ライフサイエンスコーパス: chordate

1 ascidian Ciona intestinalis, an invertebrate chordate.

2 ity underlying swimming behavior in a simple chordate.

3 mains of any non-biomineralized, total-group chordate.

4 nt to approach regenerative event in a basal chordate.

5 ter in embryos of amphioxus, an invertebrate chordate.

6 ase compensation ever observed in an aquatic chordate.

7 pressing microvillar photoreceptors of early chordates.

8 munity to Staphylococcus aureus infection in chordates.

9 ovelty and one of the defining characters of chordates.

10 A, is an essential signaling molecule in all chordates.

11 aryngeal muscle development and evolution in chordates.

12 n to cell cycle arrest and egg activation in chordates.

13 group to echinoderms, and closely related to chordates.

14 ons analogous to those demonstrated in other chordates.

15 n unambiguously identified in non-vertebrate chordates.

16 aving a tapered notochord is present in many chordates.

17 ut are absent, or divergent, in invertebrate chordates.

18 the Deuterostomia and as the sister taxon to chordates.

19 ous median fin fold that is plesiomorphic to chordates.

20 nary origins of cardiopharyngeal networks in chordates.

21 Sea squirts are simple invertebrate chordates.

22 iple kingdoms and phyla, from prokaryotes to chordates.

23 verse as nematodes and arthropods up through chordates.

24 o facilitate posterior somite development in chordates.

25 de gap-junction proteins in prechordates and chordates.

26 s specify the neural plate border throughout chordates.

27 morphosis may be an ancestral feature of the chordates.

28 irst report of the TERT gene in invertebrate chordates.

29 e from segmented taxa, namely arthropods and chordates.

30 st regulatory cascades underlying the OET in chordates.

31 previously were thought to be restricted to chordates.

32 me 500 million years ago in ancestral marine chordates.

33 with echinoderms form a sister group of the chordates.

34 ree mechanisms are conserved from insects to chordates.

35 here also shows evidence of CPA in tunicate chordates.

36 nce for interpretation of myomeres in fossil chordates.

37 family from lancelets, the most basal extant chordates.

38 ic organism groups but not in prokaryotes or chordates.

39 required for limb growth in both insects and chordates.

40 rast, it is controversial whether it acts in chordates.

41 ctional conservation of X-type lectins among chordates.

42 tes that share features with echinoderms and chordates.

43 provide the foundation for the emergence of chordates.

44 s ancestor to hemichordates, echinoderms and chordates.

45 tary neural crest cells existed in ancestral chordates.

46 data for arthropods, mollusks, annelids, and chordates (77 species total) and found significant phylo

47 Colonial ascidians are the only chordates able to undergo whole body regeneration (WBR),

48 rphological disparity of extinct lampreys, a chordate affinity for T. gregarium resolves the nature o

49 Microvillar photoreceptors of the primitive chordate amphioxus also express melanopsin and transduce

50 A putative proto-MHC exists in the chordate amphioxus and in the fruit fly, indicating that

51 t/beta-catenin and RA signaling in the basal chordate amphioxus during the gastrula stage, which is t

52 Hox clusters of vertebrates and the basal chordate amphioxus have similar organization to the hemi

53 The basal chordate amphioxus is uniquely positioned to address the

54 The basal chordate amphioxus resembles vertebrates in having a dor

55 during the gastrula stage, we used the basal chordate amphioxus, in which gastrulation involves very

56 eport the discovery of ProtoRAG in the lower chordate Amphioxus, the long-anticipated TE related to t

57 The invertebrate chordate amphioxus, which expresses Hh in its notochord

58 hromosome-scale sequence of the invertebrate chordate amphioxus.

59 Here we show that the genome of the basal chordate, amphioxus, contains homologs of most vertebrat

60 In contrast, the basal chordate, amphioxus, has a single SoxE gene and lacks NC

61 propose that the neural plate borders of the chordate ancestor already produced migratory peripheral

62 on of the gene complement of the last common chordate ancestor but also partial reconstruction of its

63 noid receptors originated in an invertebrate chordate ancestor of urochordates, cephalochordates and

64 ning mechanisms present in the free-swimming chordate ancestor.

65 that was present in the common ambulacrarian/chordate ancestor.

66 Genomic data from both chordate and angiosperm genomes fit these predictions: E

67 r-clades of animals: metazoans, bilaterians, chordate and non-chordate deuterostomes, ecdysozoan and

68 16-cell stage of the Ciona embryo, a marine chordate and performed a computational search for cell-s

69 iding high quality, integrated annotation on chordate and selected eukaryotic genomes within a consis

70 otation, databases and other information for chordate and selected model organism and disease vector

71 hat pattern the nervous system in embryos of chordates and annelids are surprisingly similar.

72 origin in the most recent common ancestor of chordates and annelids.

73 olecules (RGMs) are found in vertebrates and chordates and are involved in embryonic development and

74 l conservation of MRF-directed myogenesis in chordates and demonstrate for the first time that the Al

75 laterians, the BMP-active side is ventral in chordates and dorsal in many other bilaterians.

76 and protostomes, as it is distinguishable in chordates and echinoderms.

77 r the origin of this field in non-vertebrate chordates and its evolution in vertebrates.

78 tions, querying tools and access methods for chordates and key model organisms.

79 litate the access of genomic annotation from chordates and key model organisms.

80 in, first appeared in the common ancestor of chordates and nematodes and evolved rapidly via duplicat

81 hich was recruited as an Esrp target in stem chordates and subsequently co-opted into the development

82 As chordates and the closest relatives of vertebrates, tuni

83 rods and a duplex retina provided primitive chordates and vertebrates with similar sensitivity and d

84 lude histocompatibility systems in primitive chordates and vertebrates.

85 the maps and early development are shared by chordates and which distinguish vertebrates.

86 IFalpha gene from amphioxus, an invertebrate chordate, and identified several alternatively spliced H

87 s from 26 animal species, from cnidarians to chordates, and evaluated the substitution rates (omega)

88 of FKBP4 and FKBP5 is very similar among the chordates, and gene expression is influenced by both gen

89 families, connexins, which are exclusive to chordates, and innexins/pannexins, which are found throu

90 demarcating vertebrates from more primitive chordates, and is essential for normal cardiac function.

91 lochordata) belongs to the most basal extant chordates, and knowledge of their brain organization app

92 oad mesodermal Pax III expression outside of chordates, and raises the possibility that such expressi

93 y is required for notochord formation in all chordates, and that it controls transcription of a large

94 n of nonchordate deuterostomes, invertebrate chordates, and vertebrates.

95 eceptors (RARs) that regulate development of chordate animals.

96 odel of the evolution of RAR function during chordate anterior-posterior patterning.

97 Vertebrates diverged from other chordates approximately 500 million years ago and have a

98 and echinoderm grouping and we conclude that chordates are monophyletic.

99 o vertebrates and urochordates, meaning that chordates are paraphyletic.

100 rtebrates have helped establish these marine chordates as model organisms for the study of developmen

101 ts gene targets, we demonstrate that, in the chordate ascidian Ciona intestinalis, miR-124 plays an e

102 ascidian Ciona intestinalis, an invertebrate chordate belonging to the sister group of vertebrates.

103 e been used as model organisms to understand chordate biology because of their close evolutionary rel

104 hord is necessary for the development of the chordate body plan and for the formation of the vertebra

105 basic patterning mechanisms involved in the chordate body plan and the origin of vertebrates.

106 hat the anterior-posterior organization of a chordate body plan can be developed without the classica

107 Ciona tadpole larvae exhibit a basic chordate body plan characterized by a small number of ne

108 is to support the hypothesis that an inverse chordate body plan emerged from an indirect-developing a

109 an urochordate Oikopleura dioica maintains a chordate body plan throughout life, and yet its genome a

110 and provides insight in to the origin of the chordate body plan.

111 a key step to understanding the evolution of chordate body plan.

112 The notochord is a defining feature of the chordate body plan.

113 n innovation essential for the origin of the chordate body plan.

114 nsights into the origins of deuterostome and chordate body plans.

115 The chordate Botryllus schlosseri is an emerging model for a

116 Histocompatibility in the basal chordate Botryllus schlosseri is controlled by the polym

117 The basal chordate Botryllus schlosseri undergoes a natural transp

118 In the marine invertebrate chordate Botryllus schlosseri, cell corpse engulfment by

119 x (ECM) in vascular homeostasis in the basal chordate Botryllus schlosseri, which has a large, transp

120 loped in the jawed vertebrates, invertebrate chordate Botryllus, and cnidarian Hydractinia.

121 Histocompatibility in the primitive chordate, Botryllus schlosseri, is controlled by a singl

122 peculiar developmental scenario in a simple chordate, Botryllus schlosseri, wherein a normal colony

123 ntly forms in the larvae of the invertebrate chordate Branchiostoma floridae (Florida amphioxus).

124 Here we describe a gene from the chordate Branchiostoma floridae that encodes an RNA liga

125 n basal animals, such as Hydra and primitive chordates, but lack this domain in vertebrates.

126 educing the abundance of native annelids and chordates, but not mollusks or arthropods.

127 ed in vertebrates relative to non-vertebrate chordates, but the relative contribution of whole genome

128 rially iterated structures in arthropods and chordates by differentially regulating many target genes

129 ook place in the last common ancestor to the chordates by gene duplication of an ancestral Fibulin-1

130 nciple occurs in different nematodes and the chordate C. intestinalis.

131 ates and cephalochordates, and showed that a chordate can develop the phylotypic body plan in the abs

132 s botryllid ascidians represent invertebrate chordates capable of whole body regeneration in a non-em

133 ngs for the development and evolution of the chordate cardiopharyngeal mesoderm.

134 ng the genetic and cellular basis of a model chordate central pattern generator.

135 In invertebrate chordates (cephalochordates and tunicates), neural plate

136 ing the D/V and A/P axes may be an ancestral chordate character.

137 eny will help clarify the early evolution of chordate characteristics and has implications for our un

138 ay of amphioxus and ammocoetes, that loss of chordate characters during decay is non-random: the more

139 halochordates accurately represent ancestral chordate characters, which has not been tested using clo

140 Myogenesis in the tail of the simple chordate Ciona exhibits a similar reliance on its single

141 The notochord of the invertebrate chordate Ciona forms a tapered rod at tailbud stages con

142 s of the single MRF gene of the invertebrate chordate Ciona intestinalis (Ci-MRF).

143 nd that heart progenitor cells of the simple chordate Ciona intestinalis also generate precursors of

144 esis using the notochord of the invertebrate chordate Ciona intestinalis as a model.

145 arly heart specification in the invertebrate chordate Ciona intestinalis is similar to that of verteb

146 e, we investigate this process in the simple chordate Ciona intestinalis Previous studies have implic

147 Here, we employ the invertebrate chordate Ciona intestinalis to delineate an essential in

148 We exploit wild populations of the marine chordate Ciona intestinalis to show that levels of buffe

149 In the simple chordate Ciona intestinalis, the notochord plate consist

150 gulating PNS development of the invertebrate chordate Ciona intestinalis.

151 for neural tube closure in the invertebrate chordate Ciona intestinalis.

152 iating cardiopharyngeal cell lineages in the chordate Ciona robusta.

153 gene regulatory network in the invertebrate chordate, Ciona intestinalis.

154 vo signaling dynamics using the invertebrate chordate, Ciona intestinalis.

155 ntify the mechanism for zippering in a basal chordate, Ciona intestinalis.

156 ppering and neural tube closure in the basal chordate, Ciona robusta.

157 Recent phylogenetic studies of chordate classes and a sea urchin have indicated that ur

158 ephalochordates (and presumably in ancestral chordates) contrast with vertebrate sensory neurons, whi

159 to a 56-amino-acid-long peptide conserved in chordates, corroborating the work published while this m

160 vealed that a local duplication of ancestral chordate Cry occurred likely before the first round of v

161 hese four residues to ssTnI and nonmammalian chordate cTnIs, whereas cTnI AH is similar to fish cTnI

162 ls: metazoans, bilaterians, chordate and non-chordate deuterostomes, ecdysozoan and lophotrochozoan p

163 f clues on the function of Leprecan in early chordate development.

164 l system for deuterostome and, by extension, chordate development.

165 cal studies, offering a simple blueprint for chordate development.

166 Although non-vertebrate chordates display nested domains of axial Hox expression

167 ochord is the defining characteristic of the chordate embryo and plays critical roles as a signaling

168 outs of gene expression in a fast-developing chordate embryo.

169 and mesoderm during early embryogenesis in a chordate embryo.

170 sion studies in sea urchin, hemichordate and chordate embryos reveal striking similarities among deut

171 In chordate embryos, the T-box transcription factor Brachyu

172 ony, reminiscent of generalized gastrulating chordate embryos.

173 ndogenous chitin and bacteria arose early in chordate evolution and are integral to the overall funct

174 It appears to have evolved during early chordate evolution and is not found in protein sequences

175 To improve our understanding of chordate evolution and the origin of vertebrates, we int

176 an emerging model organism for the study of chordate evolution, development, and gene regulation.

177 During the course of chordate evolution, Loop 1 acquired the tripeptide CPL,

178 During chordate evolution, two genome-wide duplications facilit

179 from a single ancestral gene at the onset of chordate evolution.

180 outh are of central importance for models of chordate evolution.

181 story, far outstripping any other episode in chordate evolution.

182 a floridae, and analyse it in the context of chordate evolution.

183 ccurring over the last 600+ million years of chordate evolution.

184 y vertebrate evolution and suggests an early chordate evolutionary origin for the LRRCE capping motif

185 2 alpha-helical cytokines that have been in chordates for millions of years.

186 Fossil chordates from this interval offer crucial insights into

187 A common CNS architecture is observed in all chordates, from vertebrates to basal chordates like the

188 oxus and vertebrates, suggestive of a common chordate function.

189 onstitute a basal module of RA action during chordate gastrulation.

190 The amphioxus genome contains a basic set of chordate genes involved in development and cell signalin

191 nsive and integrated source of annotation of chordate genome sequences.

192 By screening 74 chordate genomes for endogenous lentiviruses using Pol s

193 nsembl project provides genome resources for chordate genomes with a particular focus on human genome

194 ct provides genome information for sequenced chordate genomes with a particular focus on human, mouse

195 nomic information for a comprehensive set of chordate genomes with a particular focus on resources fo

196 d is not found in protein sequences from non-chordate genomes.

197 red their phylogenetic trees in 69 sequenced chordate genomes.

198 ervation of GC skew patterns in 60 sequenced chordates genomes.

199 nate the murky relationships among the three chordate groups (tunicates, lancelets and vertebrates),

200 The origin of chordates has been debated for more than a century, with

201 Botryllus schlosseri, a primitive chordate, has a life history that links several componen

202 ype lectins), broadly distributed throughout chordates, have been implicated in innate immunity.

203 early vertebrate evolution by remodeling the chordate head into a "new head" that enabled early verte

204 ng the conserved, primary role of FGF/Ets in chordate heart lineage specification.

205 ative morphology, embryology and genomics of chordates, hemichordates and echinoderms, which together

206 Genomic comparisons of chordates, hemichordates, and echinoderms can inform hyp

207 izable conserved sites outside of the within-chordate, highly-conserved DNA-binding domain?

208 In most chordates however, including vertebrates and ascidians,

209 Chordate in body plan and development, the larva provide

210 Ciona stands apart among chordates in having a complete larval connectome.

211 in LPM-corresponding territories of several chordates including chicken, axolotl, lamprey, Ciona, an

212 ologically disparate clade, encompassing the chordates (including vertebrates), the hemichordates (th

213 In some chordates, including the ascidian Ciona, members of the

214 Connexins are unique to chordates; innexins/pannexins encode gap-junction protei

215 nce of cannabinoid receptor orthologs in non-chordate invertebrates indicate that CB(1)/CB(2)-like ca

216 A defining feature of chordates is the unique presence of a dorsal hollow neur

217 the chordates: they diverged from the other chordates just before the lineage of vertebrates, and th

218 ible with a common morphological output, the chordate larva.

219 in all chordates, from vertebrates to basal chordates like the ascidian Ciona.

220 ator Protein 2 (Tfap2) was duplicated in the chordate lineage and is essential for development of the

221 ome and came to abut at the MHB early in the chordate lineage before MHB organizer properties evolved

222 yses placing cephalochordates basally in the chordate lineage, we propose that separate signalling ce

223 xus') are the modern survivors of an ancient chordate lineage, with a fossil record dating back to th

224 rvation of dorsal organizer formation in the chordate lineage.

225 if prior to the divergence of echinoderm and chordate lineages.

226 se vertebrates are derived from 17 ancestral chordate linkage groups (and 19 ancestral bilaterian gro

227 scribes and characterizes the first putative chordate luciferase.

228 PR55), or vertebrates (CB2 and DAGLbeta), or chordates (MAGL and COX2), or animals (DAGLalpha and CB1

229 In chordates, mechanosensory and chemosensory neurons of th

230 Recently in amphioxus, the most basal chordate, melanopsin-expressing photoreceptors were char

231 r of the T-box gene family, is a key gene in chordate mesoderm development.

232 ported anatomical features, including in the chordate Metaspriggina and the arthropod Mollisonia.

233 Here, we leveraged the simplicity of the chordate model Ciona to profile chromatin accessibility

234 , we used single-cell genomics in the simple chordate model Ciona to reconstruct developmental trajec

235 In a primitive chordate model of natural chimerism, one chimeric partne

236 ascidian Ciona intestinalis provide a simple chordate model with which to study collective migration.

237 Using Ciona intestinalis as a simple chordate model, we show that bipotent cardiopharyngeal p

238 nderstanding chordate origins and polarizing chordate molecular and morphological characters.

239 Approximately 500 Mya in early chordates Nav channels evolved a motif that allowed them

240 as a highly conserved channel distinctive of chordate nervous systems and show that protons are not e

241 -lateral organization similar to that of the chordate neural plate.

242 cuolization and stiffening, gave rise to the chordate notochord.

243 the sea urchin, and the nematode and in the chordate notochord.

244 Tunicates are chordates only as larvae, following metamorphosis the ad

245 nteresting features previously thought to be chordate or vertebrate specific.

246 ese fossils cannot be placed reliably in the chordate or vertebrate stem because they could represent

247 om the ascidian Ciona intestinalis, a simple chordate organism whose nervous system in the larval sta

248 hordata, making it integral to understanding chordate origins and polarizing chordate molecular and m

249 A chordate ortholog of UNC-3, Ciona intestinalis COE, was

250 cters, which has not been tested using close chordate outgroups.

251 cient genome duplications from the ancestral chordate Per gene.

252 ive immunity due to their unique position in chordate phylogeny.

253 er, in the context of a new understanding of chordate phylogeny.

254 Shh zli regulatory network that predates the chordate phylum.

255 i is a colonial urochordate that follows the chordate plan of development following sexual reproducti

256 relatively higher preservation potential of chordate plesiomorphies will thus result in bias towards

257 opneust worms and colonial pterobranchs, and chordates possess a defined dorsal-ventral axis imposed

258 ively from fungi to nematodes and insects to chordates, potentially paralleling the increasing comple

259 todermal tissues, a characteristic common to chordate primary embryonic organizers.

260 ons of cannabinoid receptors in invertebrate chordates prior to the emergence of CB(1) and CB(2) rece

261 ds (CIs) of Botryllus schlosseri, a colonial chordate, provide niches for maintaining cycling stem ce

262 ptional preservation of soft-bodied Cambrian chordates provides our only direct information on the or

263 rontal eye" of amphioxus, our most primitive chordate relative, has long been recognized as a candida

264 ) formation in vertebrates and their closest chordate relatives.

265 sally branching vertebrates and invertebrate chordates, remains fragmentary and is impeded by concept

266 In arthropods, annelids and chordates, segmentation of the body axis encompasses bot

267 Although certain ecdysozoans and chordates segregate their germline during embryogenesis,

268 tation, databases, and other information for chordate, selected model organism and disease vector gen

269 range transition from ancestral invertebrate chordates (similar to amphioxus and tunicates) to verteb

270 resources to facilitate genomic analysis in chordate species with an emphasis on human, major verteb

271 tives in the sea urchin confirms a number of chordate specific inventions.

272 ably evolved in the deuterostomes and may be chordate-specific.

273 bias towards wrongly placing fossils on the chordate stem.

274 phenomena, which may be conserved among the chordate subphyla.

275 long revolved around whether more primitive chordates, such as tunicates and cephalochordates, antic

276 Comparison with other chordates suggests that the emergence of a persistent No

277 em cells in Botryllus schlosseri, a colonial chordate that undergoes weekly cycles of death and regen

278 Sea urchins share a molecular heritage with chordates that includes the IL17 system.

279 ell specification within the CNS of a simple chordate, the ascidian Ciona intestinalis.

280 c networks in the tadpole larva of a sibling chordate, the ascidian, Ciona intestinalis.

281 5 elongases, from amphioxus, an invertebrate chordate, the sea lamprey, a representative of agnathans

282 on are similar in all deuterostomes, but, in chordates, the anterior-posterior axis is established at

283 ing receptors is therefore apparent in early chordates; the decrease in photopigment expression-and l

284 e transitions leading up to the invertebrate chordates themselves are more controversial.

285 dence from amphioxus suggests that ancestral chordates then concentrated neurosecretory cells in the

286 ircuits in arthropods correspond to those in chordates, thereby implying their origin before the dive

287 key position in the phylogenetic tree of the chordates: they diverged from the other chordates just b

288 present in Nematodes, Cnidaria and primitive chordates, this method could also have high potential fo

289 we identified 17 metazoan PSC-CTRs spanning chordates to arthropods, and examined their sequence fea

290 h of the axis occurred in an ancestor to the chordates to regulate the differentiation of a subset of

291 s in general, we propose the family arose in chordates to support a more diverse range of synaptic an

292 to skeletal muscle in vertebrates extends to chordates, to trunk muscles in the cephlochordate Amphio

293 mprise vertebrates, the related invertebrate chordates (tunicates and cephalochordates) and three oth

294 bsequent to divergence of the more primitive chordates (tunicates, etc.) in the last common ancestor

295 Olfactory sensory neurons (OSNs) in chordates usually have multiple cilia, each with a centr

296 in phyla-spanning arthropods, nematodes, and chordates utilize self-cleaving ribozymes of the hepatit

297 ion and diversification of ColA genes at the chordate-vertebrate transition may underlie the evolutio

298 to the regulatory network of PNG activity in chordates, we investigated the roles played by PNG homol

299 We interpret our results through a chordate-wide comparison of expression patterns and disc

300 criptional orientation as their orthologs in chordates, with hox1 at the 3' end of the cluster.