ライフサイエンスコーパス: cholic

1 e deoxycholic acid > chenodeoxycholic acid > cholic acid > hyodeoxycholic acid > ursodeoxycholic acid

2 treatments with cholesterol (-41%, P < .05), cholic acid (-72%, P < .005), and deoxycholic acid (-62%

3 Some mice were placed on diets containing cholic acid (1%) or cholestyramine (2%) or high-fat diet

4 were fed a control diet or control diet plus cholic acid (1%) or ursodeoxycholic acid (1%) for 10 day

5 igs by PET/CT using the tracers derived from cholic acid (3alpha-OH, 7alpha-OH, 12alpha-OH), ursodeox

6 acid composition changed from predominantly cholic acid (57%) in wild-type to chenodeoxycholic acid

7 ra from three small molecules: phenylalanine-cholic acid (a microbially conjugated bile acid), phenyl

8 ther DCA or UCA, and intact rabbits fed 0.5% cholic acid (CA) (enlarged endogenous bile acid pool) we

9 m concentrations of unconjugated primary BAs cholic acid (CA) and chenodeoxycholic acid (CDCA) and se

10 -tandem mass spectrometry (HPLC-MS/MS), with cholic acid (CA) and chenodeoxycholic acid (CDCA) chemic

11 (CYP8b1) is required for the biosynthesis of cholic acid (CA) and hence helps determine the ratio of

12 gene (Cyp8b1) results in complete absence of cholic acid (CA) and its derivatives.

13 rmer approach to describe the interaction of cholic acid (CA) and phenol (PhOH) with ceria NPs with a

14 Cholic acid (CA) diet was used to assess susceptibility

15 -PXR double null or FPXR-null) mice fed a 1% cholic acid (CA) diet.

16 We demonstrate that after 7 days of cholic acid (CA) feeding to wild-type animals, weanling

17 mice were fed a diet supplemented with 0.5% cholic acid (CA) for 21 days.

18 The role of cholic acid (CA) in cholesterol absorption in humans rem

19 [14C]chenodeoxycholic acid (CDCA), and [14C]cholic acid (CA) in cultured human fibroblasts was nonsa

20 Here, we found that cholic acid (CA) levels were increased in patients and m

21 ted microbiota-derived bile acids, including cholic acid (CA) that induced expression of ILC2-activat

22 diates is believed to determine the ratio of cholic acid (CA) to chenodeoxycholic acid (CDCA) biosynt

23 e therefore measured the kinetics of DCA and cholic acid (CA) using stable isotopes, serum sampling,

24 containing complex of lsBSH bound to GCA and cholic acid (CA), a product.

25 Total biliary bile acids, cholic acid (CA), and CA/chenodeoxycholic acid (CDCA) ra

26 sign to examine the role of the primary BAs, cholic acid (CA), and chenodeoxycholic acid (CDCA) as we

27 e uptake and efflux, respectively, of CGamF, cholic acid (CA), glycoCA (GCA), tauroCA, and taurolitho

28 ning diet for bile acid depletion, or a 0.2% cholic acid (CA)-containing diet for 1 week before treat

29 (HF) diets are frequently supplemented with cholic acid (CA).

30 hydroxylated/non-12alpha-hydroxylated BA and cholic acid (CA)/chenodeoxycholic acid (CDCA) ratios com

31 om AGS patients had greater chenodeoxycholic/cholic acid (CDCA/CA), bile salt, cholesterol and phosph

32 ne supplemented with 1% cholesterol and 0.5% cholic acid (ECD).

33 cture of TcdB bound to inhibitory bile acids cholic acid (methyl ester) and taurochenodeoxycholic aci

34 D), a diet enriched in fat, cholesterol, and cholic acid (Paigen diet), or a diet enriched in lipid a

35 her pretreatment percentages of unconjugated cholic acid [CA; area under the ROC curve (AUC): 0.70 (9

36 dels of liver injury (bile duct ligation, 1% cholic acid [CA] fed, and the Mdr2(-/-) mouse).

37 .8% of the bile acids in duodenal bile, with cholic acid accounting for 82.4% +/- 5.5% of the total.

38 nificantly higher levels of L-isoleucine and cholic acid along with 7-ketodeoxycholic acid.

39 Lysophosphatidylcholine (20:4) and cholic acid also contributed significantly to the differ

40 ice and increased bile acid pool size, while cholic acid also induced Cyp7a1 in DKO mice, suggesting

41 lithogenic diet (LD; 1.0% cholesterol, 0.5% cholic acid and 17% triglycerides), as well as distal in

42 evere effects of a diet containing both 0.5% cholic acid and 2% cholesterol.

43 baseline revealed predominantly unconjugated cholic acid and absence of the usual glycine and taurine

44 nied by increased hepatic taurine-conjugated cholic acid and beta-muricholic acid as well as hepatic

45 In contrast, treatment with cholic acid and BM 15.766 further inhibited delta 7-redu

46 creased total plasma BA level while lowering cholic acid and chenodeoxycholic acid concentrations.

47 l cholestatic parameters, taurine species of cholic acid and chenodeoxycholic acid correlated with se

48 hepatic synthesis of the primary bile acids cholic acid and chenodeoxycholic acid is completed.

49 Conjugated cholic acid and chenodeoxycholic acid were synthesized i

50 fold and fourfold increases in the uptake of cholic acid and chenodeoxycholic acid, respectively, ove

51 primary products of bile acid biosynthesis, cholic acid and chenodeoxycholic acid, were capable of m

52 alpha-hydroxylase catalyzes the synthesis of cholic acid and controls the ratio of cholic acid over c

53 nt bile salts-glyco- and tauro-conjugates of cholic acid and DCA- varied by ~30-fold and measured bet

54 n was achieved using a combined treatment of cholic acid and distilled water.

55 Finally, both cholic acid and Ruminiclostridium 5 prior to CDR were as

56 ifically, conjugates have been prepared from cholic acid and spermine in which the hydrophilic face o

57 icity associated with a diet containing 0.5% cholic acid and the much more severe effects of a diet c

58 ary inulin fibre triggers microbiota-derived cholic acid and type 2 inflammation at barrier surfaces

59 ylase (12 alpha-hydroxylase) is required for cholic acid biosynthesis.

60 MnhF mediates the efflux of radiolabeled cholic acid both in S. aureus and when heterologously ex

61 gamma-lyase was decreased when mice were fed cholic acid but increased when they were placed on diets

62 rol or triglyceride levels in these mice; 1% cholic acid caused a redistribution of cholesterol from

63 A BA overload, feeding 0.5% cholic acid chow for 6 days, resulted in adaptive respon

64 undertaken to determine the extent to which cholic acid conjugates of insulin were absorbed from the

65 Unconjugated cholic acid continued to be present in high concentratio

66 Mice challenged with cholic acid developed hypercholanemia and a hepatic gene

67 KO mice on a cholic acid diet had higher hepatic and serum bile acid

68 bile acid levels by feeding mice with a 0.2% cholic acid diet strongly promoted N-nitrosodiethylamine

69 ice (Ghr(-/-)) fed with a diet containing 1% cholic acid displayed an increase in hepatocyte ROS prod

70 lar overall affinity, but the derivatives of cholic acid displayed much higher Hill coefficients, a m

71 Hepatic expression of G9a-DN in mice fed cholic acid disrupted bile acid homeostasis, resulting i

72 stration of epiallopregnanolone sulfate with cholic acid exacerbated the hypercholanemia and resulted

73 e triglycerides and raise HDL in cholesterol/cholic acid fed rats.

74 Cholic acid feeding resulted in greatly increased propor

75 Cholic acid feeding resulted in reduced pancreatic beta-

76 Cholic acid feeding reverses hepatomegaly and hypertrigl

77 e in 55%, P < 0.01; and liver radiation plus cholic acid followed by cell transplantation was most ef

78 57BL/6J-db/db mice and their lean mates with cholic acid for 12 weeks.

79 andard chow or a diet supplemented with 0.5% cholic acid for 2 weeks.

80 trate that mice fed a diet supplemented with cholic acid have reduced fertility subsequent to testicu

81 ession was repressed by a diet containing 1% cholic acid in male mice but was induced by the same die

82 mulated in a dose-response manner by dietary cholic acid in rats.

83 Microbiota decreases the level of cholic acid in the gut, impairs TET1 expression and supp

84 decreased by 80% and selectively enriched in cholic acid in the Slc10a2-/- mice.

85 e causes a structural change in A22 and that cholic acid inhibits this change.

86 We show that Clostridium scindens converts cholic acid into the secondary bile acid deoxycholic aci

87 (HET), and wildtype (WT) mice a cholesterol/cholic acid lithogenic diet (LD) for up to 56 days and d

88 Delivery of cholic acid mimics inulin-induced type 2 inflammation, w

89 dle' for binding of nucleic acids, while the cholic acid moieties are likely to interact with the lip

90 c acid-derived dimeric amphiphiles where two cholic acid moieties are tethered through carboxyl termi

91 ies of novel cationic amphiphiles containing cholic acid moieties linked via alkylamino side chains.

92 a derivative (amphiphile 5) containing four cholic acid moieties.

93 In contrast, neither cholic acid nor conjugated bile acids affected the level

94 Long-term treatment with cholic acid normalized liver enzymes and prevented progr

95 ced on standard diets, diets containing 0.5% cholic acid or 1.25% cholesterol, or lithogenic diets.

96 tly attenuated both in vitro when exposed to cholic acid or bile, and in vivo in the gallbladders and

97 1(-/-) mice are fed a diet containing either cholic acid or chenodeoxycholic acid, expression of CYP7

98 ed AOM-induced neurological decline, whereas cholic acid or deoxycholic acid feeding worsened AOM-ind

99 Thus, only cholesterol and not cholic acid or lovastatin could reduce elevated plasma 7

100 sis of cholic acid and controls the ratio of cholic acid over chenodeoxycholic acid in the bile.

101 Cholic acid plus chenodeoxycholic acid levels measured b

102 healthy animals in which liver radiation and cholic acid produced hepatic steatosis and loss of injur

103 A diet containing 1% cholic acid reduced the expression of the human gene in

104 ats preconditioned with liver radiation plus cholic acid resulted in less hepatic copper, indicating

105 vity increased 66% (P < 0.05) with increased cholic acid synthesis (P < 0.01).

106 a-hydroxylase activity 54%, mRNA levels 86%, cholic acid synthesis 38%, and hepatic LDL receptor-medi

107 12alpha-hydroxylase (CYP8B1) is required for cholic acid synthesis and plays a critical role in intes

108 these bile acid receptors in mice increased cholic acid synthesis and the bile acid pool, liver fibr

109 Bile acid depletion stimulated cholic acid synthesis by up-regulating cholesterol 7alph

110 Cholic acid synthesis decreased at 24 hours but returned

111 ted elevated cholesterol 7alpha-hydroxylase, cholic acid synthesis, and hepatic LDL receptor binding

112 droxylase), the specific enzyme required for cholic acid synthesis.

113 e/CYP8b1 is the specific enzyme required for cholic acid synthesis.

114 al bile drainage for 5 days, which maximized cholic acid synthesis.

115 bile acid to approximately 80% and decreased cholic acid to 3% of the total biliary bile acids, the r

116 levels of this enzyme determine the ratio of cholic acid to chenodeoxycholic acid and thus the hydrop

117 and hyodeoxycholic acid, and higher ratio of cholic acid to chenodeoxycholic acid were predictive of

118 in the early period, whereas the addition of cholic acid to chow prevented deaths in the later period

119 sufficient for the eight-step conversion of cholic acid to DCA.

120 The hydroxyl at the C-3 of cholic acid was converted to an amino group, and the res

121 logy revealed only minor pathology, although cholic acid was elevated in the serum of mutant mice, an

122 A DNA that binds either Cibacron blue or cholic acid was isolated and partially characterized.

123 [14C]Cholic acid was taken up in similar amounts by strain DH

124 roup, and the resulting amino-functionalized cholic acid was used as a monomer to prepare amide-linke

125 ort oligos that bind either Cibacron blue or cholic acid were enriched from random oligonucleotide po

126 The complexes of cyclohexylacetic acid and cholic acid with beta-cyclodextrin were studied by NMR d

127 lational level by free or taurine-conjugated cholic acid within the small intestine.

128 on limits of approximately 40 femtomole (for cholic acid) and identification through CEC/MS/MS.

129 r high-fat diet with FXR agonists (GW4064 or cholic acid) for 1 week; 2) C57BLKS/J-db/db mice and the

130 Since a bile acid (cholic acid) is required for the diet induced changes in

131 while bile from gallstone subjects contained cholic acid, 45%; chenodeoxycholic acid, 43%; deoxycholi

132 inous xanthomatosis (CTX) subjects contained cholic acid, 85%; chenodeoxycholic acid, 7%; deoxycholic

133 Simulated annealing and docking of cholic acid, a natural substrate, onto the protein surfa

134 ogenic diet (containing 1% cholesterol, 0.5% cholic acid, and 15% dairy fat), small-intestinal transi

135 fed the Paigen diet (1.25% cholesterol, 0.5% cholic acid, and 15% fat) without or with ezetimibe (7 m

136 in their gallbladders, bile more enriched in cholic acid, and a 13% decrease in plasma cholesterol le

137 ted free cholesterol, cholesterol esters and cholic acid, and associated changes to metabolism of sph

138 herogenic (Ath) diet containing cholesterol, cholic acid, and fat, but the effect of these components

139 Cholesterol, cholic acid, and lovastatin, alone or in combinations, w

140 We show that MdrT can export cholic acid, and that DeltamdrT bacteria are significant

141 c carboxylic compounds, arachidonic acid and cholic acid, but not by their non-carboxylic analogues.

142 nine physiologically relevant derivatives of cholic acid, chenodeoxycholic acid, and deoxycholic acid

143 ted with increased 12alpha-hydroxylated BAs (cholic acid, deoxycholic acid, and their conjugated form

144 ding oleic acid, 1-hydroxy-2-naphthoic acid, cholic acid, deoxycholic acid, dioctylsulfosuccinic acid

145 No significant changes were detected for cholic acid, deoxycholic acid, or chenodeoxycholic acid.

146 molecular umbrella conjugates, derived from cholic acid, deoxycholic acid, spermidine, lysine, and 5

147 n rats treated with cholesterol, sitosterol, cholic acid, deoxycholic acid, ursodeoxycholic acid, cho

148 the terminal amino groups of spermidine with cholic acid, followed by condensation with bis(3-O-[N-1,

149 steroidal bis-(N-phenyl)ureas, derived from cholic acid, form crystals in the P6(1) space group with

150 After liver radiation or cholic acid, hepatic lipid peroxidation levels increased

151 series of molecular umbrellas, derived from cholic acid, L-lysine, spermidine, and Cascade Blue, to

152 of these amphiphiles, which are derived from cholic acid, lysine, and p-phenylenediamine, can produce

153 holestanoic acid, the 27-carbon precursor of cholic acid, must be activated to its CoA derivative bef

154 t of animals with the hydrophobic bile salt, cholic acid, or liver radiation before cell transplantat

155 is enzyme to activate the primary bile acid, cholic acid, to its CoA derivative.

156 r PET of the endogenous glycine conjugate of cholic acid, we report here a radiosynthesis of N-(11)C-

157 re strikingly sensitive to a diet containing cholic acid, which results in toxic accumulation of hepa

158 rved an increase in an endogenous bile acid, cholic acid-7-sulfate (CA7S), in the GI tract of both mi

159 d TGR5 agonist with anti-diabetic properties-cholic acid-7-sulfate (CA7S)-that is elevated following

160 purified to homogeneity using 2', 5'-ADP and cholic acid-agarose affinity chromatography.

161 or-knockout mice (Ldlr+/-) fed a cholesterol/cholic acid-containing diet also had increased aortic le

162 vels modulated by feeding cholestyramine- or cholic acid-containing diets; (2) analysis of primary HS

163 Here, we present the synthesis of cholic acid-derived dimeric amphiphiles where two cholic

164 educed only 20%, indicating that the smaller cholic acid-enriched bile acid pool was sufficient to fa

165 After bile duct ligation or upon a cholic acid-enriched diet, TGR5 KO mice exhibited more s

166 Transporter protein and mRNA levels in cholic acid-fed rats increased approximately threefold a

167 rocholate uptake into membrane vesicles from cholic acid-fed rats increased twofold above uptake into

168 estasis induced by bile duct ligation and 1% cholic acid-feeding, evidenced by increased liver necros

169 he synthesis and antibacterial activities of cholic acid-peptide conjugates (CAPs), demonstrating tha

170 the use of spermidine, spermine, lysine, and cholic acid.

171 nullizygous mice and was further elevated by cholic acid.

172 to bind Cibacron blue columns and elute with cholic acid.

173 h fat, high cholesterol diet containing 0.5% cholic acid.

174 g at C12 to ultimately produce the bile acid cholic acid.

175 all molecules, such as (-)-santonin and beta-cholic acid.

176 d serum contained predominantly unconjugated cholic acid.

177 by the binary combination of cholesterol and cholic acid.

178 tion of glycine followed by conjugation with cholic acid.

179 d specifically induced by the bile component cholic acid.

180 repress the mdrT promoter in the presence of cholic acid.

181 dimethylammonio]-1-propanesulfonic acid, and cholic acid.

182 enic diet containing 1% cholesterol and 0.5% cholic acid.

183 iating detergents such as octyl glucoside or cholic acid.

184 acids before PEBD consisted predominantly of cholic acid.

185 The diffusion coefficient of the 1:1 cholic acid/beta-cyclodextrin complex, K(a) = 5900 +/- 8

186 8B1 axis increases the relative abundance of cholic-acid-derived bile acids and induces physiological

187 ar polyethylene glycol (PEG) block dendritic cholic acids (CA) copolymers (telodendrimers), for the t

188 four distinct human IBD cohorts showed that cholic acids conjugated to Glu, Ile/Leu, Phe, Thr, Trp o

189 /g and comprised mainly chenodeoxycholic and cholic acids.

190 of HepaRG cells with high concentrations of cholic and chenodeoxycholic acids induced a delayed oxid

191 of bile acid synthesis capable of generating cholic and chenodeoxycholic acids.

192 e bile salts were generated by coupling with cholic and chenodeoxycholic acids.

193 g, representing 2%-4% of the bile acid pool; cholic and delta 22-beta-muricholic acids were the major

194 investigate the effects of chenodeoxycholic, cholic, and deoxycholic acid in unconjugated (CDCA, CA,

195 e (mean +/- SD) for 98 patients at entry for cholic (CA), chenodeoxycholic (CDCA), deoxycholic (DCA),

196 Plasma cholic, chenodeoxycholic, deoxycholic, lithocholic or ur

197 (11)C-methyl-taurine conjugates derived from cholic, chenodeoxycholic, deoxycholic, ursodeoxycholic,

198 ps positioned to accommodate the amphipathic cholic core of bile acids, a fingerprint of key residues

199 of a lysine conjugated bile acid, which was cholic or ursodeoxycholic.

200 s; and the glycine and taurine conjugates of cholic, ursodeoxycholic, chenodeoxycholic, deoxycholic,

201 he carboxylic group of a bile acid which was cholic, ursodeoxycholic, or cholylglycine; and 2) nitrob