ライフサイエンスコーパス: chromatin structure

1 s that reflects the corresponding changes in chromatin structure.

2 impaired host defense, while allowing proper chromatin structure.

3 epair in eukaryotes requires manipulation of chromatin structure.

4 nscription factors and molecules that change chromatin structure.

5 n, chromatin accessibility, and higher-order chromatin structure.

6 criptional modulation and spatial changes in chromatin structure.

7 ilitating protection through modification of chromatin structure.

8 and differentiation through organization of chromatin structure.

9 ranscription factor process overseeing local chromatin structure.

10 ranscriptome, proteome and three-dimensional chromatin structure.

11 rregular nucleosome spacing may affect local chromatin structure.

12 ionally modifying histones and/or remodeling chromatin structure.

13 along the genome with concurrent changes to chromatin structure.

14 ic nuclear mesh that can regulate interphase chromatin structure.

15 endent changes in the composition of nascent chromatin structure.

16 tion that necessitates epigenomic changes in chromatin structure.

17 bly, dissociating prior to the maturation of chromatin structure.

18 lication and is facilitated by a decondensed chromatin structure.

19 using Shannon's entropy, associating it with chromatin structure.

20 egulation of genes involved in apoptosis and chromatin structure.

21 e these data with high-resolution maps of 3D chromatin structure.

22 gulator of cat-3 expression by affecting its chromatin structure.

23 es for modeling and visualizing higher order chromatin structure.

24 chromosomes to regulate gene expression and chromatin structure.

25 he molecular mechanisms whereby HMGNs affect chromatin structure.

26 er interactions and topology of higher-order chromatin structure.

27 at regulates gene expression by modifying 3D chromatin structure.

28 operative manner to form a stable repressive chromatin structure.

29 er-relationships between DNA methylation and chromatin structure.

30 t the promoter, suggesting they might affect chromatin structure.

31 esult, activates gene expression by altering chromatin structure.

32 lex patterns of viral gene transcription and chromatin structure.

33 gene expression through organization of the chromatin structure.

34 pha3 helix play organismal roles in defining chromatin structure.

35 tral role in gene regulation by manipulating chromatin structure.

36 ole of transcription in the establishment of chromatin structure.

37 g sister chromatid cohesion and higher-order chromatin structure.

38 ng complexes, and disruption of higher-order chromatin structure.

39 o the functional stability of a higher-order chromatin structure.

40 the nucleosome and epigenetic marks on local chromatin structure.

41 leosome remodelling and modulation of the 3D chromatin structure.

42 n topologically engage chromatin to regulate chromatin structure.

43 ns play critical roles in adaptive tuning of chromatin structures.

44 nomic enhancers confined within these static chromatin structures.

45 pecific interactions in dynamic higher-order chromatin structures.

46 ich is critical for stabilizing higher-order chromatin structures.

47 which are the key components of higher-order chromatin structures.

48 lding features without altering higher-order chromatin structures.

49 ays of nucleosomes to fold into more compact chromatin structures.

50 ave critical roles in organizing large-scale chromatin structures(3,5,6).

51 Here we report the dynamics of 3D chromatin structure across a time course of estradiol (E

52 rtant for gene regulation, and studies of 3D chromatin structure across species and cell types have i

53 Chromatin structure affects DNA replication patterns, bu

54 esin, which suggests that the maintenance of chromatin structure after DNA breakage involves basic me

55 hromatin marks, and reveal that higher-order chromatin structure after fertilization coincides with a

56 n to reveal that epigenetic modifications of chromatin structure also have a major influence on the s

57 by numerous mechanisms, including modifying chromatin structure and altering the function of chromat

58 sis using a restriction enzyme as a probe of chromatin structure and as a proxy for transcription fac

59 rated to explore the role of this protein in chromatin structure and cardiac phenotype.

60 use fibroblasts induces abnormal large-scale chromatin structure and chromosome instability.

61 's chromatin association, thereby modulating chromatin structure and coordinating gene expression in

62 Higher-order chromatin structure and DNA methylation are implicated i

63 Genes encoding proteins that regulate chromatin structure and DNA modifications [i.e., chromat

64 scape of histone modifications, and modulate chromatin structure and dynamics and thereby crucially r

65 In vitro, we study how higher-order chromatin structure and dynamics change during cell diff

66 er communication (EPC); however, the role of chromatin structure and dynamics in this process remains

67 introduce a computational model to simulate chromatin structure and dynamics.

68 ows the study of cell-to-cell variability in chromatin structure and dynamics.

69 l networks and analytical tools to interpret chromatin structure and dynamics.

70 ategy to illuminate the interplay between 3D chromatin structure and epigenetic dynamics.

71 the most outstanding scientists studying how chromatin structure and epigenetic mechanisms regulate g

72 Bub), a modification that broadly influences chromatin structure and eukaryotic transcription.

73 ing of the basic biology and biochemistry of chromatin structure and function at genome scales has le

74 mentally induced epigenetic dysregulation of chromatin structure and function in neocortical GABAergi

75 that are driving toward an understanding of chromatin structure and function, from the nanometer to

76 bind specifically to nucleosomes and affect chromatin structure and function, including transcriptio

77 isk, as well as the functional regulation of chromatin structure and function, we create a catalog of

78 ations in CRFs and how these influence tumor chromatin structure and function, which in turn leads to

79 tions (PTMs) that cooperatively modulate the chromatin structure and function.

80 alized histone variants promotes altering of chromatin structure and function.

81 al modifications (PTMs) of histones regulate chromatin structure and function.

82 has been instrumental to our current view of chromatin structure and function.

83 riants can replace core histones to regulate chromatin structure and function.

84 fies histones in vivo and induces changes in chromatin structure and function.

85 ely charged H4 histone tail is important for chromatin structure and function.

86 able, but its mechanistic role in modulating chromatin structure and functions remains unknown.

87 Histone acetylation regulates chromatin structure and gene expression and is removed b

88 for 6mA in modulating three-dimensional (3D) chromatin structure and gene expression in this divergen

89 e neurons contributes to its local impact on chromatin structure and gene expression.

90 ested to play key roles in the regulation of chromatin structure and gene expression.

91 d histone modifications and their impacts on chromatin structure and gene expression.

92 ven leukemogenesis is mediated by changes in chromatin structure and gene expression.

93 Thus, vitamin D directly affects chromatin structure and gene regulation at thousands of

94 Histones are essential elements of chromatin structure and gene regulation in eukaryotes.

95 carboxy-terminal domain (H1 CTD) influences chromatin structure and gene regulation remain unclear.

96 siae to investigate the influence of Nap1 on chromatin structure and histone dynamics during distinct

97 is essential to the maintenance of telomere chromatin structure and integrity.

98 vates gene transcription by influencing both chromatin structure and interplay with nonhistone protei

99 Histone methylation regulates chromatin structure and is implicated in DNA repair.

100 nd reported here extend our understanding of chromatin structure and its potential roles in gene regu

101 and tissue repertoires of RNA transcription, chromatin structure and modification, DNA methylation, c

102 PH vascular cells is perpetuated by an open chromatin structure and multiple transcription factors (

103 skewing towards an inflammatory state, with chromatin structure and phenotype typical of WNT transcr

104 st-translational modification that regulates chromatin structure and plays an important role in gene

105 vators and repressors and include studies on chromatin structure and post-translational modifications

106 The RSC complex remodels chromatin structure and regulates gene transcription.

107 ranscriptional regulation, determined by the chromatin structure and regulatory elements interacting

108 emarkable tolerance for major disruptions in chromatin structure and reveal a role for Suv39h2 in dep

109 xperience is integrated at the level of both chromatin structure and synaptic physiology.

110 luripotent stem cell-derived neurons altered chromatin structure and that these effects could be bloc

111 We investigated the relationship between chromatin structure and thymine DNA glycosylase (TDG) us

112 he mechanisms underlying context-specific 3D chromatin structure and transcription during cellular di

113 rotein 4 (BRD4) is an important regulator of chromatin structure and transcription, yet factors modul

114 ear enzyme involved in the regulation of the chromatin structure and transcription.

115 l groups has a key role in the regulation of chromatin structure and transcription.

116 control of alternative pre-mRNA splicing by chromatin structure and transcriptional elongation.

117 these enzymes likely lead to differences in chromatin structure and, thereby, transcriptional contro

118 uman erythroblasts and found that, globally, chromatin structures and compartments A/B are highly sim

119 egulators that bind to nucleosomes and alter chromatin structures and dynamics.

120 c modifications and their relationships with chromatin structures and gene expression.

121 fully Bayesian method to infer ensembles of chromatin structures and to determine the optimal number

122 lex involved in gene repression and telomere chromatin structure, and a DAXX-SETDB1-KAP1-HDAC1 comple

123 R, comparable rates of ICL/R, more condensed chromatin structure, and higher sensitivity than LR5 cel

124 Nucleolar morphology is controlled by chromatin structure, and the high levels of euchromatic

125 ribute to the cell-cycle slowing, changes in chromatin structure, and the onset of transcription asso

126 different inheritance patterns, time scales, chromatin structures, and environmental exposures, all o

127 ossible effects of the H4 tail compaction on chromatin structure are discussed within a qualitative m

128 Mechanisms by which higher order chromatin structures are established and maintained are

129 to recent in situ Hi-C data, we found the 3D chromatin structures are highly conserved across various

130 required to sustain these complex interphase chromatin structures are unknown.

131 cleosome-enriched signals, learns the unique chromatin structure around accessible regions, and then

132 ing of transcription factors associated with chromatin structure around methyl-valleys.

133 compaction and fragmentation of higher-order chromatin structure as an enabling characteristic in ear

134 expression, transcription factor binding and chromatin structure as cells differentiate.

135 ethylation quantitative trait loci influence chromatin structure, as well as RNA and protein abundanc

136 tly with CBP, eRNAs contribute to the unique chromatin structure at active enhancers, which, in turn,

137 mains challenging to profile high-resolution chromatin structure at cis-regulatory elements (CREs).

138 etylation in orchestrating the remodeling of chromatin structure at DSBs to facilitate repair.

139 Chromatin structure at NSRs and NDRs was well maintained

140 extensively studied, less is known about the chromatin structure at pol III promoters in human cells.

141 d role for SFK activity in the regulation of chromatin structure at promoters in eukaryotic cells via

142 ping showed that ZL0580 induces a repressive chromatin structure at the HIV LTR.

143 Chromatin structure at the length scale encompassing loc

144 es, this model enables de novo prediction of chromatin structures at five-kilo-base resolution.

145 entromeres are defined by a self-propagating chromatin structure based on stable inheritance of CENP-

146 els, with little known about the dynamics of chromatin structure between these scales due to a lack o

147 ant life is accompanied by global changes in chromatin structure but only localized changes in DNA me

148 ent stabilization of higher order 'tertiary' chromatin structures but do not alter the intrinsic abil

149 tors that alter the epigenetic landscape and chromatin structure, but how HUSH recognizes target loci

150 mes to promote the formation of higher-order chromatin structure, but the underlying molecular detail

151 e a routine task to map epigenetic marks and chromatin structure by deep sequencing methods.

152 atment regimen can lead to remodeling of the chromatin structure by histone modifications and recruit

153 capture techniques allow us to characterize chromatin structure by mapping contacts between chromoso

154 It hydrolyses ATP to remodel chromatin structure by sliding and evicting histone octa

155 which reconstructs ensembles of single-cell chromatin structures by deconvolving Hi-C data and ident

156 Chromatin structure can also influence alternative splic

157 er understanding of how enzymatic changes in chromatin structure can modify the skin immune system an

158 For proper information output, higher-order chromatin structures can be regulated dynamically.

159 amage response and repair, transcription and chromatin structure, cell cycle and cell death, as well

160 inactivated by the assembly of a repressive chromatin structure composed of deacetylated histones.

161 omplex 1 (PRC1), which mediates higher-order chromatin structures, contributes little to gene repress

162 it is known that an epigenetic remodeling of chromatin structure controls developmental plasticity in

163 ey challenge is in understanding the role of chromatin structure (CS) in cellular processes and its i

164 Analysis of higher-order chromatin structure data and RNA polymerase II ChIA-PET

165 s, frogs, fish and mice - have revealed that chromatin structure, dedicated enhancers and transcripti

166 These alterations in chromatin structure directly resulted in up-regulated ge

167 on that warrants inheritance of a repressive chromatin structure during cell division, thereby assuri

168 cancer, the in-situ higher-order folding of chromatin structure during malignant transformation rema

169 ling and might be crucial for transitions in chromatin structure during reprogramming.

170 of nucleosome-free DNA regions can modulate chromatin structure/dynamics and, in turn, affect the ra

171 h gradient-seq provides a genome-wide map of chromatin structure, elucidating subtypes of repressed d

172 ges and cardiomyocytes, with dynamic data on chromatin structure, epigenetics and transcription facto

173 blished many seminal papers in the fields of chromatin structure, epigenetics, and regulation of tran

174 uclei can impair nuclear integrity and alter chromatin structure, especially in fragile cells such as

175 factors but also dependent on the underlying chromatin structure, especially on covalent histone modi

176 ates to genetic (DNA motifs) and epigenetic (chromatin structure) features of the genome.

177 s represent an important class of regulatory chromatin structures for the spatiotemporal control of t

178 tilization triggers assembly of higher-order chromatin structure from a condensed maternal and a naiv

179 that differentiates the special centromeric chromatin structures from bulk nucleosomes.

180 ing multiple RNA classes, thereby regulating chromatin structure, gene expression and differentiation

181 ylation (DNAm) has been linked to changes in chromatin structure, gene expression and disease.

182 ly associating domains (TADs) contributes to chromatin structure, gene expression and recombination.

183 roles of these interactions in regulation of chromatin structure, gene expression, RNA processing, an

184 ion to regulate gene expression by affecting chromatin structure, gene transcription, pre-mRNA proces

185 DNA sequence, despite the huge disruption to chromatin structure generated by unwinding the parental

186 c chromatin contact domains and identify how chromatin structure guides precise expression of multipl

187 Once a permissive chromatin structure has assembled, transgene expression

188 ported in 1997, the available information on chromatin structure has increased very rapidly.

189 technologies originally designed to capture chromatin structure have been shown to effectively compl

190 he newly identified principles of endogenous chromatin structure have key implications for epigenetic

191 The three distinct chromatin structures identified in this work define uniq

192 ons in biology education and the study of 3D chromatin structure; (ii) expanded public data hubs, inc

193 DNA replication, indicative of a decondensed chromatin structure in all regions of the replicating ge

194 e associated with albinism, we described the chromatin structure in cells at two distinct transcripti

195 Here we use ATAC-seq to profile the chromatin structure in four distinct populations of cell

196 l for investigating the role of higher-order chromatin structure in gene regulation.

197 -Seq) has been utilized to study genome-wide chromatin structure in human cancer cell lines, yet nume

198 t CNVs may repress recombination by altering chromatin structure in meiosis.

199 vide a model system for studying the role of chromatin structure in modulating alternative splicing d

200 Comparison of chromatin structure in normal and H1-depleted CD8(+) T c

201 pothesize that this is due to alterations of chromatin structure in PH cells, resulting in functional

202 ow that H2A.B KO males have globally altered chromatin structure in postmeiotic germ cells.

203 cocaine dependence through alterations in 3D chromatin structure in the caudate nucleus.

204 ich reinforces a notion of a central role of chromatin structure in the regulation of cellular DDR re

205 However, the re-organization of 3D chromatin structure in this process remains poorly under

206 he utricle correlates with a more accessible chromatin structure in utricle supporting cells compared

207 We have recently shown that altered chromatin structure in yeast induces respiration by a me

208 its RGG domain to regulate human interphase chromatin structures in a transcription-dependent manner

209 ased studies have indicated higher levels of chromatin structures including compartments and topologi

210 This globally altered chromatin structure increased the expression of genes en

211 Both DNA-binding proteins and changes in chromatin structure influence the positioning of genes a

212 optical density of the nucleus, and how the chromatin structure influences on these biophysical valu

213 By overlaying chromatin structure information and gene expression data

214 The modulation of chromatin structure is a key step in transcription regul

215 Regulation of chromatin structure is critical for brain development an

216 Chromatin structure is dynamically reorganized at multip

217 The integrity of the chromatin structure is essential to every process occurr

218 tent cells, suggesting that lineage-specific chromatin structure is established in tissue progenitor

219 Open chromatin structure is important for DNA damage response

220 The role for other effects on chromatin structure is less understood.

221 to excise 5fC from DNA, indicating that the chromatin structure is likely a key determinant of wheth

222 ionship between active DNA demethylation and chromatin structure is often implied, direct experimenta

223 Chromatin structure is tightly intertwined with transcri

224 In order to determine the role of SV40 chromatin structure late in infection, we mapped the loc

225 rol module governed by a renal cell-specific chromatin structure located distal to Cyp27b1 that media

226 male mammals adopts an atypical higher-order chromatin structure, manifested as a global loss of loca

227 vation in intergenic regions suggesting that chromatin structure may affect mutation rate.

228 hermophila and suggest that the higher-order chromatin structures may play important roles during the

229 , Viets et al. (2019) show that proteins and chromatin structure mediate pairing and argue against a

230 e that the nucleosome spacing and associated chromatin structure modulations may play an important ro

231 shows that only two features of pre-existing chromatin structure-namely, cohesin binding and transcri

232 cations have been associated with changes in chromatin structure necessary for transcription, replica

233 tures and compare them to recently published chromatin structures obtained through microscopy.

234 The chromatin structure of a CHE-1 target locus is less comp

235 The chromatin structure of DNA determines genome compaction

236 analysis to show substantial differences in chromatin structure of pol II and pol III promoters, and

237 Our results indicate that the preformed chromatin structure of the Shh locus is sustained by mul

238 d transcription factors indicated changes in chromatin structure, offering clues to the observed phen

239 To better understand the impact of chromatin structure on regulation of the prostate cancer

240 igenetic features associated with high-order chromatin structure, opening new directions in the study

241 e gene expression in cis by modulating local chromatin structure, or in trans via transcripts derived

242 rmational dynamics within the nucleosome and chromatin structure play a key role in this regulatory f

243 Alterations in chromatin structure play a major role in the epigenetic

244 hromatin throughout their life cycles, since chromatin structure plays a major role in the regulation

245 Chromatin structure plays a pivotal role in facilitating

246 Although chromatin structure plays a substantial role in controll

247 ing proteins and can also involve changes in chromatin structure, potentially through nongenetic mech

248 ctive patterns in transcriptional abundance, chromatin structure, promoter shape, and sequence contex

249 st that Pol III transcription is involved in chromatin structure re-organization during the onset of

250 Simulated chromatin structures recapitulate known features of geno

251 first direct evidence that the higher order chromatin structure regulates active DNA demethylation t

252 istone post-translational modifications, and chromatin structure regulation, are critical for the int

253 romatin remodelling complex, are critical in chromatin structure regulation.

254 nique mechanical properties to their cognate chromatin structures remains elusive.

255 f BFT on other epigenetic processes, such as chromatin structure, remains unexplored.

256 ncreased presence of the nucleosome-evicting chromatin structure remodeling (RSC) complex, and are en

257 er and known to regulate oncogenesis through chromatin structure remodeling and controlling protein a

258 gnal is necessary to complete the changes in chromatin structure required for gene expression to occu

259 uced ERK activation initiates the changes in chromatin structure required for viral reactivation but

260 In the absence of H2Bub1, incomplete chromatin structures resulted in several replication def

261 Enzymatic probes of chromatin structure reveal accessible versus inaccessibl

262 analyze the fluctuation and heterogeneity of chromatin structures revealed by single-cell imaging and

263 ylation in response to both viruses regulate chromatin structure, RNA metabolism, and cell adhesion,

264 rticular Hi-C, have generated new details of chromatin structure, spawning a number of novel biologic

265 nd allows a detailed analysis of alternative chromatin structure states.

266 enes are significantly enriched for bivalent chromatin structure, suggesting this configuration may i

267 We also find that the chromatin structure surrounding the androgen receptor (A

268 ires an integrated understanding of telomere chromatin structure (telosomes), telomeric origins of re

269 w gene expression is controlled by examining chromatin structure, TFs and epigenetic regulators assoc

270 ion, small RNAs, chromatin modifications and chromatin structure that accompany reproductive developm

271 t unintegrated HIV-1 DNA adopts a repressive chromatin structure that competes with the transcription

272 ults revealed an AR-ERG-centric higher-order chromatin structure that drives coordinated gene express

273 Heterochromatin is a distinctive chromatin structure that is essential for chromosome seg

274 progenitor cells displayed global changes in chromatin structure that likely hindered effective dista

275 uisites for further assembly of higher-order chromatin structures that are refractory to transcriptio

276 Telomeres are specialized chromatin structures that protect chromosome ends from d

277 BRCA1 to postdamage nuclear foci, and these chromatin structures then restrict the amplitude of BRCA

278 ruit methyl-CpG binding proteins that affect chromatin structure through the activity of histone deac

279 Guided by chromatin structure, through the use of Chromosome Confo

280 ur data support a model where Bcd influences chromatin structure to gain access to concentration-sens

281 lecular function in establishing appropriate chromatin structure to regulate crucial NC stem-cell sig

282 demethylases, and result in modification of chromatin structure to repress or activate transcription

283 erentially to chromatin, where some regulate chromatin structure, transcription and RNA processing(1-

284 s modulation of plant hormone levels, and of chromatin structure, transcription, and translation.

285 egulatory mechanisms including modulation of chromatin structure, transcriptional activation and post

286 eins identified were involved in maintaining chromatin structure, transcriptional regulation, RNA pre

287 y, we review a polymer method to reconstruct chromatin structure using crosslinkers between chromatin

288 Modulation of chromatin structure via histone modification is a major

289 Dynamic regulation of chromatin structure via post translational modification

290 mutational burden is known to be coupled to chromatin structure, we examine how somatic mutations ar

291 ncer (Ealpha) is in an open and unmethylated chromatin structure well before activation.

292 ropose that the tDNAs primarily affect local chromatin structure, which results in effects on long-ra

293 F binding, the master regulator of mammalian chromatin structure, which, in turn, controls splicing i

294 SAF-A oligomerization decompacts large-scale chromatin structure while SAF-A loss or monomerization p

295 in histones controls the gene expression and chromatin structure with major health implications via a

296 leosomes and linker DNA to form higher order chromatin structures with distinct transcriptional outco

297 with the disruption and re-establishment of chromatin structure within a cell cycle remains largely

298 technology to test this model by determining chromatin structure within cells at gene resolution has

299 isms responsible for alterations in gene and chromatin structure within skin immunocytes could provid

300 endent loop extrusion generates higher-order chromatin structures within the one-cell embryo.