ライフサイエンスコーパス: cholesterol ester

1 ls of lipid droplets (structures enriched in cholesterol esters).

2 pid conversion of lipoprotein cholesterol to cholesterol ester.

3 on of the disease accompanies an increase in cholesterol esters.

4 ame disease with a reduction in the level of cholesterol esters.

5 culum (ER) to store triacylglycerol (TG) and cholesterol esters.

6 lglycerols, phospholipids, galactolipids, or cholesterol esters.

7 f apolar lipids, including triglycerides and cholesterol esters.

8 me, which increased high-density lipoprotein cholesterol esters.

9 ontained primarily triglycerides rather than cholesterol esters.

10 s are not as atherogenic as those containing cholesterol esters.

11 ccumulation of sphingomyelin, ceramides, and cholesterol esters.

12 hospholipids, triglycerides, wax esters, and cholesterol esters.

13 asis of cholesterol through the formation of cholesterol esters.

14 ome foam cells by progressively accumulating cholesterol esters.

15 ctivity and esterification of cholesterol to cholesterol esters.

16 e transfer of phospholipids, cholesterol, or cholesterol esters.

17 f membrane phospholipids, triglycerides, and cholesterol esters.

18 onformation for LCAT catalyzed generation of cholesterol esters.

19 sion of glucose carbons to triglycerides and cholesterol esters.

20 ease in the formation of [14C]oleate-labeled cholesterol esters.

21 n (HDL) and mediates the selective uptake of cholesterol esters.

22 r HDL in connection with selective uptake of cholesterol esters.

23 o of PUFAs to SFAs in both phospholipids and cholesterol esters.

24 ellular cholesterol with fatty acids to form cholesterol esters.

25 e affected cells accumulate large amounts of cholesterol esters.

26 tein due to cellular damage from accumulated cholesterol esters.

27 atory capacity and increased accumulation of cholesterol esters.

28 differentiate unesterified cholesterol from cholesterol esters.

29 cholesterol in membranes by converting it to cholesterol esters.

30 one sensitive lipase (HSL) hydrolyzes luteal cholesterol esters.

31 such as triacylglycerol, phospholipids, and cholesterol esters.

32 ral lipids, including triacylglycerol and/or cholesterol esters.

33 erum lipid alterations were localized to the cholesterol esters; 22:6n-3 in the cholesterol esters of

34 crease), triacylglycerol (64% decrease), and cholesterol esters (58% decrease) were significantly dim

35 As esterification proceeds cholesterol esters accumulate within the hydrophobic cor

36 th HCR and LCR rats, while producing greater cholesterol ester accumulation in LCR compared to HCR ra

37 our results provide brand new insight about cholesterol ester accumulation in macrophages and foam c

38 elopment of atherosclerosis, but its role in cholesterol ester accumulation in macrophages and format

39 hat these receptors mediated the majority of cholesterol ester accumulation in macrophages exposed to

40 angier disease, characterized by low HDL and cholesterol ester accumulation in macrophages.

41 We suggest a mechanism for cholesterol ester accumulation in the OS and that activi

42 take mechanisms may contribute to macrophage cholesterol ester accumulation in vivo and suggest that

43 expected, ox-LDL induced significantly more cholesterol ester accumulation in WT and LDLR-/- compare

44 In the liver of ACAT2 ASO-treated mice, cholesterol ester accumulation was dramatically reduced,

45 LXRalpha, including hypercorticosteronemia, cholesterol ester accumulation, and adrenomegaly.

46 argeting of these master regulators affected cholesterol-ester accumulation in foam cells of the THP1

47 cid, sphingomyelin, the ganglioside GM3, and cholesterol esters, all of which suggest common pathogen

48 There was also a considerable increase in cholesterol esters, although free cholesterol persisted

49 ontained 11% less phospholipid and 633% more cholesterol ester and a total of 3 apoA-I molecules per

50 and apo A-I transport rate and increased HDL cholesterol ester and apo A-I fractional catabolic rate.

51 HDL decrease to be due to both decreased HDL cholesterol ester and apo A-I transport rate and increas

52 ipid omega-3 docosahexaenoic acid (22:6) and cholesterol ester and phospholipid arachidonic acid (20:

53 lcohol intake were associated with the serum cholesterol ester and phospholipid levels of several fat

54 ncreased (all p's < 0.05), whereas levels of cholesterol ester and phospholipid linoleic acid (18:2)

55 coholic drinks per week increased, levels of cholesterol ester and phospholipid palmitic acid (16:0)

56 ttes smoked per day increased, the levels of cholesterol ester and phospholipid palmitoleic acid (16:

57 dramatic increase in the abundances of total cholesterol ester and triglyceride lipids in the SW620 c

58 acyltransferase, the enzymes responsible for cholesterol ester and triglyceride synthesis, respective

59 d to restore the 18:1 and 16:1 levels of the cholesterol ester and triglycerides to the levels found

60 osphatidylcholines, phosphatidylcholines and cholesterol esters and an increase in phosphatidylethano

61 fects directed by elevated free cholesterol, cholesterol esters and cholic acid, and associated chang

62 icient mice contained substantial amounts of cholesterol esters and exhibited no reduction in cholest

63 Importantly, a significant increase in cholesterol esters and GM3 was recapitulated in the tran

64 scavenger receptor B1, regulating uptake of cholesterol esters and HDL by the liver.

65 ase-I deficiency reduced the accumulation of cholesterol esters and phospholipids in macrophages incu

66 ccumulation of ceramides, sphingomyelin, and cholesterol esters and protects motor neurons against de

67 ylinositol, and decreased incorporation into cholesterol esters and secreted triacylglycerol.

68 en; but in women, only SFAs and PUFAs in the cholesterol esters and the ratio of PUFAs to SFAs were i

69 tical cells greatly increased the storage of cholesterol esters and triacylglycerols concomitant with

70 e for SCD1 (SCD-/-) are deficient in hepatic cholesterol esters and triglycerides despite the presenc

71 d by SCD1 are necessary to synthesize enough cholesterol esters and triglycerides in the liver and su

72 lation of lipids that consisted primarily of cholesterol esters and triglycerides in type 2 epithelia

73 re key precursors of membrane phospholipids, cholesterol esters and triglycerides, SCD is pivotal in

74 is, storage, utilization, and degradation of cholesterol esters and triglycerides; multiple, differen

75 Triglyceride, free cholesterol, cholesterol ester, and phospholipid concentrations in th

76 riacylglycerol (TAG), free cholesterol (FC), cholesterol ester, and phospholipid contents in normal l

77 ed with the lipid accumulation (cholesterol, cholesterol ester, and phospholipid) and cholesterol cry

78 animal cell lipid droplets are cholesterol, cholesterol ester, and triglyceride, but the protein com

79 mpartments, including phospholipids, plasma, cholesterol esters, and adipose tissue.

80 mutants there is a reduction in the pool of cholesterol esters, and cholesterol-mediated suppression

81 s of oxidized neutral lipids: triglycerides, cholesterol esters, and fatty acids.

82 he fatty acid content of triacylglycerol and cholesterol esters, and in the positioning of specific f

83 f dietary lipids, mediates the absorption of cholesterol esters, and is dependent on bile salts for o

84 n and is known to transfer triacylglycerols, cholesterol esters, and phospholipids.

85 normal rates of synthesis of triglycerides, cholesterol esters, and phospholipids.

86 ed within lipid droplets as triacylglycerol, cholesterol esters, and retinol esters; esterified to fo

87 ls and delivered to the lysosome where their cholesterol esters are cleaved off by acid lipase.

88 that in the Cyp27a1(-/-)Cyp46a1(-/-) retina, cholesterol esters are generated by and accumulate in th

89 Cholesterol esters are subsequently internalized to a no

90 a fast response time of 4 s; it could detect cholesterol ester as low as 0.05 microM (S/N=3).

91 eatic islets may result from accumulation of cholesterol esters as analysis of islet gene expression

92 SE] 0.17 [0.03], P = 5.76 x 10(-10); XXLVLDL cholesterol ester: B [SE] 0.17 [0.03], P = 9.74 x 10(-10

93 ctivated the transfer of fluorescent-labeled cholesterol esters between high and low density lipoprot

94 A new function of MTP in cholesterol ester biosynthesis has been reported.

95 n macrophages and is a rate-limiting step in cholesterol ester breakdown.

96 The synthesis of cholesterol esters by acyl-CoA:cholesterol acyltransfera

97 asured the incorporation of [14C]oleate into cholesterol esters by acyl-CoA:cholesteryl acyltransfera

98 take of sterols and their incorporation into cholesterol esters by SR-BI from LDL was largely a selec

99 r receptor coordinates the regulation of HDL cholesterol ester catabolism and bile acid synthesis in

100 EDSS was inversely correlated with cholesterol ester CE(16:0) in both MS cohorts.

101 Body mass index and change in cholesterol ester (CE) 18:2/18:1 ratio accounted for 26%

102 Here, we show that cholesterol ester (CE) and triacylglycerol levels are el

103 -CoA:cholesterol acyltransferase and neutral cholesterol ester (CE) hydrolase; however, in the intact

104 Renal cortical-free cholesterol (FC) and cholesterol ester (CE) levels were determined 3, 5, 7, o

105 ic lipidomics that Trem2 deficiency leads to cholesterol ester (CE) overload in microglia.

106 the diet-related lipids, 10 lipids [5 known: cholesterol ester (CE)(22:5)B, phosphatidylcholine (PC)(

107 sfer protein (CETP) mediates the transfer of cholesterol esters (CE) from atheroprotective high-densi

108 difficult to analyze neutral lipids such as cholesterol esters, cerebrosides, and triglycerides dire

109 cells (RCs), plasma phospholipids (PLs), and cholesterol esters (CEs) in response to a low-fat diet (

110 erlapping cases)].Baseline concentrations of cholesterol esters (CEs) were inversely associated with

111 ore principally triacylglycerides (TAGs) and cholesterol esters (CEs), have been implicated in produc

112 Levels of individual species of cholesterol esters (CEs), lysophosphatidylcholines, phos

113 posed of different amounts of phospholipids, cholesterol esters (CEs), triglycerides (TGs), and apoli

114 L, are primary sources of lipids, delivering cholesterol esters, cholesterol, and phospholipids to tr

115 significantly decreased ratios of individual cholesterol esters/cholesterol and total cholesterol est

116 ual cholesterol esters/cholesterol and total cholesterol esters/cholesterol than those in Groups 3 (p

117 Molar ratios of cholesterol/cholesterol ester, cholesteryl ester/triglyceride, and c

118 ol and a markedly reduced rate of plasma HDL cholesterol ester clearance.

119 resulted in increases in plasma and hepatic cholesterol ester concentrations and reductions in free

120 ility through a reduction in macrophages and cholesterol ester content and an increase in volume of c

121 in association with reduced triglyceride and cholesterol ester content in kidney cortices when compar

122 l absorption in the intestine, and decreased cholesterol ester content in the liver and plasma lipopr

123 e characterized by high triglyceride and low cholesterol ester content is highly prevalent among chil

124 with either lipoprotein (adjusted for equal cholesterol ester content) down-regulated this expressio

125 etary cholesterol mass absorption, and liver cholesterol ester content.

126 l also results in increased triglyceride and cholesterol ester contents in kidney cortices, where lip

127 e mainly composed of a triglyceride (TG) and cholesterol-ester core surrounded by a phospholipid and

128 lipid saturation, rather than the amount of cholesterol esters, could be a factor in the observed co

129 there was significantly more cholesterol and cholesterol esters deposited on galyfilcon A (5.77 +/- 1

130 fied lipoproteins and has been implicated in cholesterol ester deposition in macrophages.

131 method of quantification of cholesterol and cholesterol esters derived from contact lenses, both in

132 ing from the accumulation of cholesterol and cholesterol esters derived from plasma lipoproteins is i

133 ycine, with decreases in total and D-serine, cholesterol esters, diacylglycerides, triacylglycerides,

134 ), but not wild-type macrophages, accumulate cholesterol ester droplets when incubated with surfactan

135 It is well established that cholesterol ester-enriched foam cells are the hallmark o

136 gh the majority of exogenous cholesterol and cholesterol ester enters the cell by LDL-receptor-mediat

137 beta-HSD1-null macrophages show 76% enhanced cholesterol ester export.

138 to investigate links between childhood serum cholesterol ester fatty acid (CEFA) proportions and adul

139 it appears that ACAT2 is the sole source of cholesterol esters for VLDL and chylomicron assembly.

140 Cholesterol ester formation also is hypothesized to be i

141 latter enzyme appears to be responsible for cholesterol ester formation and secretion in lipoprotein

142 Taken together, the data suggest that cholesterol ester formation by ACAT1 supports separate f

143 tcome is consistent with the hypothesis that cholesterol ester formation by ACAT2 may be coupled to l

144 culum of many types of cells, that catalyzes cholesterol ester formation from cholesterol and fatty a

145 lesterol to ldlA7-SRBI cells also stimulated cholesterol ester formation in a chloroquine-sensitive f

146 Two enzymes are responsible for cholesterol ester formation in tissues, acyl coenzyme A:

147 duced cholesterol accumulation and increased cholesterol ester formation.

148 o study the details of apoA-I-LCAT-catalyzed cholesterol ester formation.

149 t that fat quality as reflected in the serum cholesterol ester fraction in childhood is independently

150 The cholesterol ester fraction of plasma lipids was reduced

151 otal lipids from all tissues measured and in cholesterol esters from adrenal glands.

152 (HDL) that mediates the selective uptake of cholesterol esters from circulating HDL.

153 acyltransferase stimulating the formation of cholesterol esters from free cholesterol.

154 The uptake of cholesterol esters from high density lipoproteins (HDLs)

155 otein (CETP) facilitates the transfer of HDL cholesterol esters from plasma to the liver.

156 both the selective uptake of lipids, mainly cholesterol esters, from HDL to cells and the efflux of

157 species (23 known), including acylcarnitine, cholesterol esters, glycerophospholipids, sphingomyelins

158 fic lipid classes in the order cholesterol > cholesterol esters > phospholipids.

159 Cholesterol ester had little effect on the phase-transit

160 ase (ACAT), which catalyzes the formation of cholesterol esters, has been proposed as a strategy to r

161 of the nascent particle with cholesterol or cholesterol ester have been implicated.

162 ts indicate that leptin and insulin regulate cholesterol-ester homeostasis in macrophages and, theref

163 ssette transporter A1 (ABCA1) and of neutral cholesterol ester hydrolase (NCEH1).

164 ditis elegans encodes an ortholog of neutral cholesterol ester hydrolase 1 (NCEH-1), an IIS downstrea

165 Kelch domain containing 3 (KLHDC3), neutral cholesterol ester hydrolase 1 (NCEH1) and acyl-CoA synth

166 heavy chain (Nefh)], and metabolic [neutral cholesterol ester hydrolase 1 (Nceh1), adenylate kinase

167 Neutral cholesterol ester hydrolase was co-localized with autoph

168 nger Receptor class B type 1 (SR-BI)-Neutral Cholesterol Ester Hydrolase-dependent pathway.

169 ed PKA activity including phosphorylation of cholesterol-ester hydrolase (CEH)/hormone-sensitive lipa

170 he following apparently disparate reactions: cholesterol ester hydrolysis (CEH), fatty acyl Coenzyme

171 Cholesterol ester hydrolysis was also more rapid in J774

172 f phospholipid, unesterified cholesterol and cholesterol ester in the corneal stroma; this is believe

173 tion resulted in accumulation of radioactive cholesterol ester in the intestine and the liver of the

174 of Nile red labeling revealed a reduction in cholesterol esters in AD synaptosomes.

175 ellular accumulation of free cholesterol and cholesterol esters in macrophages.

176 emonstrate the crucial role of ACAT2-derived cholesterol esters in the development of atherosclerosis

177 gallstone formation, and the accumulation of cholesterol esters in the plasma lipoproteins.

178 In addition, cholesterol esters in very small VLDL (XS-VLDL-CE) becam

179 ased levels of sphingomyelin, ceramides, and cholesterol esters; in the Cu/ZnSOD mutant mice, these a

180 by 42.29% indicating that triglycerides and cholesterol esters increased and the protein content dec

181 FA) content and release, and cholesterol and cholesterol esters increased linearly up to 25 mm glucos

182 ellular accumulation of free cholesterol and cholesterol esters induced by the exposure to LDL choles

183 C-C8-434, which only abrogates production of cholesterol esters, induced an increase in size of dropl

184 is characterized by the initial movement of cholesterol esters into a reversible plasma membrane poo

185 Serum cholesterol ester is the most suitable serum fraction to

186 the flat surfaces, which are parallel to the cholesterol ester layers in the core and may interact wi

187 and adrenal membranes, and markedly reduced cholesterol ester levels in adrenal glands and peritonea

188 rnal cohort; specifically, a 10% increase in cholesterol ester levels was related to a lower odds rat

189 observation coincides with the 6-fold lower cholesterol ester mass in TgDelta6 -/- mouse plasma comp

190 sterically block the oxidation of the longer cholesterol ester molecules.

191 ce on the HFD had hepatic enrichment of most cholesterol esters, monoglycerides, and certain sphingol

192 palmitic acid (16:0) and oleic acid (18:1), cholesterol ester myristic acid (14:0), and phospholipid

193 ss (NL) mode for the loss of cholestane from cholesterol esters (NL 368.5) and specific selected reac

194 and convert excess retinal cholesterol into cholesterol esters, normally present in the retina in ve

195 ons and could account for the lower level of cholesterol esters observed in Md compared with Mn.

196 o obtain the mono- and disodium salts of the cholesterol ester of PFA.

197 ed to the cholesterol esters; 22:6n-3 in the cholesterol esters of alcohol-exposed infants increased

198 ransferase (LCAT) catalyzes the formation of cholesterol esters on high density lipoproteins (HDL) an

199 cterized by the accumulation of cholesterol, cholesterol esters, other neutral lipids and glycogen.

200 MAPK with anisomycin increased the ratio of cholesterol esters over free cholesterol, whereas inhibi

201 deficient mice was qualitatively similar in cholesterol ester, phosphatidylcholine, and phosphatidyl

202 n of ions derived from individual species of cholesterol esters, phospholipids, and triacylglycerols

203 In this study, we demonstrate that ACAT and cholesterol esters play a crucial role in the optimal re

204 oA-I, Delta6 apoA-I was found exclusively in cholesterol ester-poor HDL, and lipid-free HDL fractions

205 n (IDL) and HDL particle concentrations, and cholesterol-ester-poor, triglyceride-rich HDL particles.

206 h DeltasseJ bacteria led to higher levels of cholesterol ester production in HeLa cells and RAW macro

207 esterol biosynthesis and decreased levels of cholesterol esters, relative to the offspring of males f

208 and apoE in cholesteryl efflux from cells to cholesterol ester-rich (CE-rich) HDL(2) acceptors (see t

209 In steroidogenic cells, the cholesterol ester-rich lipid storage droplets are encoat

210 nt-exposed macrophages massively accumulated cholesterol ester-rich lipid-droplets and surfactant had

211 Lipoprotein(a) is an atherogenic, cholesterol ester-rich lipoprotein of unknown physiologi

212 Serum cholesterol ester SFA and PUFA associations were support

213 abolism of fatty acids to triacylglycerol or cholesterol esters, since the incubation of cells with b

214 hanges were measured in the phospholipid and cholesterol ester species directly in the chloroform/met

215 idonic acid, accumulated in phospholipid and cholesterol ester species of peritoneal cells, but not i

216 high resolution data on the acylglycerol and cholesterol ester species that were affected by the comp

217 ids were nearly depleted in phospholipid and cholesterol ester species.

218 acid (22:6 n-3) in phospholipid, but not in cholesterol ester, species.

219 eral lipid classes, including sterol lipids (cholesterol esters), sphingolipids (dihydroceramide, hex

220 y conserved role in mitochondrial transport, cholesterol ester storage and steroid-hormone synthesis.

221 iciency in this model, through regulation of cholesterol ester storage, suggesting that pharmacologic

222 respectively, but neither phospholipids nor cholesterol esters substitute for FA and CHOL, respectiv

223 ddition, less hydrolyzed oleate was used for cholesterol ester synthesis and beta-oxidation.

224 The importance of cholesterol ester synthesis by acyl CoA:cholesterol acyl

225 he underlying mechanism involves the lack of cholesterol ester synthesis in the intestine and a resul

226 2 (ACAT2) in mice results in a reduction in cholesterol ester synthesis in the small intestine and l

227 iacsin C, which blocks both triglyceride and cholesterol ester synthesis, cleared most of the lipid d

228 osomes with cholesteryl esters also inhibits cholesterol ester synthesis.

229 rol and phospholipid synthesis and away from cholesterol ester synthesis.

230 but did not channel endogenous FA away from cholesterol ester synthesis.

231 roscopy has been used to quantify lipid wax, cholesterol ester terpenoid and glyceride composition, s

232 tively, P < 0.04) and the molar ratio of LDL cholesterol ester the sum of LDL alpha-tocopherol and LD

233 iated cholesterol by promoting the uptake of cholesterol esters, thereby preventing oxLDL-induced dep

234 e pathway by converting cholesterol to inert cholesterol esters, thereby preventing the negative feed

235 B concentrations and the molar ratio of LDL cholesterol ester to apolipoprotein B (P < 0.01).

236 I also facilitated the clearance of cellular cholesterol ester to HDL(3).

237 The mass ratios of cholesterol ester to sitosterol ester formed by ACAT1 an

238 fer of LCAT-derived high-density lipoprotein cholesterol ester to the liver, LCAT overexpression stil

239 e examined the contribution of ACAT2-derived cholesterol esters to atherosclerosis by crossing ACAT2-

240 lurea 15d, which demonstrated a reduction in cholesterol ester transfer activity (48% of predose leve

241 90, p = 0.002) between the rate constant for cholesterol ester transfer and interfacial exclusion pre

242 The cholesterol ester transfer protein (CETP) facilitates th

243 Cholesterol ester transfer protein (CETP) moves triglyce

244 Cholesterol ester transfer protein (CETP) plays an impor

245 ssociated with higher baseline HDL-C levels, cholesterol ester transfer protein (CETP) rs3764261 and

246 Despite years of development, no cholesterol ester transfer protein inhibitor has yet bee

247 sclerotic Events), a trial of torcetrapib (a cholesterol ester transfer protein inhibitor), that invo

248 there has been disappointment with the first cholesterol ester transfer protein inhibitor, there is e

249 Cholesterol ester transfer protein inhibitors (CETPIs) r

250 ailed to demonstrate cardiac benefits, and 3 cholesterol ester transfer protein inhibitors have also

251 conducted a systematic portfolio analysis of cholesterol ester transfer protein inhibitors, a drug cl

252 oprotein convertase subtilisin/kexin type 9, cholesterol ester transfer protein inhibitors, and thyro

253 For the 3 discontinued cholesterol ester transfer protein inhibitors, we found

254 a secretory phospholipase A2 in concert with cholesterol ester transfer protein may contribute to the

255 from transgenic mice expressing hApoA-I and cholesterol ester transfer protein transgenes.

256 only in subjects taking dalcetrapib, a CETP (cholesterol ester transfer protein) modulator.

257 mino acids, and agents capable of inhibiting cholesterol ester transfer protein, among others.

258 n A-I, lecithin:cholesterol acyltransferase, cholesterol ester transfer protein, hepatic lipase, phos

259 ipoprotein A-I production or the activity of cholesterol ester transfer protein, it is less clear whe

260 transferase, phospholipid transfer protein, cholesterol ester transfer protein, paraoxonase 1 and pl

261 ctors (lecithin-cholesterol acyltransferase, cholesterol ester transfer protein, phospholipid transfe

262 es were: ABCA1, lipoprotein lipase (LPL) and cholesterol ester transfer protein, plasma for high-dens

263 and likely other apolipoproteins, facilitate cholesterol ester transfer protein-mediated lipid exchan

264 tivity on the ability of apoA-IV to activate cholesterol ester transfer protein.

265 cluding trials evaluating ezetimibe, niacin, cholesterol-ester transfer protein inhibitors, and PCSK9

266 e and PCSK9 inhibitors but not for niacin or cholesterol-ester transfer protein inhibitors.

267 r improved ASCVD risk or adverse events with cholesterol-ester transfer protein inhibitors.

268 We treated apoE-deficient, cholesterol ester transport protein (CETP) transgenic, a

269 tra and quantify the amounts of cholesterol, cholesterol esters, triglycerides and phospholipids, and

270 esis of all lipoprotein lipids (cholesterol, cholesterol esters, triglycerides, and phospholipids); a

271 acetate incorporation into free cholesterol, cholesterol esters, triglycerides, free fatty acids, and

272 phospholipid in HDL, but also stimulates HDL cholesterol ester uptake by hepatocytes.

273 n exert a significant influence on selective cholesterol ester uptake by SR-BI and may consequently i

274 Unexpectedly, selective cholesterol ester uptake from AI/AII-rHDL was not compro

275 f cholesterol from low density lipoproteins, cholesterol ester uptake from HDL does not involve the i

276 intenance of caveolae cholesterol content by cholesterol ester uptake from HDL.

277 diameter; which may facilitate preferential cholesterol ester uptake from large lipid-loaded HDL(2).

278 The efficiency of selective cholesterol ester uptake in terms of SR-BI-associated rH

279 I (SR-BI), an HDL receptor that mediates HDL cholesterol ester uptake into cells, is required for the

280 -BI binds ligand and then mediates selective cholesterol ester uptake with an efficiency dependent on

281 HDL receptor and shown to mediate selective cholesterol ester uptake.

282 -BI-specific binding and selective uptake of cholesterol ester using reconstituted HDLs (rHDLs) that

283 toma cell lines increased levels of cellular cholesterol ester, validating a role for GLO1 in cholest

284 although incorporation into phospholipid and cholesterol ester was no different than wild-type contro

285 e cholesterol derived from the hydrolysis of cholesterol ester was rapidly transported back to the pl

286 n interquartile increment of a fatty acid in cholesterol esters were 1.26 (95% confidence interval (C

287 Nevertheless, cholesterol esters were discovered to be abundant in hum

288 se crosses") with melting characteristics of cholesterol esters were identified within diffuse Bruch'

289 PUFAs in serum cholesterol esters were measured at baseline in 60-year-

290 id standards composed of different waxes and cholesterol esters were measured.

291 ites-triacylglycerols, phosphatidylcholines, cholesterol esters-were validated at Bonferroni signific

292 oduction and a reduced ability to accumulate cholesterol esters when exposed to modified lipoproteins

293 ulation of cholesterol (free cholesterol and cholesterol esters), whereas activation of autophagy wit

294 ate was also investigated as a model for the cholesterol esters which abound in vivo.

295 uteal cells store cholesterol in the form of cholesterol esters, which are postulated to provide subs

296 of baseline fatty acid composition in plasma cholesterol esters with 6-year incidence of hypertension

297 eromas were characterized by accumulation of cholesterol esters with apolipoprotein B near the intima

298 acid composition of plasma phospholipids and cholesterol esters with carotid artery intima-media thic

299 ntracellular accumulation of HDL-derived [3H]cholesterol esters without internalization or degradatio

300 phingomyelins, bismethyl phosphatidic acids, cholesterol ester, zymosterol ester, hexosyl ceramides w