ライフサイエンスコーパス: cholic acid

1 nullizygous mice and was further elevated by cholic acid.

2 to bind Cibacron blue columns and elute with cholic acid.

3 h fat, high cholesterol diet containing 0.5% cholic acid.

4 g at C12 to ultimately produce the bile acid cholic acid.

5 all molecules, such as (-)-santonin and beta-cholic acid.

6 d serum contained predominantly unconjugated cholic acid.

7 by the binary combination of cholesterol and cholic acid.

8 tion of glycine followed by conjugation with cholic acid.

9 d specifically induced by the bile component cholic acid.

10 repress the mdrT promoter in the presence of cholic acid.

11 dimethylammonio]-1-propanesulfonic acid, and cholic acid.

12 enic diet containing 1% cholesterol and 0.5% cholic acid.

13 iating detergents such as octyl glucoside or cholic acid.

14 acids before PEBD consisted predominantly of cholic acid.

15 the use of spermidine, spermine, lysine, and cholic acid.

16 /g and comprised mainly chenodeoxycholic and cholic acids.

17 Some mice were placed on diets containing cholic acid (1%) or cholestyramine (2%) or high-fat diet

18 were fed a control diet or control diet plus cholic acid (1%) or ursodeoxycholic acid (1%) for 10 day

19 igs by PET/CT using the tracers derived from cholic acid (3alpha-OH, 7alpha-OH, 12alpha-OH), ursodeox

20 while bile from gallstone subjects contained cholic acid, 45%; chenodeoxycholic acid, 43%; deoxycholi

21 acid composition changed from predominantly cholic acid (57%) in wild-type to chenodeoxycholic acid

22 rved an increase in an endogenous bile acid, cholic acid-7-sulfate (CA7S), in the GI tract of both mi

23 d TGR5 agonist with anti-diabetic properties-cholic acid-7-sulfate (CA7S)-that is elevated following

24 treatments with cholesterol (-41%, P < .05), cholic acid (-72%, P < .005), and deoxycholic acid (-62%

25 inous xanthomatosis (CTX) subjects contained cholic acid, 85%; chenodeoxycholic acid, 7%; deoxycholic

26 ra from three small molecules: phenylalanine-cholic acid (a microbially conjugated bile acid), phenyl

27 Simulated annealing and docking of cholic acid, a natural substrate, onto the protein surfa

28 .8% of the bile acids in duodenal bile, with cholic acid accounting for 82.4% +/- 5.5% of the total.

29 purified to homogeneity using 2', 5'-ADP and cholic acid-agarose affinity chromatography.

30 nificantly higher levels of L-isoleucine and cholic acid along with 7-ketodeoxycholic acid.

31 Lysophosphatidylcholine (20:4) and cholic acid also contributed significantly to the differ

32 ice and increased bile acid pool size, while cholic acid also induced Cyp7a1 in DKO mice, suggesting

33 lithogenic diet (LD; 1.0% cholesterol, 0.5% cholic acid and 17% triglycerides), as well as distal in

34 evere effects of a diet containing both 0.5% cholic acid and 2% cholesterol.

35 baseline revealed predominantly unconjugated cholic acid and absence of the usual glycine and taurine

36 nied by increased hepatic taurine-conjugated cholic acid and beta-muricholic acid as well as hepatic

37 In contrast, treatment with cholic acid and BM 15.766 further inhibited delta 7-redu

38 creased total plasma BA level while lowering cholic acid and chenodeoxycholic acid concentrations.

39 l cholestatic parameters, taurine species of cholic acid and chenodeoxycholic acid correlated with se

40 hepatic synthesis of the primary bile acids cholic acid and chenodeoxycholic acid is completed.

41 Conjugated cholic acid and chenodeoxycholic acid were synthesized i

42 fold and fourfold increases in the uptake of cholic acid and chenodeoxycholic acid, respectively, ove

43 primary products of bile acid biosynthesis, cholic acid and chenodeoxycholic acid, were capable of m

44 alpha-hydroxylase catalyzes the synthesis of cholic acid and controls the ratio of cholic acid over c

45 nt bile salts-glyco- and tauro-conjugates of cholic acid and DCA- varied by ~30-fold and measured bet

46 n was achieved using a combined treatment of cholic acid and distilled water.

47 Finally, both cholic acid and Ruminiclostridium 5 prior to CDR were as

48 ifically, conjugates have been prepared from cholic acid and spermine in which the hydrophilic face o

49 icity associated with a diet containing 0.5% cholic acid and the much more severe effects of a diet c

50 ary inulin fibre triggers microbiota-derived cholic acid and type 2 inflammation at barrier surfaces

51 on limits of approximately 40 femtomole (for cholic acid) and identification through CEC/MS/MS.

52 ogenic diet (containing 1% cholesterol, 0.5% cholic acid, and 15% dairy fat), small-intestinal transi

53 fed the Paigen diet (1.25% cholesterol, 0.5% cholic acid, and 15% fat) without or with ezetimibe (7 m

54 in their gallbladders, bile more enriched in cholic acid, and a 13% decrease in plasma cholesterol le

55 ted free cholesterol, cholesterol esters and cholic acid, and associated changes to metabolism of sph

56 herogenic (Ath) diet containing cholesterol, cholic acid, and fat, but the effect of these components

57 Cholesterol, cholic acid, and lovastatin, alone or in combinations, w

58 We show that MdrT can export cholic acid, and that DeltamdrT bacteria are significant

59 The diffusion coefficient of the 1:1 cholic acid/beta-cyclodextrin complex, K(a) = 5900 +/- 8

60 ylase (12 alpha-hydroxylase) is required for cholic acid biosynthesis.

61 MnhF mediates the efflux of radiolabeled cholic acid both in S. aureus and when heterologously ex

62 gamma-lyase was decreased when mice were fed cholic acid but increased when they were placed on diets

63 c carboxylic compounds, arachidonic acid and cholic acid, but not by their non-carboxylic analogues.

64 ther DCA or UCA, and intact rabbits fed 0.5% cholic acid (CA) (enlarged endogenous bile acid pool) we

65 m concentrations of unconjugated primary BAs cholic acid (CA) and chenodeoxycholic acid (CDCA) and se

66 -tandem mass spectrometry (HPLC-MS/MS), with cholic acid (CA) and chenodeoxycholic acid (CDCA) chemic

67 (CYP8b1) is required for the biosynthesis of cholic acid (CA) and hence helps determine the ratio of

68 gene (Cyp8b1) results in complete absence of cholic acid (CA) and its derivatives.

69 rmer approach to describe the interaction of cholic acid (CA) and phenol (PhOH) with ceria NPs with a

70 Cholic acid (CA) diet was used to assess susceptibility

71 -PXR double null or FPXR-null) mice fed a 1% cholic acid (CA) diet.

72 We demonstrate that after 7 days of cholic acid (CA) feeding to wild-type animals, weanling

73 mice were fed a diet supplemented with 0.5% cholic acid (CA) for 21 days.

74 The role of cholic acid (CA) in cholesterol absorption in humans rem

75 [14C]chenodeoxycholic acid (CDCA), and [14C]cholic acid (CA) in cultured human fibroblasts was nonsa

76 Here, we found that cholic acid (CA) levels were increased in patients and m

77 ted microbiota-derived bile acids, including cholic acid (CA) that induced expression of ILC2-activat

78 diates is believed to determine the ratio of cholic acid (CA) to chenodeoxycholic acid (CDCA) biosynt

79 e therefore measured the kinetics of DCA and cholic acid (CA) using stable isotopes, serum sampling,

80 containing complex of lsBSH bound to GCA and cholic acid (CA), a product.

81 Total biliary bile acids, cholic acid (CA), and CA/chenodeoxycholic acid (CDCA) ra

82 sign to examine the role of the primary BAs, cholic acid (CA), and chenodeoxycholic acid (CDCA) as we

83 e uptake and efflux, respectively, of CGamF, cholic acid (CA), glycoCA (GCA), tauroCA, and taurolitho

84 ning diet for bile acid depletion, or a 0.2% cholic acid (CA)-containing diet for 1 week before treat

85 (HF) diets are frequently supplemented with cholic acid (CA).

86 hydroxylated/non-12alpha-hydroxylated BA and cholic acid (CA)/chenodeoxycholic acid (CDCA) ratios com

87 ar polyethylene glycol (PEG) block dendritic cholic acids (CA) copolymers (telodendrimers), for the t

88 her pretreatment percentages of unconjugated cholic acid [CA; area under the ROC curve (AUC): 0.70 (9

89 dels of liver injury (bile duct ligation, 1% cholic acid [CA] fed, and the Mdr2(-/-) mouse).

90 rol or triglyceride levels in these mice; 1% cholic acid caused a redistribution of cholesterol from

91 om AGS patients had greater chenodeoxycholic/cholic acid (CDCA/CA), bile salt, cholesterol and phosph

92 nine physiologically relevant derivatives of cholic acid, chenodeoxycholic acid, and deoxycholic acid

93 A BA overload, feeding 0.5% cholic acid chow for 6 days, resulted in adaptive respon

94 four distinct human IBD cohorts showed that cholic acids conjugated to Glu, Ile/Leu, Phe, Thr, Trp o

95 undertaken to determine the extent to which cholic acid conjugates of insulin were absorbed from the

96 or-knockout mice (Ldlr+/-) fed a cholesterol/cholic acid-containing diet also had increased aortic le

97 vels modulated by feeding cholestyramine- or cholic acid-containing diets; (2) analysis of primary HS

98 Unconjugated cholic acid continued to be present in high concentratio

99 ted with increased 12alpha-hydroxylated BAs (cholic acid, deoxycholic acid, and their conjugated form

100 ding oleic acid, 1-hydroxy-2-naphthoic acid, cholic acid, deoxycholic acid, dioctylsulfosuccinic acid

101 No significant changes were detected for cholic acid, deoxycholic acid, or chenodeoxycholic acid.

102 molecular umbrella conjugates, derived from cholic acid, deoxycholic acid, spermidine, lysine, and 5

103 n rats treated with cholesterol, sitosterol, cholic acid, deoxycholic acid, ursodeoxycholic acid, cho

104 Here, we present the synthesis of cholic acid-derived dimeric amphiphiles where two cholic

105 8B1 axis increases the relative abundance of cholic-acid-derived bile acids and induces physiological

106 Mice challenged with cholic acid developed hypercholanemia and a hepatic gene

107 KO mice on a cholic acid diet had higher hepatic and serum bile acid

108 bile acid levels by feeding mice with a 0.2% cholic acid diet strongly promoted N-nitrosodiethylamine

109 ice (Ghr(-/-)) fed with a diet containing 1% cholic acid displayed an increase in hepatocyte ROS prod

110 lar overall affinity, but the derivatives of cholic acid displayed much higher Hill coefficients, a m

111 Hepatic expression of G9a-DN in mice fed cholic acid disrupted bile acid homeostasis, resulting i

112 ne supplemented with 1% cholesterol and 0.5% cholic acid (ECD).

113 educed only 20%, indicating that the smaller cholic acid-enriched bile acid pool was sufficient to fa

114 After bile duct ligation or upon a cholic acid-enriched diet, TGR5 KO mice exhibited more s

115 stration of epiallopregnanolone sulfate with cholic acid exacerbated the hypercholanemia and resulted

116 e triglycerides and raise HDL in cholesterol/cholic acid fed rats.

117 Transporter protein and mRNA levels in cholic acid-fed rats increased approximately threefold a

118 rocholate uptake into membrane vesicles from cholic acid-fed rats increased twofold above uptake into

119 Cholic acid feeding resulted in greatly increased propor

120 Cholic acid feeding resulted in reduced pancreatic beta-

121 Cholic acid feeding reverses hepatomegaly and hypertrigl

122 estasis induced by bile duct ligation and 1% cholic acid-feeding, evidenced by increased liver necros

123 e in 55%, P < 0.01; and liver radiation plus cholic acid followed by cell transplantation was most ef

124 the terminal amino groups of spermidine with cholic acid, followed by condensation with bis(3-O-[N-1,

125 57BL/6J-db/db mice and their lean mates with cholic acid for 12 weeks.

126 andard chow or a diet supplemented with 0.5% cholic acid for 2 weeks.

127 r high-fat diet with FXR agonists (GW4064 or cholic acid) for 1 week; 2) C57BLKS/J-db/db mice and the

128 steroidal bis-(N-phenyl)ureas, derived from cholic acid, form crystals in the P6(1) space group with

129 e deoxycholic acid > chenodeoxycholic acid > cholic acid > hyodeoxycholic acid > ursodeoxycholic acid

130 trate that mice fed a diet supplemented with cholic acid have reduced fertility subsequent to testicu

131 After liver radiation or cholic acid, hepatic lipid peroxidation levels increased

132 ession was repressed by a diet containing 1% cholic acid in male mice but was induced by the same die

133 mulated in a dose-response manner by dietary cholic acid in rats.

134 Microbiota decreases the level of cholic acid in the gut, impairs TET1 expression and supp

135 decreased by 80% and selectively enriched in cholic acid in the Slc10a2-/- mice.

136 e causes a structural change in A22 and that cholic acid inhibits this change.

137 We show that Clostridium scindens converts cholic acid into the secondary bile acid deoxycholic aci

138 Since a bile acid (cholic acid) is required for the diet induced changes in

139 series of molecular umbrellas, derived from cholic acid, L-lysine, spermidine, and Cascade Blue, to

140 (HET), and wildtype (WT) mice a cholesterol/cholic acid lithogenic diet (LD) for up to 56 days and d

141 of these amphiphiles, which are derived from cholic acid, lysine, and p-phenylenediamine, can produce

142 cture of TcdB bound to inhibitory bile acids cholic acid (methyl ester) and taurochenodeoxycholic aci

143 Delivery of cholic acid mimics inulin-induced type 2 inflammation, w

144 dle' for binding of nucleic acids, while the cholic acid moieties are likely to interact with the lip

145 c acid-derived dimeric amphiphiles where two cholic acid moieties are tethered through carboxyl termi

146 ies of novel cationic amphiphiles containing cholic acid moieties linked via alkylamino side chains.

147 a derivative (amphiphile 5) containing four cholic acid moieties.

148 holestanoic acid, the 27-carbon precursor of cholic acid, must be activated to its CoA derivative bef

149 In contrast, neither cholic acid nor conjugated bile acids affected the level

150 Long-term treatment with cholic acid normalized liver enzymes and prevented progr

151 ced on standard diets, diets containing 0.5% cholic acid or 1.25% cholesterol, or lithogenic diets.

152 tly attenuated both in vitro when exposed to cholic acid or bile, and in vivo in the gallbladders and

153 1(-/-) mice are fed a diet containing either cholic acid or chenodeoxycholic acid, expression of CYP7

154 ed AOM-induced neurological decline, whereas cholic acid or deoxycholic acid feeding worsened AOM-ind

155 Thus, only cholesterol and not cholic acid or lovastatin could reduce elevated plasma 7

156 t of animals with the hydrophobic bile salt, cholic acid, or liver radiation before cell transplantat

157 sis of cholic acid and controls the ratio of cholic acid over chenodeoxycholic acid in the bile.

158 D), a diet enriched in fat, cholesterol, and cholic acid (Paigen diet), or a diet enriched in lipid a

159 he synthesis and antibacterial activities of cholic acid-peptide conjugates (CAPs), demonstrating tha

160 Cholic acid plus chenodeoxycholic acid levels measured b

161 healthy animals in which liver radiation and cholic acid produced hepatic steatosis and loss of injur

162 A diet containing 1% cholic acid reduced the expression of the human gene in

163 ats preconditioned with liver radiation plus cholic acid resulted in less hepatic copper, indicating

164 vity increased 66% (P < 0.05) with increased cholic acid synthesis (P < 0.01).

165 a-hydroxylase activity 54%, mRNA levels 86%, cholic acid synthesis 38%, and hepatic LDL receptor-medi

166 12alpha-hydroxylase (CYP8B1) is required for cholic acid synthesis and plays a critical role in intes

167 these bile acid receptors in mice increased cholic acid synthesis and the bile acid pool, liver fibr

168 Bile acid depletion stimulated cholic acid synthesis by up-regulating cholesterol 7alph

169 Cholic acid synthesis decreased at 24 hours but returned

170 ted elevated cholesterol 7alpha-hydroxylase, cholic acid synthesis, and hepatic LDL receptor binding

171 droxylase), the specific enzyme required for cholic acid synthesis.

172 e/CYP8b1 is the specific enzyme required for cholic acid synthesis.

173 al bile drainage for 5 days, which maximized cholic acid synthesis.

174 bile acid to approximately 80% and decreased cholic acid to 3% of the total biliary bile acids, the r

175 levels of this enzyme determine the ratio of cholic acid to chenodeoxycholic acid and thus the hydrop

176 and hyodeoxycholic acid, and higher ratio of cholic acid to chenodeoxycholic acid were predictive of

177 in the early period, whereas the addition of cholic acid to chow prevented deaths in the later period

178 sufficient for the eight-step conversion of cholic acid to DCA.

179 is enzyme to activate the primary bile acid, cholic acid, to its CoA derivative.

180 The hydroxyl at the C-3 of cholic acid was converted to an amino group, and the res

181 logy revealed only minor pathology, although cholic acid was elevated in the serum of mutant mice, an

182 A DNA that binds either Cibacron blue or cholic acid was isolated and partially characterized.

183 [14C]Cholic acid was taken up in similar amounts by strain DH

184 roup, and the resulting amino-functionalized cholic acid was used as a monomer to prepare amide-linke

185 r PET of the endogenous glycine conjugate of cholic acid, we report here a radiosynthesis of N-(11)C-

186 ort oligos that bind either Cibacron blue or cholic acid were enriched from random oligonucleotide po

187 re strikingly sensitive to a diet containing cholic acid, which results in toxic accumulation of hepa

188 The complexes of cyclohexylacetic acid and cholic acid with beta-cyclodextrin were studied by NMR d

189 lational level by free or taurine-conjugated cholic acid within the small intestine.