ライフサイエンスコーパス: cholate

1 an unconjugated bile salts (deoxycholate and cholate).

2 hain acyl-CoA synthetase (VLCS) can activate cholate.

3 uires an equal molar concentration of sodium cholate.

4 not reassociate upon the addition of sodium cholate.

5 old), but did not enhance absorption of (3)H-cholate.

6 olesterol, but repressed normally by dietary cholate.

7 alpha-hydroxylase transcription by FGFR4 and cholate.

8 CoA synthetases were incapable of activating cholate.

9 F subunit in all concentrations of Chaps and cholate.

10 ole for MrpF as an efflux system for Na+ and cholate.

11 onic acid, and a low concentration of sodium cholate.

12 rophilic or hydrophobic BS; and 4) 10 mmol/L cholate.

13 of both dimyristoylglycerophosphocholine and cholate.

14 icities, where mEH preferentially transports cholate.

15 lized equally from E2M11 membranes by sodium cholate.

16 ids, with CE and TG hydrolysis stimulated by cholate.

17 dium-dependent transport of taurocholate and cholate.

18 that for HDL3-CE at either 10 or 100 microM cholate.

19 , cholesteryl hemisuccinate (CHS) and sodium cholate.

20 to the unconventional aggregation of sodium cholate.

21 n the presence of solubilizing factor sodium cholate.

22 late is a robust biofilm inducer compared to cholate.

23 ith Bio-Beads SM-2 in the presence of sodium cholate.

24 le HDL and LDL to mixed micelles with sodium cholate.

25 titive solvents with as few as three or four cholates.

26 a monomer to prepare amide-linked oligomeric cholates.

27 h EYPC/taurochenodeoxycholate = 0.6 and EYPC/cholate = 1.0 in 0.15 M NaCl, independent micelles grow

28 The systems EYPC/cholate = 1.0 in 0.4 M NaCl, EYPC/cholate = 1.2 in 0.15

29 stems EYPC/cholate = 1.0 in 0.4 M NaCl, EYPC/cholate = 1.2 in 0.15 M NaCl, and EYPC/octyl glucoside =

30 ed with purified porcine CEL without or with cholate (10 or 100 microM, concentrations achievable in

31 acities for cholesterol (19.27 mg/g), sodium cholate (8.47 mg/g), and glucose.

32 e (Cyp8b1) in mice prevents the synthesis of cholate, a primary bile acid, and its metabolites.

33 very of (3)H-taurocholate ((3)H-TC) and (3)H-cholate administered into proximal and distal intestines

34 ide, dodecyl maltoside, Tween 20, and sodium cholate allow varying degrees of Bax hetero- and homodim

35 Solubilization of rhodopsin in cholate allowed binding of the antibody, but the binding

36 rast, beta gamma in ionic detergents such as cholate and 3-[(cholamidopropyl)diethylammonio]-1-propan

37 ains underneath the concave steroid rings of cholate and capping with another rigid, symmetrically tr

38 ma2 subunit was disrupted in two detergents, cholate and Chaps (3-[(3-cholamidopropyl) dimethylammoni

39 MR and DSF, it was shown that the bile salts cholate and chenodeoxycholate interact with purified Tox

40 M demonstrated that the transporter binds to cholate and deoxycholate with micromolar affinity, and t

41 Surprisingly, cholate and deoxycholate, two of the most abundant and v

42 In wild-type mice, cholate and diosgenin both increased biliary cholesterol

43 biliary cholesterol secretion in response to cholate and diosgenin, but the choleretic effects of the

44 lesterol and by the non-cholesterol steroids cholate and diosgenin.

45 human plasma lipoproteins (TLP) with sodium cholate and its subsequent removal, has been used to stu

46 Among several determinants of cholate and lysozyme resistance in E. faecalis, IreK was

47 h concentrations of GIT antimicrobials, like cholate and lysozyme, leading us to hypothesize that res

48 Second, reutilization of cholate and other C24 bile acids requires reactivation p

49 wo 15-hLO isozymes and demonstrate that both cholate and specific LO products affect substrate specif

50 ining mixed micelles composed of bile salts (cholate and taurochenodeoxycholate, both cholanoyl deriv

51 Conjugated cholate and taurocholate directly and secondary to prima

52 Here we show that cholate and taurocholate elicit more dramatic Ca(2+) sig

53 Sodium cholate and taurocholate induced cytosolic Ca(2+) elevat

54 nation of C. difficile spores in response to cholate and taurocholate.

55 the fatty acid palmitate, and the bile acids cholate and taurocholate.

56 amples were solubilized with octyl glucoside/cholate and the subunit a was purified via the oligohist

57 l centrifugation and solubilized with sodium cholate and urea.

58 was strongly influenced by the number of the cholates and the topology of the scaffold.

59 uding the use of amides, mixed amide esters, cholate, and alkyl bridges, was explored.

60 n of GAPDH prevented repression of CYP7A1 by cholate, and blocking nuclear transport of nitrosylated

61 s, mixed micelles of phosphatidylcholine and cholate, and in vivo with native spherical lipoprotein p

62 , polydocanol, dodecyl maltoside, and sodium cholate, and no exposure of this epitope was observed in

63 different detergents, RapiGest SP and sodium cholate, and two different trypsins, sequencing grade mo

64 The results implicate cholate as an important negative regulator of bile acid

65 also exhibited sodium-dependent transport of cholate at levels 150% of taurocholate in contrast to he

66 We describe cholate-based cage amphiphiles with a unique architectur

67 Dye- and cholate-binding functions can be separated on sequences

68 Alkyl and cholate bridges were significantly less potent against H

69 than larger, more flexible ones because the cholate building blocks in the latter could rotate outwa

70 phosphatidylcholine followed by removing the cholate by dialysis.

71 6% kcal from fat and 2% cholesterol and 0.7% cholate by weight) (atherogenic diet group, n = 13), and

72 gh-fat/high-cholesterol (HF), control and 1% cholate (CA) and HF + CA.

73 , galactose elimination capacity (GEC), dual cholate (CA) clearances and shunt, perfused hepatic mass

74 henodeoxycholate (CDCA), deoxycholate (DCA), cholate (CA), and ursodeoxycholate (UDCA), act as select

75 hosphatidylcholine with the bile salts (BSs) cholate (Ch), glycocholate (GC), chenodeoxycholate (CDC)

76 O mice on the C57BL/6J background when fed a cholate-cholesterol diet.

77 expressed in COS-1 cells, hVLCS-H2 exhibited cholate:CoA ligase (choloyl-CoA synthetase) activity wit

78 the full-length A22 will bind either dye or cholate columns and elute with the other ligand, as if b

79 g an amino group at the C(3) position of the cholate component markedly increased potency (IC50 value

80 These results establish that cholesterol and cholate components of the Ath diet have distinct proathe

81 in-associated CE (4 microM), with increasing cholate concentration there was an increase in the hydro

82 in 20 mM phospholipid requires 50 mM sodium cholate, concentrations that are commonly used to recons

83 se plasma lipoprotein levels and, when fed a cholate-containing diet, decrease foam-cell lesion size.

84 rohn's-like intestinal inflammation when fed cholate-containing high fat diet (CCHF).

85 tar-like copolymer emanating from the methyl cholate core provided the requisite modification in the

86 acid, palmitoleic acid and the deoxycholate/cholate (DCA/CA) ratio, along with the dysregulation sco

87 is induced in the presence of the bile salts cholate, deoxycholate, and chenodeoxycholate, and EMSA s

88 Expression pattern and cholate-dependent, cholesterol-induced hepatomegaly in t

89 We found that cholate derivatives and the amino acid glycine act as co

90 Some cholate derivatives that are normal components of bile c

91 eroidal)-4,7-ACQ derivatives and bis(4,7-ACQ)cholate derivatives; both classes provided inhibitors wi

92 fts in both of these cell lines and that the cholate detergent removed cholesterol from these microdo

93 d through partial solubilization with sodium cholate detergent, and the partially purified receptor c

94 tituted HDL particles prepared by the sodium cholate dialysis method, has shown that mutants (Pro165-

95 1ra knockout C57BL/6J mice fed a cholesterol/cholate diet for 3 mo had a 3-fold decrease in non-high-

96 are more susceptible to high-fat-cholesterol-cholate diet-induced hepatic fibrosis than their wildtyp

97 In contrast to cholate, diosgenin treatment did not affect G5G8 express

98 treated with the above antibody in DM and in cholate, enhanced destabilization (5-fold) was observed

99 Cholate esters with phenylurea groups at the 7alpha- and

100 Cholesterol/cholate feeding resulted in down-regulation of intestina

101 Cholate feeding to rats with intact enterohepatic circul

102 The conformations of three cholate foldamers and one molecular basket were studied

103 constituted into lipid bilayers by mixing in cholate followed by dilution to re-form membranes.

104 g single-walled carbon nanotubes with sodium cholate, followed by surfactant exchange to form phospho

105 15% fat, 1.25% cholesterol, and 0.5% sodium cholate for 12 weeks, and atherosclerotic lesions at the

106 -48-deficient mice fed Paigen's diet without cholate for 20 weeks received rPAI-1(23) treatment (n=21

107 LA2 with the naturally occurring bile salts: cholate, glycocholate, taurocholate, glycochenodeoxychol

108 rom the immobilized gamma2HF subunit using a cholate gradient from 0.05 to 1.0% and greater than 40%

109 e obtained by attaching facially amphiphilic cholate groups to a covalent scaffold (calix[4]arene or

110 ained by attaching four facially amphiphilic cholate groups to a tetraaminocalixarene scaffold.

111 between the cholates) require at least five cholate groups to fold cooperatively, the 4-aminobutyroy

112 energy transfer (FRET) occurred readily in a cholate hexamer labeled with a naphthyl donor and a dans

113 In contrast to the parent cholate hexamer that folded in all micelles investigated

114 The conformation of a cholate hexamer with a clicked tether in between two tri

115 Mice fed high fat, high cholesterol, cholate (HFHCC) diet for three weeks consistently develo

116 a high-cholesterol/high-fat diet containing cholate, however, a statistically significant 40% decrea

117 GF19 each increased the ratio of muricholate:cholate in bile, inducing a more hydrophilic bile salt p

118 ms induced by an atherogenic diet containing cholate in mice deficient in apolipoprotein E.

119 nylpropionic acid, N-acetylglycoprotein, and cholate in samples from female animals.

120 atio, 0.57; P = 0.004) and higher conjugated cholate increased the likelihood of significant fibrosis

121 Cholate induced binding of SHP to HDAC2 and its recruitm

122 In contrast, cholate induced expression of genes involved in extracel

123 epatocytes, L-NAME or dithiothreitol blocked cholate-induced down-regulation of CYP7A1 without impair

124 lear transport of nitrosylated GAPDH reduced cholate-induced nitrosylation of HDAC2 and SIRT1; this e

125 a(1)AR receptor was observed by DEER, sodium cholate induces specific beta(1)AR dimerization ([Formul

126 Since cholate is a known potent inhibitor of bovine oxidase an

127 Sodium cholate is critical because it does not interfere with t

128 Elution with 10 mmol/L cholate may introduce artifactual gel-filtration peaks a

129 tenuating amphiphile charge density within a cholate micelle environment.

130 he anionic sodium dodecyl sulfate and sodium cholate micelle systems.

131 r-HDL were made from cholate mixed micelles that contained PC, apo AI, and, i

132 In the presence of cholate, multiple equivalents of cationic charge were re

133 In the absence of surfactant (sodium cholate, NaC), multilayer graphene had higher adsorption

134 bile and the bile component glyco-conjugated cholate (NaGCH, sodium glycocholate) upregulate the colo

135 a polar solvent (e.g., alcohol or DMSO), the cholate oligomer folded into a helix with the hydrophili

136 These cholate oligomers fold into helical structures with nano

137 n found previously to enhance the folding of cholate oligomers in homogeneous solution.

138 rimary and secondary BAs (such as conjugated cholate or deoxycholate) were significantly associated w

139 F nor mrpFG expression in trans enhanced the cholate or Na+ resistance of the null mutant.

140 5% cholesterol supplemented with 0.5% sodium cholate) or given methotrexate intraperitoneally.

141 of the Ath diet in which either cholesterol, cholate, or fat were omitted.

142 An eluant of 10 mmol/L cholate overestimated vesicular cholesterol and in conce

143 o unconjugated chenodeoxycholate (P = 0.04), cholate (P = 0.0004), and total primary BAs (P < 0.0001)

144 Membrane additives such as cholate produced a 2-fold increase in protein-vesicle yi

145 Deoxycholate, a metabolite of cholate produced by the normal intestinal flora, also in

146 Dietary cholesterol and cholate produced discrete gene expression patterns.

147 In hepatocytes, cholate promoted S-nitrosylation of GAPDH and its transl

148 These studies suggest that dietary cholate regulates plasma levels of apoA-I primarily by a

149 ible, 4-aminobutyroyl spacers in between the cholate repeat units had been found previously to enhanc

150 lates (with no spacing groups in between the cholates) require at least five cholate groups to fold c

151 uggest that functions in addition to Na+ and cholate resistance and pH homeostasis will be found amon

152 Cholate restores CYP7A1 regulation in vivo and in vitro.

153 he beta(1)AR dimer in the presence of excess cholate results in dimer dissociation with species occup

154 f spin-labeled beta(1)AR with CHS and sodium cholate reveal the following: CHS binds specifically to

155 homeostasis in male Wistar rats placed on a cholate-rich diet for 5 days and in cultured primary hep

156 Rats placed on cholate-rich diets and given L-NAME had increased intrah

157 line, which required no additions to the 2% cholate s/i buffer.

158 e of sodium dodecyl sulfate (SDS) and sodium cholate (SC) in aqueous solutions with and without semic

159 as the internal either turn-off (with sodium cholate (SC)) or reference (with carboxymethylcellulose

160 rsely, dimerization of CcO induced by sodium cholate significantly increases its kinetic stability of

161 Other detergents, e.g., Tween 20, sodium cholate, sodium deoxycholate, CHAPS, or CHAPSO, are comp

162 pon the addition of bile salts, e.g., sodium cholate, sodium deoxycholate, or CHAPS.

163 CNTs coated with various surfactants (sodium cholate, sodium dodecyl sulfate, and cetyl trimethylammo

164 quired the addition of cholesterol to the 2% cholate solubilization/immobilization (s/i) buffer and t

165 In Triton X-100 and sodium cholate solutions, the aggregated, unfolded, and folded

166 Cholate-stimulated ATP hydrolysis was maximal at concent

167 y demonstrating in human aortic homogenate a cholate-stimulated cholesteryl ester hydrolytic activity

168 ated cleavage was greater in the presence of cholate, suggesting that the robustness of biofilm forma

169 Feeding a cholate-supplemented diet (0.1%) resulted in a completel

170 Nonconjugated cholate supported the highest ATPase activity in ABCG5/G

171 this study, we describe the use of a sodium cholate suspension-dialysis method to adsorb the redox e

172 ell as those determined for benchmark sodium cholate suspensions of (6,5) SWNTs, are similar; likewis

173 The cyclic cholate tetramer, however, was more effective at permeat

174 A traW mutant was 100-fold more sensitive to cholate than the tra(+) strain but only marginally more

175 ydrolysis of LDL- and HDL3-CE; at 100 microM cholate, the present hydrolysis per hour was 32+/-2 and

176 herogenic diet rich in fat, cholesterol, and cholate, they rapidly developed hypercholesterolemia, at

177 of trimethylene carbonate (TMC) from methyl cholate through a combination of metal-free organo-catal

178 The total cholate to chenodeoxycholate ratio was significantly hig

179 After intravenous administration of cholate to Oatp1b2-null mice, its clearance was 50% lowe

180 While no direct binding of sodium cholate to the beta(1)AR receptor was observed by DEER,

181 den mice and did not require the addition of cholate to the diet.

182 lecules utilize the hydrophilic faces of the cholates to bind hydrophilic molecules such as glucose d

183 olecules employ the hydrophobic faces of the cholates to bind hydrophobic guests.

184 t stable in structures that allowed multiple cholates to form a microenvironment that could efficient

185 aurocholate in contrast to hepatocytes where cholate transport is only 30% of taurocholate levels, su

186 ion (88%) from DIDS inhibition of hepatocyte cholate transport, suggesting that taurocholate is also

187 In the cholate-treated NDH-1-enriched P. denitrificans membrane

188 Cholate treatment was associated with a farnesoid X rece

189 lvent (i.e., DMSO), the hydrophilic faces of cholates turned inward to form a reversed-micelle-like c

190 to a helix with the hydrophilic faces of the cholates turned inward.

191 olecular basket was obtained by linking four cholate units to a cone-shaped calix[4]arene scaffold th

192 s with 4-aminobutyroyl groups in between the cholate units were labeled with a naphthyl and a dansyl

193 levation of circulating serum amyloid A, and cholate was required for accumulation of collagen in the

194 l)dimethylammonio]-1-propanesulfonic acid or cholate), was purified to near-homogeneity by a single n

195 ium thermoautotrophicum was solubilized from cholate-washed membranes with Zwittergent 3-14 at 58 deg

196 mino acids and taurocholate, glycocholate or cholate, with an optimum at pH 5.3.

197 ential solvation of the hydrophilic faces of cholates within the molecule by the polar solvent was co