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1                    Further, correctly folded chimaeric 2S albumin proteins containing structural epit
2                              By constructing chimaeric 5-HT3A and 5-HT3B subunits we identified a reg
3                In contrast to previous data, chimaeric and mosaic embryonic melanoblast patterns sugg
4  In primary human T cells, the knock-in of a chimaeric antigen receptor (CAR) into the T-cell recepto
5 roduction of autologous T cells expressing a chimaeric antigen receptor (CAR) is time-consuming, cost
6                         The effectiveness of chimaeric antigen receptor (CAR) T cell therapies for so
7                                Resistance to chimaeric antigen receptor (CAR) T cell therapy develops
8                                              Chimaeric antigen receptor (CAR) T cells can generate du
9              The manufacturing of autologous chimaeric antigen receptor (CAR) T cells largely relies
10            Notably, activating and expanding chimaeric antigen receptor (CAR) T cells with SynVACs le
11 icity limits the anticancer applicability of chimaeric antigen receptor (CAR) T cells.
12 se results have energized the field to apply chimaeric antigen receptor (CAR) T therapy throughout on
13 nd antigen heterogeneity pose challenges for chimaeric antigen receptor (CAR)-T cell therapies applie
14 ells with an engineered T-cell receptor or a chimaeric antigen receptor and show that the cells maint
15 ogy-directed repair template can introduce a chimaeric antigen receptor gene at the T-cell receptor a
16                                   Allogeneic chimaeric antigen receptor T cells (allo-CAR T cells) de
17 ane antigen (PSMA) and infused PSMA-targeted chimaeric antigen receptor T cells after the systemic ad
18                                              Chimaeric antigen receptors (CARs) are a class of synthe
19 ostimulatory intracellular domains (ICDs) of chimaeric antigen receptors (CARs) are essential for con
20 ficacy of adoptive T-cell therapies based on chimaeric antigen receptors (CARs) is limited by the poo
21  enhanced by genetically modifying MSCs with chimaeric antigen receptors (CARs), as we show for E-cad
22 cytokines, mRNAs, vaccines and, potentially, chimaeric antigen receptors as well as of agents that mo
23 insic kinases, including, as we demonstrate, chimaeric antigen receptors being developed for cancer i
24  kinetics of exogenously expressed mRNA from chimaeric Arc constructs (Arc/MS2 mRNA) in the dendrites
25 ion embryo and fail to resume development in chimaeric assays.
26  vivo competition assay in which we prepared chimaeric blastocysts, composed of a mixture of wild-typ
27 ryos were incubated to either E7 or E10 when chimaeric brains were removed.
28                                          One chimaeric capsid composed of five different parental AAV
29 iruses (MLV) followed by selection yielded a chimaeric clone with a completely new tropism for Chines
30                                        Using chimaeric constructs from mcm sensitive and mcm insensit
31                                          The chimaeric developmental origin of this model of modulari
32                                       We use chimaeric domains to demonstrate that this internal fric
33                                        These chimaeric elements are called Pack-MULEs in this study.
34 ed that STAP cells efficiently contribute to chimaeric embryos and to offspring via germline transmis
35                                              Chimaeric embryos derived from several independent mutan
36 esentation in different cell lineages as the chimaeric embryos developed.
37 s to generate post-implantation interspecies chimaeric embryos may facilitate our understanding of ea
38                               Examination of chimaeric embryos revealed that c-myb(-/-) donor-derived
39 tion of Stella(+) cells in vitro and PGCs in chimaeric embryos, and is associated with human germ-cel
40  of the three germ layers and contributed to chimaeric embryos, with concomitant downregulation of GP
41 ent contradiction, and here we show that two chimaeric enhancers, constructed by swapping the 5' and
42               Western blot demonstrated that chimaeric envelope proteins were incorporated into retro
43 n and provides a framework for the design of chimaeric enzymes with altered specificities.
44  misalignment or ambiguity, misclustering or chimaeric EST sequences, assessing data such as raw chro
45           Our results also indicate that the chimaeric EWS-CHN gene encodes a EWS-CHN fusion protein
46 rn-3a but not Brn-3b interacts in vitro with chimaeric EWS/Fli-1, EWS/ATF-1 and EWS/ERG proteins.
47                               We have made a chimaeric fusion between the prion domains of two specie
48                                   Remarkably chimaeric fusions of sin1 with chicken sin1 sequences re
49                             However, in some chimaeric fusions that comprised the amino and carboxy t
50    This is the first vertebrate example of a chimaeric gene generated by this mechanism of exon shuff
51                                            A chimaeric gene was constructed comprising a wheat high m
52 barley plants containing the antisense SnRK1 chimaeric gene were produced by particle bombardment of
53                                 Libraries of chimaeric genes can be generated by random fragmentation
54                                The resulting chimaeric genes express SYT-SSX1 or SYT-SSX2 fusion prot
55                                     A set of chimaeric genes was constructed containing different pro
56 s to generate embryos containing male:female chimaeric gonads.
57 es lost through transfer to the nucleus, and chimaeric, half-monocot, half-dicot genes.
58 erstanding of these discrepancies, we used a chimaeric human-murine liver model to compare directly t
59 es resembles that of cancer patients who are chimaeric individuals carrying a small number of mutated
60 tively large number of YAC clones containing chimaeric inserts.
61 tion of the YAC clones were found to contain chimaeric inserts.
62                    The features of these two chimaeric IS elements are discussed in terms of possible
63 otility of wild-type KIF3A/B heterodimer and chimaeric KIF3A/A and KIF3B/B homodimers made by splicin
64 in clinical studies, we used the same murine chimaeric liver model to perform serial selection using
65                                              Chimaeric messages spliced over the breakpoint fuse the
66                              Observations on chimaeric mice argue that there must be considerable dis
67                    Previous studies of adult chimaeric mice carrying different coat colour markers ha
68                             Pten+/- mice and chimaeric mice derived from Pten+/- ES cells showed hype
69 s, we devised protocols to generate germline chimaeric mice from embryonic stem (ES) cells heavily mu
70                                  Analysis of chimaeric mice generated from these cells allows us to s
71 erated tissue using Y chromosome painting in chimaeric mice indicates that once differentiated to exp
72                        This was corrected in chimaeric mice reconstituted with bone marrow from wild-
73                   Experiments in bone marrow chimaeric mice revealed that IFN-I must act on both haem
74  capable of generating germline-transmitting chimaeric mice using only Oct4 (also known as Pou5f1) an
75                                              Chimaeric mice were made by aggregating Pax6(-/-) and wi
76                                              Chimaeric mice with a high level of mutant germ cells we
77 d EG cells contribute extensively to healthy chimaeric mice, including to the germline.
78                              Accordingly, in chimaeric mice, NMDA receptor-initiated signals are not
79 ifferentiation assays and formation of adult chimaeric mice.
80 udied its function during spermatogenesis in chimaeric mice.
81                                  Half of the chimaeric mixtures show a clear cheater and victim.
82 rrent chromosomal translocations producing a chimaeric MLL oncogene give rise to a highly aggressive
83 ver' cells in cultured pluripotent cells and chimaeric mouse embryos.
84                          Using a human liver-chimaeric mouse model and a fluorescent parasite line (P
85                      Here we develop a novel chimaeric mouse model of mCRPC to efficiently test combi
86  was validated in vivo using an HCV-infected chimaeric mouse model.
87      The translocation produces an invariant chimaeric NUP98/HOXA9 transcript containing the amino te
88 lication of methylphosphonate:phosphodiester chimaeric oligonucleotides to U937 cells reduced mRNA le
89  fusion protein E2A-HLF, indicating that the chimaeric oncoprotein probably affects cell survival rat
90                                      Using a chimaeric p53 fusion protein with the oestrogen receptor
91 s subsequently prepared from these mouse-rat chimaeric pancreata were transplanted into mice with str
92                Here, crystal structures of a chimaeric PDE5/PDE6 catalytic domain (PDE5/6cd) complexe
93                   To enable siRNA binding, a chimaeric peptide was synthesized by adding nonamer argi
94 , we show that intraspecies and interspecies chimaeric pig embryos lacking native skeletal muscle can
95 utations can be recovered in regenerated non-chimaeric plants.
96 m genomic segments to create a repertoire of chimaeric polypeptides displayed on filamentous bacterio
97 ial relationship between sister cells in non-chimaeric postimplantation epiblast by ionophoretic inje
98                Notably the generation of the chimaeric PRCC-TFE3 gene appears to be accompanied by co
99 y generating a transgenic mouse expressing a chimaeric protein in which the oxygen-dependent degradat
100                                            A chimaeric protein is synthesized from one of the derivat
101                         Through the use of a chimaeric protein microarray system together with sera f
102 combinase or a tamoxifen-inducible MerCreMer chimaeric protein was targeted to the Kit locus in mice
103 inding), resulting in a rapidly destabilized chimaeric protein.
104            In conclusion, the combination of chimaeric proteins and protein microarrays will greatly
105  sarcomas, which also express characteristic chimaeric proteins as a consequence of fusion of the TET
106          Zinc-finger recombinases (ZFRs) are chimaeric proteins comprising a serine recombinase catal
107 d-type SYT and SSX proteins, and the SYT-SSX chimaeric proteins, can modulate transcription in gene r
108                                          HVR-chimaeric rAd5 vectors expressing simian immunodeficienc
109                         We constructed novel chimaeric rAd5 vectors in which the seven short hypervar
110 anti-Ad5 immunity, the immunogenicity of HVR-chimaeric rAd5 vectors was not detectably suppressed, wh
111                                    These HVR-chimaeric rAd5 vectors were produced at high titres and
112                                     By using chimaeric receptor constructs, we have identified a regi
113 peptides loaded on MHC called V-CARMA (Viral ChimAeric Receptor MHC-Antigen) to specifically target T
114  we report that the association of these two chimaeric receptors with the histone deacetylase (HDAC)
115 rchitecture of the synapse, we constructed a chimaeric recombination site (resF) which allows Hbsu to
116                        The existence of such chimaeric RNAs has far-reaching implications for the pot
117  is visual inspection of an alignment of the chimaeric (split) reads that span a putative novel retro
118  the fungal cellulosome is an evolutionarily chimaeric structure-an independently evolved fungal comp
119 the doubly enhanced CaMV 35S promoter or the chimaeric 'Super-Promoter'.
120 y in vitro, we found that the ArtB/PltA/CdtB chimaeric toxin exhibits reduced lethality in an animal
121 ranslocations resulting in the expression of chimaeric transcription factors are frequently observed
122                                   Apparently chimaeric transcripts (from oncogenic fusion genes gener
123 y validated, novel gene fusions resulting in chimaeric transcripts in cancer cell lines and tumours.
124             Our approach involves generating chimaeric transcripts of viral RNAs (MS2 and PP7) and si
125 9-HERVH drives hESC-specific alternative and chimaeric transcripts, including pluripotency-modulating
126 ading frames, some of which are expressed as chimaeric transcripts.
127                               Some of these 'chimaeric' transcripts are formed by genetic rearrangeme
128 of peripheral blood mononuclear cells to the chimaeric vector while preserving its functions, potency
129                                         Such chimaeric viral vectors may have important practical imp
130 challenge with HIV or simian/human (SIV/HIV) chimaeric viruses (SHIVs) respectively, the long-term ef
131          Here we describe the structure of a chimaeric voltage-dependent K+ channel, which we call th
132          We isolated and mapped a single non-chimaeric YAC (17IA12, 260-280 kb) containing D6S193 and

 
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