ライフサイエンスコーパス: chloride channel

1 g a phosphorylation-activated, but ATP-gated chloride channel.

2 tion of the ancillary function of EAAT1 as a chloride channel.

3 d of five subunits arranged around a central chloride channel.

4 detect ANO4 activity as a calcium-activated chloride channel.

5 osis (CF) is caused by mutations in the CFTR chloride channel.

6 rpolarization-activated, inwardly rectifying chloride channel.

7 ing states through the MOD-1 serotonin-gated chloride channel.

8 feedback chemical synapse associated with a chloride channel.

9 lalpha gene, which encodes a glutamate-gated chloride channel.

10 rface stability, and/or function of the CFTR chloride channel.

11 ce expression of the alpha1 glycine receptor chloride channel.

12 s transmembrane conductance regulator (CFTR) chloride channel.

13 rupts both the processing and gating of this chloride channel.

14 ABA(A) receptor, a postsynaptic ligand-gated chloride channel.

15 ), a phosphorylation-activated but ATP-gated chloride channel.

16 F transmembrane conductance regulator (CFTR) chloride channel.

17 phospholipid scramblase and Ca(2+)-activated chloride channel.

18 ide removal through the concurrently opened, chloride channels.

19 ttranslational modification of CLC-K/barttin chloride channels.

20 ate recognition arose in the glutamate-gated chloride channels.

21 lar complex and function of Ca(2+)-activated chloride channels.

22 to other ion channels such as potassium and chloride channels.

23 but independent from vesicular transport and chloride channels.

24 expression of the Cl channel kidney-specific chloride channel 1 and its subunit Barttin, the urea tra

25 ductions in pathological RNA foci, rescue of chloride channel 1 protein expression, and decreased myo

26 Immunostaining suggested lower expression of chloride channel 2 and cystic fibrosis transmembrane reg

27 In Mus spretus, the chloride channel 4 gene Clcn4-2 is X-linked and dosage c

28 mutations of the chloride/proton antiporter, chloride channel-5 (CLC-5), resulting in low-molecular-w

29 tein Kinase A (PKA)-mediated facilitation of chloride channel-7 (ClC-7) delivery to lysosomes which r

30 AtCLCa (Arabidopsis thaliana Chloride Channel a) is a vacuolar NO(3) (-)/H(+) exchang

31 f the nervous system using a histamine-gated chloride channel abolishes pumping, and optogenetic stim

32 The 3-gene signature of periostin, chloride channel accessory 1 (CLCA1), and Serpin beta2 (

33 We report that expression of chloride channel accessory protein hCLCA2 is a character

34 C-RPE fully restored BEST1 calcium-activated chloride channel activity and improved rhodopsin degrada

35 Sphingomyelinase C (SMase) inhibits CFTR chloride channel activity in multiple cell systems, an e

36 nd III CFTR variants, restoring cell surface chloride channel activity in primary human bronchial epi

37 Here we report light-induced chloride channel activity of a purified ACR protein reco

38 vage and a novel mechanism for regulation of chloride channel activity specific to the mucosal interf

39 Moreover, ANO1 chloride channel activity was important for cell viabili

40 MEM16 family have either lipid scramblase or chloride channel activity.

41 uctance regulator (CFTR) that compromise its chloride channel activity.

42 ockdown or pharmacological inhibition of its chloride-channel activity reduced EGF receptor (EGFR) an

43 meric Caenorhabditis elegans glutamate-gated chloride channel alpha (GluCl), at 3.3 A resolution.

44 in glutathione S-transferase, intracellular chloride channel and annexin molecules from various sour

45 resumed to assemble into a calcium-activated chloride channel and be involved in chloride transport b

46 Ivacaftor is a potentiator of the CFTR chloride channel and is in worldwide clinical use for th

47 ClC-1 is the dominant sarcolemmal chloride channel and plays an important role in regulati

48 he removal of Ca(2+) leads to closure of the chloride channel and response termination.

49 change in the receptor, opening an intrinsic chloride channel and thereby dampening neuronal excitabi

50 hogenicity of splice site mutations of CLC-1 chloride channels and a new gene association for Anderse

51 er for Cl(-) remains unknown, blocking known chloride channels and cotransporters had little effect o

52 rty observed in endogenous calcium-activated chloride channels and could be relevant to physiological

53 ure the activity and location of subcellular chloride channels and transporters in living cells in a

54 Most mammalian chloride channels and transporters in the CLC family dis

55 interaction with claudin-4, the paracellular chloride channel, and delocalization of claudin-4 from t

56 nic anhydrase, a member of the ClC family of chloride channels, and a member of the Gpr1/Fun34/YaaH f

57 The calcium-activated chloride channel ANO1 regulates multiple physiological p

58 rated that in mouse, genetic inactivation of chloride channel Ano1/Tmem16a compromises airway barrier

59 mutations in the proposed calcium-activated chloride channel ANO5/TMEM16E gene have been identified.

60 ate the involvement of the calcium-activated chloride channel anoctamin 1 (ANO1) in esophageal prolif

61 The calcium-activated chloride channel anoctamin 1 (ANO1) is located within th

62 Mutations in human CLC-1 chloride channel are associated with the skeletal muscle

63 ClC-K chloride channels are crucial for auditory transduction

64 les for Ano1 in organogenesis, and show that chloride channels are essential for mammalian airway for

65 CLC-K/barttin chloride channels are essential for NaCl re-absorption i

66 CLC-K chloride channels are expressed in the kidney and in the

67 CLC-K chloride channels are expressed in the kidney and the in

68 mportant step in NLRP3 activation, but which chloride channels are involved is still unknown.

69 F transmembrane conductance regulator (CFTR) chloride channel at the apical plasma membrane.

70 CFTR is a major prosecretory chloride channel at the ocular surface.

71 carb and metaflumizone), the glutamate-gated chloride channel (avermectins), the octopamine receptor

72 The glutamate-gated chloride channel AVR-14 is expressed in HOA.

73 , which encodes a putative calcium-activated chloride channel belonging to the Anoctamin family of pr

74 We tested the effect of the chloride channel blocker 9-anthracenecarboxylic acid (9A

75 In addition, applying a chloride channel blocker impeded TBSV replication in Nic

76 ast IPSPs were blocked by the GABAA receptor chloride channel blocker picrotoxin, whereas the slow su

77 thiocyanatostilbene-2,2'-disulfonic acid), a chloride channel blocker previously shown to prevent 1,2

78 A glutamate transporter-associated chloride channel blocker TBOA suppresses I(RC) but not I

79 s transmembrane conductance regulator (CFTR) chloride channel, but the structural basis of blocker bi

80 cretion and activation of the Ca2+-activated chloride channel (CaCC) anoctamin 1 (ANO1, also known as

81 TMEM16A (ANO1) is a calcium-activated chloride channel (CaCC) expressed in secretory epithelia

82 function 16 (TMEM16A) is a calcium-activated chloride channel (CaCC) important for neuronal, exocrine

83 kinase A (PKA), whereas the Ca(2+)-activated chloride channel (CaCC) is activated by Ca(2+) agonists

84 at the recently identified calcium-activated chloride channel (CaCC) TMEM16A is expressed in the adul

85 The calcium-activated chloride channel (CaCC) TMEM16A plays crucial roles in r

86 n evolutionarily conserved calcium-activated chloride channel (CaCC), regulates cytoplasmic Cl(-) hom

87 vage prevent activation of calcium-activated chloride channel (CaCC)-mediated chloride transport.

88 Calcium-activated chloride channels (CaCCs) are key players in transepithe

89 Calcium-activated chloride channels (CaCCs) encoded by TMEM16A control neu

90 Calcium-activated chloride channels (CaCCs) play important roles in severa

91 e physiologically relevant calcium-activated chloride channels (CaCCs) present in many tissues.

92 Ca(2+)-activated chloride channels (CaCCs) regulate numerous physiologica

93 Ca2+ -activated chloride channels (CaCCs) regulate numerous physiologica

94 Bestrophin calcium-activated chloride channels (CaCCs) regulate the flow of chloride

95 TMEM16A forms calcium-activated chloride channels (CaCCs) that regulate physiological pr

96 TMEM16A and TMEM16B are calcium-activated chloride channels (CaCCs) with important functions in ma

97 rents carried by TRPC2 and calcium-activated chloride channels (CACCs).

98 al signaling that involves calcium-activated chloride channels (CaCCs).

99 g of lung sections, Western blot analysis of chloride channel calcium activated 3 (CLCA3) expression

100 The chloride channel calcium-activated (CLCA) family are sec

101 Here, we define a signaling pathway from chloride channel calcium-activated 1 (CLCA1) to MAPK13 t

102 PAGE and mass spectrometry identified murine chloride channel calcium-activated 1 (mCLCA1) as the 10.

103 tation-related defect in the epithelial-cell chloride channel called CF transmembrane conductance reg

104 ective cation channels, and Ca(2+)-activated chloride channels can contribute to synchronization, whe

105 s transmembrane conductance regulator (CFTR) chloride channel caused by pathogenic mutations.

106 F transmembrane conductance regulator (CFTR) chloride channels causes defective secretion by submucos

107 nsmembrane conductance regulator (CFTR) is a chloride channel central to the development of secretory

108 ) in which loss-of-function mutations in the chloride channel CF transmembrane conductance regulator

109 loblasts express anion exchanger 2 (Ae2a,b), chloride channel Cftr, and amelogenins that can bind pro

110 -and the corresponding residue (A417) in the chloride channel ClC-0-as residues that contribute to NO

111 t in loss-of-function of the skeletal muscle chloride channel ClC-1.

112 expression of adhesion molecule GlialCAM and chloride channel ClC-2, but no substantial changes in ot

113 The absence of the chloride channel CLC-3 in Clcn3(-/-) mice results in hip

114 The chloride channel CLC-3 is expressed in the brain on syna

115 by a conditional deletion of megalin or the chloride channel ClC-5 had constitutively enhanced AQP1

116 that of sodium-chloride cotransporter Nkcc, chloride channel ClC-Ka, and ClC-Ka/b accessory subunit

117 ism of anion selectivity in the human kidney chloride channels ClC-Ka and ClC-Kb is unknown.

118 etween structure and function for the kidney chloride channels ClC-Ka and ClC-Kb, and for CLC protein

119 unction of intracellular transporters of the Chloride Channel (CLC) family in eukaryotes: not only co

120 The chloride channel (CLC) family is distinctive in that som

121 nt CLCNKA gene, which encodes the K(a) renal chloride channel (ClC-K(a)).

122 investigate the role that the expression of chloride channels (ClC-1) plays on the age-dependent ele

123 tent with this, the expression of the muscle chloride channel, ClC-1, in Huntington disease muscle wa

124 LC-1, the alpha-subunit of a glutamate-gated chloride channel, confers resistance to avermectins in t

125 and glutamate uptake assays, we identified a chloride-channeling conformer, iChS, transiently accessi

126 ing significantly decreased Ca(2+)-dependent chloride channel currents activated in response to the n

127 t wild-type Arg83 and variant Gly83 ClC-K(a) chloride channel currents revealed approximately 50% los

128 ments show that Delta27-264 CFTR can restore chloride channel currents.

129 VNO and the requirement of calcium-activated chloride channels currents to mediate pheromone activati

130 In vertebrates, the chloride channel cystic fibrosis transmembrane conductan

131 is (CF) is caused by mutations in the apical chloride channel cystic fibrosis transmembrane conductan

132 pithelial chloride(-) secretion, through the chloride channels cystic fibrosis transmembrane conducta

133 ight be related to the basic cystic fibrosis chloride channel defect.

134 The calcium-dependent chloride channel DOG1 (ANO1/TMEM16A), which is strongly

135 ylation appears to play an important role in chloride channel dysfunction in certain BS variants, sug

136 ry subunit barttin might thus play a role in chloride channel dysfunction in certain variants of Bart

137 s, including the mucus metaplasia of asthma, chloride channel dysfunction of cystic fibrosis, and cil

138 this issue by showing that a plasma membrane chloride channel, encoded by ClC-a, is exclusively expre

139 lic Adenosine MonoPhosphate (cAMP)-dependent chloride channel expressed at the apical plasma membrane

140 Activation of the glutamate-gated chloride channel expressed in either rodent or human ind

141 TMEM16B (ANO2) is the Ca(2+)-activated chloride channel expressed in multiple brain regions, in

142 d anoctamin 1 (ANO1), is a calcium-activated chloride channel expressed widely mammalian cells, inclu

143 ker ATF3 following prolonged glutamate-gated chloride channel expression.

144 inoids, the gamma-aminobutyric acid receptor/chloride channel for polychlorocyclohexanes and fiproles

145 sing channelrhodopsin-2 or a light-activated chloride channel for retrograde labelling, bidirectional

146 tive allosteric modulator of glutamate-gated chloride channels found in nematodes and insects.

147 ively, and of the eukaryotic glutamate-gated chloride channel from Caenorhabditis elegans (GluCl), wh

148 n a living cell, utilizing a glutamate-gated chloride channel from the nematode Haemonchus contortus

149 bestrophin-1 (hBest1) is a calcium-activated chloride channel from the retinal pigment epithelium, wh

150 seawater is mediated by trafficking of CFTR chloride channels from intracellular vesicles to the pla

151 be mediated by ClC-Ka/K1 and ClC-Kb/K2, two chloride channels from the ClC family, or by KCl cotrans

152 rocessing and a "potentiator" to improve its chloride channel function.

153 tor (CFTR) that impair its expression and/or chloride channel function.

154 g defect that impairs protein maturation and chloride channel function.

155 GABA-gated chloride channels (GABAARs) trafficking is involved in t

156 olding/cellular processing ("correctors") or chloride channel gating ("potentiators") have been disco

157 lar targeting to the plasma membrane and its chloride channel gating.

158 protein impairs its folding, stability, and chloride channel gating.

159 These were rs2228291, in the chloride channel gene CLCN2, and rs10513488, in the pota

160 ased on the structure of the glutamate-gated chloride channel GluCl of Caenorhabditis elegans.

161 ) and Caenorhabditis elegans glutamate-gated chloride channel (GluCl) for X-ray crystallography, demo

162 f the Caenorhabditis elegans glutamate-gated chloride channel (GluCl) in complex with the allosteric

163 termination of a structure of the eukaryotic chloride channel, GluCl, is an important step toward acc

164 Glutamate-gated chloride channels (GluCls) are found only in protostome

165 from selectively activating glutamate-gated chloride channels (GluCls) in invertebrates, not affecti

166 ceptors (GlyRs) and nematode glutamate-gated chloride channels (GluCls) recombinantly expressed in Xe

167 the molecular composition of acid-activated chloride channels had remained unclear.

168 ) transmembrane conductance regulator (CFTR) chloride channel has been argued to be critical for effi

169 s transmembrane conductance regulator (CFTR) chloride channel, has been reported to regulate CFTR gat

170 s transmembrane conductance regulator (CFTR) chloride channel have identified several transmembrane s

171 Recently, calcium-activated chloride channels have been shown to contribute to VNO a

172 tions in CLCNKB, the gene encoding the renal chloride channel hClC-Kb, cause Bartter syndrome type II

173 signaling on CFTR or other calcium-activated chloride channels; here, we investigate the direct respo

174 in intact animals, using the histamine-gated chloride channel HisCl1 from Drosophila and exogenous hi

175 gineering of next-generation light-activated chloride channels (iC++) and a bistable variant (SwiChR+

176 t BEST1 assembles into a key calcium-sensing chloride channel in human RPE.

177 To test whether BEST1 functions as a chloride channel in living tissue, BEST1-mutant RPE (R21

178 s transmembrane conductance regulator (CFTR) chloride channel in many epithelia of the body.

179 onstituent of the vascular calcium-activated chloride channel in rat pulmonary artery smooth muscle.

180 e to loss-of-function mutations in the ClC-1 chloride channel in skeletal muscle, which causes involu

181 ity due to loss-of-function mutations in the chloride channel in skeletal muscle, which causes sponta

182 expression of the TMEM16B calcium-activated chloride channel in the LS and showed that TMEM16B regul

183 uggested that ClC-K2 is the main basolateral chloride channel in the thick ascending limb and in the

184 esults highlight the involvement of the ANO1 chloride channel in tumor progression and provide insigh

185 sults implicate variation in glutamate-gated chloride channels in avermectin resistance and provide a

186 escribed for its activity on glutamate-gated chloride channels in parasitic nematodes, understanding

187 It is thought to selectively activate type 2 chloride channels in the apical membrane of the intestin

188 ompounds acting, respectively, on sodium and chloride channels in the brain of fish.

189 ic approaches to establish the importance of chloride channels in the regulation of NLRP3 in murine m

190 Several chloride channels including TMEM16, bestrophin, CFTR, CL

191 s transmembrane conductance regulator (CFTR) chloride channel, including N1303K.

192 o function as the Ca(2+) activated secretory chloride channel independent of CFTR.

193 n-mediated endocytosis but was unaffected by chloride channel inhibitor, indanyloxyacetic acid 94 or

194 LRP3 activation, this was still sensitive to chloride channel inhibitors, suggesting there are additi

195 limitations by introducing a dopamine-gated chloride channel into rat dorsal striatal medium spiny n

196 l Kb gene (CLCNKB), which encodes the ClC-Kb chloride channel involved in NaCl reabsorption in the re

197 ession of Gob5, a putative calcium-activated chloride channel involved in the regulation of mucus pro

198 s transmembrane conductance regulator (CFTR) chloride channel is a member of the ATP-binding cassette

199 The ClC-2 chloride channel is expressed in the plasma membrane of

200 conductance regulator (CFTR) plasma membrane chloride channel is the most common cause of cystic fibr

201 further show that inhibition by light-gated chloride channels is mediated mainly by shunting effects

202 ANO1, a calcium-activated chloride channel, is highly expressed and amplified in h

203 s transmembrane conductance regulator (CFTR) chloride channel, leading to defective apical chloride t

204 fibrosis is caused by mutations in the CFTR chloride channel, leading to reduced airway surface liqu

205 the dopamine transporter and the amine-gated chloride channel LGC-55 to generate behaviors in Caenorh

206 The inhibitory tyramine-gated chloride channel, LGC-55, induces head relaxation and in

207 diated through activation of the amine-gated chloride channel, LGC-55.

208 in the Clcc1 gene, which encodes a putative chloride channel localized to the ER.

209 e to an effect at the nerve terminals, where chloride channels may play a more important role.

210 hannels, including CFTR and Ca(2+)-activated chloride channels mediate anion/fluid secretion.

211 increases organelle pH, suggesting that the chloride channel might regulate melanin synthesis by mod

212 Here we show that a glutamate-gated chloride channel modified to be activated by low doses o

213 ts paralogs, the TMEM16A/B calcium-activated chloride channels, mouse TMEM16F has been reported as a

214 CFTR, the chloride channel mutated in cystic fibrosis (CF) patient

215 In CFTR, the chloride channel mutated in cystic fibrosis (CF) patient

216 onductance regulator (CFTR) is an epithelial chloride channel mutated in patients with cystic fibrosi

217 Thirty-two participants had chloride channel mutations, 34 had sodium channel mutati

218 cted to those with sodium channel mutations, chloride channel mutations, and myotonic dystrophy type

219 articipants, with warm up of myotonia in 75% chloride channel mutations, but also 35.3% of sodium cha

220 In comparison with chloride channel mutations, participants with sodium mut

221 s are helpful in differentiating sodium from chloride channel myotonia.

222 ransmembrane conductance regulator (CFTR), a chloride channel normally expressed at the surface of ep

223 ally overlaps with the cohort expressing the chloride channel OCA2.

224 s transmembrane conductance regulator (CFTR) chloride channel occurs in these diarrheas.

225 ANO1/TMEM16A as the likely calcium-dependent chloride channel of exocrine glands has led to a more de

226 The chloride channel of the cystic fibrosis transmembrane co

227 of the structure, ligand-binding sites, and chloride channel of these receptors and discuss recently

228 ory circuit, GABA release directly activates chloride channels on the muscle to cause muscle relaxati

229 sins: the proton pump, Archaerhodopsin and a chloride channel opsin.

230 ), and is tightly regulated by intracellular chloride channels or transporters.

231 These results suggest that chloride channels (or transporters) provide the main pat

232 ary technique using a native histamine-gated chloride channel (Ort).

233 The proton-activated chloride channel (PAC) is active across a wide range of

234 uscle action potential amplitude in 59.3% of chloride channel participants compared with 27.6% of sod

235 Voltage-gated CLC-1 chloride channels play a critical role in controlling th

236 s transmembrane-conductance regulator (CFTR) chloride channel plays an important role in fluid and wa

237 stabilized by phosphorylation and binding of chloride channel potentiators.

238 ions of CF transmembrane receptor (CFTR) - a chloride channel present at the surface of epithelial ce

239 ted activity on invertebrate glutamate-gated chloride channels, promotes neural differentiation of PS

240 ncreased autoantibody reactivity against the chloride-channel protein anoctamin 2 (ANO2) in MS cases

241 ied increased autoantibody levels toward the chloride-channel protein Anoctamin 2 (ANO2) in MS.

242 ne conductance regulator (CFTR) protein is a chloride channel regulating fluid homeostasis at epithel

243 Calcium-activated chloride channel regulator 1 (CLCA1) activates calcium-d

244 Calcium-activated chloride channel regulator 1 (CLCA1) is one of the major

245 3, IL5, periostin (POSTN), calcium-activated chloride channel regulator 1 (CLCA1), and serpin peptida

246 an increased expression of calcium-activated chloride channel regulator 1 (CLCA1).

247 t impair the function of CFTR, an epithelial chloride channel required for proper function of the lun

248 netic disorder of the epithelial CFTR apical chloride channel resulting in multi-organ manifestations

249 CFTR protein biogenesis or its function as a chloride channel, resulting in dysregulation of epitheli

250 pports allosteric binding to glutamate-gated chloride channels similar to ivermectin.

251 ression of mPFC activity using an engineered chloride channel substantially reduced cataplexy induced

252 to Dieldrin gene, Rdl, encodes a GABA-gated chloride channel subunit that is targeted by cyclodiene

253 o mutations were detected in Glutamate-gated chloride channel subunits tested, suggesting target site

254 is provided for a role for calcium-activated chloride channels such as TMEM16a in GPCR-activation of

255 ugh interaction with other calcium-activated chloride channels, such as hBest2, 3, or 4, or transmemb

256 ia the allosteric modulation of ligand-gated chloride channels, such as hetero-oligomeric alpha1beta2

257 nsmembrane conductance regulator (CFTR) is a chloride channel that belongs to the ATP binding cassett

258 ance regulator (CFTR) protein, an epithelial chloride channel that has a key role in maintaining homo

259 Volume-regulated anion channel (VRAC) is the chloride channel that is activated upon cell swelling an

260 ectron microscopy reveals the structure of a chloride channel that is closely related to a protein th

261 ransmembrane conductance regulator (CFTR), a chloride channel that is essential for the mucociliary c

262 ANO1 is a calcium-activated chloride channel that is frequently overexpressed in hea

263 anion channel (VRAC) is a swelling-activated chloride channel that is permeable to inorganic anions a

264 ClC-2 is an inward-rectifying chloride channel that is thought to help extrude chlorid

265 CLC-2 is a voltage-gated chloride channel that is widely expressed in mammalian t

266 ate that Hodor is a pH-sensitive, zinc-gated chloride channel that mediates a previously unrecognized

267 nsmembrane conductance Regulator (CFTR) is a chloride channel that plays a critical role in the lung

268 Bestrophin 1 (hBest1) is a calcium-activated chloride channel that regulates neuronal excitability, s

269 O3, a gene encoding a predicted Ca(2+)-gated chloride channel that we show to be highly expressed in

270 t advances on sodium, calcium, potassium and chloride channels that are emerging as especially attrac

271 Glycine receptors (GlyRs) are ligand-gated chloride channels that mediate inhibitory neurotransmiss

272 ceptors (GABA(A) receptors) are ligand-gated chloride channels that play a central role in signal tra

273 s transmembrane conductance regulator (CFTR) chloride channel, the beta-2 adrenergic receptor (beta(2

274 mate transporter and also as glutamate-gated chloride channel, the chloride conductance being large e

275 spite of the many key cellular functions of chloride channels, the mechanisms that mediate their sub

276 of the receptor-activated calcium-dependent chloride channel TMEM16A (TAOS2 or ANO1) has been report

277 sion of either CFTR or the calcium-activated chloride channel TMEM16A attenuated the proinflammatory

278 Here, we report that the calcium-activated chloride channel TMEM16A is a biomarker for pancreatic c

279 The calcium-activated chloride channel TMEM16A is a member of a conserved prot

280 The calcium-activated chloride channel TMEM16A is overexpressed in a variety o

281 KEY POINTS: The calcium-activated chloride channel TMEM16A provides a pathway for chloride

282 Targeted disruption of the calcium-activated chloride channel TMEM16A, also known as ANO1, in VSMCs,

283 selective inhibitor of the calcium-activated chloride channel TMEM16A, N-((4-methoxy)-2-naphthyl)-5-n

284 molar-potency inhibitor of calcium-activated chloride channel TMEM16A.

285 Calcium-activated chloride channels TMEM16A and TMEM16B support important

286 ominated by the activity of Ca(2+)-activated chloride channels (TMEM16A), including the cystic fibros

287 expression pattern of the calcium-activated chloride channel, TMEM16B, in the LS of both male and fe

288 nt by opening the olfactory Ca(2+)-activated chloride channel to amplify the response.

289 ogical contribution of the calcium-activated chloride channel to LS neuronal signaling.

290 lucidate a), the contribution of basolateral chloride channels to the short-circuit current functiona

291 f Cajal, which express the calcium-activated chloride channel transmembrane member 16A (TMEM16A), are

292 n of genes encoding putative vacuolar NO3(-) chloride channel transporters plus electron micrographs

293 ClC-2 is a ubiquitous chloride channel usually localized to the basolateral do

294 efflux antiporter KEA3 and voltage-dependent chloride channel VCCN1 and suggest that the activity of

295 rotype 9-based delivery, the glutamate-gated chloride channel was successfully targeted to mouse sens

296 Several voltage-gated chloride channels were also identified, although these m

297 is the accessory subunit of the human ClC-K chloride channels, which are expressed in both the kidne

298 ) is a cAMP/protein kinase A (PKA)-regulated chloride channel whose phosphorylation controls anion se

299 ClC-2 is a broadly distributed chloride channel with an enigmatic neurophysiological fu

300 butyric (GABA(A)) receptors are ligand-gated chloride channels with a very rich pharmacology.