ライフサイエンスコーパス: chlorpromazine

1 using low-dose neuroleptics (haloperidol or chlorpromazine).

2 gen, dopamine, ascorbic acid, Fe(3+/2+), and chlorpromazine.

3 K+ and histamine uptake was antagonized with chlorpromazine.

4 e to their interaction with promethazine and chlorpromazine.

5 ed pesticides, polychlorinated biphenyls and chlorpromazine.

6 by the antipsychotic drugs thioridazine and chlorpromazine.

7 high doses of epinephrine, dexamethasone, or chlorpromazine.

8 rom baseline to day 2 for patients receiving chlorpromazine.

9 luoperazine and approximately 120 microM for chlorpromazine.

10 n known efflux pump inhibitors verapamil and chlorpromazine.

11 ed pit-mediated trafficking was blocked with chlorpromazine.

12 Rats were anesthetized using ketamine and chlorpromazine.

13 tamidine, and a phenothiazine antipsychotic, chlorpromazine.

14 by using the clathrin endocytosis inhibitor chlorpromazine.

15 itrophenol and 20 mV for 100 microM cationic chlorpromazine.

16 ibitors, which included the compounds W7 and chlorpromazine.

17 ly, hypoxia blunted the inhibitory action of chlorpromazine.

18 total n=949, amisulpride=20, aripiprazole=8, chlorpromazine=13, haloperidol=316, intramuscular olanza

19 ted the kinase activity, but the addition of chlorpromazine, a calmodulin antagonist, blocked its sti

20 -geminin was inhibited at 4 degrees C and by chlorpromazine, a compound that induces misassembly of c

21 Intracellular MDP uptake was inhibited by chlorpromazine, a drug that disrupts clathrin-dependent

22 f pneumococcal meningitis, mice treated with chlorpromazine, a neuroleptic with a complementary endoc

23 s a novel mode of phenothiazine action where chlorpromazine, a promising antitubercular agent and key

24 d discovery of the antipsychotic activity of chlorpromazine, a variety of therapeutic agents have bee

25 6(3+/2+), IrCl6(2-/3-), methyl viologen, and chlorpromazine all involve electron transfer that is ins

26 more effectively than either pentamidine or chlorpromazine alone.

27 W-7 and chlorpromazine also lowered levels of phosphatidylinosit

28 ed temperature or the fusion promoting agent chlorpromazine), an additional set of bands at >150 kDa,

29 e 243 to tyrosine [D243Y]) or by exposure to chlorpromazine, an agent that induces fusion pores in he

30 The cationic amphiphilic drug chlorpromazine, an inhibitor of clathrin-dependent, rece

31 Chlorpromazine, an inhibitor of clathrin-mediated endocy

32 rus entry into beta1+/+ cells was blocked by chlorpromazine, an inhibitor of clathrin-mediated endocy

33 This effect is blocked by chlorpromazine, an inhibitor of the clathrin-mediated en

34 ned the effect of amphipathic ions, cationic chlorpromazine and anionic trinitrophenol, which are tho

35 able antiprion potencies similar to those of chlorpromazine and emphasized the importance of the side

36 Finally, studies using chlorpromazine and endosomal acidification inhibitors re

37 Treatment with chlorpromazine and filipin had opposing effects on HPV31

38 Cholesterol efflux was partially blocked by chlorpromazine and hypertonic media, two inhibitors of c

39 rs of the clathrin-mediated pathway, such as chlorpromazine and hypertonic sucrose medium.

40 Both chlorpromazine and knockdown of clathrin expression by R

41 y by an excess of unlabeled histamine and by chlorpromazine and phenoxybenzamine.

42 l treatments that block endocytosis, namely, chlorpromazine and potassium depletion.

43 e surface by their oxidized forms, while for chlorpromazine and promethazine the suppression of the c

44 s, as shown by use of the clathrin inhibitor chlorpromazine and the dynamin inhibitor Dynasore.

45 ow potency antipsychotic drugs drugs such as chlorpromazine and thioridazine were more strongly assoc

46 The inhibitory effects of chlorpromazine and trans-dominant-negative forms of dyna

47 HF-HP and HF-LP received alpha-blockers (chlorpromazine and/or prazosin).

48 ministration of antipsychotic (clozapine and chlorpromazine) and psychomimetic (ketamine) drugs.

49 ee xenobiotic compounds: phenobarbital (PB), chlorpromazine, and caffeine.

50 s-flupenthixol, (+)-butaclamol, haloperidol, chlorpromazine, and fluphenazine inhibited constitutive

51 he efficacy and side effects of haloperidol, chlorpromazine, and lorazepam for the treatment of the s

52 ion was markedly reduced by trifluoperazine, chlorpromazine, and naphthalene sulfonamide (W7).

53 increase but could fuse upon the addition of chlorpromazine; and 3) at the point of the intermediate,

54 ery 4 h, or combined haloperidol at 1 mg and chlorpromazine at 12.5 mg every 4 h, until death or disc

55 at 2 mg every 4 h, neuroleptic rotation with chlorpromazine at 25 mg every 4 h, or combined haloperid

56 mbination of domperidone, dexamethasona, and chlorpromazine at night controlled toxicity in most pati

57 ative of chlorpromazine, we demonstrate that chlorpromazine binding at the beta8-beta9 loop is respon

58 , we determine the molecular determinants of chlorpromazine binding in the Erwinia ligand-gated ion c

59 bition of clathrin-mediated endocytosis with chlorpromazine blunted NKCC2 endocytosis by 54 +/- 6%, w

60 promazine, which is structurally similar to chlorpromazine but lacking both D2-effects and antipsych

61 ll gene expression, and stress resistance to chlorpromazine, but does not affect the silent HML and r

62 s half-maximally inhibited by 0.1 millimolar chlorpromazine, by 35 nanomolar K-252a and by 7 nanomola

63 aevis oocytes, we show that a small molecule chlorpromazine (CH), widely used as an antipsychotic med

64 ological and functional effects of four APs: chlorpromazine (CLP), haloperidol (HAL), risperidone (RI

65 ntagonist to full agonist by the addition of chlorpromazine (CPZ) and other cationic membrane-active

66 em using the well-known peroxidase substrate chlorpromazine (CPZ) and the hydrazine derivative isonia

67 novel and sensitive amperometric sensor for chlorpromazine (CPZ) based on reduced graphene oxide (RG

68 ociation between GM volume and age of onset, chlorpromazine (CPZ) equivalent dose, and other clinical

69 ) in 1 M KCl, Fe(CN)6(3-/4-) in 1 M KCl, and chlorpromazine (CPZ) in 10 mM HClO4.

70 stem was used to characterize the effects of chlorpromazine (CPZ) on the mechanical properties of the

71 Early hepatic effects of chlorpromazine (CPZ), a neuroleptic drug known for years

72 Chlorpromazine (CPZ), a potent nicotinic acetylcholine r

73 cs and thermodynamics for the interaction of chlorpromazine (CPZ), an antipsychotic drug used in the

74 amphipathic compounds including salicylate, chlorpromazine (CPZ), and trinitrophenol (TNP).

75 We show that chlorpromazine (CPZ)-induced repression of pol III trans

76 Finally, chlorpromazine, dibucaine, and trifluoperazine, agents t

77 pramine treatment and the antipsychotic drug chlorpromazine does not alter Gsalpha.

78 of amitriptyline, citalopram, clomipramine, chlorpromazine, doxepin, haloperidol, nortriptyline, and

79 between studies with low compared with high chlorpromazine equivalent daily dose.

80 IQ difference from comparison subjects, and chlorpromazine equivalent daily dose.

81 uding publication year; severity of illness; chlorpromazine equivalent daily dose; and mean IQ, mean

82 as a trend-level predicter, with each 100-mg chlorpromazine equivalent unit increase in dose associat

83 The patients' median dose was 68.4 mg/day of chlorpromazine equivalent.

84 ss severity, including clinical symptoms and chlorpromazine-equivalent antipsychotic dosage.

85 They were compared in terms of total chlorpromazine-equivalent daily dose, changes in total d

86 The total discharge dose in chlorpromazine equivalents for the 349 patients for whom

87 of demographic variables, illness duration, chlorpromazine equivalents of antipsychotic medication,

88 daily doses of less than or equal to 100-mg chlorpromazine equivalents or greater than 100-mg chlorp

89 otic treatment in doses of 100 mg or less of chlorpromazine equivalents or in children aged 5 to 17 y

90 promazine equivalents or greater than 100-mg chlorpromazine equivalents vs that for control medicatio

91 sions (age, sex, and antipsychotic dosage in chlorpromazine equivalents).

92 daily neuroleptic dose higher than 200 mg of chlorpromazine equivalents.

93 e, smoking, body mass index, depression, and chlorpromazine equivalents.

94 differential network analyses on cerulenin, chlorpromazine, ethionamide, ofloxacin, thiolactomycin a

95 In general, the conventional drugs, such as chlorpromazine, fluphenazine and pimozide, were more tox

96 bility of repurposing the antipsychotic drug chlorpromazine for treatment of neurological disorders a

97 For Ru(NH3)6(3+/2+), Fe(CN)6(3-/4-), and chlorpromazine, fresh PPF surfaces show electron-transfe

98 B activity is inhibited by trifluoperazine > chlorpromazine > clozapine.

99 affinity, with a rank order of haloperidol > chlorpromazine > domperidone > (+)-butaclamol > (-)-sulp

100 A combination of valproate and chlorpromazine had proven effective in managing most of

101 enzhexol, tetrabenazine, pimozide, baclofen, chlorpromazine, haloperidol, carbamazepine and acetozola

102 their antipsychotic treatment (thioridazine, chlorpromazine, haloperidol, trifluoperazine, or risperi

103 Because quinacrine and chlorpromazine have been used in humans for many years a

104 V-8 open reading frame 73 gene expression by chlorpromazine HCl, bafilomycin A, and NH(4)Cl demonstra

105 tly inhibited by preincubation of cells with chlorpromazine HCl, which blocks endocytosis via clathri

106 onventional antipsychotics (eg, haloperidol, chlorpromazine hydrochloride), with the use of a retrosp

107 o-4-chlorophenyl phenyl sulfide analogues of chlorpromazine improved inhibition approximately 40-fold

108 a model where dual action of pentamidine and chlorpromazine in mitosis results in synergistic antitum

109 Treatment with either haloperidol or chlorpromazine in relatively low doses resulted in signi

110 Since the serendipitous discovery of chlorpromazine in the 1950s, almost all current anti-sch

111 Moreover, we evaluated chloroquine and chlorpromazine in vivo using mouse-adapted SARS-CoV.

112 , we evaluated two of these, chloroquine and chlorpromazine, in vivo using a mouse-adapted SARS-CoV m

113 antipsychotic drugs, such as haloperidol and chlorpromazine, increase synthesis of the neuropeptide n

114 Chlorpromazine inhibition of DOP-4 in the nervous system

115 Chlorpromazine initiated effective pharmacotherapy for s

116 Chlorpromazine is a potent and specific inhibitor of the

117 The antipsychotic compound chlorpromazine is a widely used tool to probe the ion ch

118 Rapamycin or stress induced by chlorpromazine leads to activation of MAP kinase Mpk1/Sl

119 Dynamin inhibitors, chlorpromazine, methyl-beta-cyclodextrin, chloroquine, a

120 Unexpectedly, we do not find a chlorpromazine molecule in the channel pore of ELIC, but

121 gned to treatment with haloperidol (N = 11), chlorpromazine (N = 13), or lorazepam (N = 6).

122 ective cumulative doses (gram equivalents of chlorpromazine) of more than 5 g, 5 to 99 g, and 100 g o

123 Finally, we showed that chlorpromazine, one of the candidate drugs, can signific

124 ion is restored by the lipophilic amphiphile chlorpromazine or by the phospholipase C inhibitor U7312

125 y crystal structures of ELIC in complex with chlorpromazine or its brominated derivative bromopromazi

126 he same effect was observed upon addition of chlorpromazine or sodium deoxycholate at concentrations

127 , 12-myristate 13-acetate phorbol (PMA), W7, chlorpromazine, or the intracellular Ca+2 chelator BAPTA

128 ibody to integrin alphaVbeta3 (P=0.027), and chlorpromazine (P=0.027).

129 The pharmacologic inhibitors chlorpromazine, phorbol 12-myristate 13-acetate, and cyt

130 mg/day of olanzapine alone or 1200 mg/day of chlorpromazine plus 4 mg/day of benztropine mesylate.

131 pare the efficacy of olanzapine with that of chlorpromazine plus benztropine in patients with treatme

132 ychotics, such as risperidone, olanzapine or chlorpromazine prevented it.

133 Chlorpromazine produced the most weight gain (mean diffe

134 C for 1 h) with phenothiazine neuroleptics (chlorpromazine & promethazine) as additive neuroprotecta

135 logical conditions (pH 7) in the presence of chlorpromazine, promethazine, procaine, and dextromethor

136 drug fluoxetine, and the antipsychotic drug chlorpromazine, provides a clear self-consistent model,

137 luding haloperidol, clozapine, aripiprazole, chlorpromazine, quetiapine, olanzapine, risperidone, and

138 d cells with the membrane-destabilizing drug chlorpromazine rescued the hemifusion block and allowed

139 1-naphthalenesulfonamide, phenothiazine, and chlorpromazine, resulted in rapid apoptotic cell death i

140 (ROR = 171.44, 95% CI = 143.12-205.36), and chlorpromazine (ROR = 91.30, 95% CI = 49.91-167.03) (all

141 Olanzapine and chlorpromazine showed similar efficacy, and the total am

142 -5-chloro-1-naphthalenesulfonamide (W-7) and chlorpromazine significantly lowered all higher inositol

143 acebo or active comparators (eg, alizapride, chlorpromazine; standardized mean difference [SMD], -0.2

144 ic effects are inhibited by nystatin but not chlorpromazine, suggesting an involvement of caveolar-me

145 Pharmacologic therapy with chlorpromazine terminated the respiratory flutter and pe

146 l (to mimic cell swelling) or the cup former chlorpromazine (to mimic cell shrinkage) caused robust a

147 responded according to a priori criteria; no chlorpromazine-treated patients responded.

148 tor and cardiovascular side effects than the chlorpromazine-treated patients.

149 treated patients had fewer side effects than chlorpromazine-treated patients.

150 ds with vehicle and paradigm hepatotoxicant (chlorpromazine) treatment using an automated liquid hand

151 ve found that the commonly used neuroleptics chlorpromazine, trifluoperazine and clozapine inhibit PP

152 ion of certain cationic amphiphiles, such as chlorpromazine, trifluoperazine, and imipramine, which m

153 d higher incidence of tardive dyskinesia for chlorpromazine versus clozapine (risk differences, 5% an

154 idence showed no difference in mortality for chlorpromazine verus clozapine or haloperidol versus ari

155 The EC(50) for chlorpromazine was 3 microM, whereas quinacrine was 10 t

156 Treatment with haloperidol or chlorpromazine was associated with an extremely low prev

157 tory tests were performed in a rodent model, chlorpromazine was found to reduce the progression of ca

158 ntroduction of the first antipsychotic drug, chlorpromazine, was a milestone for psychiatry.

159 e mutants and a thiol-reactive derivative of chlorpromazine, we demonstrate that chlorpromazine bindi

160 o detect a short-lived radical metabolite of chlorpromazine which is too unstable to be detected usin

161 e effect of hypotonic stress was mimicked by chlorpromazine, which is known to cause membrane deforma

162 showed concentration-dependent inhibition by chlorpromazine, which, among other actions, blocks clath