ライフサイエンスコーパス: chromosomal break

1 outside of the primary nucleus and augments chromosomal breaks.

2 the affected sisters for hypersensitivity to chromosomal breaks.

3 d in survival of stationary-phase cells with chromosomal breaks.

4 Cells defective in NHEJ are unable to join chromosomal breaks.

5 decrease in the frequency of S mutations and chromosomal breaks.

6 (immunoglobulin heavy chain, encoded by Igh) chromosomal breaks.

7 the paucity of such templates for repair of chromosomal breaks.

8 ts following the formation of double-strand, chromosomal breaks.

9 ocytes, despite evidence for the presence of chromosomal breaks.

10 may play an important role in the repair of chromosomal breaks.

11 or endogenous retroelements in the repair of chromosomal breaks.

12 tion of homologous recombination at sites of chromosomal breaks.

13 s have the potential to become single-strand chromosomal breaks, a form of DNA damage, if they are ex

14 and (iii) exhibit an increased frequency of chromosomal breaks after IR treatment.

15 Anaphase bridges typically develop after chromosomal breaks and alterations of chromosomal struct

16 BLAP18/RMI2-depleted cells show spontaneous chromosomal breaks and are sensitive to methyl methanesu

17 elayed DNA break repair kinetics, persistent chromosomal breaks and cytogenetic profiles characterize

18 rom FA patients display elevated spontaneous chromosomal breaks and deletions and are hypersensitive

19 in S phase or are slow to replicate, and the chromosomal breaks and gaps observed in metaphase cells

20 sigma expression showed increased number of chromosomal breaks and gaps when exposed to gamma-irradi

21 ed DNA elimination encompasses high-fidelity chromosomal breaks and loss of specific genome sequences

22 It preferentially interacts with chromosomal breaks and protects DNA ends from nuclease a

23 best explained by a single event of multiple chromosomal breaks and random reassembly.

24 ells taken from patients exhibit spontaneous chromosomal breaks and rearrangements.

25 fection of B cells in vitro induced enhanced chromosomal breaks and sister chromatid exchanges.

26 duced cytidine deaminase-dependent IgH locus chromosomal breaks and translocations and were more pron

27 veral-magnitude increase in the frequency of chromosomal breaks and translocations in normal human ce

28 frequently generate AID-dependent IgH locus chromosomal breaks and translocations.

29 hereby preventing DSBs from progressing into chromosomal breaks and translocations.

30 resulting in a several-magnitude increase in chromosomal breaks and translocations.

31 g cancer cells, is more active at generating chromosomal breaks, and displays improved cellular uptak

32 MEF cells showed aneuploidy and polyploidy, chromosomal breaks, and fusions.

33 ted cell viability and increased DNA damage, chromosomal breaks, and mitotic catastrophe compared wit

34 healthy men, (a) sperm carrying postmeiotic chromosomal breaks appear to be more prevalent than thos

35 ation conditions, DNA-PKcs(-/-) B cells with chromosomal breaks are eliminated or at least prevented

36 double-strand break repair and precipitated chromosomal breaks as well as aneuploidy in primary hete

37 transformation, including etoposide-induced chromosomal breaks at the MLL and RUNX1 loci.

38 In contrast to chromosomal breaks, ATM activation is not amplified by H

39 ge-scale state transitions (LST), defined as chromosomal break between adjacent regions of at least 1

40 d the spectrum of repair events at a defined chromosomal break by using direct physical analysis of r

41 BRCA2 mutations for their ability to repair chromosomal breaks by homologous recombination.

42 RT or the RT domain of PEs in the repair of chromosomal breaks, calling for evaluation of the long-t

43 We have determined that RAG-generated chromosomal breaks can be repaired by pathways other tha

44 These chromosomal breaks can kill the cell unless repaired eff

45 Chromosomal breaks commonly affected the paternal genome

46 ted DNA transposons and the possibly related chromosomal breaks could cause changes by inducing trans

47 ister chromatid exchanges (SCEs), as well as chromosomal breaks, deletions, and rearrangements.

48 esis associated with repair of double-strand chromosomal breaks (DSBs) by homologous recombination is

49 of homing events resolve within 50 bp of the chromosomal break, enabling rapid gene drive transfer in

50 tivity to CTNAs, accumulate more DNA damage (chromosomal breaks, gamma-H2AX and neutral comets) when

51 iolet and ionizing radiation and to a single chromosomal break generated by I-SceI endonuclease.

52 forks, S-phase cell cycle arrest, increased chromosomal breaks, hypersensitivity to genotoxic agents

53 mmon in B-cell lymphomas and frequently have chromosomal breaks in immunoglobulin heavy chain (IgH) s

54 NO also induces double-stranded chromosomal breaks in replication-arrested Salmonella la

55 enetic studies revealed euploidy and limited chromosomal breaks in these lymphoid cells.

56 trongest evidence to date that AID initiates chromosomal breaks in translocations that occur in human

57 rganism; the other requires NHEJ of a single chromosomal break induced either by HO endonuclease or t

58 Repair of chromosomal breaks is essential for cellular viability,

59 germination but that the repair of cytotoxic chromosomal breaks is the most important for seed longev

60 e dicentric, suggesting that the location of chromosomal breaks leading to their formation occur in t

61 RNF168 promotes chromosomal break localization of 53BP1 and BRCA1; 53BP1

62 ll as complex CA outcomes, influenced by the chromosomal break location.

63 ts suggest that binding of the Ku complex at chromosomal breaks may be necessary to maintain the slid

64 ure to open DNA hairpins and accumulation of chromosomal breaks may reduce the proliferation and viab

65 Chromosomal breaks occur spontaneously as a result of no

66 To study the effects of chromosomal breaks on frequency of homologous recombinat

67 process responsible for inducing the primary chromosomal breaks only appears to occur during the init

68 even in untreated cycling cells, occasional chromosomal breaks or telomere-telomere fusions trigger

69 Plasmids expressing 67RuvC induce chromosomal breaks, probably as a consequence of replica

70 om junctions derived from repair at a single chromosomal break, providing mechanistic insight into tr

71 al abnormalities in the form of chromatid or chromosomal breaks, radial formation, and telomeric DNA

72 ased procedures for simultaneously detecting chromosomal breaks, rearrangements, and numerical abnorm

73 t sequencing analyses of CSR junctions and a chromosomal break repair assay indicated an impaired abi

74 with fibroblasts from unaffected daughters, chromosomal break repair was deficient in fibroblasts fr

75 the tetratricopeptide repeat factor XAB2 on chromosomal break repair, and found that XAB2 promotes e

76 Multimeric cDNA arrays probably arise during chromosomal break repair, since their appearance was str

77 ent cells are defective in homology-directed chromosomal break repair.

78 168 promotes BRCA1 and 53BP1 localization to chromosomal breaks, RNF168 affects HR similarly to 53BP1

79 of HR, the NHEJ pathway rapidly mutates the chromosomal break site.

80 response is due in part to the presence of a chromosomal break that occurs in a gene that encodes a n

81 that this block can trigger aging by causing chromosomal breaks, the repair of which results in the g

82 processes during gene conversion at a single chromosomal break, we monitored mating-type switching in

83 he introns can be used to introduce targeted chromosomal breaks, which can be repaired by transformat

84 tients were susceptible to gamma-ray-induced chromosomal breaks, which may be influenced by genetic v

85 ons and deletions of 1pter and 1cen, and (2) chromosomal breaks within the 1cen-1q12 region.