ライフサイエンスコーパス: chromatin organization

1 quantitative information needed to determine chromatin organization.

2 nd illuminated several interrelated roles in chromatin organization.

3 ociating Domains (TADs) that represent a sub-chromatin organization.

4 bodies while retaining the role of MeCP2 in chromatin organization.

5 silencing and maintenance of siRNA-dependent chromatin organization.

6 ing RNA biogenesis and, consequently, global chromatin organization.

7 stent with their ascribed role in regulating chromatin organization.

8 e trajectories are used to explore the local chromatin organization.

9 ispensable for the formation of higher order chromatin organization.

10 role in chromatin compaction and large-scale chromatin organization.

11 enable kinetochore assembly and centromeric chromatin organization.

12 es, respectively, does not alter genome-wide chromatin organization.

13 in interface influence both NE structure and chromatin organization.

14 nking transcription regulatory potential and chromatin organization.

15 ur mutations in enzymes that are involved in chromatin organization.

16 identifying SMARCA4 as a novel component of chromatin organization.

17 suggesting an inherent structural memory in chromatin organization.

18 hypothesized to control gene expression and chromatin organization.

19 lating to transcription, DNA replication and chromatin organization.

20 In eukaryotes, gene expression depends on chromatin organization.

21 DNA binding, cell cycle, differentiation and chromatin organization.

22 ally related to biological processes such as chromatin organization.

23 egation (PEV), suggesting that it influences chromatin organization.

24 ding factors, such as replication timing and chromatin organization.

25 e nuclear lamina regulates proliferation and chromatin organization.

26 rovide a useful guide for the exploration of chromatin organization.

27 hlight fundamental principles of single-cell chromatin organization.

28 lates with reduced RNA synthesis and altered chromatin organization.

29 onal links between transcriptome control and chromatin organization.

30 tic environment and ultimately restructuring chromatin organization.

31 ification regulating nucleosome dynamics and chromatin organization.

32 (tRNA) genes, which have been implicated in chromatin organization.

33 ual roles in nucleocytoplasmic transport and chromatin organization.

34 regulation, chromatin state and higher order chromatin organization.

35 , impact on gene expression, and the role of chromatin organization.

36 enetically inheritable nature of centromeric chromatin organization.

37 ge-specific regulators as well as changes in chromatin organization.

38 role of Nup157, and its paralogue Nup170, in chromatin organization.

39 les in the regulation of gene expression and chromatin organization.

40 ts into an additional layer of complexity in chromatin organization.

41 this process dramatically changed interphase chromatin organization.

42 genome-wide, three-dimensional (3D) view of chromatin organization.

43 To understand this mistargeting, we examined chromatin organization.

44 ding replication, repair, transcription, and chromatin organization.

45 studies on the influence of DNA sequence on chromatin organization.

46 p extrusion is a viable general mechanism of chromatin organization.

47 HiChIP is a powerful tool to interrogate 3D chromatin organization.

48 to determine its contribution to interphase chromatin organization.

49 ceted role in gene expression regulation and chromatin organization.

50 i-faceted picture and physical principles of chromatin organization.

51 n vivo, affecting nuclear histone levels and chromatin organization.

52 e central players in this cell type-specific chromatin organization.

53 urons in the mouse eye and nose have unusual chromatin organization.

54 ave enabled new views into several layers of chromatin organization.

55 ntal changes by regulating transcription and chromatin organization.

56 well as cell-type-independent principles of chromatin organization.

57 one-protamine exchange, sperm maturation and chromatin organization.

58 effects via self-reconstruction of disrupted chromatin organization.

59 yltransferase and defines the role of 6mA in chromatin organization.

60 ivation or knockdown, implying changes in ES chromatin organization.

61 tions, including interphase repair(8-13) and chromatin organization(14-17).

62 ntext of promoter-proximal pausing and local chromatin organization, 5' and 3' ends of nascent capped

63 leted of maternal PIWI proteins also exhibit chromatin organization abnormalities.

64 ed loop extrusion reproduces key features of chromatin organization across different organisms.

65 report an imaging technology for visualizing chromatin organization across multiple scales in single

66 s to the repair machinery and to restore the chromatin organization after repair remain elusive.

67 irus insertional mutagenesis whereby spatial chromatin organization allows distally located provirus,

68 previously unidentified type of centromeric chromatin organization among eukaryotes.

69 patterns reveals many conserved features of chromatin organization among the three organisms.

70 To systematically investigate chromatin organization and associated gene regulation ac

71 metes; proteins involved in DNA replication, chromatin organization and axoneme formation.

72 Here, we compared chromatin organization and binding dynamics for twelve M

73 mina composition underlie cell-type-specific chromatin organization and cell fate, suggesting that th

74 EL) and two significantly enriched pathways (chromatin organization and cellular stress response) sug

75 d we will discuss how epigenetic regulation, chromatin organization and circuit dynamics may contribu

76 cal roles for the AT-hook domain of MeCP2 in chromatin organization and clinical features of Rett syn

77 trotransposon families play a direct role in chromatin organization and developmental progression.

78 ngle-nucleus methyl-3C sequencing to capture chromatin organization and DNA methylation information a

79 Plants share many features of chromatin organization and DNA repair with fungi and ani

80 To conclude, chromatin organization and dynamics can be reconstructed

81 ariety of signaling processes, which control chromatin organization and dynamics.

82 nection between the pluripotency network and chromatin organization and emphasize that maintaining an

83 Thus, different layers of chromatin organization and epigenetic control mechanisms

84 linked to long-range changes in higher-order chromatin organization and epigenetic dysregulation in c

85 and hybrid mice, to investigate the diploid chromatin organization and epigenetic regulation.

86 Journal has inspired current research on how chromatin organization and epigenetics impact regulation

87 neous characterization of cell-type-specific chromatin organization and epigenome in complex tissues.

88 Despite their fundamental implications for chromatin organization and function, these opposing view

89 questions in understanding three-dimensional chromatin organization and function.

90 ing RNAs (ncRNAs) play major roles in proper chromatin organization and function.

91 of SMARCA4-dependent changes in higher-order chromatin organization and gene expression, identifying

92 re DNA binding factors with central roles in chromatin organization and gene expression.

93 ruciform structures that also have a role in chromatin organization and gene expression.

94 e and critical epigenetic marks that affects chromatin organization and gene expression.

95 mphocyte involves rapid and major changes in chromatin organization and gene expression; however, the

96 protein CTCF, which functions in genome-wide chromatin organization and gene regulation, is recruited

97 To study the relation between chromatin organization and gene regulation, we introduce

98 set of proteins that actively participate in chromatin organization and gene regulation.

99 nding factor (CTCF) functions in genome-wide chromatin organization and gene regulation.

100 TCF and cohesin contribute differentially to chromatin organization and gene regulation.

101 Chromatin organization and gene-gene interactions are cr

102 tin has provided detailed insight into local chromatin organization and has set the stage for recent

103 e known to be a major factor that influences chromatin organization and hence gene expression in the

104 ne and non-histone protein complexes defines chromatin organization and hence regulates numerous nucl

105 Our studies reveal that Snf2h controls chromatin organization and histone H1 dynamics for the e

106 ear basket nucleoporins (Tpr and Nup153) and chromatin organization and how altering the host environ

107 role of combinatorial readout in maintaining chromatin organization and in enforcing the transcriptio

108 s allows the investigation of spatiotemporal chromatin organization and its role in gene regulation a

109 nsmitted into the nucleus, where they affect chromatin organization and mechanoresponsive signaling m

110 hought to be important for processes such as chromatin organization and modulation of gene expression

111 PCs and that it plays a role in subtelomeric chromatin organization and NE tethering.

112 ic tensile loading (DL) regulates changes in chromatin organization and nuclear mechanics in MSCs.

113 epigenomics, although the role of k-mers in chromatin organization and nucleosome positioning is par

114 These structures are important for chromatin organization and our data suggest a role for U

115 The mutual dependencies between chromatin organization and patterns of epigenetic marks,

116 Understanding the role of chromatin organization and regulation in HSC homeostasis

117 ing of oncogenic mechanisms at each level of chromatin organization and regulation, and discuss new s

118 cyte differentiation with distinct levels of chromatin organization and remodeling.

119 ding cells had abnormal nuclear envelope and chromatin organization and severe defects in postembryon

120 gene expression model impairment of spatial chromatin organization and signaling pathways as underly

121 hed with expression of genes associated with chromatin organization and synaptic signalling.

122 iosis occurs amid global reprogramming of 3D chromatin organization and that strengthening of chromat

123 difications is sensitive to heterogeneity in chromatin organization and the resulting variability in

124 tes PRDM15 depletion, both in terms of local chromatin organization and the transcriptional modulatio

125 Here, we identified alterations in chromatin organization and transcript profiles associate

126 ST/EiJ and C57BL/6J mice have very different chromatin organization and transcription profiles in the

127 processes including cell fate commitment, 3D chromatin organization and transcription regulation.

128 some assembly pathway, leading to changes in chromatin organization and transcription, remains unknow

129 CHD1, and ISW2 nucleosome spacing enzymes in chromatin organization and transcription, using isogenic

130 it has emerged as an important regulator of chromatin organization and transcription.

131 Our findings demonstrate that chromatin organization and transcriptional programs are

132 The relationship between chromatin organization and transcriptional regulation is

133 ciples that capture the relationship between chromatin organization and transcriptional regulation.

134 been shown to function in signaling events, chromatin organization and transcriptional regulation.

135 tures and provided insights into the allelic chromatin organizations and functions.

136 We also found that the location of "chromatin organization" and "metabolic" genes is biased

137 nal roles of NPCs and Nups in transcription, chromatin organization, and epigenetic gene regulation i

138 modelin" that improved nuclear architecture, chromatin organization, and fitness of both human lamin

139 s that control nuclear structure, signaling, chromatin organization, and gene silencing.

140 mportant role for NE81 in nuclear integrity, chromatin organization, and mechanical stability of cell

141 DNA binding protein involved in higher-order chromatin organization, and mutations in the human CTCF

142 their transcription start site (TSS) usage, chromatin organization, and posttranscriptional conseque

143 establish a link between P-body homeostasis, chromatin organization, and stem cell potency.

144 opment that controls stem cell self-renewal, chromatin organization, and the DNA damage response, act

145 in large genomic segments reflecting spatial chromatin organization, and the magnitude of these effec

146 ach protein introduces a unique phenotype to chromatin organization, and these structures are put int

147 Differences in chromatin organization are key to the multiplicity of ce

148 The contributions of these remodelers to chromatin organization are largely combinatorial, distin

149 Both cellular nutrient metabolism and chromatin organization are remodeled in cancer cells, an

150 Analysis of chromatin organization around Nkx2.2-, Nkx6.1- and Olig2

151 Here we discuss higher-order chromatin organization as a unifying mechanism for diver

152 ces of loss of these factors on higher-order chromatin organization, as well as the transcriptome.

153 n A and C cause misshapen nuclei and altered chromatin organization associated with cancer and lamino

154 Cancer cells exhibit dramatic alterations of chromatin organization at cis-regulatory elements, but t

155 olution, and uncovered general principles of chromatin organization at different types of genomic fea

156 ts genomic targets, and perturbed high-order chromatin organization at key genes involved in heart de

157 recognition is required by ISW1a for proper chromatin organization at promoters; as well as transcri

158 ily and represses transcription by modifying chromatin organization at specific promoters.

159 hanges result in establishment of a specific chromatin organization at the RSS that facilitates acces

160 s providing a spatial framework of nucleolar chromatin organization at unprecedented detail.

161 re, and recent data have characterized their chromatin organization at very different scales, from su

162 We propose a simple model for chromatin organization based on the interaction of the c

163 a polymer model, that accounts for the local chromatin organization before and after a double-strande

164 This mechanism may more generally drive chromatin organization beyond heterochromatin.

165 ing domains (TADs) as a conserved feature of chromatin organization, but how TADs are spatially organ

166 have been implicated in maintaining an open chromatin organization, but how these processes are conn

167 results reveal a novel function of SIRT7 on chromatin organization by mediating the anchoring of L1

168 omain proteins influence gene expression and chromatin organization by way of histone demethylation,

169 hylation channels and show that higher-order chromatin organization can be predicted from their infor

170 Chromatin organization can be probed by Chromosomal Capt

171 To assess whether 3D chromatin organization changes during this transition, w

172 We show that the highly compartmentalized 3D chromatin organization characteristic of interphase nucl

173 eq data to predict two important features of chromatin organization: chromatin interaction hubs and t

174 brane-chromatin interactions impairs mitotic chromatin organization, chromosome segregation and cytok

175 ence that variations in different aspects of chromatin organization collectively define gene expressi

176 ved from multiple tissues, consistent with a chromatin organization common to epithelial cell lines.

177 ome arrays, highlighting a key difference in chromatin organization compared to model organisms.

178 Chromatin organization contributes to regional variation

179 Higher-order chromatin organization controls transcriptional programs

180 Defective chromatin organization correlates with altered RNA polym

181 In the latter, pore clustering resulted in chromatin organization defects and led to a significant

182 r data uncover how IBPs dynamically regulate chromatin organization depending on distinct cofactors.

183 he unique contributions by SA1 and SA2 to 3D chromatin organization, DNA replication fork progression

184 Thus, chromatin organization during development is regulated b

185 ) approach, we examined the reprogramming of chromatin organization during early development in mice.

186 ltiplexed 4C-seq to study dynamic changes in chromatin organization during early G1.

187 t in regulating DNA methylation dynamics and chromatin organization during early heart development.

188 een proposed to mediate spatial and temporal chromatin organization during gene regulation.

189 east cancer tissues, changes in higher-order chromatin organization during tumorigenesis have not bee

190 key mechanosensor and can directly influence chromatin organization, epigenetic modifications, and ge

191 clin loci, indicating a disruption to normal chromatin organization essential to life-cycle progressi

192 dels, this dynamic plasticity of large-scale chromatin organization explains how localized changes in

193 rces to the nucleus, resulting in changes to chromatin organization, followed by nuclear deformation.

194 germline may permit rapid reconstitution of chromatin organization following fertilization.

195 Unraveling the principles of cardiac chromatin organization for next generation therapies in

196 comb-repressed states, and observed distinct chromatin organizations for each state.

197 view current knowledge of the main levels of chromatin organization, from the scale of nucleosomes to

198 uild the nuclear lamina and are required for chromatin organization, gene expression, cell cycle prog

199 skeletal organization, mechanical stability, chromatin organization, gene regulation, genome stabilit

200 concerted alterations in the expression of "chromatin organization" genes and inferred that TBT-disr

201 Chromatin organization has a fundamental impact on the w

202 e, we summarize the current principles of 3D chromatin organization, how the integrity of the 3D geno

203 find that the naturally occurring changes in chromatin organization impart a regulation on the spatia

204 ng that cross-linking captured a specialized chromatin organization imposed by Sir proteins.

205 periments provide partial information on the chromatin organization in a cell population, namely the

206 antitative understanding of lamin-associated chromatin organization in a crowded macromolecular envir

207 mpact on the molecular and spatial (nuclear) chromatin organization in Arabidopsis with distinct role

208 les including NE reassembly, cell cycle, and chromatin organization in cells, and subtly alters its n

209 esolution imaging approach for investigating chromatin organization in complex tissues.

210 Spt16 has a broad role in regulating chromatin organization in gene bodies, including those n

211 critical roles of nucleosome positioning and chromatin organization in gene regulation during reprogr

212 How condensin contributes to chromatin organization in interphase is less well unders

213 chromatin interactions contribute to shaping chromatin organization in interphase.

214 nology, which provides an integrated view of chromatin organization in its native structural and func

215 Here, we perform Hi-C analysis to examine 3D chromatin organization in male germ cells during spermat

216 ne-dense A compartment, revealing a role for chromatin organization in meiotic recombination.

217 ding the powerful role played by large-scale chromatin organization in normal and aberrant lineage-sp

218 In contrast, much less is known about chromatin organization in plants.

219 indings reveal a dual role of CTCF-dependent chromatin organization in promoting myelinogenic program

220 To study three-dimensional chromatin organization in rare cell types, we developed

221 ates the development of methods that measure chromatin organization in single cells.

222 While we have a good understanding of chromatin organization in space, for example in fixed sn

223 However, the higher-order chromatin organization in T. thermophila is still largel

224 Here we show that neuronal chromatin organization in the female ventral hippocampus

225 in the NPC is crucial to control large-scale chromatin organization in the nucleus.

226 tor impaired nerve regeneration, implicating chromatin organization in the regenerative competence.

227 Chromatin organization in the stem cell state is known t

228 Here, we explored the higher-order chromatin organization in the two distinct nuclei of T.

229 l, we demonstrated the distinct higher-order chromatin organization in the two nuclei of the T. therm

230 which dynamic tensile loading (DL) regulates chromatin organization in this cell type.

231 so function in mitochondrial respiration and chromatin organization in ways that may not involve tran

232 Bayesian framework to model allele-specific chromatin organizations in diploid genomes.

233 either act as E3 ubiquitin ligase or affect chromatin organization, inhibits the transcriptional act

234 sregulated gene expression due to changes in chromatin organization into active and inactive compartm

235 , we investigate cell-to-cell variability of chromatin organization into topologically associating do

236 An open and decondensed chromatin organization is a defining property of pluripo

237 Chromatin organization is a highly orchestrated process

238 nexpectedly, the subsequent establishment of chromatin organization is a prolonged process that exten

239 Genome-wide mapping of three dimensional chromatin organization is an important yet technically c

240 Chromatin organization is critical for cell growth, diff

241 Chromatin organization is crucial for regulating gene ex

242 Three-dimensional (3D) chromatin organization is important for proper gene regu

243 ed when the replication fork passes, but how chromatin organization is re-established following repli

244 ed quantitative framework describing spatial chromatin organization is still lacking.

245 n TC-NER, particularly in the context of the chromatin organization, is unclear.

246 is known in molecular detail of centromeric chromatin organization, its propagation through cell div

247 This shift to a repressive chromatin organization may be important to inhibit local

248 ggest the novel possibility that H1-mediated chromatin organization may contribute to the epigenetic

249 n in vivo study of how genetic variation and chromatin organization may dictate susceptibility to DNA

250 ation" genes and inferred that TBT-disrupted chromatin organization might be able to self-reconstruct

251 as an input to an energy landscape model for chromatin organization [Minimal Chromatin Model (MiChroM

252 ific roles in transcriptional regulation and chromatin organization need further characterization.

253 We conclude that cell-type-specific chromatin organization occurs at the submegabase scale a

254 ity of our approach to deliver insights into chromatin organization of great biological relevance.

255 We have analyzed the 3D chromatin organization of Hox clusters during their earl

256 role in insulator function and higher-order chromatin organization of mammalian genomes.

257 is therefore well-suited to characterize the chromatin organization of single cells in heterogeneous

258 ssion, conceivably by mediating higher-order chromatin organization of subtelomeres and Tf2 elements,

259 The distinct chromatin organization of the CCA response elements appe

260 spatiotemporally integrate to the functional chromatin organization of the cell nucleus.

261 deletion within the Ifng-as1 locus disrupted chromatin organization of the extended Ifng locus, impai

262 yc transcription in cis without altering the chromatin organization of the locus.

263 icant insight into Xist binding patterns and chromatin organization of the Xi.

264 Our results demonstrate that the global chromatin organization of zygote nuclei is fundamentally

265 However, the impact of this spatial chromatin organization on gene expression and its degree

266 To investigate the impact of chromatin organization on gene regulation, we performed

267 eukaryotic protein production, histone-based chromatin organization paved the path to eukaryotic geno

268 ecently, the influence of telomere length on chromatin organization prior to senescence has revealed

269 should shed light on the relationships among chromatin organization, protein-DNA interactions, and ge

270 The dynamics of chromatin organization regulates DNA accessibility to eu

271 on upon nucleosome binding and its impact on chromatin organization remain unknown.

272 y, dynamics, and relation to other layers of chromatin organization remained elusive.

273 Chromatin organization remains complex and far from unde

274 to transcription, molecular, and cytological chromatin organization remains elusive.

275 fectors include regulators of transcription, chromatin organization, RNA processing, and translation,

276 altering the expression of genes involved in chromatin organization, signaling, adhesion, motility, d

277 ever, most of published genome-wide unbiased chromatin organization studies have used cultured cell l

278 Features of higher-order chromatin organization-such as A/B compartments, topolog

279 gions of DNA, thereby mediating higher order chromatin organization that is critical for sister chrom

280 ity, consistent with higher-order changes in chromatin organization that mark (1) the beginning of re

281 s share a deeply evolutionarily conserved 3D chromatin organization that predates the Cambrian explos

282 n were predisposed to obesity due to altered chromatin organization that subsequently biased DNA meth

283 d positioning of gene loci and regulation of chromatin organization through protein complexes and non

284 r self-renewal and that it acts with HIRA in chromatin organization to link epigenetic organization t

285 The relationships of higher order chromatin organization to mammalian gene expression rema

286 e contribution of human subtelomeric DNA and chromatin organization to telomere integrity and chromos

287 volved in many nuclear activities, including chromatin organization, transcription and replication.

288 ds of proteins involved in processes such as chromatin organization, transcription, DNA repair, macro

289 ending the nuclear envelope and required for chromatin organization, transcriptional regulation and m

290 at ancestral TBT exposure induces changes in chromatin organization transmissible through meiosis and

291 igger nuclear actin-dependent alterations in chromatin organization, uncovering a general cellular me

292 In mammals, chromatin organization undergoes drastic reprogramming a

293 ors investigate changes to transcription and chromatin organization upon stress and find that activat

294 believed to be a crucial player in bacterial chromatin organization via its DNA-bridging activity.

295 hain locus V(D)J recombination requires a 3D chromatin organization which permits widely distributed

296 combination (NAHR) are more prone to disrupt chromatin organization while processed pseudogenes can c

297 ok an independent and orthogonal analysis of chromatin organization with mouse pressure-overload mode

298 By associating variation in chromatin organization with mutations in SETD2, which en

299 asets provide insights into high-dimensional chromatin organization, yet introduce new computational

300 t structural and functional components of 3D chromatin organization, yet the relationship between the