ライフサイエンスコーパス: chlorohydrin

1 to rationalize the increased activity of the chlorohydrin.

2 ydrin is more stable than the epimeric trans-chlorohydrin.

3 predominantly ( approximately 94%) a single chlorohydrin.

4 iol), and a structurally related cholesterol chlorohydrin.

5 derived unsaturated terminal epoxide 17 (and chlorohydrin 16), efficiently generates a substituted tr

6 bocation intermediate from the hydrolysis of chlorohydrin 5 is different than the cis/trans tetrol ra

7 s, it is proposed that the S(N)1 reaction of chlorohydrin 5 yields a different distribution of carboc

8 rahydrobenzo[a]pyr ene (1) to its trans-9,10-chlorohydrin (5) with excellent yield and purity by the

9 stane-(3beta,5alpha)-diol), cholesterol beta-chlorohydrin (5alpha-chlorocholestane-(3beta, 6beta)-dio

10 ovel dichlorinated sterol, cholesterol alpha-chlorohydrin (6beta-chlorocholestane-(3beta,5alpha)-diol

11 and synthesized were of particular interest, chlorohydrin 7 and epoxide 6, which are reactive analogu

12 again contrasts with the hydrolysis of trans-chlorohydrin 8, which undergoes hydrolysis to give tetro

13 ide (DE-2) with HCl, which yields only trans-chlorohydrin 8.

14 The hydrolysis of cis-chlorohydrin 9 in 10:90 dioxane-water solutions yields t

15 ion rate depression in the hydrolysis of cis-chlorohydrin 9 is observed, which shows that hydrolysis

16 s show that the aldolization intermediate (a chlorohydrin adduct) can be trapped with tert-butyl isoc

17 Further, the dichlorination of a (Z)-allylic chlorohydrin affords with high selectivity a stereotetra

18 The related unsaturated chlorohydrins also undergo intramolecular cyclopropanati

19 otected bromohydrins, as well as a protected chlorohydrin and a homologated bromohydrin, are coupled

20 The chlorohydrin and epoxide show increased cytotoxicity com

21 The contraceptive activity of alpha-chlorohydrin and its apparent specificity for the sperm

22 The cytotoxicity associated with the chlorohydrins and chlorotyrosines in low masses (9-52 g)

23 the concentrations of lipid-bound oleic acid chlorohydrins and protein-bound chlorotyrosines, which a

24 reduction, t-butylamine displacement of the chlorohydrin, and a conjugate addition of the hindered s

25 s an epoxide, a cis chlorohydrin, or a trans chlorohydrin, and the major diol hydrolysis product from

26 were favorable for the phosphatidylglycerol chlorohydrins, and they were therefore proposed as the b

27 At mixing ratios of 600 ppbv, HOCl forms chlorohydrins by adding across carbon-carbon double bond

28 ysulfone 10 and chloroketone 14 derived from chlorohydrins by oxidation proved to be inhibitors of ca

29 o-tetrasubstituted cyclohexenone to give the chlorohydrin, catalyzed by two stereoselective redox enz

30 Oleic acid 9,10-chlorohydrin concentrations were 2.4-2.7 nmol/g for chlo

31 Oleic acid 9,10-chlorohydrin concentrations were 2.4-2.7 nmol/g for chlo

32 and chiral derivatives of the danicalipin A chlorohydrin core in a confined, mostly hydrophobic envi

33 way may have biological significance because chlorohydrins could form in serum or in cells with relat

34 m involving turnover-limiting acylation of a chlorohydrin-derived borinic ester.

35 After base-mediated ring closure of the chlorohydrin enantiomers, the epoxides were converted di

36 Fatty acid chlorohydrins (FA-Cl) were measured in adipose tissue, a

37 The hydrolysis of the trans chlorohydrin formed from the reaction of 5b with HCl exh

38 s relies on L-proline catalysis to install a chlorohydrin function that masks the sensitive C16-C17 e

39 ally, increased concentrations of oleic acid chlorohydrin have been found in plasma of human patients

40 (5b and 7b), along with their cis and trans chlorohydrins, have been determined in dioxane/water sol

41 conversion of lipid-bound oleic acid to 9,10-chlorohydrins in chlorine-treated glyceryl trioleate and

42 mical calculations that suggest that the cis-chlorohydrin is more stable than the epimeric trans-chlo

43 whereas the yield of trans adducts from the chlorohydrin is not significantly changed.

44 DE-1 reacts with HCl to give mainly the cis-chlorohydrin is rationalized by quantum chemical calcula

45 across the double bond to form the two 9,10-chlorohydrin isomers at a 100% yield.

46 synthesis of these compounds where a related chlorohydrin may yield both THF- and epoxide-containing

47 es cis adducts and now report that the trans chlorohydrin of anti-BPDE (trans-BPDCH) is an intermedia

48 In plasma, only the chlorohydrin of oleic acid was detected.

49 not only of free fatty acids but also of the chlorohydrins of both oleic and linoleic acids from adip

50 potential chlorine specific markers were all chlorohydrins of unsaturated pulmonary surfactant phosph

51 f whether the precursor is an epoxide, a cis chlorohydrin, or a trans chlorohydrin, and the major dio

52 The chlorohydrin retains the psorospermin-like DNA alkylatio

53 The chlorohydrin ring opened form of the epoxide was also pr

54 This chlorohydrin was assigned structure 9, in which the chlo

55 ion rate depression for the reaction of the chlorohydrin was observed, and the rate data are fit to

56 ytotoxicity LC(50) value for oleic acid 9,10-chlorohydrins was 0.106 mM.

57 Chlorohydrins were also instilled in the rats' peritonea

58 Administration of 250-muM lipid chlorohydrins, which is the concentration found in ascit

59 nal and chloromethyl phenyl sulfone afforded chlorohydrins, which were converted into epoxysulfones b