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1 ment epithlium (RPE) defects and loss of the choriocapillaris.
2 eration of the RPE, and secondary leakage of choriocapillaris.
3 ffectiveness may be limited by damage to the choriocapillaris.
4 e across Bruch's membrane (BrM) to reach the choriocapillaris.
5 r RPE-derived VEGF in the maintenance of the choriocapillaris.
6 using behavior was observed in the subfoveal choriocapillaris.
7 , but perhaps also in the maintenance of the choriocapillaris.
8 al pigment epithelium (RPE)-Bruch's membrane-choriocapillaris.
9 d RPE is a critical function mediated by the choriocapillaris.
10 GA, RPE atrophy was more severe than loss of choriocapillaris.
11 No area was completely devoid of choriocapillaris.
12 neurosensory retina, and reperfusion of the choriocapillaris.
13 between the retinal pigmented epithelium and choriocapillaris.
14 es in a thinned retina with abnormal RPE and choriocapillaris.
15 onstrated that the bolus of dye perfused the choriocapillaris.
16 ypically more sluggish in CNV than in normal choriocapillaris.
17 ment epithelium (RPE), Bruch's membrane, and choriocapillaris.
18 ns extended in both the outer retina and the choriocapillaris.
19 vascular network in the outer retina and the choriocapillaris.
20 racellular lipid and vasodegeneration of the choriocapillaris.
21 seen in the deep capillary plexus (DCP) and choriocapillaris.
22 ll, mature-appearing B cells that spared the choriocapillaris.
23 ll, mature-appearing B cells that spared the choriocapillaris.
24 n face image averaging on OCTA images of the choriocapillaris.
25 xuses but also a vascular rarefaction of the choriocapillaris.
26 nal pigment epithelium (RPE), and underlying choriocapillaris.
27 ike deposits in Bruch's membrane, as well as choriocapillaris.
28 ed to OCTA flow deficits at the level of the choriocapillaris.
29 AMN may result from a vascular insult in the choriocapillaris.
30 a of RPE loss showed persistent but rarefied choriocapillaris.
31 scularization) compared with nonpathological choriocapillaris (205.1 +/- 46.9 PMNs/mm2 in pathologica
32 ent epithelial (RPE) complex, 78.22 (24.39); choriocapillaris, 25.77 (17.57); Sattler layer, 18.59 (1
33 HGF/SF was most intense at the level of the choriocapillaris, a finding that is significant because
36 alyses highlight a necessary balance between choriocapillaris anatomical and functional parameters to
38 aked 4 h after LPS injection in the temporal choriocapillaris and 4 and 36 h after LPS injection in t
39 increased over background binding to healthy choriocapillaris and blocked by an Scg3-neutralizing ant
40 terol is localized mainly to deposits in the choriocapillaris and Bruch's membrane and on the surface
41 ature, like that of the yolk sac and the eye choriocapillaris and hyaloid vascular systems, develops
43 g of the ligand-modified quantum dots in the choriocapillaris and intraretinal capillaries upon i.v.
44 cular loss during disease progression in the choriocapillaris and larger vessels in the deeper choroi
47 source is the choriocapillaris, and both the choriocapillaris and photoreceptors require trophic and
49 be another oxidative injury stimulus to the choriocapillaris and RPE, and may explain the associatio
50 er 1 (NBC1) is specifically expressed in the choriocapillaris and that missense mutations in CA4 link
51 pvOCT imaging of the microvasculature of the choriocapillaris and the anterior choroidal vasculature
52 likely to disseminate, can be traced to the choriocapillaris and the draining vortex veins and 2) HG
53 en the number of hyperreflective foci in the choriocapillaris and the Sattler layer and disease durat
55 AC was localized to Bruch's membrane and the choriocapillaris and was detectable at low levels as ear
56 al and choroidal circulations (including the choriocapillaris) and avoidance of dye injection-related
58 tive foci in the Bruch membrane/RPE complex, choriocapillaris, and Sattler layer increased proportion
59 prominent at the Bruch membrane/RPE complex, choriocapillaris, and Sattler layer, correlate with dise
60 olved images of the retinal vasculature, the choriocapillaris, and the vessels in Sattler's and Halle
61 municates with the central retinal vein, the choriocapillaris, and with large veins of the optic nerv
62 generated using the "retina," "avascular," "choriocapillaris," and "outer retina to choriocapillaris
66 tree, classifying the transcriptome of human choriocapillaris, arterial, and venous endothelial cells
68 al FAs and with incomplete RPE repopulation, choriocapillaris atrophy, and outer retinal degeneration
69 a progressive degeneration characterized by choriocapillaris atrophy, RPE and BrM abnormalities, cul
70 minent outer collagenous layer deposits, and choriocapillaris basement membrane duplication/splitting
74 e was to examine the feasibility of rotating choriocapillaris, Bruch's membrane (BM), and retinal pig
76 oxidized lipoprotein deposits located in the choriocapillaris, Bruch's membrane, and retinal pigment
77 in AMD retina and significantly lower in the choriocapillaris, Bruch's membrane, and RPE basal lamina
78 condition resulting from undulations in the choriocapillaris, Bruch's membrane, retinal pigment epit
79 lasma LDL readily enters the RPE through the choriocapillaris but is not found homogeneously througho
80 dest positional or hydrostatic pressure, the choriocapillaris capacity is, and this is measurable in
81 revealed elevated zinc concentrations in the choriocapillaris (CC) (mean 45, range 28-77 ppm), retina
82 udy was to examine the relationships between choriocapillaris (CC) and retinal pigment epithelial cha
83 structural and functional maturation of the choriocapillaris (CC) and to determine when fenestration
84 lexus (SVP), deep capillary plexus (DCP) and choriocapillaris (CC) as detected on optical coherence t
86 stood, particularly the relationship between choriocapillaris (CC) dysfunction and phenotypic variabi
87 measure the age-dependent changes in macular choriocapillaris (CC) flow deficits (FDs) in normal eyes
88 n strategy that was developed to measure the choriocapillaris (CC) flow deficits (FDs) under drusen w
89 t rates (ERs) of geographic atrophy (GA) and choriocapillaris (CC) flow deficits (FDs), mean choroida
90 en RPE-BM distances and previously published choriocapillaris (CC) flow deficits in any subregions.
95 (SCP) and deep (DCP) capillary plexuses and choriocapillaris (CC) in patients with Best vitelliform
97 ment of vascular density (VD) of retinal and choriocapillaris (CC) in various stages of diabetic reti
99 graphy angiography (OCTA) of the retinal and choriocapillaris (CC) vasculatures in normal subjects an
101 angiography (OCTA) data were collected, and choriocapillaris (CC), Sattler's layer, and Haller's lay
105 y plexus (SCP), deep capillary plexus (DCP), choriocapillaris (CC)] was calculated at baseline and at
107 ls and AMD or GA eyes (P > 0.05), suggesting choriocapillaris changes are more prevalent in AMD than
109 ssive age-related changes in the RPE-Bruch's-choriocapillaris complex that have features that may be
110 nges in the retinal pigment epithelium (RPE)/choriocapillaris complex were quantified in dry and wet
111 larged Haller vein bordering the infiltrate, choriocapillaris compression and loss of choroidal archi
112 l choriocapillaris in 25 (83%), and abnormal choriocapillaris confined to the tumor apex in 17 (58%).
113 on these anatomical analyses reveal that the choriocapillaris contains regions where the transport of
114 subRPE lipid-rich deposits called drusen and choriocapillaris degeneration), and HIF-alpha stabilizat
115 wet age-related macular degeneration (ARMD), choriocapillaris degeneration, and glomerular thrombotic
118 gic analysis revealed a similar reduction in choriocapillaris density in the irradiated area of eyes
120 structural aging to the RPE-Bruch's membrane-choriocapillaris developed in mice treated with low-dose
123 upport the view that the human HVS, like the choriocapillaris, develops by hemo-vasculogenesis, the p
124 uman eyes, we show that the thickness of the choriocapillaris does not vary significantly over large
133 ), choroidal thickness (in micrometers), and choriocapillaris-equivalent thickness (CCET, in micromet
135 ve analysis of the choroidal vasculature and choriocapillaris-equivalent thickness demonstrated excel
136 ation of choroidal vasculature thickness and choriocapillaris-equivalent thickness of the macula, and
137 e interval [CI] 163.7-180.5 mum) and average choriocapillaris-equivalent thickness was 23.1 mum (95%
138 hickness was 8.0% (95% CI 6.3%-9.4%), and of choriocapillaris-equivalent thickness was 27.9% (95% CI
143 plicated in future longitudinal studies, the choriocapillaris FD may prove to be a useful parameter f
145 nolayer provides barrier resistance, induces choriocapillaris fenestration, and supports the formatio
148 visible on blue autofluorescence, while the choriocapillaris filling was normal on fluorescein angio
153 such as the choroidal vascularity index and choriocapillaris flow area, which are crucial for a thor
162 d a significant topographic association with choriocapillaris flow deficits percentage (CC FD%; beta
167 ies and vascular dropout observed within the choriocapillaris for pvOCT are compared with regional GA
168 In addition, RGCC was the most up-regulated choriocapillaris gene in a donor diagnosed with AMD.
174 n 1 eye, below the Bruch membrane within the choriocapillaris in 1 eye, and in the larger choroidal v
176 ralesional granularity in 14 (47%), abnormal choriocapillaris in 25 (83%), and abnormal choriocapilla
180 luation, GA eyes showed persisting, rarefied choriocapillaris in correspondence of retinal pigment ep
182 in the retinal pigment epithelium (RPE) and choriocapillaris in eyes of deceased donors with age-rel
183 RPE basal lamina, intercapillary septa, and choriocapillaris in eyes with AMD may be permissive for
184 otal number of PMNs was increased within the choriocapillaris in five diabetic eyes (170.9 +/- 12.9 P
185 lusion we report quantitative mapping of the choriocapillaris in myopic eyes compared with an age-mat
189 ents with STGD revealed an extensive loss of choriocapillaris in the central area with persisting tis
190 RPE atrophy was significantly narrower than choriocapillaris in the control subject and in normal ar
191 generate local, repetitive angiograms of the choriocapillaris in the rat and to assess the similarity
192 epithelium (RPE), Bruch's membrane, and the choriocapillaris in the setting of characteristic extrac
193 of spatial variations in the anatomy of the choriocapillaris in three additional human eyes indicate
194 inal layers, retinal pigment epithelium, and choriocapillaris in treatment and control eyes were unre
198 n ciliary body, retinal pigmented epithelium-choriocapillaris, iris, and neurosensory retina are pred
200 enular vessels connected to the plane of the choriocapillaris is non-random, and that venular inserti
201 l abnormalities supports the hypothesis that choriocapillaris is the primary site of pathology in SC,
202 subfoveal medium choroidal vessel layer and choriocapillaris layer thickness were significantly redu
203 subfoveal medium choroidal vessel layer and choriocapillaris layer thicknesses are significantly red
204 nd that of the medium choroidal vessel layer-choriocapillaris layer was 52.9 +/- 20.6 mum beneath the
206 s and metabolites between the retina and the choriocapillaris, leading to photoreceptor dysfunction a
208 In inactive scars, the areas of retinal and choriocapillaris lesions were similar and did not change
217 In contrast, after 4 days of hyperoxia the choriocapillaris lumenal diameters and percent vascular
218 r contour (n = 15) and thinned or compressed choriocapillaris (n = 2), thinned (n = 3) or thickened (
219 stabilization or STAT3 overactivation induce choriocapillaris neovascularization and type-I wet AMD p
222 with RPD have significantly larger areas of choriocapillaris nonperfusion compared with eyes with dr
223 n VEGFrpe-/- mice) results in the absence of choriocapillaris, occurrence of microphthalmia, and the
224 ally, loss of endothelial cells (ECs) of the choriocapillaris occurs early in AMD concomitant with el
225 tive evaluation of endothelial injury in the choriocapillaris of live animals, which detects disease
227 he feasibility of noninvasively studying the choriocapillaris of the living rat using the technique o
228 rat and to assess the similarity between the choriocapillaris of the rat and that of the subhuman pri
230 e averaging can improve visualization of the choriocapillaris on OCTA images, transforming the images
231 ry detail, they do not adequately reveal the choriocapillaris or other microvascular features beneath
232 r," "choriocapillaris," and "outer retina to choriocapillaris (ORCC)" slabs automatically provided by
236 sensitivity, supporting the hypothesis that choriocapillaris perfusion correlated with macular funct
237 visual acuity deficits (LLVADs) and central choriocapillaris perfusion deficits were investigated to
238 g the choroidal vascularity index (CVI), and choriocapillaris perfusion density (PD) on structural OC
239 alized, patient regained visual function and choriocapillaris perfusion was completely restored.
241 revealed a pathologic neovascular network in choriocapillaris plexus, probably the result of a fibrov
242 ks, average inner retinal PO2, normalized to choriocapillaris PO2, was higher in diabetic rats than i
244 was found to cause significant inhibition of choriocapillaris regeneration without apparent effect on
247 space up to 3 months after surgery, and the choriocapillaris remains patent in the transplant bed, a
248 ing potential insight into the mechanisms of choriocapillaris response to complement injury and choro
249 atrophy (GA) is characterized by the loss of choriocapillaris, retinal pigment epithelium (RPE) and p
252 of the retina and retinal pigment epithelium-choriocapillaris (RPE-CC) complex and increased reflecti
257 he disease, the area of hypoperfusion in the choriocapillaris significantly increased as visualized o
258 percentage was measured from a 16-mum thick choriocapillaris slab after compensation and binarizatio
259 OCTA manifested a focal dark area in the choriocapillaris slab corresponding to flow signal voids
262 voids forms a scale invariant pattern in the choriocapillaris starting at a size much smaller than a
263 the role of RPE-derived soluble VEGF on the choriocapillaris survival, we used mice that produce onl
264 al thickness, resulting in rescue of the RPE/choriocapillaris that continues to perfuse, hence sparin
265 We show that as a result of the form of the choriocapillaris, the blood flow is decomposed into a te
266 dly leads to vision loss and ablation of the choriocapillaris, the major blood supply for the outer r
267 AMD) is characterized by degeneration of the choriocapillaris, the vascular supply of retinal photore
269 (35%) choroidal shadowing deep to the nevus, choriocapillaris thinning overlying the nevus (94%), ret
271 e similarity between the rat and the primate choriocapillaris, thus indicating that the rat is an acc
272 otoreceptors consume glucose supplied by the choriocapillaris to support phototransduction and outer
274 vide a characterization of the human RPE and choriocapillaris transcriptome, offering potential insig
276 electin glycoprotein ligand-Ig (rPSGL-Ig) in choriocapillaris using a scanning laser ophthalmoscope (
278 aocular pressure normalized, the retinal and choriocapillaris vascular perfusion showed focal defects
280 and drusen, (2) RPE cell bodies, and (3) the choriocapillaris' vascular density and rod- and cone-med
282 im of this study was to evaluate retinal and choriocapillaris vessel density using optical coherence
284 r lesions that destroyed photoreceptors, the choriocapillaris was also compromised, even when no chan
287 tension within both the outer retina and the choriocapillaris was present in 90% and 69% of cases on
288 ntrols in CRVO group (p < 0.001) and PFVD of choriocapillaris was significantly reduced compared to c
290 cular features of the retinal plexus and the choriocapillaris were analyzed on OCTA and compared with
294 betic and nondiabetic choroidal capillaries (choriocapillaris) were analyzed in the flat perspective
295 a reticulum of flattened laminae, and in the choriocapillaris where ovoid-to-spindle-shaped SM cells
296 ebrates branched geometries predominate, the choriocapillaris, which is the microvascular bed that is
297 y slower subsequent revascularization of the choriocapillaris, which paralleled the RPE wound healing
298 eability capillaries are also present in the choriocapillaris, which supplies the retinal pigment epi
299 sed numbers of PMNs were present in areas of choriocapillaris with pathological changes (loss in APas
300 hich photoreceptors acquire glucose from the choriocapillaris with the help of the retinal pigment ep