ライフサイエンスコーパス: chromosomal aberration

1 patient-derived iPSCs devoid of the original chromosomal aberration.

2 phomas display remarkably elevated levels of chromosomal aberrations.

3 e the incidence of sperm carrying structural chromosomal aberrations.

4 gene expression, independent of the specific chromosomal aberrations.

5 ckpoint arrest mechanisms and yield of gross chromosomal aberrations.

6 ion of translocation breakpoints and related chromosomal aberrations.

7 very short telomeres and very high rates of chromosomal aberrations.

8 icant increase in ionizing radiation-induced chromosomal aberrations.

9 ic chromosomal elements required for complex chromosomal aberrations.

10 nderstanding disease conditions that involve chromosomal aberrations.

11 very unfaithful DSB repair mechanism causing chromosomal aberrations.

12 utants and accumulated significantly greater chromosomal aberrations.

13 s and lead to the generation of a variety of chromosomal aberrations.

14 ing high-throughput genome-wide scanning for chromosomal aberrations.

15 -CGH is a powerful tool for the detection of chromosomal aberrations.

16 le method for characterizing a wide range of chromosomal aberrations.

17 Pot1a deficient cells resulted in increased chromosomal aberrations.

18 nd exhibit an increased incidence of induced chromosomal aberrations.

19 mors, respectively, alongside characteristic chromosomal aberrations.

20 HNSCC contains a complex pattern of chromosomal aberrations.

21 he tumors shows that the tumors have various chromosomal aberrations.

22 NA replication forks, engendering structural chromosomal aberrations.

23 identify chromosomal instability and clonal chromosomal aberrations.

24 lting in impaired HR and the accumulation of chromosomal aberrations.

25 excision repair, thus increasing the risk of chromosomal aberrations.

26 uding excessive homologous recombination and chromosomal aberrations.

27 reaks have an increased level of spontaneous chromosomal aberrations.

28 se to ICRF-193 displayed a high incidence of chromosomal aberrations.

29 ls homozygous for BRCA2 inactivation display chromosomal aberrations.

30 ed decreased growth, cytopathic effects, and chromosomal aberrations.

31 helial tumors from surviving cells that have chromosomal aberrations.

32 1, markers of cytolytic activity, and fewer chromosomal aberrations.

33 t no significant differences in all analyzed chromosomal aberrations.

34 ncreased micronuclei formation and numerical chromosomal aberrations.

35 mic damage, including repeat instability and chromosomal aberrations.

36 fication, used to identify known and unknown chromosomal aberrations.

37 duced ability to form cell-cell contacts and chromosomal aberrations.

38 resulted in double-strand breaks (DSBs) and chromosomal aberrations.

39 ilable gene expression profiles to determine chromosomal aberrations.

40 d apoptosis, and facilitated accumulation of chromosomal aberrations.

41 tid exchanges, replication origin firing and chromosomal aberrations.

42 ssion, resulting in extensive DNA damage and chromosomal aberrations.

43 vated levels of methylation-induced DSBs and chromosomal aberrations.

44 l assays for detection of gene mutations and chromosomal aberrations.

45 emia and were associated with multiple major chromosomal aberrations.

46 chronic injury that promotes DNA damage and chromosomal aberrations.

47 a result of an accumulation of mutations and chromosomal aberrations.

48 age, rendering the cells more susceptible to chromosomal aberrations.

49 ndent growth, focus formation, invasion, and chromosomal aberrations.

50 h poor prognosis harbored significantly more chromosomal aberrations (13.9 per case; P = 0.008).

51 d levels of sister chromatid exchange, gross chromosomal aberrations, 53BP1 foci, and micronuclei.

52 Some chromosomal aberrations (+7p/q, -9p, -10q, -13q, +19q) w

53 reover, HMGA2 alone was sufficient to induce chromosomal aberrations, a hallmark of deficiency in NHE

54 The chromosomal aberrations account for substantial changes

55 Mining this resource, we find that most chromosomal aberrations accumulate late during breast tu

56 otent stem cells (hPSCs) are known to harbor chromosomal aberrations, affecting their tumorigenic pot

57 heckpoint, decreased survival, and increased chromosomal aberrations after DNA damage.

58 ed frequencies of zygotes with sperm-derived chromosomal aberrations after matings with wild-type mal

59 ntiated the cell death response and enhanced chromosomal aberrations after PhIP treatment, while ATM

60 showed decreased cell survival and increased chromosomal aberrations after radiation exposure indicat

61 manifest by decreased cellular survival and chromosomal aberrations after such treatment.

62 We propose that DSBs and chromosomal aberrations after treatment with N-alkylator

63 47,XXY and its variants, is the most common chromosomal aberration among men, with estimated frequen

64 ic induction of Rsf-1 expression resulted in chromosomal aberration and clonal selection for cells wi

65 I(-/-) MEFs display increased frequencies of chromosomal aberration and micronuclei formation and exh

66 genes in AML has been attributed to specific chromosomal aberrations and abnormalities involving mixe

67 ined olaparib/AZD6738 treatment induces more chromosomal aberrations and achieves this at lower conce

68 osome instability as evidenced by structural chromosomal aberrations and aneuploidy, yet they display

69 ations of this pathway could result in gross chromosomal aberrations and aneuploidy.

70 ient animals exhibit genomic instability and chromosomal aberrations and are prone to tumorigenesis.

71 Spectral karyotyping data showed several chromosomal aberrations and array comparative genomic hy

72 ne the search for candidate genes underlying chromosomal aberrations and assist in the definition of

73 Translocations are a common class of chromosomal aberrations and can cause disease by physica

74 eptual framework for the connections between chromosomal aberrations and cancer.

75 pment of acute myeloid leukaemia with common chromosomal aberrations and cell autonomous progression.

76 genome instability primarily in the form of chromosomal aberrations and confirms the central role of

77 In the absence of Bid, mice accumulate chromosomal aberrations and develop a fatal myeloprolife

78 ased levels of mitomycin C-inducible complex chromosomal aberrations and elevated gammaH2AX nuclear f

79 ficient for telomerase and WRN helicase show chromosomal aberrations and elevated recombination rates

80 Gene fusions are the result of chromosomal aberrations and encode chimeric RNA (fusion

81 Our data support a link between chromosomal aberrations and epigenetic mechanisms in GTS

82 ic fibroblast cells from increased number of chromosomal aberrations and fragments induced by BCR-ABL

83 ortalized lines exhibiting a small number of chromosomal aberrations and functionally normal p53.

84 he siTop1 cells is genomic instability, with chromosomal aberrations and histone gamma-H2AX foci asso

85 ion was established between the frequency of chromosomal aberrations and immune or human papillomavir

86 sion of the pol beta G231D variant increased chromosomal aberrations and induced cellular transformat

87 HGSC exhibits high rates of chromosomal aberrations and knowledge of causative mecha

88 ytogenetic profiles characterized by complex chromosomal aberrations and massive fragmentation.

89 prospective treatment trials, for secondary chromosomal aberrations and mutations in N-/KRAS, KIT, F

90 ccumulation of genomic abnormalities such as chromosomal aberrations and polyploidy.

91 pes of tumor cells lacking Brca2 had various chromosomal aberrations and ranged from diploid to hyper

92 of the BTB complex likely serves to prevent chromosomal aberrations and rearrangements.

93 As a result of this, chromosomal aberrations and single- and double-strand br

94 The 8q24 region is a gene desert, although chromosomal aberrations and somatic amplification involv

95 luorescence in situ hybridization to compare chromosomal aberrations and telomere shortening in non-d

96 d from HCV-infected patients showed frequent chromosomal aberrations and that HCV infection of B cell

97 SMYD5 depletion resulted in chromosomal aberrations and the formation of transformed

98 ultiple functional genomic datasets studying chromosomal aberrations and their downstream effects on

99 ivation of ALT and engenders cancer-relevant chromosomal aberrations and tumor formation.

100 instability, resulting in an accumulation of chromosomal aberrations and tyrosine kinase inhibitor-re

101 Cells lacking RAD17 exhibited acute chromosomal aberrations and underwent endoreduplication

102 have elevated levels of DNA damage, acquire chromosomal aberrations, and are hypersensitive to agent

103 on against cisplatin and mitomycin C-induced chromosomal aberrations, and both are necessary for the

104 accumulation of BER intermediate substrates, chromosomal aberrations, and cellular transformation.

105 ith restored cell cycle progression, reduced chromosomal aberrations, and enhanced DNA damage toleran

106 s together with clinical prognostic factors, chromosomal aberrations, and gene expression-based high-

107 comparative genomic hybridization to detect chromosomal aberrations, and GNAQ, GNA11, BRAF, NRAS, an

108 aphidicolin triggered increased cell death, chromosomal aberrations, and H2AX phosphorylation, a mar

109 tive damage, DNA adducts, DNA strand breaks, chromosomal aberrations, and heritable mutations in sper

110 to carcinomas, a subset feature large-scale chromosomal aberrations, and highly conserved molecular

111 tions, diagnostic yield for various types of chromosomal aberrations, and issues that affect test int

112 in a decreased rate of proliferation, fewer chromosomal aberrations, and suppression of Ras-induced

113 of function after SDRT yielded DSB unrepair, chromosomal aberrations, and tumor clonogen demise.

114 Furthermore, increased chromosomal aberrations, aneuploidy, and centrosome abno

115 Chromosomal aberrations are a hallmark of acute lymphobl

116 Chromosomal aberrations are a hallmark of human cancers,

117 Chromosomal aberrations are an important consequence of

118 These types of chromosomal aberrations are common in numerous human can

119 The consequences of these chromosomal aberrations are difficult to study in cancer

120 Aneuploidy and chromosomal aberrations are hallmarks of most human epit

121 Chromosomal aberrations are known to drive AML and are t

122 sides ultraviolet (UV)-indicative mutations, chromosomal aberrations are prominent.

123 Chromosomal aberrations as assessed by karyotyping were

124 NA single-strand breaks as well as increased chromosomal aberrations as compared with beta-pol(+/+) l

125 rug resistance was associated with increased chromosomal aberrations as shown by spectral karyotyping

126 tress also resulted in a higher frequency of chromosomal aberrations as well as defective replication

127 tudy emphasizes the impact of both secondary chromosomal aberrations as well as gene mutations for ou

128 ypified by numerous structural and numerical chromosomal aberrations as well as mutations in a number

129 recurrent patterns of occurrence of distinct chromosomal aberrations as well as their interrelationsh

130 he entire CASK locus, but contain additional chromosomal aberrations as well.

131 of spontaneous replication fork stalling and chromosomal aberrations, as well as fewer camptothecin (

132 The most frequent chromosomal aberrations associated with HSTCL are isochr

133 Chromosomal aberrations associated with lung cancer are

134 The goal of this study was to identify chromosomal aberrations associated with poor outcome in

135 To identify the chromosomal aberrations associated with the progression

136 By analyzing chromosomal aberrations at 7q21, we refined the minimal

137 ys provide reliable genotypes and can detect chromosomal aberrations at a high resolution.

138 tools for calling genotypes and identifying chromosomal aberrations at an order-of-magnitude greater

139 onic, unrepaired oxidative DNA damage caused chromosomal aberrations at remarkably high frequencies u

140 ell gene expression profiles with numbers of chromosomal aberrations (based on single-nucleotide poly

141 resent eSNP-Karyotyping for the detection of chromosomal aberrations, based on measuring the ratio of

142 is clinical phenotype and a de novo balanced chromosomal aberration (BCA).

143 neoplasms has revealed distinct patterns of chromosomal aberrations between benign melanocytic nevi

144 reas the vast majority of melanoma expresses chromosomal aberrations, blue nevi, congenital nevi, and

145 types, is only infrequently associated with chromosomal aberrations, but it was recently shown that

146 profiles can be utilized for the analysis of chromosomal aberrations by comparing gene expression lev

147 Chromosomal aberrations (CAs) in blood lymphocytes have

148 ring studies, mainly by studying (classical) chromosomal aberrations (CAs) or micronuclei (MN) as mar

149 es leads to genomic instability, spontaneous chromosomal aberrations, cell cycle defects, altered nuc

150 rmation of gamma-H2AX foci, micronuclei, and chromosomal aberrations (chromatid breaks and radials) r

151 d to 0.14 nmol/L C-1027, 92% of cells showed chromosomal aberrations compared with only 2.9% after tr

152 duced levels of methylation-induced DSBs and chromosomal aberrations compared with wild-type cells.

153 progamming efficiency and 2-fold decrease in chromosomal aberrations, compared to those in iPS cells

154 Some chromosomal aberrations completely derepress Scr even in

155 n also explain how the occurrence of certain chromosomal aberrations (copy number gain, LOH, and soma

156 log-defective cell lines exhibit spontaneous chromosomal aberrations, defective DNA repair, and reduc

157 uggest that the mechanism of GAA/TTC-induced chromosomal aberrations defined in yeast can also operat

158 The high-risk chromosomal aberrations del(17p13), t(4;14), and +1q21 a

159 risk of embryos with paternally transmitted chromosomal aberrations depends on the efficiency of mat

160 ities that might be expected from the severe chromosomal aberrations detected at the cellular level.

161 In conclusion, three of nine patients with chromosomal aberrations developed tumor recurrence or pr

162 the identification of multiple mutations and chromosomal aberrations driving the progression of myelo

163 wn to inhibit the synthesis of DNA and cause chromosomal aberrations due to inhibition of ribonucleot

164 c telomere dysfunction enhanced the rates of chromosomal aberrations during hepatocarcinogenesis, but

165 ial to contribute to genetic instability and chromosomal aberrations during tumor progression.

166 High-CK with >=5 chromosomal aberrations emerges as prognostically advers

167 ICL agents; 80136342 did not cause increased chromosomal aberrations, enhanced FANCD2 monoubiquitinat

168 e hematopoietic clone often characterized by chromosomal aberrations expands and outcompetes normal s

169 ysfunction as a plausible contributor to the chromosomal aberrations found in complex sarcomas.

170 on of ATR(ki) produced a 10-fold increase in chromosomal aberrations, further emphasizing the vital r

171 recessive genetic disorder characterized by chromosomal aberrations, genetic instability, and cancer

172 many previously unrecognized submicroscopic chromosomal aberrations (genomic disorders).

173 Similar chromosomal aberrations have been identified in the mono

174 Among prognostic markers reviewed, chromosomal aberrations have been validated and are curr

175 We summarized the total level of chromosomal aberration in a given tumor in a univariate

176 This study shows a pattern of chromosomal aberration in melanoma that is distinct from

177 One recurring chromosomal aberration in uterine leiomyomata is rearran

178 n summary, low-pass GS identified underlying chromosomal aberrations in 1 in 9 RM-affected couples, e

179 We use it to study chromosomal aberrations in 141 gliomas and compare the r

180 ple mutations, and up to 80% show additional chromosomal aberrations in a nonrandom pattern.

181 The finding of frequent numerical chromosomal aberrations in atypical nodular proliferatio

182 increased frequency of chromosomal aberrations in blood lymphocytes was signifi

183 of replication stress-induced DNA breaks and chromosomal aberrations in BRCA1/2-deficient cells.

184 The high level of spontaneous chromosomal aberrations in Brca2 mutant cells was largel

185 oviding the first comprehensive catalogue of chromosomal aberrations in cancer GEMMs.

186 s in Cancer (GISTIC), designed for analyzing chromosomal aberrations in cancer.

187 n significantly reduce the appearance of new chromosomal aberrations in cells lacking WRN, similar to

188 corneal fibroblasts identified age-dependent chromosomal aberrations in cells of older donors but not

189 Recent investigations of chromosomal aberrations in chronic lymphocytic leukemia

190 We investigated the susceptibility to chromosomal aberrations in chronic myelogenous leukemia

191 comparative genomic hybridization to analyze chromosomal aberrations in different types of proliferat

192 on of multiple networking genes by recurrent chromosomal aberrations in gliomas deregulates critical

193 ively little bias the presence and extent of chromosomal aberrations in human DNA.

194 In addition, these compounds cause chromosomal aberrations in humans and treated human cell

195 roach that detects multiple disease-specific chromosomal aberrations in interphase nuclei using combi

196 Frequent chromosomal aberrations in intracranial tumors were gain

197 ued the defects of DSB repair and alleviated chromosomal aberrations in Mcph1(-/-)p53(-/-) MEFs.

198 The high frequency of chromosomal aberrations in melanomas and their relative

199 l cycle, they manifested a spectrum of gross-chromosomal aberrations in mitosis.

200 11;18)(q21;q21) and aneuploidy are recurrent chromosomal aberrations in mucosa-associated lymphoid ti

201 Surprisingly, the ensuing chromosomal aberrations in p97-deficient cells are allev

202 inocyte hyperproliferation and appearance of chromosomal aberrations in premalignant cells, thereby i

203 ffect of MLH1 deficiency on the formation of chromosomal aberrations in response to cross-linking age

204 ying 109,000 and 317,000 SNP loci, to detect chromosomal aberrations in samples bearing constitutiona

205 Because chromosomal aberrations in sperm can arise from defectiv

206 The aim of this study was to analyze chromosomal aberrations in terms of frequency and impact

207 In humans, chromosomal aberrations in the DLX5/6 region, some of wh

208 uencing, we obtained a sequence-level map of chromosomal aberrations in the genome of the MCF-7 breas

209 ative Genomic Hybridization (CGH) can reveal chromosomal aberrations in the genomic DNA.

210 ve mature B-cell neoplasms reveals recurrent chromosomal aberrations in the majority of cases.

211 ction, linking chromosome end maintenance to chromosomal aberrations in this disease.

212 %, as well as significant induction of gross chromosomal aberrations in thyroidal TPC-1 cells followi

213 ulticolor FISH indicated that the structural chromosomal aberrations in tumor endothelial cells were

214 umors, and was associated with various other chromosomal aberrations including frequent loss of 22q.

215 somal analysis of these MSCs showed multiple chromosomal aberrations including fusion, fragmentation,

216 Nine of 23 patients showed chromosomal aberrations, including all 3 patients with t

217 Telomere-specific damage induces chromosomal aberrations, including chromatid telomere lo

218 Whereas chromosomal aberrations, including complicons, are usefu

219 Newly detected chromosomal aberrations, including somatic uniparental d

220 WRN results in replication abnormalities and chromosomal aberrations, indicating that WRN plays a rol

221 ve shown that FHIT is commonly the target of chromosomal aberrations involving the long arm of human

222 ith low-grade dysplasia displayed detectable chromosomal aberrations, IPMNs with moderate and high-gr

223 Risk association of chromosomal aberrations is not only a priori treatment d

224 thods for analyzing array-CGH data to detect chromosomal aberrations is very important for the diagno

225 e kinase inhibitors (TKIs) and/or additional chromosomal aberrations leading to disease relapse and/o

226 analyzed the prevalence and distribution of chromosomal aberrations leading to position effects (dis

227 001, regardless of CBP mutational status and chromosomal aberration, leads to eradication of drug-res

228 epress three classes of genetic alterations (chromosomal aberrations, loss of gene function and incre

229 ata suggest that sensitivity to BPDE-induced chromosomal aberrations may contribute to the risk of de

230 s in a cancer algorithm was used to identify chromosomal aberrations, MuTect and VarScan2 were used t

231 with childhood-onset melanoma had numerical chromosomal aberrations never observed in the adjacent C

232 FLCs contain mutations and chromosomal aberrations not previously associated with l

233 Chromosomal aberrations of MLL in acute leukemias are we

234 n cancer cells are characterized by numerous chromosomal aberrations of uncertain pathogenetic signif

235 ch invade more aggressively, exhibit various chromosomal aberrations on fragile regions, including th

236 BRCA2 prevents chromosomal aberrations on replication stalling, which a

237 ics approach to discover candidate oncogenic chromosomal aberrations on the basis of outlier gene exp

238 27 (96.2%) of the melanomas had some form of chromosomal aberration, only 7 (13.0%) of the benign nev

239 not repaired with high fidelity can lead to chromosomal aberrations or mitotic cell death.

240 Cytogenetic nomenclature is used to describe chromosomal aberrations (or lack thereof) in a collectio

241 al, which was associated with polyploidy and chromosomal aberrations (P < 0.001).

242 w acquisition of acute myeloid leukemia-type chromosomal aberrations, particularly involving the EVI1

243 developmental delay and autism-predisposing chromosomal aberration; pathogenesis of which may be med

244 loSCT in patient subgroups with nonfavorable chromosomal aberrations, patients older than 45 years, a

245 The chromosomal aberration patterns of the parental tumors w

246 terized noise per probe, and the severity of chromosomal aberrations per chromosomal region may vary

247 Two pregnancies, one with a chromosomal aberration predicted to be of unknown clinic

248 For allanalyzed chromosomal aberrations, progression-free survival (PFS)

249 ameliorates replication fork instability and chromosomal aberrations provoked by aldehyde-induced BRC

250 ced carcinogenesis by promoting formation of chromosomal aberrations, rather than simply by affecting

251 3 or REV7-depleted cells displayed increased chromosomal aberrations, residual DSBs and sites of HR r

252 may contribute to accumulation of secondary chromosomal aberrations responsible for CML relapse and

253 ccounting for the high levels of spontaneous chromosomal aberrations seen in BRCA2-defective cells.

254 It is revealing that many chromosomal aberrations, some associated with malignanci

255 BLM deficient cells accumulate extensive chromosomal aberrations stemming from dysfunctions in ho

256 aryotype (CK) defined by the presence of >=3 chromosomal aberrations (structural and/or numerical) id

257 Additionally, chromosomal aberration studies with the SATE prodrug in

258 potent stem cells (hPSCs) frequently acquire chromosomal aberrations such as aneuploidy in culture.

259 Cryptic chromosomal aberrations, such as regions of uniparental

260 Known genetic causes include chromosomal aberrations, such as the duplication of the

261 ls demonstrate unusually high frequencies of chromosomal aberrations, suggesting the involvement of c

262 d many consistent (clonal) along with unique chromosomal aberrations, suggesting the presence of chro

263 In 70-80% of cases, the chromosomal aberration t(2;5)(p23;q35) results in the ju

264 large-cell lymphomas with the characteristic chromosomal aberration t(2;5)(p23;q35).

265 Fusion genes are chromosomal aberrations that are found in many cancers a

266 e characterization of genes altered by gross chromosomal aberrations that cause human disease.

267 ouse cells in vivo may allow accumulation of chromosomal aberrations that could lead to tumorigenesis

268 fy associations between driver mutations and chromosomal aberrations that define two tumor clusters,

269 On the basis of the pattern of chromosomal aberrations that disrupt Scr gene silencing,

270 ique combination of numerical and structural chromosomal aberrations that globally influence mRNA and

271 sites of chromosome breaks, and to identify chromosomal aberrations that have not been detected with

272 that although telomere dysfunction provokes chromosomal aberrations that initiate carcinogenesis, te

273 Many cancers are characterized by chromosomal aberrations that may be predictive of diseas

274 sfunction as a mechanism driving the radical chromosomal aberrations that typify cancer genomes.

275 rcomas and lymphomas revealed aneuploidy and chromosomal aberrations that were absent in Trp53(515C/5

276 Of 272 recurrent chromosomal aberrations that were associated with gene-e

277 on intermediates reduces the accumulation of chromosomal aberrations that would otherwise occur as a

278 anslocations are among the most common human chromosomal aberrations, the constitutional t(11;22)(q23

279 lar systems analysis can be applied to other chromosomal aberrations to further our etiological under

280 CGH analysis revealed a recurrent pattern of chromosomal aberrations typical for HNSCC.

281 2 phases, and cells lacking CYREN accumulate chromosomal aberrations upon damage induction, specifica

282 Further analysis of chromosomal aberrations, using CGH and spectral karyotyp

283 owest observed effect level for induction of chromosomal aberrations was 0.85 microg/mL MMS and 1.40

284 In patients with adverse-risk chromosomal aberrations, we found no significant influen

285 Chromosomal aberrations were detected in 60% of the GSD

286 High frequencies of chromosomal aberrations were detected in spermatocytes w

287 Moreover, elevated levels of chromosomal aberrations were detected, including telomer

288 eam signaling intermediates was defined, and chromosomal aberrations were determined by single nucleo

289 Several chromosomal aberrations were examined as proof of concep

290 isons and confounding effects of stage, five chromosomal aberrations were significantly associated wi

291 The most frequent chromosomal aberrations were translocations involving MY

292 Most frequent chromosomal aberrations were trisomy 22 (18%) and trisom

293 Some breaks were manifested as chromosomal aberrations when the G2 checkpoint of CNDAC-

294 reprogramming efficiency, 4-fold increase in chromosomal aberrations, whereas overexpression of Delta

295 ation defects, hyperrecombination events and chromosomal aberrations, which are hallmarks of cancer.

296 y induce DNA double-strand breaks (DSBs) and chromosomal aberrations, which are thought to arise when

297 to malignancy without acquiring large-scale chromosomal aberrations, which is a phenomenon not repor

298 ata indicated that helical domain II induced chromosomal aberrations, which mimicked those induced by

299 an induce genomic instability with increased chromosomal aberrations, which ultimately leads to tumor

300 olycomb group proteins, is disrupted by most chromosomal aberrations within the Scr gene.