ライフサイエンスコーパス: chromosomal breakage

1 dification increases S phase progression and chromosomal breakage.

2 ch NHEJ events can be selected after precise chromosomal breakage.

3 e telomeric bridges to form, with subsequent chromosomal breakage.

4 ays that facilitate cell survival and reduce chromosomal breakage.

5 rradiation and enhanced radiosensitivity and chromosomal breakage.

6 week hepatocytes were aneuploid, and 32% had chromosomal breakage.

7 uctures that stall DNA replication and cause chromosomal breakage.

8 acterized by microcephaly, short stature and chromosomal breakage.

9 -DNA plays a role in the generation of these chromosomal breakages.

10 re alive and well with resolution of earlier chromosomal breakage abnormalities in peripheral blood l

11 ivity and the S-phase checkpoint and reduced chromosomal breakage after irradiation in AT cells.

12 GGT+ population had a 28 +/- 5% incidence of chromosomal breakage and a 17 +/- 5% incidence of chromo

13 demonstrate that CIN in terms of ICL-induced chromosomal breakage and defective chromatid cohesion is

14 In plants and animals, chromosomal breakage and fusion events based on conserve

15 a modest but noticeable decrease in induced chromosomal breakage and interchange frequencies, sugges

16 l cycle-regulated nuclease, markedly limited chromosomal breakage and led to further accumulation of

17 d2(-/-) mice displayed a higher magnitude of chromosomal breakage and micronucleus formation than the

18 DNA in both Ascaris and Parascaris, ensuring chromosomal breakage and providing a fail-safe mechanism

19 Common fragile sites (CFSs) are hot spots of chromosomal breakage, and CFS breakage models involve pe

20 icient mice revealed aneuploidy, spontaneous chromosomal breakage, and frequent translocation events.

21 dren show signs of growth failure, increased chromosomal breakage, and NK cell deficiency.

22 tion fork restart, and enhancing DNA damage, chromosomal breakage, apoptosis, and replication stress.

23 autosomal recessive disease associated with chromosomal breakage as well as pancytopenia, skin pigme

24 In chromosomal breakage assays, all control cells were mito

25 Common fragile sites predispose to specific chromosomal breakage associated with deletion, amplifica

26 te, acetaldehyde, associated with widespread chromosomal breakage at a concentration not producing br

27 supraphysiological RNR activity and reduced chromosomal breakage at fragile sites.

28 somes in a specific genetic background cause chromosomal breakage at heterochromatic knob sites durin

29 DNA cross-links is the main cause of DSB and chromosomal breakage at low and moderate Cr(VI) doses.

30 nd are indicative of replication pausing and chromosomal breakage at the accompanying fragile sites.

31 chromosome 16p13.1-p13.3, suggesting that a chromosomal breakage between Nubp2 and Nubp1 probably oc

32 s in single-stranded DNA (ssDNA) can lead to chromosomal breakage during DNA replication.

33 One of the two chromosomal breakage events in recurring translocations

34 Spontaneous chromosomal breakages frequently occur at genomic hot sp

35 the ends of chromosomes that protect against chromosomal breakage-fusion-bridge cycles in dividing ce

36 transposon ends, which initiate McClintock's chromosomal breakage-fusion-bridge cycles in maize.

37 nd this can result in fusions which initiate chromosomal breakage-fusion-bridge cycles, causing genom

38 hese rearrangements required a minimum of 20 chromosomal breakages/fusions.

39 We observed ICL-induced chromosomal breakage in 9 of 17 (53%) HNSCC cell lines d

40 ) proliferation, which can be accompanied by chromosomal breakage in activated hematopoietic stem cel

41 RAD52 promotes stalled fork degradation and chromosomal breakage in BRCA2-defective cells.

42 to potential mechanisms for the induction of chromosomal breakage in cancer cells.

43 We here investigated fork progression and chromosomal breakage in human cells in response to a pan

44 Inactivation of FANCM was responsible for chromosomal breakage in one cell line, whereas in two ot

45 croM doses of Cr(VI) caused 10-15 times more chromosomal breakage in primary human bronchial epitheli

46 r FA consists of cytogenetic quantitation of chromosomal breakage in response to diepoxybutane (DEB)

47 malize cell growth, cell-cycle kinetics, and chromosomal breakage in the presence of MMC.

48 n occurred through CACTA transposon-mediated chromosomal breakage in wild soybean c.

49 Recent mouse genetic models indicate that chromosomal breakage is common at sites of transcription

50 These results favor the model in which the chromosomal breakage leading to MLL translocations in DN

51 Large-scale Transitions (LSTs), defined as chromosomal breakages leading to gains or losses of at l

52 points, together with the region of frequent chromosomal breakage mapped by FISH analysis, further co

53 notypes, per se, are neither associated with chromosomal breakage nor with significant DDR activation

54 study to demonstrate that specific sites of chromosomal breakage observed during a period of chromos

55 Analysis of the chromosomal breakage regions suggests a sequence-indepen

56 ss-linking agents is a frequent finding, and chromosomal breakage responses to MMC may be a sensitive

57 Chromosomal breakage resulting from stabilization of DNA

58 so induced unrestrained fork progression and chromosomal breakage, suggesting fork remodeling as a gl

59 C and FANCG disruption increased spontaneous chromosomal breakage, supporting the role of these genes

60 Recently, it was demonstrated that this chromosomal breakage syndrome is caused by mutations in

61 other normal individuals or from people with chromosomal breakage syndromes do not yield PCR junction

62 l in other bone marrow failure syndromes and chromosomal breakage syndromes.

63 Depletion of Plx1 leads to accumulation of chromosomal breakage that is prevented by the addition o

64 ons (LST) are genomic alterations defined as chromosomal breakages that generate chromosomal gains or

65 sal prevents fork degradation, but increases chromosomal breakage, uncoupling fork protection, and ch

66 which are regions of the genome that exhibit chromosomal breakage under conditions of mild replicatio

67 the mutant mice showed hypersensitivity and chromosomal breakage when treated with mitomycin C, a DN

68 Pfhrp2 deletion only occurred by chromosomal breakage with subsequent telomere healing.