ライフサイエンスコーパス: chloro

1 piro[cyclopropane-1,2'-quinoline] (6) and 6'-chloro-1'-methyl-3',4'-dihydro-1'H-spiro[cyclopropane-1,

2 cursor 3-bromo-1-(tert-butyldimethylsilyl)-2-chloro-1,2-dihydro-1,2-azaborine (2) to furnish new 2,3-

3 gave 4-N-(2-phthalimidoethyl)-N-alkylamino-5-chloro-1,2-dithiol-3-thiones that quantitatively cycload

4 ) with N-bromosuccinimide and Palau'chlor (2-chloro-1,3-bis(methoxycarbonyl)guanidine) followed by hy

5 nal alkynes with formation of 1,3-enyne or 1-chloro-1,3-enyne derivatives, respectively; the reaction

6 nzonitrile (73, IC(50) = 12 nM) and 4-({5-[4-chloro-1-(2H-indazol-6-yl)-1H-1,2,3-benzotriazol-6-yl]-1

7 structure determination of (E)-1,2-bis{(E)-2-chloro-1-(chloroimino)-2,2-dinitroethyl}diazene) (10), N

8 lic organochalcogen compounds derived from 2-chloro-1-formyl-3-hydroxymethylenecyclohexene (16) are d

9 classical heterocyclization starting from 5-chloro-1-methyl-4-nitropyrazole and (ii) a three-step cr

10 ancement by the biocatalyzed conversion of 4-chloro-1-naphthol to insoluble benzo-4-chlorocyclohexadi

11 te starting from enantiomerically pure (R)-2-chloro-1-phenylethanol, which was transformed into (18)O

12 s includes an asymmetric methallylation of 3-chloro-1-phenylpropan-1-one catalyzed by the highly effe

13 yield, starting from the readily available 3-chloro-1-phenylpropan-1-one.

14 o[ e][1,2,4]triazine were synthesized from 3-chloro- (1c) and 3-iodobenzo[ e][1,2,4]triazine (1d) obt

15 xemplified by 5-((5-([1,1'-biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzo ic ac

16 triazole, 14 for tolyltriazole, and 14 for 5-chloro-1H-benzotriazole.

17 Compound 16 (N-{2-[4-(5-chloro-1H-indol-3-yl)-1,2,3,6-tetrahydropyridin-1-yl]eth

18 recognition of substrates with 2'-azido, 2'-chloro, 2'-amino, or arabinose sugars.

19 PET scans of individuals injected with 2-chloro-2'-deoxy-2'-(18)F-fluoro-9-beta-d-arabinofuranosy

20 wo candidate compounds-[(18)F]Clofarabine; 2-chloro-2'-deoxy-2'-[(18)F]fluoro-9-beta-d-arabinofuranos

21 To assess the efficacy of cladribine (2-chloro-2'-deoxyadenosine) in the treatment of ECD.

22 AM and its two brominated analogues (i.e., N-chloro-2,2-bromochloroacetamide and N-chloro-2,2-dibromo

23 .e., N-chloro-2,2-bromochloroacetamide and N-chloro-2,2-dibromoacetamide) was quantitatively determin

24 ad of DCAM, a previously unreported N-DBP, N-chloro-2,2-dichloroacetamide (N-Cl-DCAM), was confirmed

25 inhibitors of LTC4S led to (1S,2S)-2-({5-[(5-chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino

26 ositive allosteric modulator PNU120596 [N-(5-chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-u

27 H-pyrrole-2-one with dichloromethyl group, 3-chloro-2,5-pyrroledione).

28 Oral administration of 2-((4-chloro-2,6-difluorobenzyl)amino)-7-oxo-5-propyl-4,7-dihy

29 tic properties led to the discovery of 5-((5-chloro-2-((3R,5S)-4,4-difluoro-3,5-dimethylpiperidin-1-y

30 hlorophenoxy)butanoic16 acid (2,4-DB), and 5-chloro-2-(2,4-dichlorophenoxy)phenol (triclosan)) were m

31 translocator protein (TSPO) imaging using 6-chloro-2-(4'-(123)I-iodophenyl)-3-(N,N-diethyl)-imidazo[

32 ((2,4-dichlorophenoxy)acetic acid (2,4-D), 4-chloro-2-15 methylphenoxy)acetic acid (MCPA), 4-(2,4-dic

33 nds), (2) a novel TGR5 antagonist (m-tolyl 5-chloro-2-[ethylsulfonyl] pyrimidine-4-carboxylate [SBI-1

34 olboranes that are excellent precursors to 1-chloro-2-arylpropyl radicals.

35 derivatives, it was possible to prepare B-(1-chloro-2-arylpropyl)catecholboranes that are excellent p

36 1,4-dial (BDA) and its chlorinated analogue, chloro-2-butene-1,4-dial (Cl-BDA), after the chlorinatio

37 chemical shift difference for tricarbonyl(1-chloro-2-deuteriomethylbenzene) chromium(0) was computed

38 previously described kinase inhibitors-3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(3-methyl-1H-pyrazol-5

39 fficient route for the preparation of (2S)-2-chloro-2-fluorolactone 29 is described.

40 for 4-[(3S,3'S,3'aS,5'R,6'aS)-6-chloro-3'-(3-chloro-2-fluorophenyl)-1'-(cyclopropylme thyl)-2-oxo-1,2

41 pounds, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide (1, IC(50) 0.0192 muM) and N-[

42 uM) and N-[3,5-bis(trifluoromethyl)phenyl]-4-chloro-2-hydroxybenzamide (14, IC(50) 0.0231 muM), displ

43 vel substituted N-(4-amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide analogues as potent HAdV inhib

44 chosen Cl-oHBI@Pd(6)(TPT)(4) (Cl-oHBI = 5-(5-chloro-2-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H

45 ared by in-situ grafting polymerization of 3-chloro-2-hydroxypropyl methacrylate (HPMA-Cl) and follow

46 omising candidate, Ru2(chp)4ONO2 (4, chp = 6-chloro-2-hydroxypyridinate), displays a set of signals c

47 ichloroisopropyl) phosphate (TDCIPP), tris(1-chloro-2-isopropyl) phosphate (TCIPP), triphenyl phospha

48 in-1-yl)methyl)phenol (compound 3) and 4-((6-chloro-2-methoxyacridin-9-yl)amino)-2-((4-(2-(dimethylam

49 Two of the new compounds, 4-((6-chloro-2-methoxyacridin-9-yl)amino)-2-((4-cyclohexylpipe

50 eviously described ERCC1-XPF inhibitor 4-((6-chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazi

51 demonstrated with the lead compound 2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimi

52 nopyridine anticancer compound (3-amino-N-(3-chloro-2-methylphenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,

53 of isobutyraldehyde; cyclotrimerization of 2-chloro-2-methylpropanal; dehydochlorination of 2,4,6-tri

54 )-mediated dehalogenation of 4-bromobenzyl-2-chloro-2-phenylacetate to 4-bromobenzyl-2-phenylacetate

55 isoquinoline (3), 2-(p-tolyl)pyridine (4), 4-chloro-2-phenylquinoline (5), or 2-(2,4-difluorophenyl)p

56 dichloro-2-propyl) phosphate (BDCIPP), bis(1-chloro-2-propyl) phosphate (BCIPP), diphenyl phosphate (

57 lphenyl phenyl phosphate (tb-PPP), and bis(1-chloro-2-propyl) phosphate (BCIPP)] using negative elect

58 Tris(1-chloro-2-propyl) phosphate (TCIPP) was the most abundant

59 temporal distribution are given for Tris-(1-chloro-2-propyl) phosphate (TCiPP), EHDPP, tri-n-butyl p

60 he pattern was generally dominated by tris(1-chloro-2-propyl) phosphate (TCPP), although tri-n-butyl

61 ng/L) followed in decreasing order by tris(1-chloro-2-propyl)phosphate (TCIPP; max: 14500 ng/L), bis(

62 Tris-(1-chloro-2-propyl)phosphate (TCPP) was the most abundant c

63 While tris-2-chloroethyl phosphate, tris(1-chloro-2-propyl)phosphate and tris-1,3-dichloropropylpho

64 sphate, tris(2-chloroethyl)phosphate, tris(1-chloro-2-propyl)phosphate, and triphenyl phosphate conce

65 yl-1,3-pentanediol diisobutyrate, and tris(1-chloro-2-propyl)phosphate, which stood out from other na

66 were BDE-47 and -99 among PBDEs, tris[(2R)-1-chloro-2-propyl] phosphate among OPFRs, and 2-ethylhexyl

67 ntagonists capsazepine (CPZ) and BCTC ((4-(3-chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-pi

68 rgent synthesis, p-Cl substituents in tris(4-chloro-2-pyridylmethyl)amine (TPMA(3Cl) ) were replaced

69 2-Chloro-, 2-bromo-, and 2-iodothiophenes undergo photoche

70 catalytic activity of ALP towards 5-bromo-4-chloro 3-indolyl phosphate (BCIP).

71 demonstrated for 4-[(3S,3'S,3'aS,5'R,6'aS)-6-chloro-3'-(3-chloro-2-fluorophenyl)-1'-(cyclopropylme th

72 hydrochlorofluorocarbon HCFC-1233zd(E) (E-1-chloro-3,3,3-trifluoroprop-1-ene trans-CF3CH horizontal

73 ecular simulation revealed 2-chloro-N (1)-[4-chloro-3-(2-pyridinyl)phenyl]-N (4),N (4)-bis(2-pyridiny

74 identification of new Mtb ThyX inhibitors, 2-chloro-3-(4-methanesulfonylpiperazin-1-yl)-1,4-dihydrona

75 lted in the identification of compound (Z)-4-chloro-3-(5-((3-(2-ethoxy-2-oxoethyl)-2,4-dioxothiazolid

76 ty acids and found that the analogue 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadec

77 ll-molecule allosteric modulator Org27569 [5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperid

78 ollowed by reaction with DMF gave 2-formyl-4-chloro-3-fluoropyridine 10 regioselectively, which was c

79 ines (3-8) was investigated, starting from 4-chloro-3-fluoropyridine.

80 This method involves the Ugi-4CR of 2-chloro-3-formyl quinolines 1a-h, amines 2a-d, 2-chloroac

81 via base-mediated divergent annulation of 4-chloro-3-formylcoumarin and tetrahydroisoquinoline as a

82 or (NMDAR) glycine site antagonist, and of 4-chloro-3-hydroxyanthranilic acid (4-Cl-3-HAA), a suppres

83 l 4-chloroacetoacetate (COBE) to ethyl (S)-4-chloro-3-hydroxybutanoate ((S)-CHBE) catalyzed by AdhS.

84 oles using sequential arylation of 5-bromo-6-chloro-3-iodo-1-methyl-1H-pyrrolo[2,3-b] pyridine is est

85 chloroaniline, 2,3,5,6-tetrachloroaniline, 4-chloro-3-methylphenol, pentylbenzene, pyrene, and bromop

86 the coupling between N-tosylhydrazones and 2-chloro-3-nitroimidazo[1,2-a]pyridines leading to the for

87 rile (1) in the presence of HCl to produce 2-chloro-3-phenyl-4(3H)-quinazoliniminium chloride (Qz) in

88 ne derivative (11)C-GMOM ((11)C-labeled N-(2-chloro-3-thiomethylphenyl)-N'-(3-methoxyphenyl)-N'-methy

89 With 3'-chloro-4'-(alpha-d-mannopyranosyloxy)biphenyl-4-carbonit

90 liferative than CA-4, indicating that the 3'-chloro-4'-ethoxyphenyl moiety was a good surrogate for t

91 4-ylethynyl]pyridine (basimglurant, 2) and 2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1

92 onitrile (NEU-924, 83) for T. cruzi and N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-7-(4-((4-methyl-1,

93 inhibitors for each pathogen, such as 4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-6-(4-((4-met

94 henyl)benzamide dihydrochloride] and 2 [N-(3-chloro-4-((4,5-dihydro-1H-imidazol-2-yl)amino)phenyl)-4-

95 and selective SPAK inhibitor, 5-chloro-N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)

96 tructure of PPARgamma bound to 2-chloro-N-(3-chloro-4-((5-chlorobenzo[d]thiazol-2-yl)thio)phenyl)-4-(

97 n of a series of mGlu1 PAMs based on an N-(3-chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran

98 glutamate-evoked response was observed for 7-chloro-4-(2-fluoroethyl)-3,4-dihydro-2H-1,2,4-benzothiad

99 From this library, we identified 7-chloro-4-(4-(2,4-dinitrophenylsulfonyl)piperazin-1-yl)qu

100 MX (3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone) is a

101 rination, such as the highly mutagenic MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone) or h

102 ich led to the discovery of (2R)-1-[4-(4-{[5-chloro-4-(pyrazolo[1,5-a]pyridin-3-yl)-2-pyrimidinyl]ami

103 2-Chloro-4-[(2-hydroxy-2-methyl-cyclopentyl)amino]-3-methy

104 selective S1P1 receptor agonists (Z,Z)-5-(3-chloro-4-[(2R)-2,3-dihydroxy-propoxy]-benzylidene)-2-pro

105 hit 1 to the potent and selective compounds chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-

106 sly described "GPR39-selective" agonist N-[3-chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4- pyrimidin

107 ridinyl crotonamide Michael acceptor and a 3-chloro-4-fluoroaniline, indicating these as optimized 6-

108 The lead structure, (3-chloro-4-fluorophenyl)(4-fluoro-4-(((2-(pyridin-2-yloxy)

109 tagonists including 1,1-bis(3'-indolyl)-1-(3-chloro-4-hydroxy-5-methoxyphenyl)methane (Cl-OCH3) decre

110 Among them, compound 6c, 2-acetyl-10-((3-chloro-4-methoxybenzyl)amino)-1,2,3,4-tetrahydrobenzo[b]

111 N-(3-(1H-1,2,4-triazol-1-yl)propyl)-5-(3-chloro-4-methoxyphenyl)oxazole-4-carboxa mide (PF-048023

112 nuclear Pd(atz,ur) complex at 457nm by the 2-chloro-4-nitrophenol (2-CNP) which produced from the rea

113 duced from the reaction of the enzyme with 2-chloro-4-nitrophenyl-alpha-d-maltotrioside (CNPG3) subst

114 nalog as well as the kynurenic acid analog 7-chloro-4-oxo-1H-quinoline-2-carboxylic acid (7-chlorokyn

115 ed conversion of the non-native substrate 5'-chloro-5'-deoxyadenosine (5'-ClDA) into 5'-fluoro-5'-deo

116 in the SAM-forming enzyme SalL tolerates 5'-chloro-5'-deoxyadenosine (ClDA) analogues modified at th

117 sodium hydrogen carbonate in acetonitrile, 7-chloro-5-(4-fluorophenyl)-1,3-dihydro-2,3,4-benzothiadia

118 rifluoromethyl) pyridine-2-acetic acid and 3-chloro-5-(trifluoromethyl) picolinic acid was elucidated

119 thyl benzamide and subsequent formation of 3-chloro-5-(trifluoromethyl) pyridine-2-acetic acid and 3-

120 lying matrix-matched calibration and using 2-chloro-5-bromoanisole as surrogate standard.

121 nitrogenous heterocyclic compounds (e.g., 3-chloro-5-hydroxy-1H-pyrrole-2-one with dichloromethyl gr

122 we found that the activation of HCAR1 with 3-chloro-5-hydroxybenzoic acid (3Cl-HBA) decreased miniatu

123 (11)C-CNS5161 (N-(2-chloro-5-methylthiophenyl)-N'-(3-methylthiophenyl)-N'-(1

124 target effects of the PPARgamma antagonist 2-chloro-5-nitro-N-phenylbenzamide (GW9662) involving PPAR

125 using the widely used PPARgamma antagonist 2-chloro-5-nitro-N-phenylbenzamide (GW9662).

126 the following: (1) how ROSI and/or GW9662 (2-chloro-5-nitro-N-phenylbenzamide; PPARgamma antagonist)

127 The reaction also works with 4-chloro-5H-1,2,3-dithiazol-5-one and -thione, giving the

128 N-(4-Chloro-5H-1,2,3-dithiazol-5-ylidene)anilines react with

129 While the reaction of several (4-chloro-5H-1,2,3-dithiazol-5-ylidene)methanes with DABCO

130 e' functional groups, such as the fluoro(5), chloro(6,7), bromo(7,8), phosphonate(9), enediyne(10,11)

131 fter bezafibrate ( approximately 18-fold), 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio acetic acid (

132 liferator-activated receptor (PPAR) alpha [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY

133 eridine class, also known as VUF11211 [(S)-5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)-3-ethylpi

134 ists of distinct chemotypes: VUF11211 [(S)-5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)-3-ethylpi

135 ethyl-3-methoxybenzylamine (NPS R-568) and 2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylp

136 NH-, and N, N-DABOs carrying 2,6-difluoro, 2-chloro-6-fluoro, or 2,6-dichloro substituted benzyl moie

137 A comparison of the effects of the 6-(2-chloro-6-fluorobenzyl)-2-(alkylthio)pyrimidin-4(3H)-ones

138 se with (1) either a 2,6-difluorostyryl or 2-chloro-6-fluorostyryl subunit, (2) either an N-methylami

139 Similarly, antioxidant (Z)-N-tert-butyl-1-(2-chloro-6-methoxyquinolin-3-yl)methanimine oxide (17) is

140 Especially, QN ( Z)- N-tert-butyl-1-(2-chloro-6-methoxyquinolin-3-yl)methanimine oxide (23) was

141 9-Substituted 2-chloro-6-sulfonylpurines provide 6-azido-2-sulfonylpurin

142 acids in the samples were derivatized with 4-chloro-7-nitro-2,1,3-benzoxadiazole (NBD-Cl) prior to CE

143 We recently discovered 10-chloro-7H-benzimidazo[2,1-a]benzo[de]iso-quinolin-7-one

144 ds, rapidly and in excellent yields, using 9-chloro-9-phenylfluorene (PhFCl)/N-methylmorpholine (NMM)

145 C-(2-ethyl-2H-tetrazol-5-yl)-adenosine and 2-chloro-adenosine derivatives was synthesized as novel, h

146 ic residues increased potency, 2-iodo- and 2-chloro-adenosine-5'-O-[(phosphonomethyl)phosphonic acid]

147 , or n-octyl3Al, with triphenylalane or aryl(chloro)alanes is reported.

148 Bromo-chloro alkenes (Br-Cl PXAs) have been used for over 30 y

149 industrial technical product, C(12-30) bromo-chloro alpha-alkenes (CAS RN 68527-01-5).

150 ce of the rationally designed MALDI matrix 4-chloro-alpha-cyanocinnamic acid (ClCCA) in comparison to

151 n treated with a strong base, forms an alpha-chloro-alpha-fluorocarbanion that adds to nitroarenes at

152 ing PCET, formation and reaction of an alpha-chloro-alpha-hydroxy benzyl radical, and 1,3-chlorine at

153 up of the benzophenone moiety, as well as 4'-chloro and 2,2-dimethy substituents.

154 the potentially genotoxic 3-nitro group by 3-chloro and 3-fluoro substituents, resulting in compounds

155 6,6'-phenyl BTPhen derivatives (including 4-chloro and 4-bromo) in five simple steps.

156 lfonyl-substituted carbanions carrying alpha-chloro and alpha-bromo substituents (1a-e) with quinone

157 rties were optimized by introducing the para-chloro and aminopyrrolidine groups.

158 , thienylation occurs with modest yield from chloro and bromo derivatives (via photogenerated triplet

159 Effects of chloro and bromo substitution at the 4-position of the p

160 A chloro and ethoxy group at the meta- and para-positions,

161 lic bromonium ions; however, in the cases of chloro and fluoro derivatives, open forms are more prefe

162 Two analogues, IndCl-o-chloro and IndCl-o-methyl, induced proliferation and dif

163 Aromatic cyano, chloro, and bromo functionalities are tolerated by the t

164 Comparison of the dynamics of the chloro- and bromo-complexes shows that inertial effects

165 identify both polyhalogenated (mixed bromo-/chloro- and polybromo-) dibenzo-p-dioxins and dibenzofur

166 al profiles of the yet-unsynthesized bromo-, chloro-, and fluoro- analogues show a progressive loweri

167 to allow alkyl-, aryl-, heteroaryl-, bromo-, chloro-, and nitro-containing diorgano dichalcogenides a

168 vel one-step synthesis of anthraquinones and chloro anthraquinones from simple ketone precursors and

169 hydrate (165% [161-176]) > 2,2-dichloro- > 2-chloro approximately 2,2,2-trifluoroethanol > ethanol.

170 Two chemically very similar chloro-aromatic fragments differ strongly in their poten

171 provided the insight that trans-tetra-ortho-chloro azobenzene is conformationally flexible and thus

172 of this substitution pattern to tetra-ortho-chloro azobenzene.

173 2-aminopyridines/pyrazines/pyridazine with 2-chloro benzene sulfonyl chloride followed by a Cu(I)-cat

174 of pyridines/pyrazines/pyridazines on the 2-chloro benzene sulfonyl chloride, followed by Cu(I)-cata

175 2-aminopyridines/pyrazines/pyridazine and 2-chloro benzene sulfonyl chloride.

176 h small-molecule organic surface modifier, 4-chloro-benzoic acid (CBA), via a simple spin-coating met

177 -carbonyl)-2-methyl-azetidine-2-carbonyl]-(3-chloro -benzyl)-amino]-butyric acid 99 (GLPG0974), is ab

178 Thus, alpha-chloro-beta-(organoselenyl) enamide derivatives were exc

179 three different types of compounds: E-alpha-chloro-beta-(organoselenyl)enamides, 4-(organochalcogeny

180 The alpha-chloro-beta-aminoketone intermediates featuring a chlori

181 on, are used to produce the respective alpha-chloro-beta-fluoroalkylcarbonyl products in excellent yi

182 be grown to give the corresponding acyclic 7-chloro(bromo)-hepta-2,6-dienylmalonates.

183 Chloro, bromo, and iodo derivatives can be obtained succ

184 Direct comparison of the chloro, bromo, and iodopyrazoles in the Suzuki-Miyaura r

185 tners with sensitive functionalities such as chloro, bromo, hydroxy, and cyano were also amenable to

186 Fluoro, chloro, bromo, iodo, and gem-dihaloalkenes are viable su

187 al, and replacement of the 5-iodo group with chloro, bromo, or fluoro groups led to losses in potency

188 while controlling the formation of regulated chloro-bromo-DBPs (Cl-/Br-DBPs).

189 ee, photoinduced, dual C-H/C-X borylation of chloro-, bromo-, and iodoarenes.

190 <10 to 3830 ng/L (gemfibrozil), and those of chloro/bromo byproducts ranged from <4 to 370 ng/L (dibr

191 kenes to form chloro, difluoromethylated and chloro, carbomethoxydifluoromethylated products.

192 y enriched beta-thio-alpha-hydroxy and alpha-chloro carboxylic acid and ester building blocks by diaz

193 The resulting Ru(II) chloro complex was converted into the catalytically acti

194 however, these readily convert into neutral chloro-complexes.

195 The chloro compounds are generated by treating 3-aminocycloh

196 for syn versus anti oxidative addition of 3-chloro-cyclopentene to Pd(0)L(n) was investigated using

197 On the alpha3beta2 subtype, only the chloro derivative 2a showed full agonist activity and su

198 The chloro derivative reacts with N2O with loss of N2 to for

199 The chloro-derivative [Pd(16) Na(2) O(26) (OH)(3) Cl(3) ((CH

200 ts, we designed the di-ortho-fluoro di-ortho-chloro (dfdc) azobenzene and provided computational evid

201 With a ( R)-di-chloro,di-gold-DTBM-SEGPHOS complex as the catalyst, com

202 itions (ATRA) to unactivated alkenes to form chloro, difluoromethylated and chloro, carbomethoxydiflu

203 l chloride, followed by Cu(I)-catalyzed ipso chloro displacement to C-N bond formation resulting in a

204 f 3-hydroxyanthranilate 3,4-dioxygenase by 6-chloro-dl-tryptophan prevented both increased lactate pr

205 ompatibility of electron-withdrawing fluoro, chloro, ester, and nitro and electron-donating methyl, m

206 etric reductive cross-coupling between alpha-chloro esters and aryl iodides is developed.

207 )-N,N'-1,2-ethanediylidenebis(2, 2-dinitro-2-chloro-ethanamine) (12) was helpful in their characteriz

208 acing environmentally detrimental hydro- and chloro-fluorocarbons.

209 ing opening of a cis-dialkyl substituted syn-chloro-gem-chlorofluorocyclopropane, in violation of the

210 t-order kinetic dependence on both the alpha-chloro glycinate and the nucleophile, consistent with ra

211 hilic allylation of readily accessible alpha-chloro glycinates.

212 The chloro group was substituted with a chiral amine, allowi

213 the positions bearing the amino, ethyl, and chloro groups.

214 ent of H2Q with the higher-potential EPTM, 2-chloro-H2Q, allows for faster O2 reduction rates at high

215 stable intermediate products, such as the N-chloro-haloacetamides (N-chloro-HAMs), may form during t

216 ped for the detection of a family of seven N-chloro-haloacetamides (N-Cl-HAMs).

217 ucts, such as the N-chloro-haloacetamides (N-chloro-HAMs), may form during the course of HAN chlorina

218 oss the dihalogenated HBQs: iodo- > bromo- > chloro-HBQs (P < 0.05).

219 PAd3 during Suzuki-Miyaura cross-coupling of chloro(hetero)arenes (40 examples) at low Pd loading, in

220 oad substrate scope that includes bromo- and chloro(hetero)arenes, primary anilines, secondary amines

221 Notably, the HIPP derivative 4-chloro-HIPP biochemically and biologically phenocopied m

222 Whereas the related chloro-hydride complex, trans-H(Cl)Pt(P(t)Bu3)2, does no

223 Thus, the o-Methyl and o-Chloro IndCl analogues represent a class of ERbeta ligan

224 of carboxylic acids, the synthesis of alpha-chloro ketones and pyrazoles, and palladium-catalyzed cy

225 sion by combined bath-application of NMDA (7-chloro-kynurenic acid) and AMPA (CNQX) receptor blockers

226 epared by stoichiometric substitution of one chloro ligand in the parent, neutral W-oxo-alkylidene-NH

227 In response to high [K(+)], caffeine, and 4-chloro-m-cresol (4-CMC), the maximal tensions generated

228 Both 4-chloro-m-cresol and halothane caused adenosine accumulat

229 d blood lymphocytes incubated with 0-10 mM 4-chloro-m-cresol or 0-10.7 mM halothane.

230 Similarly, at 1 mM 4-chloro-m-cresol or 0.96 mM halothane, adenosine levels w

231 acteristic analyses showed areas under the 4-chloro-m-cresol receiver-operating characteristic curves

232 Although 4-chloro-m-cresol receiver-operating characteristic curves

233 a-susceptible B cells treated with 0.75 mM 4-chloro-m-cresol relative to controls.

234 the ryanodine receptor Ca channels agonist 4-chloro-m-cresol was compared in blood lymphocytes from m

235 mework was applied and validated for PCMC (4-chloro-m-cresol), household derived antimicrobial agent

236 (p approximately 0.0001), suggesting that 4-chloro-m-cresol-induced adenosine could readily distingu

237 Two unnatural bromo-chloro-malbrancheamide analogues were generated through

238 bers, either a ryanodine receptor agonist (4-chloro-meta-cresol) or depolarizing pulses were used.

239 were reduced, and consequently, SOCE after 4-chloro-meta-cresol-induced store depletion was suppresse

240 on) of a tethered acridine ligand (9-amino-6-chloro methoxyacridine) into duplex DNA.

241 followed by molecular simulation revealed 2-chloro-N (1)-[4-chloro-3-(2-pyridinyl)phenyl]-N (4),N (4

242 small-molecule agonist [JNJ-63533054, (S)-3-chloro-N-(2-oxo-2-((1-phenylethyl)amino)ethyl) benzamide

243 cocrystal structure of PPARgamma bound to 2-chloro-N-(3-chloro-4-((5-chlorobenzo[d]thiazol-2-yl)thio

244 The availability of 2-chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxyp

245 One of these compounds is 7-chloro-N-(4-ethoxyphenyl)-4-quinolinamine, an inhibitor

246 novel potent and selective SPAK inhibitor, 5-chloro-N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-m

247 azolo[5,4-c]pyridin-3-ol hydrochloride and 4-chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]]benza

248 modulator of the GABAA delta subunit, DS2 (4-chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]benzam

249 ontaining delta subunits were sensitive to 4-chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]benzam

250 Atrazine (6-Chloro-n-ethyl-n'-(1-methylethyl)-triazine-2,4-diamine),

251 contrast, the radical cation derived from 4-chloro-N-methyl-N-(2-phenylcyclopropyl)aniline (8) under

252 yzed [3+2] annulation reaction between bromo-chloro-naphthalene dicarboximide and thiophene- and indo

253 increase linearly with the dipole moments of chloro-, nitro- dichloro-, and dinitro- (o-, m-, and p-)

254 A facile one-pot synthesis of 4-chloro or 4-bromonicotinic acid esters with optional 2-

255 tituent on the 4-phenylimidazole, but a para-chloro or bromo substituent engendered a second closed c

256 cement of a polar pyrazole group by a simple chloro or trifluoromethyl group led to improved Caco-2 p

257 ) and protonation of the thiophene ring in 2-chloro(or bromo)-5-(1'-Me(3)SiO-1'-trifluoromethyl-alkyl

258 -directed functionalization took place and 3-chloro- or 3-bromobipyridine N-oxides were obtained in h

259 xcellent regioselectivities through either a chloro- or a bromocyclization, using Koser's reagent and

260 Using NCS or NBS (N-chloro- or N-bromosuccinimide) and 5 mol % Pd(OAc)2 in c

261 yl boronates, which may contain an alkyl-, a chloro-, or a bromo-substituted Z-alkene, can either be

262 ition, di-trifluoromethylthiolation of delta-chloro-p-quinone methide and scalability are demonstrate

263 comparison to having electron withdrawing p-chloro (PClB) or p-cyanobenzyl ether (PCNB) protecting g

264 overall chlorination rate depending on the (chloro)phenol identity and chloride concentration.

265 The aqueous chlorination of (chloro)phenols is one of the best-studied reactions in t

266 2 and Cl2O, may play in the chlorination of (chloro)phenols.

267 on with 3-(5-tert-butyl-isoxazol-3-yl)-2-[(3-chloro-phenyl)-hydrazono]-3-oxo-propionitril e, an EPAC-

268 ieved by N(6)-substitution with a 2-fluoro-4-chloro-phenyl- or a methyl- group.

269 show that the selective Epac activator 8-(4-chloro-phenylthio)-2'-O-methyladenosine-3', 5-cyclic mon

270 low detection to 119 pg m(-3) for ethanol, 2-chloro-, phosphate (3:1) (TCEP).

271 activity, a variety of substitutions at the chloro position only increased its IC50 by 2-3-fold.

272 Propofol and 4-chloro-propofol bind with 5-fold selectivity to beta (+)

273 With azine-linked N2-COF photosensitizer, chloro(pyridine)cobaloxime co-catalyst, and TEOA donor,

274 Here, we present azide-functionalized chloro(pyridine)cobaloxime hydrogen-evolution cocatalyst

275 sed to involve formation of a putative alpha-chloro pyridinium carbamate intermediate, which appeared

276 ethyl p-nitrophenyl phosphonate (pNPP) or a chloro-pyrimidine (CP) group, respectively, to give cova

277 While PPh(3) (2 equiv) reacts with the chloro reagent in toluene to give the expected iminophos

278 for chloroplast ribosomal RNA processing and chloro-ribosome assembly.

279 ) is obtained from the reaction of the alpha-chloro silyl functionalized heavier vinylidene analogue

280 the unprecedented hydroborylene-coordinated (chloro)(silyl)nickel(II) complex 3, {[cat((TMS) L)Si](Cl

281 Facile nucleophilic replacement of the alpha-chloro substituent is shown to lead to further diverse f

282 to give in 92% yield a phosphine adduct of a chloro substituted germyl-germylene (2).

283 When starting from 7-chloro-substituted 2,3,4-benzothiadiazepine 2,2-dioxide,

284 eted with the synthesis of the corresponding chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-benzothi

285 More specifically, Z-chloro-substituted allylic pinacolatoboronate is first o

286 ved between the product distributions of the chloro-substituted and the thiadiazolo-fused derivatives

287 receptor potentiator in vitro, whereas the 7-chloro-substituted compound 36c emerged as the most prom

288 e group transfer of both P and Cl atoms from chloro-substituted dibenzo-7lambda(3) -phosphanorbornadi

289 alized quinolines by selective metalation of chloro-substituted quinolines with metal amides followed

290 Trp-248 was further confirmed by ZnClTerp, a chloro-substituted version of ZnTerp that showed no inhe

291 M(3) subtype selectivity over M(2), while 3'-chloro substitution substantially increased affinity thr

292 nd C18-O bonds have been created using alpha-chloro sulfide intermediates and [2,3] sigmatropic rearr

293 inylzinc bromide with an electrophilic alpha-chloro sulfide, and last by ring-closing metathesis reac

294 carbon-carbon bond formation using an alpha-chloro sulfide, regioselective hydrozirconation of an in

295 tion of an alkynylzinc reagent with an alpha-chloro sulfide.

296 d levetiracetam-huprine and levetiracetam-(6-chloro)tacrine hybrids to hit amyloid, tau, and choliner

297 anufacturing byproduct summation operator-3'-chloro-TCC C (r = 0.79), and summation operator-2'-hydro

298 re not the most enthalpic binders; instead a chloro-thiophene fragment binds more enthalpically.

299 Herein, we report that the reaction of a chloro titanium triamidoamine complex with magnesium eff

300 ne, a class 3a carcinogen, is a pesticide of chloro triazine family and is known to severely affect t