ライフサイエンスコーパス: chloroethyl

1 arrest in response to exposure to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) alone; however, 70-80%

2 e 5-day cycle (1omega) of low-dose 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and a second group rec

3 esponse to the chemotherapy agents 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and cis-diamminedichlo

4 ating-agent-induced methylation by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) at the O(6) position o

5 al administration of radiation and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) chemotherapy in three

6 to inhibit MGMT and to potentiate 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a MGMT-positive hum

7 Low concentrations of diamide plus 1,3-bis(2 chloroethyl)-1-nitrosourea (BCNU) increased intracellula

8 tentiate the antitumor efficacy of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) is being tested in cli

9 The bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) is cytotoxic primarily

10 ion of eNOS, by exposure to either 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) or glutathione reducta

11 tion of 30 mg/kg 6-BG and 10 mg/kg 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) or with 40 mg/kg BCNU

12 onal cycles of chemotherapy using 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) resulted in similar in

13 ter resistance to cell killing by 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) than overexpression of

14 ured with buthionine sulfoximine and 1,3-bis(chloroethyl)-1-nitrosourea (BCNU) to inhibit glutathione

15 th adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) would lead to an incre

16 stance to the cytotoxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a CNU commonly used f

17 study, we examined the effects of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a commonly used CNU,

18 rly hematopoietic progenitors from 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a stem cell toxin, an

19 agenic effects of temozolomide and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), and no further sensit

20 -disulfide oxidoreductase enzymes (1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), arsenite, and phenyla

21 The chemotherapeutic agents 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), carboplatin, and camp

22 ucts and compromise its integrity (1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), cisplatin, H(2)O(2) a

23 In combination with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), the prodrugs were not

24 and to the chloroethylating agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), with and without AGT

25 ro, 2,4-dinitrobenzene (CDNB); or 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU).

26 in of safety than the nitrosourea, 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).

27 re > 10-fold resistant to the CENU 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).

28 ncluding melphalan, cisplatin, and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).

29 sferase (AGT) and are sensitive to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).

30 ctive in enhancing cell killing by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).

31 mbucil, melphalan, and carmustine [1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)] weakly induced lucife

32 -benzylguanine (O6-BG, 20 microM) or 1,3-bis(chloroethyl)-1-nitrosourea (BCNU, 100 microM), resulted

33 roencapsulation of antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, Carmustine) into biode

34 transduction and O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea (BG/BCNU) treatment has been

35 n animals treated with carmustine (1,3-bis(2-chloroethyl)-1-nitrosourea 20 mg/kg/week, i.v. x 2; diff

36 effects of chemotherapy [25 mg/kg 1,3-bis(2-chloroethyl)-1-nitrosourea administered with a single i.

37 iving IL-2-transduced cells or 10% 1,3-bis(2-chloroethyl)-1-nitrosourea alone.

38 also protected HeLa cells against 1,3-bis(2-chloroethyl)-1-nitrosourea and methyl methanesulfonate c

39 e toxic and clastogenic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea and mitomycin C (MMC), as mea

40 rapeutic alkylating agents, namely 1,3-bis(2-chloroethyl)-1-nitrosourea and mitomycin C, indicating t

41 cells and polymers containing 10% 1,3-bis(2-chloroethyl)-1-nitrosourea had significantly improved su

42 reatine:Pi and ATP:Pi ratios after 1,3-bis(2-chloroethyl)-1-nitrosourea treatment indicate improved b

43 oximine) or glutathione reductase (1,3-bis(2-chloroethyl)-1-nitrosourea) in the presence or absence o

44 ozolomide, N-methyl-N-nitrosourea, 1,3-bis(2-chloroethyl)-1-nitrosourea, 9-aminocamptothecin, topotec

45 ne in DNA with the antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic used to c

46 of BLMVECs with the GR inhibitor, 1,3 bis-(2 chloroethyl)-1-nitrosourea, abolished the inhibitory eff

47 had been treated with carmustine (1,3-bis(2-chloroethyl)-1-nitrosourea, or BCNU).

48 0 degrees C and after addition of 1,3-bis-(2-chloroethyl)-1-nitrosourea, there was effective S-thiola

49 -mediated tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea, we performed a novel dose es

50 ze human tumor cells to killing by 1,3-bis(2-chloroethyl)-1-nitrosourea, with O6-benzyl-3'-O-(gamma-f

51 lling by the combination of BG and 1,3-bis(2-chloroethyl)-1-nitrosourea.

52 tance to the combination of BG and 1,3-bis(2-chloroethyl)-1-nitrosourea.

53 kyl N-nitrosourea-type drugs, e.g. 1,3-bis(2-chloroethyl)-1-nitrosourea.

54 ne or in combination with 13 mg/m2 1,3-bis(2-chloroethyl)-1-nitrosourea.

55 with 0.5, 1, or 2 x LD10 doses of 1,3-bis(2-chloroethyl)-1-nitrosourea.

56 therapeutic drugs temozolomide and 1,3-bis(2-chloroethyl)-1-nitrosourea.

57 lating agents, such as carmustine [1,3-bis(2-chloroethyl)-1-nitrosourea; BCNU], lomustine [1-(2-chlor

58 ere treated with the alkylator agent 1,3-bis-chloroethyl-1-nitrosourea.

59 of glutathione reductase (GR) with 1,3-bis[2-chloroethyl]-1-nitrosourea or transfection of macrophage

60 cells as compared with 19 exhibited by 4-[(2-chloroethyl)(2-mesyloxyethyl)amino]benzoyl-l-glutamic ac

61 ity differential than the published N-[4-[(2-chloroethyl)(2-mesyloxyethyl)amino]benzoyl]-l-glutamic a

62 of this class, 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)- 2(-)[[2-chloroethyl)-amino]carbonyl]hydraz

63 of this class, 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylamino)carbonylhydrazine (101M).

64 another agent, 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(4-nitrobenzyloxy)carbonyl]hy drazine (P

65 ty to sensitize 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (laromus

66 f these agents, 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carb onyl]hydra

67 cumulation of a liposome formulation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), an effec

68 motherapy regimen between procarbazine, 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), and vinc

69 r response to the chemotherapeutic drug 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in vitro.

70 ethyl)-1-nitrosourea; BCNU], lomustine [1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea; CCNU], and stre

71 and presence of sublethal nitrosourea ([1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea]; CCNU) concentr

72 -(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU), an alkylating antitum

73 without affecting [3H](+)-7-OH-DPAT (D3); N-chloroethyl-7-OH-DPATs blocked both radioligands in Acc

74 bis(2-chloroethyl)nitrosourea (BCNU)-induced chloroethyl adducts are fully converted into interstrand

75 ted esters provides CNTs functionalized with chloroethyl, allyl, and propargyl groups, which can furt

76 race impurities from the synthesis of tris(2-chloroethyl)amine (HN3) that point to the reagent and th

77 trophiles such as N-acylimidazoles and bis(2-chloroethyl)amines, covalent screening enabled the surpr

78 g PGP (N-p- inverted question markN,N-bis (2-chloroethyl)amino inverted question markphenoxycarbonyl-

79 higher than that of sarcolysin [(L-3-[bis(2-chloroethyl)amino]-L-phenylalanine] against all leukemia

80 ID50 and ID90 values for L-prolyl-L-m-[bis(chloroethyl)amino]-phenylalanyl-L-norvaline ethyl ester

81 a-glutamyl-alpha-amino-beta-[[[2-[[bis[bis(2-chloroethyl)amino]ph osp horyl]oxy]ethyl]sulfonyl]propio

82 [3,5-Difluoro-4-[bis(2-chloroethyl)amino]phenyl]carbamoyl-l-glutamic acid gave

83 coupling of two key intermediates: 4-[bis(2-chloroethyl)-amino]-L-phenylalanine ethyl ester trifluor

84 s(methylsulfonyl)-1-(2-chloroethyl)- 2(-)[[2-chloroethyl)-amino]carbonyl]hydrazine, was further evalu

85 Electrophilic modules, whether N-chloroethyl aniline or diazirine, have reactive profiles

86 th induced proximity; however, probes with N-chloroethyl aniline were more reactive and more specific

87 ompounds consist of 4-(3-aminopropyl)-N,N-(2-chloroethyl)-aniline linked to 2-(4'-hydroxyphenyl)-3-me

88 We converted PVC and styrene in up to 89% (1-chloroethyl)benzene in less than 1 h of white light irra

89 tothermally recycled styrene achieved 84% (1-chloroethyl)benzene under white LED light in 1 h, and co

90 S plastics via photothermal conversion to (1-chloroethyl)benzene, a commodity chemical with excellent

91 is (chloromethyl)-propane-1,3-diyltetrakis(2-chloroethyl) bisphosphate (V6)).

92 -bis(chloromethyl)propane-1,3-diyltetrakis(2-chloroethyl) bisphosphate, known as V6, is a flame retar

93 this N-substituent could be cleaved using 1-chloroethyl chloroformate.

94 -32 by S-(2-chloroethyl)glutathione and S-(2-chloroethyl)cysteine, in peptides 1-24 and 45-58, was si

95 N-chloroethyl derivatives of 7-hydroxy-1,2,3,4-tetrahydron

96 Dichloroborane adducts of monoglyme and beta-chloroethyl ether also showed high reactivity, even at r

97 Dioxane, ethyl acetate, and beta-chloroethyl ether form relatively stable boron trichlori

98 Monoglyme and beta-chloroethyl ether give stable dichloroborane adducts req

99 ether, dioxane, anisole, ethyl acetate, beta-chloroethyl ether, and monoglyme, were examined as prosp

100 xyphenylsulfone (D-8) (<=230 ng/g ww), bis(2-chloroethyl)ether-4,4'-dihydroxydiphenyl sulfone monomer

101 d sulfur mustard and its chemical simulant 2-chloroethyl ethyl sulfide (CEES) with half-lives less th

102 Mass spectra for xenon, 2-chloroethyl ethyl sulfide (CEES), and octane were acquir

103 r the oxidation of a mustard gas analogue, 2-chloroethyl ethyl sulfide (CEES), in the presence of an

104 photooxidation of a mustard-gas simulant, 2-chloroethyl ethyl sulfide (CEES), is studied using a por

105 ch we probed by the selective oxidation of 2-chloroethyl ethyl sulfide (CEES).

106 for binding the sulfur mustard surrogate, 2-chloroethyl ethyl sulfide (CEES).

107 parent fabric for a mustard gas simulant, 2-chloroethyl ethyl sulfide (CEES).

108 oxidation of the sulfur mustard simulant, 2-chloroethyl ethyl sulfide (CEES).

109 lytically active for the photooxidation of 2-chloroethyl ethyl sulfide (CEES, a chemical warfare simu

110 The hydrolysis of 2-chloroethyl ethyl sulfide has been examined in an effort

111 d the adsorption behaviors of n-hexane and 2-chloroethyl ethyl sulfide to explore the structure-prope

112 dditional products in the disappearance of 2-chloroethyl ethyl sulfide with k3 in particular causing

113 nethiol) and one S-type vesicant simulant (2-chloroethyl ethyl sulfide) were found in each case (samp

114 xidation (O(2) oxidation of the thioether, 2-chloroethyl ethyl sulfide, CEES) led to the discovery th

115 Detection of the CWA simulants 2-chloroethyl ethyl sulfide, triethyl phosphate, and dimet

116 CEES to the comparatively nontoxic product 2-chloroethyl ethyl sulfoxide (CEESO) without formation of

117 ES was transformed selectively to nontoxic 2-chloroethyl ethyl sulfoxide and vinyl ethyl sulfoxide us

118 A compound (Alchemix) with the bis-chloroethyl functionality confined to one side chain alk

119 by thioredoxins alkylated at Cys-32 by S-(2-chloroethyl)glutathione and S-(2-chloroethyl)cysteine, i

120 mutations seen in other organisms with S-(2-chloroethyl)glutathione or ethylene dibromide.

121 The synthetic analog S-(2-chloroethyl)glutathione was used to produce DNA damage;

122 -based assays accompanied replacement of the chloroethyl group with unhalogenated substituents.

123 In contrast, O(6)-(2-chloroethyl)guanine lesions produced by agents such as l

124 (aminocarbonyl)-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydr azi nes were synthesized and primarily

125 ylating species 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine (90CE) after bioreductive activati

126 yloxycarbonyl)-1, 2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines (4, 6, and 7) were synthesized an

127 ed by agents such as lomustine and the N3-(2-chloroethyl)imidazotetrazine mitozolomide rapidly evolve

128 The 2-chloroethyl moiety on selected dithiazoles was also modi

129 ell-line panel at the NCI, indicate that the chloroethyl moiety plays a major role in the enhanced ac

130 wley rats were administered 50 mg/kg i.p. N-(chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) or were

131 NE in the spinal cord dorsal horn with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (D

132 inistered the noradrenergic neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (D

133 males with the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (D

134 by cortical NA denervation with DSP-4 [N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride] a

135 rats and in rats pretreated with DSP-4 [N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine], a neurotoxin t

136 tau transgenic mice with the neurotoxin N-(2-chloroethyl)-N-ethyl-bromobenzylamine (DSP-4) starting a

137 both O6-benzylguanine (O6BG) and N,N'-bis(2-chloroethyl)-N-nitroso-urea (BCNU) stably increased the

138 en a single dose of 35 mg/m(2) of N,N'-bis(2-chloroethyl)-N-nitrosourea (BCNU), which was otherwise i

139 and are sensitive to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea (BCNU).

140 synthesis, complicates the use of N,N-bis(2-chloroethyl)-N-nitrosourea as a GR inhibitor.

141 (DBT-FG) sensitized the tumors to N,N'-bis(2-chloroethyl)-N-nitrosourea chemotherapy, as measured by

142 reports of various GR inhibitors, N,N-bis(2-chloroethyl)-N-nitrosourea, an anticancer drug with IC(5

143 olar range, it is more potent than N,N-bis(2-chloroethyl)-N-nitrosourea, which is currently the most

144 such alkylating chemotherapeutic drugs as 2-chloroethyl-N-nitrosourea (CNU) derivatives is countered

145 nes and alkylating antitumor drugs such as 2-chloroethyl-N-nitrosourea (CNU).

146 MT caused increased cellular resistance to 2-chloroethyl-N-nitrosourea suggests a therapeutic signifi

147 on induced by alkylating agents, including 2-chloroethyl-N-nitrosourea-based antitumor drugs.

148 in (SAP) +/- intraperitoneal injection of N-[chloroethyl]-N-ethyl-2-bromobenzylamine (DSP-4) (noradre

149 -nitrobenzyl ester (9) and carbamic acid, (2-chloroethyl)nitroso-2,3,4, 6-tetra-O-acetyl-1-alpha,beta

150 One compound, carbamic acid, (2-chloroethyl)nitroso-4-acetoxybenzyl ester (3), was selec

151 rementioned compound, both carbamic acid, (2-chloroethyl)nitroso-4-nitrobenzyl ester (9) and carbamic

152 Seven new (2-chloroethyl)nitrosocarbamates have been synthesized as p

153 er treatment, a time interval in which bis(2-chloroethyl)nitrosourea (BCNU)-induced chloroethyl adduc

154 ic effects of the antitumor agents 1,3-bis(2-chloroethyl)-nitrosourea (BCNU) and temozolomide were st

155 ismatched-BALB/c model followed by N,N-bis(2-chloroethyl)-nitrosourea (BCNU) treatment to enhance don

156 rstrand cross-linking reaction of N,N'-bis(2-chloroethyl)-nitrosourea (BCNU) were investigated using

157 link induction and cytotoxicity of 1,3-bis(2-chloroethyl)-nitrosourea (BCNU).

158 he 5-member exocyclic ring and are formed by chloroethyl nitrosoureas, which are used in cancer thera

159 ide] into the homobenzylic C-Cl bond of 4-(2-chloroethyl)phenol 1.

160 nt (e.g., t(1/2) (HD) approximately 18 s, (2-chloroethyl phenyl sulfide, C(6)H(5)SCH(2)CH(2)Cl) appro

161 Reactions of alpha-chloroethyl phenyl sulfone (14) and ethyl 2-chloropropio

162 Fmoc-4-(1-chloroethyl)-phenylalanine (5) was synthesized in four s

163 While tris-2-chloroethyl phosphate, tris(1-chloro-2-propyl)phosphate

164 loro-isopropyl) phosphate (TDCIPP) and bis(2-chloroethyl) phosphate (BCEP)-tris(2-chloroethyl) phosph

165 ations of nine urinary OPE biomarkers: bis(2-chloroethyl) phosphate (BCEtp), bis(1-chloro-2-propyl) p

166 ng/g) had higher concentrations than tris(2-chloroethyl) phosphate (GM: 1608 ng/g) and triphenyl pho

167 Tris(2-chloroethyl) phosphate (TCEP) and hexachlorocyclohexane

168 Furthermore, tris (2-chloroethyl) phosphate (TCEP), a known carcinogen, was f

169 These OPEs include tris(2-chloroethyl) phosphate (TCEP), tris(2-chloroisopropyl) p

170 ris(2-butoxyethyl) phosphate (TBOEP), tris(2-chloroethyl) phosphate (TCEP), tris(2-chloroisopropyl) p

171 e analyzed for three halogenated OPs (tris(2-chloroethyl) phosphate (TCEP), tris(2-chloroisopropyl) p

172 One mattress contained high levels of tris(2-chloroethyl) phosphate (TCEP), which has been prohibited

173 or exposure pathway for SigmaTCPP and tris(2-chloroethyl) phosphate (TCEP), while participants had hi

174 loroisopropyl) phosphate (TCIPP), and tris(2-chloroethyl) phosphate (TCEP).

175 c risk, with a main contribution from tris(2-chloroethyl) phosphate (TCEP).

176 d bis(2-chloroethyl) phosphate (BCEP)-tris(2-chloroethyl) phosphate (TCEP).

177 phosphate, diethyl cyanophosphonate, tris (2-chloroethyl) phosphate and dichlorvos).

178 hloro-2-propyl)phosphate (TDCIPP) and tris(2-chloroethyl)phosphate (TCEP).

179 propyl)phosphate (TCPP or TCIPP), and tris(2-chloroethyl)phosphate (TCEP).

180 hosphate (TDCIPP; max: 3150 ng/L) and tris(2-chloroethyl)phosphate (TCEP; max: 8450 ng/L).

181 phosphate or TCIPP (303 ng m(-3)) and tris(2-chloroethyl)phosphate or TCEP (139 ng m(-3)), which are

182 to 150 pg/m3, and tributyl phosphate, tris(2-chloroethyl)phosphate, tris(1-chloro-2-propyl)phosphate,

183 Bis-2-chloroethyl-phosphate was not associated with alteration

184 In this work, five OPAs [tris(2-chloroethyl) phosphite, triphenyl phosphite, tris(2,4-di

185 pha-amino-beta(2-ethyl-N,N,N', N'-tetrakis(2-chloroethyl)phosphorodiamidate)-sulfonyl-propionyl-( R)-

186 )methanes with DABCO failed to give {4-[N-(2-chloroethyl)piperazin-1-yl]-5H-1,2,3-dithiazol-5-ylidene

187 ct with DABCO in hot PhCl to give N-{4-[N-(2-chloroethyl)piperazin-1-yl]-5H-1,2,3-dithiazol-5-ylidene

188 n-retrocycloaddition strategies from 4-[N-(2-chloroethyl)piperazin-1-yl]-5H-1,2,3-dithiazole-5-thione

189 gallamine (M2), and 4-4-diphenylacetoxy-N-(2-chloroethyl)-piperidine hydrochloride (4-DAMP mustard; M

190 ) receptor inhibitor, 4-diphenylacetoxy-N-(2-chloroethyl)-piperidine hydrochloride (4-DAMP; 10(-5) M)

191 3 receptor antagonist 4-diphenylacetoxy-N-(2-chloroethyl)-piperidine hydrochloride had no effect.

192 Six (2-chloroethyl)porphyrins were synthesized from a common di

193 gave 5-substituted 3-(chloromethyl)- or 3-(2-chloroethyl)pyrazoles.

194 D, bis(2-chlororethyl) sulfide) and a range (chloroethyl) sulfide simulants of variable lipophilicity

195 exposure to the DNA-damaging compound bis-(2-chloroethyl) sulfide.

196 toxic chemical warfare agent mustard (bis(2-chloroethyl)sulfide) in the environment and during its d

197 face or within the droplet core, a range of (chloroethyl) sulfides, including HD, spanning some 7 ord

198 he A1/A2 purinergic receptor blocker 7-(beta-chloroethyl) theophylline (CET; given at 5 x 10-6 M and

199 receptor affinity-enhancing effects of 7-(2-chloroethyl) vs 7-methyl were comparable to the known en

200 ance affinity over hydrogen, except for 7-(2-chloroethyl), which enhanced the affinity of theophyllin