Hook3 and Hok1 rescues the hok1 mutant

153 sed in Escherichia coli, gonococcal NarQ and chimaeras of E. coli and gonococcal NarQ are ligand-inse

154 higher-order structure, through stages using chimaeras of ex-fetu and PSC-derived cells to a system t

155 Here, we tested chimaeras of rat Kv1.2 with the hERG channel for functio

156 Using cell-specific markers and chimaeras of wild-type and rzpA- cells, we show that rZI

157 did the human 'book of life' evolve to be a chimaera, part animal and part bacterium?

158 lular or functional categories, but may be a chimaera partially supported by organelle robbery.

159 yoid and gill arches, whereas holocephalans (chimaeras) possess a single hyoid arch ray-supported ope

160 Since 2013, over 100 cases of Mycobacterium chimaera prosthetic valve endocarditis and disseminated

161 Proteolysis-targeting chimaera (PROTAC) technology is an emerging approach for

162 tion platforms such as proteolysis-targeting chimaeras (PROTACs)(1,2) and others (for example, dTAGs(

163 on of auto-inhibition, proteolysis targeting chimaeras (PROTACs), use of cysteine reactive inhibitors

164 Proteolysis-targeting chimaeras (PROTACs), which induce proteolysis by recruit

165 Mouse chimaeras reconstituted with wild-type, Nek7(-/-) or Nlr

166 This is the first report of M. chimaera recovery from household water.

167 The resulting chimaeras retain the respective functional hallmarks of

168 Assembly of FtsZ chimaeras revealed that the protofilaments assemble via

169 A chimaera S-peptide composed of the 10th beta-strand of G

170 tions dictate amyloid seeding specificity: a chimaera seeded by S. cerevisiae fibres efficiently cata

171 stribution of homozygous mutant cells in the chimaeras showed that the cell-autonomous removal of Pax

172 In mouse chimaeras, Sox9-/- cells are excluded from all cartilage

173 ns, adult skeletal tissues in a holocephalan chimaera (spotted ratfish) and two elasmobranchs (small-

174 PCR demonstrated identical patterns among M. chimaera strains from heater-cooler unit water circuits

175 Mycobacterium chimaera strains were characterized by randomly amplifie

176 nses to acute infections by adopting a mixed chimaera strategy in which T cells lacking the high-affi

177 Chimaera studies were performed to assess the role of NL

178 The resulting chimaeras survive and develop normally.

179 Conversely, a MEK1-MEK5 chimaera that phosphorylated ERK1/2 independently of Cu

180 A Sup35 chimaera that traverses the transmission barrier between

181 Moreover, beta-arrestin/arrestin chimaeras that are defective in either beta2AR or clathr

182 They produced high-contribution chimaeras that yielded germline transmission.

183 an mixed-sex chimaeras, in chicken mixed-sex chimaeras the donor cells were excluded from the functio

184 Analogous to proteolysis-targeting chimaeras, the vaccine consists of lymph-node-targeting

185 ansmit through the germ line via ES-cell rat chimaeras to create p53 gene knockout rats.

186 unctions of the organizer, using quail-chick chimaeras to distinguish graft- and host-derived cells,

187 Existing strategies use bifunctional chimaeras to mediate extracellular protein degradation.

188 harks and skates, and holocephalans, such as chimaeras) to understand their evolution.

189 ust pipeline for the discovery of novel gene chimaeras using high-throughput sequencing, opening up a

190 M chimaera was inhibited by 21 (5%) of 400 compounds in th

191 Mycobacterium chimaera was isolated from cardiac tissue specimens, blo

192 By analysing c-myb(-/-) chimaeras we show that no mature cells of any lymphoid o

193 Using this chimaera, we show that the influence of environment and

194 and protein engineering with a novel fusion chimaera, we solved the structure of the human OX2R boun

195 g chromatin assembled from histone H3/CENP-A chimaeras, we demonstrate that the conserved carboxy ter

196 ted biological activity of EGF receptor/CD45 chimaeras, we propose that dimerization and active-site

197 he microsurgical construction of quail-chick chimaeras, we show that the caudal boundary of the presu

198 Patients infected with M. chimaera were more likely to be prescribed an immunosupp

199 f Na+ channel slow inactivation, Na+ channel chimaeras were constructed with domains from hH1 and mu1

200 Germline chimaeras were derived from cultures that underwent a mu

201 A series of chimaeras were generated to map the critical region in B

202 Chimaeras were made by incorporating these ES cells into

203 The generated intraspecies chimaeras were viable and displayed normal histology, mo

204 nt stem cells that can contribute to primary chimaeras when introduced into pre-implantation embryos.

205 Similarly, in vitro the purified chimaera, when seeded with different species of Sup35 fi

206 Notably, ES cells robustly colonise chimaeras, whereas EpiSCs show little or no contribution

207 e synthesized stimuli that we call 'auditory chimaeras', which have the envelope of one sound and the

208 rditis or vascular graft infection due to M. chimaera, which became clinically manifest with a latenc

209 sal jawed vertebrates: the sharks, rays, and chimaeras, which have one of the greatest ranges of repr

210 These initial lysosome-targeting chimaeras, which we term LYTACs, consist of a small mole

211 sue penetration properties, also inhibited M chimaera with a mean MIC of 6.25 mug/mL.

212 extracellular region of CD5, expressed as a chimaera with rat CD4 domains 3 and 4 (cCD5d1-3-CD4d3+4)

213 Further, acoustic chimaera with speech-like ENVs which had intelligible co

214 Examination of chimaeras with a high proportion of mutant cells showed

215 ak) mutant, which lacks all RGCs, we created chimaeras with eyes that contained single RGCs.

216 uripotency were confirmed by contribution to chimaeras with germline transmission.