ライフサイエンスコーパス: chiral ligand

1 t can be formed by appropriate choice of the chiral ligand.

2 nd could be minimized through the use of the chiral ligand.

3 red to the same reaction in the absence of a chiral ligand.

4 group and the stereodirecting phenyl of the chiral ligand.

5 specific preactivation protocols, and excess chiral ligand.

6 imilar to an axial chirality in the designed chiral ligand.

7 ctive catalyst species that is oligomeric in chiral ligand.

8 ity when bioxazolines (BiOX) are used as the chiral ligand.

9 way to overcome the deactivating effect of a chiral ligand.

10 us placement of fluorine substituents in the chiral ligand.

11 cols without the use of (-)-sparteine as the chiral ligand.

12 e of a commercially available Ni complex and chiral ligand.

13 with (S)-SEGPHOS, the same enantiomer of the chiral ligand.

14 lectivities are achieved using TangPHOS as a chiral ligand.

15 en demonstrated for a Sm(III) complex with a chiral ligand.

16 stituted pi-allyl complexes with DPPBA-based chiral ligands.

17 s of Lewis acidic metal salts coordinated to chiral ligands.

18 xplore starting points for the design of new chiral ligands.

19 chiroptical responses even in the absence of chiral ligands.

20 losely tied to the development of customized chiral ligands.

21 halides without exogenous redox chemistry or chiral ligands.

22 pling is stereoconvergent in the presence of chiral ligands.

23 m the commonly observed chirality induced by chiral ligands.

24 erovskite nanocrystals in the absence of any chiral ligands.

25 gs enabled by the development of a series of chiral ligands.

26 as protected 1,2-amino alcohol motifs and as chiral ligands.

27 lective reduction of cyclic imines employing chiral ligands.

28 uses commercially available cobalt salts and chiral ligands.

29 supply issues relating to these widely used chiral ligands.

30 yclohexadienones using transition metals and chiral ligands.

31 ly with the most acidic member of a suite of chiral ligands.

32 nly recently emerged as a versatile class of chiral ligands.

33 Cu(II) ions with ditopic bisoxazoline-based chiral ligands.

34 cally active compounds, natural products and chiral ligands.

35 In the crossover reactions with 9 out of 12 chiral ligands, 10-75% less elimination to 1-phenylbutad

36 d only on a case-by-case basis using bespoke chiral ligands(11) or in a diastereoselective fashion gu

37 91 to 94% ee for a range of substrates when chiral ligand 14 is employed.

38 The trimeric complex ion (three chiral ligands-2 mol of the analyte and 1 mol of the ref

39 When present in chiral ligands(3), catalysts(4) and auxiliaries(5), quat

40 (CDR) of rac-2-lithio-N-Boc-piperidine using chiral ligand 8 or its diastereomer 9 in the presence of

41 nd order in TMEDA and 0.5 and 0.265 order in chiral ligands 8 and 10, respectively.

42 hyl carbonate was examined with 12 different chiral ligands across a range of scaffold types.

43 ls, where it is difficult to discern whether chiral ligands affect only the surface atoms or the enti

44 The chiral ligands allow the full control of stereochemistry

45 g and destabilizing interactions between the chiral ligand and allene-yne PKR substrates.

46 lides [Cu(II) or Ag(I)] with the appropriate chiral ligand and C60 is described.

47 With use of a chiral ligand and imides as carbon nucleophiles, a 3,4-a

48 rom the inorganic sublattice rather than the chiral ligand and is an excitonic phenomenon driven by e

49 ric repulsions between the t-Bu group of the chiral ligand and the alpha-methylene hydrogens of the e

50 Match/mismatch effects between the chiral ligand and the chiral TADDOL-phosphate counterion

51 The system is flexible in terms of both the chiral ligand and the nature of the external olefin.

52 of the catalysts was the crucial role of the chiral ligand and the nature of the metal ions, which pr

53 (1) has potential utility as a scaffold for chiral ligands and as a modified backbone unit for pepti

54 ls represent potentially useful synthons for chiral ligands and auxiliaries.

55 which are further applied in preparation of chiral ligands and biologically active molecules.

56 s can be readily derivatized to yield planar chiral ligands and catalysts for asymmetric catalysis as

57 ds in natural products, bioactive molecules, chiral ligands and catalysts, but biocatalytic methods f

58 idely used as precursors to, or directly, as chiral ligands and catalysts.

59 ciated with the use of enantiomerically pure chiral ligands and catalysts.

60 mol % of easily accessible amino acid-based chiral ligands and commercially available AgOAc.

61 information on the plethora of sulfur-based chiral ligands and organocatalysts used in asymmetric sy

62 he development of synthetic building blocks, chiral ligands and organocatalysts.

63 e new building blocks for the synthesis of P-chiral ligands and organocatalysts.

64 interest owing to their privileged status as chiral ligands and pharmacophores(2-4).

65 structural features of the amino acid-based chiral ligands and the chiral ligand's effectiveness in

66 talysts originating from the coordination to chiral ligands and those which are solely composed of op

67 al-at-metal" examples (i.e., systems without chiral ligands) and heterometallic (i.e., mixed metal sy

68 of commercially available metal catalyst and chiral ligand, and gives the highest yields and selectiv

69 tive ester are exposed to a nickel catalyst, chiral ligand, and metal reductant, alpha-amido ketones

70 re valuable and widely used building blocks, chiral ligands, and catalysts that are effective across

71 serving for example as bioactive molecules, chiral ligands, and chiral catalysts.

72 acilitate the synthesis of natural products, chiral ligands, and pharmaceutical intermediates.

73 n allow for applications in optoelectronics, chiral ligands, and planar chiral materials.

74 s require the use of precious metals, costly chiral ligands, and/or forcing reaction conditions.

75 These chiral ligands are easy to prepare and flexible for modi

76 e of chiral induction was also observed when chiral ligands are electronically tuned in the same mann

77 Two easily accessible chiral ligands are identified as optimal for reactions o

78 iral organocatalysts or metal complexes with chiral ligands are used, has become the most valuable me

79 probing speciation of uranyl complexes when chiral ligands are used, without the need for synthetic

80 Typically, metal catalysts bearing chiral ligands as well as chiral organocatalysts have be

81 previously required fundamentally different chiral ligands, as well as a novel oxygen-linked scaffol

82 he AA2 moiety of the peptidic segment of the chiral ligand associates and delivers HNC to the activat

83 The chiral ligand, base, solvent, and stoichiometry are eval

84 r Ni-electrocatalytic conditions using a new chiral ligand based on PyBox, resulting in amides with a

85 group of the propargyl alcohol moiety and a chiral ligand basic group offers a novel asymmetric indu

86 (IV)cyclic intermediate, induced by a simple chiral ligand-BINAP [2,2'-bis(diphenylphosphino)-1,1',-b

87 d cascades that exploit a simple, recyclable chiral ligand can convert symmetrical ketoesters to comp

88 Catalytic alkylations with Et2Zn require a chiral ligand carrying two amino acid moieties (valine a

89 inc to aromatic nitroalkenes by known copper-chiral ligand catalysts.

90 lts were compared with those of two existing chiral ligands, Chiraphite and BINAPHOS, whose utility i

91 opment of iridium-based systems with various chiral ligand classes, as well as studies of their react

92 mediate the electroreduction of the Cr(III)/chiral ligand complex.

93 resolved diastereomeric 2-lithiopyrrolidine-chiral ligand complexes provided the enantiomerically en

94 rate that lower alkene amounts and/or higher chiral ligand concentration can minimize the deleterious

95 st effectively promoted in the presence of a chiral ligand containing a single amino acid (benzyl cys

96 pargyl acetates and propargyl acetals in the chiral ligand-controlled Rautenstrauch reaction.

97 ective dearomatization is achieved via metal-chiral ligand cooperation.

98 en developed recently, and this new class of chiral ligands could enable their modification for asymm

99 The complex of palladium(0) and the chiral ligand derived from the diamide of trans-1,2-diam

100 smox]12(OH2)3}.212H2O (1), where hismox is a chiral ligand derived from the natural amino acid l-hist

101 hich are valuable in medicinal chemistry and chiral ligand design.

102 tituted biaryls that can be useful in future chiral ligand designs.

103 tereoselective dihydroxylation employing the chiral ligand (DHQ)2PHAL was used as the key step to int

104 ccurs with racemic cyclic electrophiles, the chiral ligand employed reacts kinetically faster with th

105 Pd(0) complex equipped with H(8)-BINAPO as a chiral ligand enables the direct functionalization of a

106 The combination of chiral ligand exchange on Cu(II) complexes in aqueous ba

107 L-His was used as a chiral ligand-exchange selector and copper (II) as a cen

108 tion of an open tubular capillary column for chiral ligand-exchange separation and determination of m

109 The newly designed chiral ligand exhibits high diastereoselective control d

110 covery of the monophosphine (S)-AntPhos as a chiral ligand for the enantioselective hDA of acyclic di

111 Phos, had previously only been employed as a chiral ligand for transition metals, not as an efficient

112 iral Cdots core with arginine enantiomers as chiral ligands for comparing the pH sensitivity of enant

113 onal groups and were successfully applied as chiral ligands for metal catalysis.

114 he development of supramolecularly assembled chiral ligands for metal complexes.

115 ass of chemical modalities that may serve as chiral ligands for metal-based catalysts or as catalysts

116 Nowadays, design of the new chiral ligands for organometallic catalysts is often bas

117 ovides new insight into an emerging class of chiral ligands for stereoconvergent Ni and Ni/photoredox

118 y functional theory (DFT) based screening of chiral ligands for transition-metal-catalyzed reactions

119 system comprising CuBr.SMe2 and TaniaPhos as chiral ligands gives rise to a range of branched product

120 the years cooperative assistance of multiple chiral ligands has been applied to control only chiral c

121 ic 2-lithiopyrrolidines in the presence of a chiral ligand have been achieved.

122 ome proliferator activated receptors (PPARs) chiral ligands have been designed following the accepted

123 on nucleophiles and heteronucleophiles, many chiral ligands have been developed.

124 as well as enantioselective protocols using chiral ligands have been successfully developed during t

125 on transition metals coordinated to suitable chiral ligands, heterogeneous chiral catalysts could off

126 The rational design of chiral ligands identified a new class of carboxamide-con

127 The method can determine if a chiral ligand imparts the observed selectivity by stabil

128 nvestigation of the bicyclic derivative as a chiral ligand in metal catalysis is also conducted.

129 Employing a chiral ligand in the allylation preserved the reaction e

130 ing resin 12 has subsequently been used as a chiral ligand in the catalytic addition at 0 degrees C o

131 horamidite was identified to be an effective chiral ligand in the palladium-catalyzed reaction.

132 als and by the use of commercially available chiral ligands in 52-96% yield and 93:7 to >99:1 enantio

133 Furthermore, assessment of a number of chiral ligands in a challenging asymmetric Suzuki-Miyaur

134 The utility of these chiral ligands in asymmetric catalysis is also demonstra

135 of dihedral angles, which may be explored as chiral ligands in enantioselective catalysis if decorate

136 t2Zn and Me2Zn, promoted by amino acid-based chiral ligands in the presence of Al-based alkoxides, af

137 tereodiscriminating fragments for some known chiral ligands including the Masamune dimethylborolane,

138 practical as well as efficient, because the chiral ligand is both readily prepared from R,R- or S,S-

139 nstance, whereby the performance of a single chiral ligand is enhanced not by modification of the arc

140 0.1-1 mol % catalyst (4 degrees C), and the chiral ligand is readily prepared from commercially avai

141 er via chiral resolution or by employment of chiral ligands is described, characterization techniques

142 More importantly, using this type of chiral ligands, it is possible to perform desymmetrizing

143 or a range of delta-substituted dienals when chiral ligand L3 is employed.

144 Chiral ligand L4 was found to be optimal in the DAAA of

145 Is) between the N-benzyl and the rest of the chiral ligand limit the N-benzyl conformers.

146 The easy recovery of the chiral ligand makes the application of these new catalys

147 catalysis is achieved for the first time via chiral ligand metal cooperation.

148 tive approach to this traditional metal-plus-chiral-ligand method has emerged.

149 Using a modular amino acid based chiral ligand motif, a library of ligands was synthesize

150 However, bespoke chiral ligands must typically be identified for each new

151 A novel chiral ligand, named MAdPHOS, bearing a P-stereogenic ph

152 n the design and development of the types of chiral ligands needed to achieve these reactions and an

153 e or dynamic resolution in the presence of a chiral ligand of N-Boc-2-lithiopiperidine followed by th

154 inetic resolution of secondary alcohols as a chiral ligand on palladium and as an exogenous chiral ba

155 We propose that well-organized chiral ligands on the surface of self-assembled nanostru

156 The trimeric complex ions (three chiral ligands--one of the analyte and two of the refere

157 Chiral ligands play a central role in enantioselective t

158 DHQD)(2)PHAL (DHQD) or (DHQ)(2)PHAL (DHQ) as chiral ligands, proceeded more readily and in higher yie

159 achiral counterion (equimolar to the neutral chiral ligand-proton complex present at low catalyst loa

160 c interactions between the substrate and the chiral ligand, rather than through precoordination by a

161 from palladium(II) trifluoroacetate and the chiral ligand (S)-t-BuPyOx.

162 the amino acid-based chiral ligands and the chiral ligand's effectiveness in reactions involving ach

163 substrates and the use of a high-throughput chiral ligand screening platform.

164 The chiral ligand (-)-sparteine and PdCl(2) catalyze the ena

165 rofile largely from the stabilization of the chiral ligand sphere by London dispersion (LD) interacti

166 ed in our previous studies using the related chiral ligand sSPhos.

167 catalyst derived from a copper salt and the chiral ligand StackPhos, pyrazine is readily dearomatize

168 The chiral-ligand strategy has proven applicable to a wide v

169 tform for exploring the relationship between chiral ligand structure and enantioselective olefin oxid

170 al Lewis acids derived from relatively small chiral ligands, suggesting the pyrazolidinone templates

171 atives constitute a new family of tridentate chiral ligands thanks to the presence of an additional s

172 the presence 0.5-10 mol % of a Zr salt and a chiral ligand that contains two inexpensive amino acids

173 pensive metal salt (AgOAc) and an air stable chiral ligand that is prepared in three steps from comme

174 cular cycloadditions using a C (2)-symmetric chiral ligand that stabilizes a metal-metal bond.

175 A new series of modular chiral ligands that are derived from amino acids were pr

176 Supported by an optimized chiral ligand, the Co(II)-based metalloradical system ca

177 Supported by an optimal chiral ligand, the Co(II)-based metalloradical system, w

178 in the presence of an appropriate ancillary chiral ligand, the opposite regiochemistry can be observ

179 With (S)-t-Bu-PyOX as the chiral ligand, this method delivers a variety of alpha-t

180 In the presence of appropriate chiral ligands, this reaction is rendered enantioselecti

181 steering of substrates by the C-terminus of chiral ligands through ionic interactions.

182 zed enantioselective transformations rely on chiral ligands tightly bound to the metal to induce asym

183 atter compound has the potential to act as a chiral ligand to metal centers.

184 d asymmetrically using phthalazinamine-based chiral ligand to provide 9 chiral addition products in 9

185 m each play a distinct role: one serves as a chiral ligand to provide stereoinduction in the addition

186 irectly ionized in the presence of Pd(0) and chiral ligands to afford alkylation products with regio-

187 The development of chiral ligands to direct the course and stereoselectivit

188 of a large and chemically diverse set of 30 chiral ligands to effect asymmetric cyclization of 2-(N,

189 l counterion can be combined additively with chiral ligands to enable an asymmetric transformation th

190 The coordination of chiral ligands to Lewis acid metal derivatives, a useful

191 l catalysts relies on direct complexation of chiral ligands to produce a sterically constrained react

192 he synthesis of drugs, natural products, and chiral ligands used in enantioselective catalysis.

193 A simple norephedrine-based chiral ligand was synthesized that gives alkylation prod

194 high enantiomeric excess when an appropriate chiral ligand was used.

195 The utility of the carbenes as chiral ligands was examined in the Rh-catalyzed asymmetr

196 The conformational flexibility of the chiral ligands was found to be an important factor in th

197 actions catalyzed by complexes of nonracemic chiral ligands were also conducted, and the first enanti

198 Ruthenium complexes employing axially chiral ligands were found to be effective asymmetric hyd

199 A range of N-substituents and chiral ligands were investigated for the dynamic resolut

200 ic alcohols can be carried out in water with chiral ligands, which incorporate sulfonamide and hydrox

201 With the support of new-generation HuPhyrin chiral ligands whose cavity environment can be fine-tune

202 Furthermore, we prepared a larger chiral ligand with isoquinoline donors, which, unlike th

203 merically enriched starting material using a chiral ligand with the opposite configuration, enables c

204 We designed three closely related chiral ligands with different point chiralities, and obs

205 methylene C-H bonds can be achieved by using chiral ligands with opposite configuration to construct

206 The design of chiral ligands with the right configuration is fundament