ライフサイエンスコーパス: chimera

1 known as PROTACs (for 'proteolysis-targeting chimeras').

2 SCs) into wild-type (WT) blastocysts (mdx/WT chimera).

3 removes PCR-mediated recombinant sequences (chimeras).

4 ted a productive membrane interaction of the chimera.

5 are ineffective in neutralizing the PDF2180 chimera.

6 eavable linker connects the two modules of a chimera.

7 of dynamin isoforms in CME using domain swap chimeras.

8 aking over entire organs within intraspecies chimeras.

9 -S1 (K(1)k (+2) ) is reduced for both exon 3 chimeras.

10 ls that regulates expression levels of these chimeras.

11 tem cell differentiation in pig interspecies chimeras.

12 tation and other forms of human-animal brain chimeras.

13 extra-embryonic lineages when implanted into chimeras.

14 ng with wild-type cells in mixed bone marrow chimeras.

15 e the identification of true cancer-specific chimeras.

16 ents and expression of transcription-induced chimeras.

17 mHTT protein, such as proteolysis-targeting chimeras.

18 cytometry analyses in mixed bone-marrow (BM) chimeras.

19 loid development using a series of radiation chimeras.

20 y 37% and 60%, respectively, in DC-LMP1/CD40 chimeras.

21 ows the study of human NBs in mouse-human NC chimeras.

22 ert blastula cells into WT to produce embryo chimeras.

23 free Il-18 levels, in comparison with WT->WT chimeras.

24 hey colonize somatic tissues and germline in chimeras.

25 icient for the efficient Golgi export of Tac chimeras.

26 e cAMP-signaling potencies of AM and AM2/IMD chimeras.

27 icient chimeras compared with NGAL-deficient chimeras.

28 pha12), G(alpha13), G(alpha14) and G(alphaz) chimeras.

29 esis of two novel bridged morpholine-proline chimeras 4 and 5, which represent rigid conformationally

30 icroglia residing in the human brain, making chimeras a superior tool to study microglia in human dis

31 and a CfaE-heat-labile toxin B subunit (LTB) chimera admixed with double mutant heat-labile toxin (LT

32 In studies of bone-marrow chimeras, adoptive cell transfer experiments, and analys

33 nd clinically in patients who are full donor chimeras after hematopoietic stem cell transplantation a

34 responses by Zbtb32(-/-) mice or bone marrow chimeras against a panel of chronic and acute challenges

35 Domain swap chimeras also revealed previously unknown functional dif

36 The SCZ glial chimeras also showed delayed astrocytic differentiation

37 Chimera analyses demonstrate that the PIEZO2 beam is a k

38 Bone marrow chimera and adoptive transfer studies indicate that thes

39 ological levels of suPAR, as evidenced by BM chimera and BM ablation and cell transfer studies.

40 erties of circadian clock gene 2 hydrophobin chimera and homogeneity of the layer was evidenced by at

41 CD30-AshR-negative control chimera and prostate specific membrane antigen (PSMA)-As

42 ular graphics software packages such as UCSF Chimera and VMD.

43 We used mixed bone marrow chimeras and adoptive transfer of naive CD4(+) T cells a

44 sotropy FRET (psAFRET) with a number of test chimeras and example oligomeric complexes inside living

45 Using bone marrow chimeras and immunohistology, we identified the TLR2-exp

46 Wild-type Treg cells in mixed bone marrow chimeras and in Tet2/3(fl/fl)Foxp3(WT/Cre) heterozygous

47 oon APOL1 orthologs, along with interspecies chimeras and individual amino acid substitutions, to ide

48 Incorporating Galpha(12)/Galpha(13) chimeras and individual residue swap mutations into thes

49 nscriptome assembly base coverage, number of chimeras and number of recovered full-length transcripts

50 Using chimeras and point mutants we have mapped the binding si

51 e to derivatives of the three germ layers in chimeras and produce primordial germ cell-like cells in

52 development in limited-dilution bone marrow chimeras and show that higher TCR avidity correlates wit

53 We constructed a set of CyaA/HlyA chimeras and show that the CyaC-acylated segment and the

54 herefore, focusing on PAK1 and PAK6, we used chimeras and truncation mutants to investigate their dif

55 (Zika virus and Japanese encephalitis virus chimera), and the VRC 320, done in one centre, assessed

56 of both the 14-3-3 and ACD dimers within the chimera, and indicate that the chimera retains the overa

57 mes (MAGs); but gaps, local assembly errors, chimeras, and contamination by fragments from other geno

58 ransgenic mice, MAIThighHLA-DR4+ bone marrow chimeras, and humanized NOD-scid IL-2Rgammanull mice to

59 ype library with approximately 560 synthetic chimeras, and select several functional variants.

60 galectins, galectin-2 (proto-), galectin-3 (chimera-) and galectin-4 (tandem repeat-type), was selec

61 with CfaEB or, even better, when a CfaE-LTB chimera antigen was used instead.

62 is models, the latter permitting a radiation chimera approach to help identify the CCL17 responding c

63 optive transfer, transgenic, and bone marrow chimera approaches to show increased infiltration and pr

64 truct a mapping of the vertex model into the Chimera architecture of the D-Wave machine, initiating a

65 Most (93%) of these well-localizing chimeras are also functional light-gated channels.

66 to a variably 5'-truncated L1, but how U6/L1 chimeras are formed requires elucidation.

67 Once modified ESCs are ready, NBC chimeras are generated in ~3 weeks via injection of ESCs

68 Chondrichthyes - sharks, rays, skates, and chimeras, are among the most threatened and data deficie

69 and the maturation of proteolysis targeting chimeras as promising chemical tools to exploit the ubiq

70 Further, the characterization of a DGAT2 chimera between Arabidopsis and B. napus demonstrates th

71 ling pathway, by a cytosolic, membrane-bound chimera between the AP20187-inducible F(V)2E dimerizatio

72 yte chemoattractant protein-3 (MCP-3)) using chimeras between CCL7 and the non-cognate ligand CCL2 (f

73 o fungal immunity by preventing formation of chimeras between genetically non-identical colonies.

74 GxYR(204) as a TGN retention signal by using chimeras between MERS-CoV M and the M protein of infecti

75 In bone marrow chimeras between Slc7a2(-/-) and WT mice, the recipient

76 basis of these divergent responses using MR chimeras between the zebrafish and human MR coupled with

77 of binding CR3, a CyaA(1-710)/HlyA(411-1024) chimera bound the LFA-1 receptor and effectively deliver

78 solved three crystal structures of this TdT chimera bound to several DNA substrates at 1.96-2.55 ang

79 This infliximab-bovine IgG1 chimera (bovinized infliximab) retained the antigen bind

80 ve Arthus reaction could be induced in HoxB8 chimeras but not in irradiated, nontransplanted control

81 s, SRRM1 and SF3B1, affect not only cis-SAGe chimeras, but also other types of chimeric RNAs in a gen

82 xN serum triggered robust arthritis in HoxB8 chimeras, but not in irradiated, nontransplanted control

83 We also reported a cholera toxin (CT)-like chimera (called dsc(19)CfaE-CTA2/CTB) in which the CTA1

84 yncytium formation of the fusogenic gB/VSV-G chimera can be significantly inhibited by only a subset

85 ntly, a BIR3-GASSHO1 (GSO1)/SCHENGEN3 (SGN3) chimera can partially complement sgn3 Casparian strip fo

86 was transcribed CD30 aptamer-RORgammat shRNA chimera (CD30-AshR-RORgammat).

87 xpression and localization data from 218 ChR chimeras chosen from a 118,098-variant library designed

88 icus did not assemble as first prepared, but chimeras combining capsid surface loops from R. norvegic

89 nce of actin is completely reversed for each chimera compared with the native isoforms.

90 ficantly attenuated NCGN in IL-17A-deficient chimeras compared with MPO-deficient mice receiving wild

91 marrow, as well as in NGAL/IL-17A-deficient chimeras compared with NGAL-deficient chimeras.

92 crobiota-nourishing immunity, a host-microbe chimera composed of the microbiota and host factors that

93 intracellular Ca(2+) imaging to characterize chimeras composed of capsaicin-sensitive rat TRPV1 (rTRP

94 gB's fusion activity, we generated a set of chimeras composed of gB and VSV-G or gp64, respectively.

95 e efficacy (PE) of a refined and more stable chimera comprised of a pentameric B subunit of ETEC heat

96 At high chimera concentrations (25 nm), the interaction with LFA

97 Most of these peptide-MBP chimeras conferred tolerance to high concentrations of c

98 Bone marrow chimeras confirmed that vascular Nck1, but not hematopoi

99 Hybridization studies show that TMO chimeras consisting of alternating TMO and DNA-pS subuni

100 We found that chimeras containing rat E570-V686 swapped into chicken r

101 Our recombinant penton base chimera contains polypeptide domains designed for noncov

102 n docking, and MD simulations of peptide-MBP chimeras corroborated the extent of Cu(2+) binding among

103 in vivo chimeric and survival capacities of chimeras created by injecting tetraploid embryonic stem

104 tibodies (solanezumab, crenezumab, and their chimera, CreneFab).

105 As expected, DC-LMP1/CD40/Ldlr(-/-) chimeras (DC-LMP1/CD40) showed increased antigen-present

106 with highly complex dynamics, including weak chimeras, decoupled states, traveling waves, and inhomog

107 Finally, we showed that chimera-derived melanoma cell lines retain regulatory al

108 mdx/WT chimeras developed cardiomyopathic features and dystroph

109 Moreover, DC-LMP1/CD40 chimeras developed inflammatory bowel disease characteri

110 DAF(-/-) mice or DAF(-/-) to WT bone marrow chimeras did not.

111 study examined the feasibility of virus-host chimera DNA (vh-DNA), generated from junctions of hepati

112 The refined chimera, dsc(14)CfaE-sCTA2/LTB, was highly immunogenic i

113 Spiral wave chimera dynamics is exhibited experimentally for much of

114 E2A and the oncogenic chimera E2A-PBX1 contain three transactivation domains (

115 This mutant chimera enabled us to determine the cryoelectron microsc

116 included capsid protein-transcription factor chimeras; endonuclease chimeras; enzymes for detoxificat

117 -transcription factor chimeras; endonuclease chimeras; enzymes for detoxification; antimicrobial pept

118 Here, we show that chimeras, exemplified by mixed threose nucleic acid (TNA

119 ynamical behavior is found, with spiral wave chimeras exhibited at small values of the time delay in

120 cerebral organoid and human iPSC/mouse brain chimera experimental systems that provide an opportunity

121 e a powerful resource to complement ESC-GEMM chimera experiments in vitro and in syngeneic grafts in

122 Bone marrow chimera experiments indicated that the observed enhanced

123 Furthermore, radiation chimera experiments reveal how bone marrow from the V154

124 Bone marrow chimera experiments showed that CD137L-deficient hematop

125 lowest-expressing parent; 12% of the tested chimeras express at even higher levels than any of the p

126 The majority of the chimeras express, with 89% of the tested chimeras outper

127 ping thymic iNKT cells that emerged in these chimeras expressed the exhaustion marker PD1 and respond

128 on of mice with a murine gammaherpesvirus 68 chimera expressing LANA, where the virus was highly defi

129 ng steps, such as paired-end reads assembly, chimera filtering, Operational Taxonomic Unit (OTU) clus

130 n PSCs have demonstrated dual competency for chimera formation and direct responsiveness to primordia

131 Efficient chimera formation and lung complementation required newl

132 Chimeras formed from combinations of canine parvovirus a

133 d MLL1 can result in the displacement of MLL chimeras from chromatin in leukemic cells.

134 , and results in the displacement of the MLL chimeras from chromatin.

135 o create a large set of functionally diverse chimeras from three sequence-diverse channelrhodopsins (

136 The resulting chimera (GBF1-ARNO-GBF1 [GARG]) targets like GBF1, suppo

137 We found that all hatched offspring from the chimera GE hens were derived from the donor rare heritag

138 The resulting chimeras generated offspring with targeted mutations in

139 of the injected, ESC-derived donor cells in chimeras generated via NBC.

140 Using bone marrow chimeras, GILT expression in thymic epithelial cells (TE

141 adjacent motif (PAM) preferences and the M44 chimera has higher specificity relative to wild-type (WT

142 rgen display, bead-based assays, and protein chimeras have been used in epitope discovery.

143 of several examples of BRIL-membrane protein chimera highlight the effectiveness of the sABs as unive

144 ctional compounds, multitargeting molecules, chimeras, hybrids, engineered compounds.

145 yping of AtEDS1 variants and AtPAD4-AtSAG101 chimeras identify closely aligned a-helical coil surface

146 Finally, we show that a dicot GRF-GIF chimera improves regeneration efficiency in citrus, sugg

147 erences between the Shaker-VSD and Kv1.2/2.1 chimera in the S2-S3 linker and S3 transmembrane region,

148 Here, we report that receptor chimera in which the extracellular LRR domain of BIR3 is

149 sion of a series of Nav1.9-Nav1.7 C-terminal chimeras in HEK293 cells identified a 49-amino-acid-long

150 lity of endogenous pH-sensitive FAP-receptor chimeras in high-throughput analysis of endocytosis.

151 e of contributing to intra- or inter-species chimeras in vivo.

152 udied the hemolytic function of LukE-LukS-PV chimeras, in which areas of sequence divergence (diverge

153 tural features with the homologous Kv1.2/2.1 chimera, including a transition from alpha-helix to 3(10

154 This pore-domain chimera is permeable to Na(+), K(+), and Ca(2+) ions, an

155 The mechanisms for how this group of chimeras is formed are not yet clear, in part due to the

156 Using bone marrow chimeras, lineage labeling, and proliferation studies, w

157 3-dimensional models were created using UCSF Chimera linked with Assemble2.

158 ped, we revealed that O-glycan-deficient Tac chimeras localize at the interior of the trans-Golgi cis

159 f BirA* with NF186, Ndel1, and Trim46; these chimeras map the molecular organization of AIS intracell

160 The construction of bone marrow chimera mice demonstrated that STAT6 KO in either the CN

161 Bone marrow (BM) chimera mice revealed that mucosal repair depended on TN

162 In a third chimera, mitochondrial mCherry did not transfer to G85R

163 ding prompted us to develop a competitive BM chimera model, which demonstrated that expression of BM-

164 f IL4Ra-deficient neutrophils in competitive chimera models and wild-type mice treated with IL-4.

165 e- and sex-matched wild-type and bone marrow chimera mouse models.

166 otif in the context of a full-length channel chimera, Nav1.9-Ct49aa(Nav1.7), which displayed signific

167 Here we engineer and examine a chimera of human 14-3-3 tethered to a nearly complete pa

168 We demonstrate SNAPS can detect shedding in chimeras of diverse cell surface receptors, leading to n

169 Studies using chimeras of IR(extracellular domain)/IGF1R(intracellular

170 tional units for DAA and CFA by constructing chimeras of the decay-accelerating factor (DAF) that exh

171 s of NV1027, NV10128 and NV10129, we created chimeras of the three enzymes and monitored their cataly

172 Various chimeras of VACV-A6 and YLDV-97 were constructed, but on

173 dual were selected for testing as HCDR3 loop chimeras on the MR78 Ab framework.

174 g ZW (female) and ZZ (male) cells in gonadal chimeras, or by altering oestrogen levels of ZW and ZZ e

175 the chimeras express, with 89% of the tested chimeras outperforming the lowest-expressing parent; 12%

176 In human artery-SCID chimeras, PD-1 blockade exacerbated vascular inflammatio

177 novel technology, PHOtochemically TArgeting Chimeras (PHOTACs) or opto-PROTAC, which is light-induce

178 cymaae, intradermal (i.d.) immunization with chimera plus single-mutant heat-labile toxin [LT(R192G)]

179 Research that uses stem cell-based chimeras promises to advance our understanding of human

180 t the development of a proteolysis targeting chimera (PROTAC) based on the combination of the unique

181 degraders based on the proteolysis targeting chimera (PROTAC) concept.

182 graders based upon the proteolysis targeting chimera (PROTAC) concept.

183 sign is based upon the proteolysis-targeting chimera (PROTAC) concept.

184 potent small-molecule proteolysis-targeting chimera (PROTAC) degraders selective for TRKA over TRKB

185 es for conversion into proteolysis-targeting chimera (PROTAC) degraders.

186 Current efforts in the proteolysis targeting chimera (PROTAC) field mostly focus on choosing an appro

187 targeting MCL1 using a proteolysis targeting chimera (PROTAC) methodology leading to successful degra

188 Proteolysis targeting chimera (PROTAC) recruits an E3 ligase to a target prote

189 By using a proteolysis-targeting chimera (PROTAC) strategy that couples an allosteric, re

190 tidomimetics, and novel proteolysis-targeted chimera (PROTAC) technology that have deepened our under

191 , we report the use of proteolysis-targeting chimera (PROTAC) technology to reduce the platelet toxic

192 developed a series of proteolysis-targeting chimera (PROTAC) that allosterically target BCR-ABL1 pro

193 ues identified a novel proteolysis targeting chimera (PROTAC), ARV-825 (ARV), that efficiently degrad

194 ith small-molecule BET proteolysis-targeting chimera (PROTAC), ARV-825, resulted in marked downregula

195 nto DT2216, a BCL-X(L) proteolysis-targeting chimera (PROTAC), that targets BCL-X(L) to the Von Hippe

196 of a proof-of-concept proteolysis-targeting chimera (PROTAC), which efficiently degrades histone dea

197 nd proteins, including proteolysis targeting chimera (PROTAC)-like molecules.

198 logical inhibition, or proteolysis targeting chimera (PROTAC)-mediated degradation of HPK1 improves t

199 her shRNA knockdown or proteolysis-targeting chimera (PROTAC)-mediated degradation reduced liver TG c

200 degraders based on the proteolysis targeting chimeras (PROTAC) concept.

201 and peptides and even PROteolysis TArgeting Chimeras (PROTACs) and proteins.

202 Proteolysis-targeting chimeras (PROTACs) and related molecules that induce tar

203 Proteolysis targeting chimeras (PROTACs) are bispecific molecules containing a

204 PROteolysis-TArgeting Chimeras (PROTACs) are hetero-bifunctional molecules tha

205 tionally, bifunctional proteolysis targeting chimeras (PROTACs) containing a VHL ligand can hijack th

206 protein degradation by proteolysis targeting chimeras (PROTACs) has gained tremendous momentum for it

207 PROteolysis-TArgeting Chimeras (PROTACs) have been developed for targeting spe

208 ion approaches such as proteolysis targeting chimeras (PROTACs) offer new ways to address disease thr

209 Hetero-bifunctional PROteolysis TArgeting Chimeras (PROTACs) represent a new emerging class of sma

210 Proteolysis targeting chimeras (PROTACs) represent an exciting inhibitory moda

211 eloped CDK4/6-targeted proteolysis-targeting chimeras (PROTACs) that inhibit CDK6 enzymatic activity

212 Using PROteolysis TArgeting Chimeras (PROTACs) to degrade proteins that are importan

213 he burgeoning field of proteolysis-targeting chimeras (PROTACs), which are capable of modulating prot

214 tion of Cx43-copy number in mdx/WT-Cx43(+/-) chimeras protected them from both cardiac and skeletal m

215 An efficient BRET from Nanoluc-Halotag chimera protein (H-Luc) to a coumarin substrate yields t

216 sed a strategy based on the polio:rhinovirus chimera PVSRIPO, devoid of viral neuropathogenicity afte

217 lts, and Rag2(-/-) gammac(-/-) hematopoietic chimeras reconstituted with cd69(-/-) stem cells.

218 pletion of BRD4 by BET proteolysis-targeting chimera reduced c-Myc levels and exerted synergistic let

219 bitor or degrader (BET-proteolysis targeting chimera) repressed RUNX1 and its targets, inducing apopt

220 Dishevelled provided that these Dishevelled chimeras retained a DIX head or tail surface capable of

221 rs within the chimera, and indicate that the chimera retains the overall architecture of the native c

222 Bone marrow chimeras revealed STING-mediated MCMV control in hematol

223 Mixed bone marrow chimeras revealed that Itch acts within B cells to limit

224 Additional studies using bone marrow chimeras revealed that this hyperinflammatory phenotype

225 e conditional endoplasmic reticulum-retained chimera, revealed that clathrin and AP-1 silencing disru

226 genous nuclease, or a ribonuclease targeting chimera (RIBOTAC).

227 cin A5 conjugates and ribonuclease targeting chimeras (RIBOTACs), that allow for the targeted degrada

228 dation of RNA targets (ribonuclease-targeted chimeras, RIBOTACs) and direct cleavage by small molecul

229 r the recovery of replication fitness in the chimera RNA.

230 Lymphocytes from mixed chimeras showed no response to host or donor antigens, s

231 th alpaca or human BTN3 or alpaca/human BTN3 chimeras showed that alpaca Vgamma9Vdelta2 TCRs recogniz

232 f acidic amino acids to the GFP::SpxA2(tail) chimera stabilized GFP, while deletion of the acidic res

233 Based on the proteolysis targeting chimera strategy, we previously developed the first HDAC

234 Consistent with this, bone marrow chimera studies show that aberrant Pkhd1 must be express

235 ransplantation studies and mixed bone marrow chimera studies suggested an involvement of inflammatory

236 ein but partially sequestered in the MA(NOS) chimera, suggesting that the unusual FIV sequence is con

237 ly reduces the Golgi residence time of a Tac chimera suggests that N-glycans might have a similar eff

238 s expressing monomeric ITAM or hemITAM gamma-chimeras, support model predictions that short distances

239 Several RdRP chimeras supported the growth of infectious poliovirus,

240 Using the proteolysis targeting chimera technology, we discovered a first-in-class PRMT5

241 ompound 10), using the proteolysis targeting chimera technology.

242 The RNAi scaffold is a general utility chimera that contains a functional RNA duplex with paire

243 Furthermore, we constructed G and F chimeras that allowed us to map the overall regions in G

244 ynthetic bacterium, producing macromolecular chimeras that display mechanisms of polychromatic solar

245 -lineage leukemia 1 (MLL1) gene generate MLL chimeras that drive the pathogenesis of acute myeloid an

246 r creating monodisperse, genetically encoded chimeras that enable bioactive proteins to be immobilize

247 Only chimeras that lacked GILT in both TECs and hematopoietic

248 iNKT cells in bone marrow chimeras that reconstituted thymic cellularity developed

249 status, and in tolerant mixed hematopoietic chimeras, the co-existence of these cells with donor leu

250 city of the bound CyaA(1-710)/HlyA(411-1024) chimera to penetrate cells and deliver the AC enzyme int

251 een the abilities of NUP98-PHD finger fusion chimeras to associate with H3K4me3-enriched chromatin an

252 on, we expressed truncated forms and protein chimeras to gain a deeper understanding of toxin specifi

253 udies provided a basis for constructing P450 chimeras to gain further insight into the features dicta

254 We created bone marrow chimeras to test the role of IRF3 within leukocytes vers

255 a G(alpha16), and via a G(alpha16)/G(alphaz) chimera, to stimulate IP(1) accumulation.

256 ally produce adhesion complex proteins, this chimera trafficked to the tips of filopodia and was also

257 f-principle evidence for the hypothesis that chimera-type galectin-3 design makes functional antagoni

258 Expression of these chimeras under the control of the endogenous promoter of

259 ve and functional PTK2 proteolysis-targeting chimeras utilizing von Hippel-Lindau and cereblon ligand

260 Truncation and chimera versions of TPX2 suggest that TPX2-tubulin co-co

261 Unexpectedly, the MYO10-MYO7B chimera was able to deliver CDHR2 and CDHR5 to distal ti

262 ORgammat shRNA moiety of CD30-AshR-RORgammat chimera was cleaved and released by Dicers.

263 Substrate promiscuity of the most active chimera was further assessed with a substrate library.

264 Although this chimera was inactive, we demonstrate fructose transport

265 Moreover, the chimera was safe and highly immunogenic when administere

266 rabinose-inducible, rapidly folding OmpA-GFP chimera was utilized to jam the SecYEG channels with an

267 ion properties, a set of TAL claudin protein chimeras was created and analyzed.

268 In mixed chimeras we demonstrate that IL-21 promotes T(H)2 respon

269 To identify low KM chimeras we developed a suitable bacterial selection sys

270 Moreover, using radiation chimeras we find that T cell lymphopenia depends on T ce

271 Using chimeras, we analyzed the role of leader and follower ce

272 opments in transgenic lines and human-rodent chimeras, we anticipate that in coming years, a clearer

273 Using reconstituted Las1 HEPN-HEPN' chimeras, we defined the molecular requirements for RNA

274 Using ClpS mutants and ClpS-ClpA chimeras, we establish that engagement of the intrinsica

275 Using TM4SF40-TM4SF20 chimeras, we identified Pro-29 of TM4SF20 as another imp

276 Using mini-G(sq) and -G(si) chimeras, we observed a coupling rank order of mG(s) > m

277 Importantly, using mixed bone marrow chimeras, we revealed that the proinflammatory phenotype

278 Using zebrafish chimeras, we show increased incidence of invasive melano

279 lyzing CD160(-/-) mice and mixed bone marrow chimeras, we show that CD160 is not essential for NKT ce

280 Using mouse chimeras, we show that the transcription factors Tbx1 an

281 By generation of fusion-active gB chimeras, we were able to identify target structures of

282 ry and structure-guided approaches, a set of chimeras were created that altered the targeting specifi

283 Mixed bone marrow chimeras were established in which all B cells were deri

284 To visualize T95 dynamics, fluorescent chimeras were expressed in triadin knockout myotubes, an

285 yelinated shiverer mice, the resultant glial chimeras were hypomyelinated; this defect could be rescu

286 These gB chimeras were intrinsically fusion active and led to the

287 The chimeras were less effective than SAMD14 itself in rescu

288 Human artery-NSG chimeras were treated with anti-CD28 domain antibody or

289 These models, together with bone marrow chimeras, were used to explore the role of adaptive and

290 e NCC-derived cells expanded in interspecies chimeras, whereas adjacent human donor NCC-derived cells

291 ma unlike to Galpha(i2-13)QL, the reciprocal chimera, which similarly to Galpha(i2)QL could not inter

292 The ESCs produce high-contribution chimeras, which recapitulate the melanoma phenotypes of

293 Furthermore, by composing a four-CCP DAF-MCP chimera with robust CFA (for C3b and C4b) and DAA (for c

294 -mediated editing to the generation of mouse chimeras with ESC-reconstituted forebrain regions that c

295 decided to humanize gpASNase1 by generating chimeras with hASNase1 through DNA shuffling.

296 fic regulatory T (Treg) cells was present in chimeras with increased deletion of TRP1-specific thymoc

297 Surprisingly, chimeras with IRF3-KO bone marrow showed little protecti

298 howed little protection from sepsis, whereas chimeras with IRF3-KO stroma showed a substantial degree

299 Chronic infection of Zbtb32(-/-) chimeras with murine cytomegalovirus led to nearly 20-fo

300 om the inhibitory effects of NAM S37a on: 1) chimeras with swapped ectodomain, 2) stepwise N-terminal