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1 rly endosome indicating translocation of the chimeric toxin.
2 n be manipulated by molecular engineering of chimeric toxins.
3 e conclude that biochemical targeting of the chimeric toxin and physical targeting of ionizing radiat
4 l or systemic toxicity was observed with the chimeric toxin and radiation.
5 ant cells exhibited similar responses to the chimeric toxins and interleukins when compared with that
6 enotype, we constructed enzymatically active chimeric toxins and mutant toxins that contained single
7 old mice given nasal tetanus toxoid plus the chimeric toxin as adjuvant were protected from lethal ch
8                         Here, we developed a chimeric toxin-based delivery platform by fusing the rec
9 ype s1/m1 toxin was added to HeLa cells, the chimeric toxin completely inhibited the activity of the
10 te in blastocyst activation, the toxicity of chimeric toxins composed of HB-EGF or TGF-(&agr;) couple
11                            Analysis of these chimeric toxins confirmed that toxin-induced signal tran
12 oops exist in the HCs of BoNT/C, D, G, and a chimeric toxin DC.
13 ct rabbit portal vein smooth muscle with the chimeric toxin DC3B (10(-6) M, 48 h; ; ) ADP-ribosylated
14                   CD4-PE40 and 3B3(Fv)-PE38, chimeric toxins designed to target the HIV envelope (Env
15                                          The chimeric toxins had attenuated affinity for binding to h
16      Of interest, a corresponding hIL4-based chimeric toxin, hIL4-PE38QQR, is poorly active or not ac
17                                          The chimeric toxins, however, were much less potent than wt
18                 We show that this engineered chimeric toxin irreversibly cleaves and inactivates intr
19 ible to hIL13-PE38QQR, and the action of the chimeric toxin is not blocked by hIL4 on all these cells
20                             As a first step, chimeric toxins of ProTx II and PaTx I were synthesized
21 udy the proteolytic processing of PE-derived chimeric toxins, TGFalpha-PE38 (transforming growth fact
22 ndent manner and reduced the binding of this chimeric toxin to HEp-2 cells.
23 branes and signal transduction, CT and LTIIb chimeric toxins were prepared.