ライフサイエンスコーパス: chimeric mouse

1 The chimeric mouse (Agtr1a -/- <--> +/+) is made up of wild-

2 olk sac hematopoietic progenitor assays, and chimeric mouse analysis, we found that Hex is required f

3 The clinical application of rituximab (chimeric mouse anti-human CD20 mAb, Rituxan, IDEC-C2B8),

4 Development of the chimeric mouse antihuman CD20 antibody, Rituximab, prese

5 Furthermore, chimeric mouse bone marrow studies showed that resident

6 ith studies using novel Tg mice expressing a chimeric mouse-BoPrP gene.

7 luripotent stem cell (hPSC)-based microglial chimeric mouse brain model by transplanting hPSC-derived

8 Single-cell RNA-sequencing of the microglial chimeric mouse brains reveals that xenografted hPSC-deri

9 s interneuron production in DS organoids and chimeric mouse brains, and improves behavioral deficits

10 ts has led to the development of human glial chimeric mouse brains, which provides new opportunities

11 When wild-type veins were grafted into a chimeric mouse carrying TIE2-LacZ genes in bone marrow c

12 on and its mode of action, we have generated chimeric mouse embryos and performed tissue layer recomb

13 ax6 in eye and nasal development we produced chimeric mouse embryos composed of wild-type and Sey mut

14 Using scRNA-Seq analysis of chimeric mouse embryos lacking the major erythroid regul

15 Analysis of staged chimeric mouse embryos with a high contribution from emb

16 CVRI in establishing left-right asymmetry in chimeric mouse embryos.

17 nd Sey/+ cells with continued development in chimeric mouse eyes.

18 e structural analysis of PrP(Sc), a redacted chimeric mouse-hamster PrP of 106 amino acids (MHM2 PrP1

19 When transplanted into naive recipients, chimeric mouse hearts had significantly prolonged surviv

20 These data demonstrate that chimeric mouse-human antibodies are a viable alternative

21 occurred after introduction of cetuximab, a chimeric mouse-human antibody, for cancer treatment.

22 Consistent with this, an aglycosyl chimeric mouse-human DII-FL MAb (E28) variant that lacks

23 IgG1kappa constant domains and the resulting chimeric mouse-human genes were cloned into plant expres

24 Cetuximab, a chimeric mouse-human IgG1 monoclonal antibody against th

25 ride (LPS) were used to generate a series of chimeric mouse-human monoclonal antibodies with identica

26 Transgenic (Tg) mouse lines that express chimeric mouse-human prion protein (PrP), designated MHu

27 understand TERT protein function by creating chimeric mouse-human TERT proteins.

28 ablish a plant-based production system for a chimeric mouse-human version of mAb 62-71-3, to characte

29 r immunotherapy of B-cell malignancies using chimeric (mouse/human) or radiolabeled murine monoclonal

30 Native chimeric (mouse/human) snRNP particles were used to immu

31 Studies using nAChR chimeric mouse/human alpha6 subunits indicated that resi

32 epsilon primary transcript were expressed as chimeric mouse/human anti 5-dimethylamino-1-naphthalenes

33 Therefore, we have constructed a chimeric mouse/human antibody based on the structure of

34 egrin alphaIIbbeta3 inhibitor abciximab is a chimeric mouse/human antibody that induces thrombocytope

35 a FAD-linked human PS1 variant (A246E) and a chimeric mouse/human APP harboring mutations linked to S

36 Studies involving WT or gain-of-function chimeric mouse/human beta3 subunits narrowed the search

37 from structural insights on the topology of chimeric mouse/human CD3epsilondelta dimers.

38 of regulatory interactions between CFTR and chimeric mouse/human ENaCs suggest that the 20 C-termina

39 oped a new knock-in mouse model of HD with a chimeric mouse/human exon 1 containing 140 CAG repeats i

40 Using chimeric mouse/human hybrid TfR1 constructs, we determin

41 Mice expressing chimeric mouse/human PrP transgenes were produced.

42 o address this issue, we developed a prestin chimeric mouse in which both ROSA26 wild-type (WT) and p

43 In contrast, rat hepatocytes in chimeric mouse livers displayed rat kinetics despite the

44 ection of woodchuck hepatocytes in uPA/RAG-2 chimeric mouse livers.

45 in radiolabeled cross-linked fibrin in TM-/- chimeric mouse lung as compared with wild-type mice.

46 the progression of prion disease in a unique chimeric mouse model (see the related article beginning

47 we present a doxycycline-inducible CIC::DUX4 chimeric mouse model and a cancer line derived from it,

48 man fluorescent endometriotic cell lines and chimeric mouse model as preclinical testing platform, ou

49 In this report, a chimeric mouse model based on CD40 knockout and wild-typ

50 We anticipate that this intraspecies chimeric mouse model can serve as a valuable tool for ba

51 Using a chimeric mouse model for renal ischemia-reperfusion inju

52 A chimeric mouse model harboring genetic LOX depletion rev

53 n in vitro liver-stage growth assay and in a chimeric mouse model harboring human hepatocytes.

54 We created a chimeric mouse model in which A(2A)Rs on bone marrow-der

55 -relevant molecular pathways, we generated a chimeric mouse model in which sarcoma-associated genetic

56 sis, we enhanced beta-catenin signaling in a chimeric mouse model in which the stem cell selection co

57 The establishment of this chimeric mouse model is a significant advance toward und

58 Using a newly developed chimeric mouse model of AAA, we now demonstrate that mac

59 Here we use a chimeric mouse model of chronic myeloid leukaemia (CML)

60 ing both in vitro analysis and a human glial chimeric mouse model of JCV infection, we found that div

61 d hepatocyte culture model and a human liver chimeric mouse model to dissect the roles of ORF3 in gt3

62 g in endothelial repair in apoE(-/-) mice, a chimeric mouse model was created by bone marrow transpla

63 This human liver chimeric mouse model will expand the experimental possib

64 In a chimeric mouse model, B2G1 and polyclonal Ig preparation

65 ased HBV infection systems and a human-liver chimeric mouse model, IFN-a subtype-mediated antiviral r

66 In a human synovium chimeric mouse model, silencing ORAI3 expression in adop

67 Using a human liver-chimeric mouse model, we show that a monoclonal antibody

68 HCV quasispecies challenge in a human liver-chimeric mouse model.

69 patient-derived envelopes and a human-liver chimeric mouse model.

70 nd from the liver and serum of a human liver chimeric mouse model.

71 ection against Pf infection in a human liver-chimeric mouse model.

72 those observed in the in vivo HBV infection chimeric mouse model.

73 Cell-specific depletion and chimeric mouse models revealed that GC B cells drive TBM

74 r three-dimensional fibrosis and human liver chimeric mouse models that CLDN1 is a mediator and targe

75 In chimeric mouse models YTHDF2-deficient plasma cells fail

76 ripotent stem cell (iPSC)-based organoid and chimeric mouse models, we report that DS microglia exhib

77 Using in vitro cell culture and human liver-chimeric mouse models, we show that a human mAb targetin

78 the cochlear partition, similar to all other chimeric mouse models.

79 ive or noninvasive Salmonella organisms, and chimeric mouse studies revealed the key role of MyD88-de

80 l grafting approach to surgically assemble a chimeric mouse that was part wild-type (WT) and part cir

81 Flow cytometry data showed that the chimeric mouse thymic epithelial cells (TECs) were deriv

82 een fluorescence protein (GFP) hematopoietic chimeric mouse, we determined that 90% of the dividing c