ライフサイエンスコーパス: chondrogenic

1 lineages such as adipogenic, osteogenic, and chondrogenic.

2 r shortly after adipogenic (few minutes) and chondrogenic (3-4 hours) commitment in contrast to osteo

3 differentiation switches from osteogenic to chondrogenic, a process that could be mimicked by chemic

4 The direct effect of VEGF on the in vitro chondrogenic ability of mouse MDSCs was tested using a p

5 er these conditions, the cells showed robust chondrogenic activity in micromass culture, and generate

6 ells that can differentiate into osteogenic, chondrogenic, adipogenic, and myogenic lineages.

7 rious lineages of cells, such as osteogenic, chondrogenic, adipogenic, myogenic, and neurogenic cells

8 hat Wnt/beta-catenin signaling regulates the chondrogenic and adipogenic differentiation of pericytes

9 Overexpression of sox9 rescued the zebrafish chondrogenic and craniofacial phenotype generated by ddr

10 ion of these snoRNAs is altered this affects chondrogenic and hypertrophic gene expression.

11 ilage nodule formation and overexpression of chondrogenic and matrix genes in limb bud mesenchymal ce

12 or neuronal differentiation while decreasing chondrogenic and osteogenic differentiation.

13 Using chondrogenic and osteogenic markers we show that rediffe

14 differentiated in three dimensions (3D) into chondrogenic and osteogenic spheroids, which were confir

15 the time the limb mesenchyme segregates into chondrogenic and perichondrogenic condensations.

16 ormal telomere lengths and osteoblastogenic, chondrogenic, and adipogenic differentiation potentials.

17 ous lineages in vitro, including osteogenic, chondrogenic, and adipogenic lineages.

18 Cs were able to differentiate to adipogenic, chondrogenic, and neurogenic lineages.

19 entiation of pericytes along the adipogenic, chondrogenic, and osteogenic lineages may contribute to

20 for tri-lineage differentiation (adipogenic, chondrogenic, and osteogenic).

21 nd was induced during the differentiation of chondrogenic ATDC5 and N1511 cells.

22 After Chadl shRNA knockdown, chondrogenic ATDC5 cells increased their differentiation

23 The majority of studies have focused on chondrogenic (but not specifically articular cartilage)

24 lateral meniscus in medial OA patients have chondrogenic capacity in vitro and hence could represent

25 To test roles for such Wnt-mediated anti-chondrogenic capacity in vivo, we created conditional mu

26 tudied genes and showed differences in their chondrogenic capacity when compared with a healthy contr

27 ress cartilage matrix production in a murine chondrogenic cell line.

28 experiments in Caenorhabditis elegans and in chondrogenic cell lines implicated variants in genes nec

29 ox9 and its target genes required for normal chondrogenic cell proliferation and differentiation.

30 MP) signaling was activated with the ectopic chondrogenic cells and chondrocytes, as indicated by pho

31 differentiate into myogenic, osteogenic and chondrogenic cells in culture.

32 Here we show that Smpd3 expression in ATDC5 chondrogenic cells is downregulated by parathyroid hormo

33 re all significantly lower in CypA knockdown chondrogenic cells than in wild-type cells, indicating t

34 ne the minimum effective atRA concentration, chondrogenic cells transfected with a retinoic acid resp

35 This results in fewer chondrogenic cells within the developing vertebral body,

36 s (smooth muscle, adipogenic, osteogenic and chondrogenic cells).

37 D+ fibro-adipogenic progenitors, TPPP3/PRG4+ chondrogenic cells, and ITGA7+ smooth muscle-mesenchymal

38 9), one of the earliest markers of committed chondrogenic cells, is reduced in Cav3.2(-/-) tracheas.

39 d differentiate into smooth muscle cells and chondrogenic cells, thus contributing to vascular remode

40 staining for the presence of osteogenic and chondrogenic cells.

41 g, cell migration, and cell proliferation in chondrogenic cells.

42 expression and function in developing ATDC5 chondrogenic cells.

43 tic protein 2 pretreated ATDC5 and C3H10T1/2 chondrogenic cells.

44 Condensation of pre-osteogenic, or pre-chondrogenic, cells is the first of a series of processe

45 ids encoding for either osteogenic (BMP2) or chondrogenic (combination of TGF-beta3, BMP2 and SOX9) g

46 the presumptive cranial base did not undergo chondrogenic commitment as determined by the loss of Sox

47 ipid scarcity as an important determinant of chondrogenic commitment, reveal a role for FOXO transcri

48 The digit pre-chondrogenic condensates also become wider, thicker and

49 Normally, these cells surrounding the chondrogenic condensation are exposed to IHH, as evidenc

50 s, Ddrgk1-/- mice displayed delayed limb bud chondrogenic condensation, decreased SOX9 protein expres

51 on hindlimb buds then develop transitory pre-chondrogenic condensations of the tibia, fibula, and foo

52 Although Ihh(-/-) cells organize into chondrogenic condensations similar in size and shape to

53 tterning of tissues adjacent to craniofacial chondrogenic condensations.

54 expression result in profoundly mispatterned chondrogenic condensations.

55 pon seeding, and constructs were cultured in chondrogenic conditions for 28 d.

56 uration, intramembranous bone formation, and chondrogenic condylar growth.

57 llagen mRNA revealed a high level of mRNA in chondrogenic constructs compared with that in undifferen

58 icate for the first time that SIRT1 supports chondrogenic development of MSCs at least in part throug

59 e as a means of assessing the progression of chondrogenic development of the tissues.

60 in mouse limbs supports a role for DOT1L in chondrogenic differentiation and adult articular cartila

61 te that atelocollagen scaffolds improve hMSC chondrogenic differentiation and are a potential approac

62 findings demonstrate that sex influences the chondrogenic differentiation and articular cartilage reg

63 d with female MDSCs, male MDSCs display more chondrogenic differentiation and better cartilage regene

64 somerase previously shown to be required for chondrogenic differentiation and endochondral ossificati

65 we unveil the role of CypA in signal-induced chondrogenic differentiation and endochondral ossificati

66 ional factor, which plays a critical role in chondrogenic differentiation and endochondral ossificati

67 the transformation of the surfaceome during chondrogenic differentiation and phenotypic changes duri

68 entiation and, in particular, adipogenic and chondrogenic differentiation are poorly defined.

69 like cartilage constructs by stimulating MSC chondrogenic differentiation as cell sheets.

70 down of Rab23 also resulted in inhibition of chondrogenic differentiation as well as down-regulation

71 that the antiviral protein viperin controls chondrogenic differentiation by influencing secretion of

72 s their protein secretion and the outcome of chondrogenic differentiation by influencing transforming

73 sion of hypoxia-related markers and enhanced chondrogenic differentiation compared to BMSCs cultured

74 tured with primary OA chondrocytes underwent chondrogenic differentiation even in the absence of grow

75 oint synovium that undergo proliferation and chondrogenic differentiation following injury in vivo.

76 beta expression and Wnt signaling to promote chondrogenic differentiation in mouse iPSCs in vitro.

77 that Nkx3.2 is required for Sox9 to promote chondrogenic differentiation in satellite cells.

78 eoblast differentiation and leads to ectopic chondrogenic differentiation in the bone-forming region

79 tant cells are defective in osteoblastic and chondrogenic differentiation in tri-lineage differentiat

80 by atRA or thalidomide perturbed subsequent chondrogenic differentiation in vitro.

81 one morphogenetic proteins (BMPs) to promote chondrogenic differentiation in vitro.

82 nt DNA hypomethylation was identified during chondrogenic differentiation including changes at many k

83 erexpression of Sox9 restores the defects in chondrogenic differentiation induced by Kindlin-2 deleti

84 The control of angiogenesis during chondrogenic differentiation is an important issue affec

85 Chondrogenic differentiation is pivotal in the active re

86 Expression levels of the chondrogenic differentiation markers and transcriptional

87 f neuronal fates in chicken neural explants, chondrogenic differentiation of 10T1/2 cells, and Gli ac

88 vity of the Runx2 gene within the context of chondrogenic differentiation of a mesenchymal progenitor

89 the influence of other growth factors on the chondrogenic differentiation of ADAS cells is not fully

90 a molecular route that may explain impaired chondrogenic differentiation of cells from individuals w

91 ased IGF-1 from Coa could effectively induce chondrogenic differentiation of embedded ADSCs in the hy

92 emical gel composition was used to influence chondrogenic differentiation of encapsulated stem cells.

93 obal Notch inhibition reduces osteogenic and chondrogenic differentiation of FCSCs.

94 th NB250 and NB260, as well as Nodal, induce chondrogenic differentiation of human adipose-derived st

95 trate the functional role of miR-146b in the chondrogenic differentiation of human bone marrow derive

96 Chondrogenic differentiation of human bone marrow derive

97 fate (CS) and their ability to stimulate the chondrogenic differentiation of human bone marrow-derive

98 the first time to enhance proliferation and chondrogenic differentiation of human mesenchymal stem c

99 ith cell-mediated degradation aligned to the chondrogenic differentiation of human mesenchymal stem c

100 orphogenetic signals from OA chondrocytes on chondrogenic differentiation of human mesenchymal stem c

101 terials support the survival and promote the chondrogenic differentiation of human mesenchymal stem c

102 sion pattern of miR-140 was monitored during chondrogenic differentiation of human MSCs in pellet cul

103 ect of OA chondrocyte-secreted morphogens on chondrogenic differentiation of human MSCs was evaluated

104 ng a small number of chondrocytes to promote chondrogenic differentiation of human MSCs while prevent

105 cence staining were used to characterize the chondrogenic differentiation of human MSCs.

106 t culture systems, we evaluated the in vitro chondrogenic differentiation of LacZ- and BMP-4-transduc

107 Histogenesis relies on cues that promote the chondrogenic differentiation of mesenchymal cells, where

108 In developing limb buds of mutant mice, chondrogenic differentiation of mesenchymal condensation

109 Two of these lncRNAs are upregulated during chondrogenic differentiation of mesenchymal stem cells (

110 et cultures, the nanofiber scaffolds enhance chondrogenic differentiation of mesenchymal stems cells

111 Actively steering the chondrogenic differentiation of mesenchymal stromal cell

112 drocytes, and its expression declined during chondrogenic differentiation of MSC.

113 the role of SIRT1-mediated signaling during chondrogenic differentiation of MSCs in vitro.

114 Chondrogenic differentiation of MSCs is currently trigge

115 ox9 may act as a molecular switch during the chondrogenic differentiation of muscle progenitor cells,

116 In micromass cultures, chondrogenic differentiation of mutant chondrocytes is d

117 pathway effectively promoted osteogenic and chondrogenic differentiation of PCDSCs in vitro and indu

118 transforming growth factor-beta3 induces the chondrogenic differentiation of pericytes by inducing Wn

119 n signaling inhibits adipogenic and enhances chondrogenic differentiation of pericytes.

120 thways that control the early osteogenic and chondrogenic differentiation of periosteal stem/progenit

121 g bone morphogenic protein 2 (BMP-2)-induced chondrogenic differentiation of pluripotent C3H10T1/2 ce

122 atabolic events in chondrocytes and enhances chondrogenic differentiation of precursor cells in an in

123 ticular chondrocytes was less inhibitory for chondrogenic differentiation of precursor cells than con

124 LacZ; the addition of TGFbeta1 did not alter chondrogenic differentiation of the BMP-4-transduced MDS

125 Finally, we performed chondrogenic differentiation of the iPSCs in order to pr

126 role for elevated P in promoting osteogenic/chondrogenic differentiation of VSMC, whereas elevated C

127 We hypothesized that MSCs undergoing chondrogenic differentiation produce an intermediate cyt

128 t effective mechanism by which to direct the chondrogenic differentiation program into either permane

129 hondrogenesis will enable us to improve hESC chondrogenic differentiation protocols.

130 A 3-week chondrogenic differentiation results demonstrated that c

131 Results support 3D MSC sheets' chondrogenic differentiation to hyaline cartilage in vit

132 at up-regulation of Rab23 can indeed inhibit chondrogenic differentiation with a concomitant down-reg

133 nes in MDSCs that were stimulated to undergo chondrogenic differentiation with BMP-4 and transforming

134 ed to condense into cellular bodies, undergo chondrogenic differentiation, and form cartilagenous tis

135 3-transfected ATDC5 and N1511 cells promoted chondrogenic differentiation, but the suppression of end

136 impact various cellular properties including chondrogenic differentiation, leading us to hypothesize

137 ass cultures, which faithfully mimic in vivo chondrogenic differentiation, loss of HMGN1 accelerates

138 During both osteogenic and chondrogenic differentiation, these miRNAs, in general,

139 ication, including stimulation of osteogenic/chondrogenic differentiation, vesicle release, apoptosis

140 level of Rab23 protein led to inhibition of chondrogenic differentiation, we characterized ATDC5 cel

141 mising strategy for enhanced hMSC growth and chondrogenic differentiation, which are critical compone

142 id scaffolds, SF clones displayed consistent chondrogenic differentiation, while BM clones were varia

143 e substrate for MSC attachment and enhancing chondrogenic differentiation.

144 icating that CypA plays a functional role in chondrogenic differentiation.

145 orted the conclusion that CypA is needed for chondrogenic differentiation.

146 r verified the effects of CypA deficiency on chondrogenic differentiation.

147 0.15 kPa in stem cells to 0.71 kPa following chondrogenic differentiation.

148 er their use is limited by the efficiency of chondrogenic differentiation.

149 g that muscle satellite cells have undergone chondrogenic differentiation.

150 tion status of MSC and that HMGB2 suppresses chondrogenic differentiation.

151 itched osteogenic ESC differentiation toward chondrogenic differentiation.

152 ymal stem cells (MSCs) during osteogenic and chondrogenic differentiation.

153 tiation both in vitro and in vivo and led to chondrogenic differentiation.

154 signals results in cell cycle withdrawal and chondrogenic differentiation.

155 is necessary for mesenchymal aggregation and chondrogenic differentiation.

156 e healing in mice and has a critical role in chondrogenic differentiation.

157 We hypothesized that viperin plays a role in chondrogenic differentiation.

158 tably decreased, mechanical loading restored chondrogenic differentiation.

159 roliferation or influencing their osteogenic/chondrogenic differentiation.

160 c differentiation, but normal adipogenic and chondrogenic differentiation.

161 rthritis (OA) and their potential to support chondrogenic differentiation.

162 Turing-like mechanism generating stripes of chondrogenic domains.

163 10 ng/mL PDGF) supplementation of serum-free chondrogenic expansion medium enhances the post-expansio

164 is speculated that Coa-mediated delivery of chondrogenic factor IGF-1 with the aid of adipose-derive

165 associated with persistent expression of the chondrogenic factor Sox9 and down-regulation of beta-cat

166 s function in a molecular hierarchy in which chondrogenic factors dominate.

167 revents chondrogenesis in these cells, while chondrogenic factors Nkx3.2 and Sox9 act downstream of T

168 ensitive to sequential addition of the three chondrogenic factors PDGF, TGFbeta and BMP.

169 persists; accordingly, cells maintain their chondrogenic fate and the developed digits are shorter t

170 ions providing novel molecular insights into chondrogenic fate commitment and differentiation.

171 The results show that chondrogenic function of SoxE regulators can be traced t

172 35a, miR-205, and miR-217) also regulate the chondrogenic GATA transcription factor tricho-rhino-phal

173 qPCR and TaqMan qPCR were used to assess chondrogenic gene and miRNA expression.

174 rdependence of cytoskeletal organization and chondrogenic gene expression is regulated, at least in p

175 apy improved the BMP-4- and TGFbeta3-induced chondrogenic gene expression of MDSCs in vitro and impro

176 In this study, the pre-chondrogenic gene expression profile was used as a start

177 activation of mTOR, cell proliferation, and chondrogenic gene expression.

178 uired for Sox9 to control chondrogenesis and chondrogenic gene expression.

179 r collagen (ColA) genes--suggesting that the chondrogenic gene regulatory network evolved in the comm

180 e biologic pathways and, most importantly, a chondrogenic gene subset, whose functional characterizat

181 sFlt-1 treatment improved the expression of chondrogenic genes in MDSCs that were stimulated to unde

182 th PGC-1alpha and Sox9 induced expression of chondrogenic genes, including Col2a1, followed by chondr

183 , cartilage tissue growth, and expression of chondrogenic genes, including Indian hedgehog (Ihh), a c

184 Furthermore, ECM1 and progranulin chondrogenic growth factor constitute an interaction net

185 ion by associating with and inactivating GEP chondrogenic growth factor.

186 GDF5 is a pro-chondrogenic growth factor.

187 f SNORD26 or SNORD96A resulted in changes in chondrogenic, hypertrophic, rRNA and osteoarthritis rela

188 ny generated using such small molecules were chondrogenic in vitro, and expressed trunk paraxial meso

189 for 3 days in static condition, followed by chondrogenic induction culture using a see-saw shaker fo

190 ll plates, and were subjected to preliminary chondrogenic induction for 3 days in static condition, f

191 Concurrent chondrogenic induction in the apical compartment enabled

192 the molecular signals that are required for chondrogenic induction in the trunk and head.

193 alginate cultures of MSCs were treated with chondrogenic induction medium with/without the SIRT1 inh

194 eta1), the most common growth factor used in chondrogenic induction medium.

195 ts, and describe a tailorable system for the chondrogenic induction of hMSCs without necessitating cu

196 provide an advantageous environment for the chondrogenic induction of human mesenchymal stem cells (

197 hesize that shaking culture might affect the chondrogenic induction of induced pluripotent stem cell

198 scs in Transwell inserts following isotropic chondrogenic induction with transforming growth factor b

199 apoptosis and inhibited both osteogenic and chondrogenic lineage commitment.

200 senchymal precursors that are destined for a chondrogenic lineage during endochondral ossification.

201 their in vivo survival and commitment to the chondrogenic lineage in a microenvironment comprising ch

202 nd and differentiate adult stem cells into a chondrogenic lineage is an important step in the develop

203 The effects of I-PTH on the chondrogenic lineage of the mandibular condylar cartilag

204 inted oMSCs could be differentiated down the chondrogenic lineage to generate cartilage-like structur

205 utgrowth, these progenitors segregate into a chondrogenic lineage, located in the center of the limb

206 primed to differentiate along osteogenic or chondrogenic lineage.

207 iR-199a(*) increased the expression of these chondrogenic marker genes.

208 IVD, and a marked decrease in expression of chondrogenic markers - type II collagen, sox9, aggrecan,

209 zed by the expression of both osteogenic and chondrogenic markers.

210 velopment and led to decreased levels of the chondrogenic master transcription factor sox9 and its do

211 Over 56 days of culture in chondrogenic media, printed constructs increased in comp

212 a pellet culture system for 14 days in basal chondrogenic medium (CM), CM with TGFbeta1, CM with BMP-

213 ge matrix proteins in vitro when cultured in chondrogenic medium containing TGFss3 or BMP2.

214 ures were predifferentiated for 2 weeks in a chondrogenic medium, and hypertrophy was induced by with

215 at high density in the presence of a defined chondrogenic medium, pericytes formed well-defined pelle

216 Since the chondrogenic mesenchyme does not express Tmem16a at any

217 and subsequent signaling interactions enable chondrogenic mesenchyme to undergo histogenesis and morp

218 on of cellular polarity within the early pre-chondrogenic mesenchyme, when skeletal shape is establis

219 suggest that activation of this ancient core chondrogenic network underlies the parallel evolution of

220 number and intensity of Alcian blue stained chondrogenic nodules in micromass cultures derived from

221 ein we report on the rapid condensation into chondrogenic nodules of cultured ank/ank bone marrow str

222 tic mesoderm (PSM) cells will adopt either a chondrogenic or lateral plate mesoderm fate.

223 patients express stem cell markers and have chondrogenic, osteogenic, and adipogenic differentiation

224 est and significantly altered expression for chondrogenic/osteogenic lineage markers.

225 ascular invasion during bone healing favours chondrogenic over osteogenic differentiation of skeletal

226 d specification and prospective isolation of chondrogenic paraxial mesoderm progeny from human plurip

227 It requires its SOX5/SOX6 chondrogenic partners to robustly activate E195 and addi

228 ud precartilage mesenchymal cells undergoing chondrogenic patterning.

229 In chondrogenic pellet culture, cells synthesized cartilage

230 ble coincidence of LOXL2 expression with the chondrogenic phase of fracture healing was found, prompt

231 We demonstrate that induction of the chondrogenic phenotype and endogenous Nkx3.2 expression

232 functionality may support the maintenance of chondrogenic phenotype and promote extracellular matrix

233 canonical markers is tenuously linked to the chondrogenic phenotype at the single-cell level.

234 type-II and CS can be used to promote a more chondrogenic phenotype in the absence of growth factors,

235 on of chondrogenesis, but cannot reverse the chondrogenic phenotype once it has been initiated, as ev

236 this by driving progenitor cells to adopt a chondrogenic phenotype through the tailoring of scaffold

237 may especially be relevant for retaining the chondrogenic phenotype, which has important implications

238 r hypoxic oxygen levels (</=8%) promotes the chondrogenic phenotype.

239 KGN appears to have weak chondrogenic potency in human BMSC cultures relative to

240 y we investigated the phenotypic markers and chondrogenic potency of avascular and vascular meniscal

241 Herein, we directly compared the in vitro chondrogenic potency of TGF-beta1 and KGN using a high r

242 altered osteoblastic function than enhanced chondrogenic potential and is not dependent on Vanin-1;

243 Many MSCs exhibit chondrogenic potential as three-dimensional (3D) culture

244 Osteogenic, adipogenic, and chondrogenic potential assays revealed retained differen

245 IFP-MSC exhibit increased clonogenicity and chondrogenic potential compared with BM-MSC.

246 e had enhanced osteogenic potential but less chondrogenic potential compared with controls.

247 xamethasone, in various combinations, on the chondrogenic potential of ADAS cells in alginate beads.

248 Here, we assessed the chondrogenic potential of adipose tissue derived human M

249 udy was undertaken to determine the in vitro chondrogenic potential of bone morphogenetic protein 7 (

250 expansion medium enhances the post-expansion chondrogenic potential of costochondral cells, evidenced

251 ll marker Sca1 and in vitro expansion on the chondrogenic potential of M- and F-MDSCs was also determ

252 Long-term culture did not affect the chondrogenic potential of M-MDSCs but did influence F-MD

253 Sca1 purification influenced the chondrogenic potential of MDSCs, especially M-MDSCs.

254 To study the chondrogenic potential of MSC and identify the condition

255 cteristics, were compared for their in vitro chondrogenic potential using pellet culture.

256 We compared the roles of increased chondrogenic potential versus altered osteoblast functio

257 The chondrogenic potential was measured by quantitative reve

258 ll sources, based on availability and innate chondrogenic potential.

259 vents in articular chondrocytes and prevents chondrogenic precursor cells from repairing cartilage le

260 terior gene expression and failure to expand chondrogenic precursor cells, leading to severe truncati

261 e mutant mice more readily differentiated to chondrogenic precursors, providing a plausible explanati

262 n and to ensure progressive establishment of chondrogenic primordia along the PD axis.

263 We further conclude that chondrogenic primordia formation, marked by initial Sox9

264 Previously, ectopic expression of this "chondrogenic" profile has been implicated in vascular ca

265 rophages are associated with HO and aberrant chondrogenic progenitor cell differentiation, while CD47

266 e the surfaceome and to define biomarkers in chondrogenic progenitor cells (CPC) derived from human O

267 Chondrogenic progenitor cells (CPCs) produced high level

268 emarkably, deletion of Tgfbr2 in myogenic or chondrogenic progenitor cells does not manifest in midli

269 that the migrating cell population included chondrogenic progenitor cells that were drawn to injured

270 death stimulated the emergence and homing of chondrogenic progenitor cells, in part via HMGB-1 releas

271 potent and expressed markers associated with chondrogenic progenitor cells.

272 copy, and migrating cells were evaluated for chondrogenic progenitor characteristics.

273 ysiological driver of proliferation of osteo-chondrogenic progenitors - by binding to an intronic GGA

274 understand signal-induced chondrogenesis of chondrogenic progenitors in physiological and pathophysi

275 inating from mesenchymal stem cells or osteo-chondrogenic progenitors.

276 hile simultaneously impairing adipogenic and chondrogenic programs.

277 n signaling to promote osteogenic, and block chondrogenic, programs of cell fate specification.

278 ohistochemical analysis also revealed higher chondrogenic protein expression.

279 have developed a reproducible and efficient chondrogenic protocol to redifferentiate chondrocytes is

280 late these genes indirectly by targeting the chondrogenic regulators SP1 and HDAC4.

281 d induced significantly higher expression of chondrogenic-related marker genes than static culture at

282 ng from hPS cells showed a relatively weaker chondrogenic response in vitro, and formed more of the f

283 The chondrogenic response of alginate-encapsulated ADAS cell

284 phenotype and border function, restrain pro-chondrogenic signaling proteins including BMPs, and rest

285 s understanding of the mode of action of the chondrogenic Sox trio.

286 iated virus (rAAV) vector overexpressing the chondrogenic sox9 transcription factor in full-thickness

287 quence and in progenitors is associated with chondrogenic specification.

288 lginate support followed by another layer of chondrogenic spheroids overlaid by the same support.

289 ver, Sox9 expression is detected not only in chondrogenic tissue but also in nonchondrogenic tissues,

290 o 95-97% (HUES7 and HUES8 cells) express the chondrogenic transcription factor SOX9.

291 Sox9b, a critical chondrogenic transcription factor, was the most signific

292 ation to identify the roles of the redundant chondrogenic transcription factors Sox5 and Sox6 in this

293 Moreover, DBP increased gene expression of chondrogenic transcription factors SOX9 (160% of control

294 Only BM-derived MSCs exhibited a chondrogenic transcriptional program with hypomethylatio

295 Numerous chondrogenic transcripts were misregulated by TCDD in th

296 hondrogenesis of ank/ank BMSCs and increased chondrogenic transdifferentiation and calcification by a

297 mesenchymal precursors and P(i) donor-driven chondrogenic transdifferentiation and calcification of a

298 ese results reveal a central role for TG2 in chondrogenic transformation of vascular smooth muscle an

299 The chondrogenic trio is required and sufficient to mediate

300 the target genes and modes of action of this chondrogenic trio.