コーパス検索結果 (１語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 nt fusion partner in leukemia patients (8p11 chromosomal rearrangements).
2 relationships and/or extremely low rates of chromosomal rearrangement.
3 4 mRNA is not exclusive to cases harboring a chromosomal rearrangement.
4 ) continuously arise and cause mutations and chromosomal rearrangements.
5 they were thought to be generated solely by chromosomal rearrangements.
6 of DNA replication errors and attenuation of chromosomal rearrangements.
7 c.131G>A variant-expressing uteri developed chromosomal rearrangements.
8 als compared with perennials, due in part to chromosomal rearrangements.
9 wth defect with sgs1Delta and elevated gross chromosomal rearrangements.
10 termine the origin and mechanisms of complex chromosomal rearrangements.
11 solution of recombination intermediates into chromosomal rearrangements.
12 ter remnants became reunited via large-scale chromosomal rearrangements.
13 fission induces the formation of large-scale chromosomal rearrangements.
14 n downregulation, in particular TRF2, favors chromosomal rearrangements.
15 h sgs1Delta and exo1Delta and elevated gross chromosomal rearrangements.
16 d disassociation and degradation, minimizing chromosomal rearrangements.
17 o promote tumorigenesis by causing oncogenic chromosomal rearrangements.
18 rtions or deletions, copy number changes and chromosomal rearrangements.
19 chromosomes, followed by numerous additional chromosomal rearrangements.
20 from the zygotic nucleus through a series of chromosomal rearrangements.
21 sruption of RAD51 activity and generation of chromosomal rearrangements.
22 mosomal fragile sites that can trigger gross chromosomal rearrangements.
23 lso shed light on the origin of endemic-like chromosomal rearrangements.
24 lternative RNA splicing events and oncogenic chromosomal rearrangements.
25 ave an intrinsic predisposition for frequent chromosomal rearrangements.
26 ve DNA elements, repair of which can lead to chromosomal rearrangements.
27 and trex2(null) cells exhibited spontaneous chromosomal rearrangements.
28 ontaneous broken chromosomes and spontaneous chromosomal rearrangements.
29 ent-related leukemias characterized by 11q23 chromosomal rearrangements.
30 ns and deletions, copy number variation, and chromosomal rearrangements.
31 ecular defects, tumor spectrum and oncogenic chromosomal rearrangements.
32 slocation is a universal mechanism producing chromosomal rearrangements.
33 end-joining, neither of which leads to gross chromosomal rearrangements.
34 iated chromosome transfer often gain massive chromosomal rearrangements.
35 ongly correlated with the formation of gross chromosomal rearrangements.
36 logous recombination, thus avoiding possible chromosomal rearrangements.
37 inational repair of a DSB and enhances gross chromosomal rearrangements.
38 but instead this pathway frequently leads to chromosomal rearrangements.
39 estrally gene-rich regions, independently of chromosomal rearrangements.
40 therapy choice using acquired mutations and chromosomal rearrangements.
41 r's gene segments limited to intralocus, cis chromosomal rearrangements.
42 (HR) in the formation of simple and complex chromosomal rearrangements.
43 but if unrestrained can result in undesired chromosomal rearrangements.
44 ematic and simple to use framework to induce chromosomal rearrangements.
45 led few inter-chromosomal but frequent intra-chromosomal rearrangements.
46 in the clinical interpretation of non-coding chromosomal rearrangements.
47 raction, possibly >50%, of mosaic diagnostic chromosomal rearrangements.
48 erve as fragile sites that generate DSBs and chromosomal rearrangements.
49 deed, RNase H-deficient cells have increased chromosomal rearrangements.
51 of 152, mostly de novo, apparently balanced chromosomal rearrangement (ABCR) breakpoints in 76 indiv
54 to be effective, NIPT must be able to detect chromosomal rearrangements across the whole genome for a
56 y number alterations, translocations, and/or chromosomal rearrangements--an be leveraged, in principl
58 display an accelerated rate of evolutionary chromosomal rearrangement and occupy a key node in the p
59 of transposable elements, small RNA content, chromosomal rearrangement and segregation distortion.
60 with exceptions, particularly in regions of chromosomal rearrangements and around the site of ancest
61 und a highly significant association of both chromosomal rearrangements and CNVs with elevated recomb
62 in whole genome sequencing, detect balanced chromosomal rearrangements and compute enrichment of mes
63 enomic region is particularly susceptible to chromosomal rearrangements and contains many genes cruci
64 ncer transcriptome and genome has identified chromosomal rearrangements and copy number gains and los
66 pretation pipeline was developed to identify chromosomal rearrangements and deletions/duplications wi
67 Here we developed a novel strategy using chromosomal rearrangements and embryonic phenotypes to p
68 gene-gene fusion transcripts, likely due to chromosomal rearrangements and expression of transcripti
69 DNA double-strand breaks (DSBs) can cause chromosomal rearrangements and extensive loss of heteroz
71 ) was recently proposed to explain clustered chromosomal rearrangements and genomic amplifications in
72 efficacy of the method for genotyping large chromosomal rearrangements and haplotyping SNPs over lon
73 In addition, we observed a higher number of chromosomal rearrangements and higher frequency of reten
74 ver outcome, thus avoiding the potential for chromosomal rearrangements and loss of heterozygosity.
76 n only detect the majority of larger (>6 Mb) chromosomal rearrangements and requires knowledge of fet
77 dure for the modeling or correction of large chromosomal rearrangements and short nucleotide repeat e
78 hat the molecular mechanisms responsible for chromosomal rearrangements and some duplicated genes hav
79 eld of existing microarray testing for large chromosomal rearrangements and targeted CNV detection.
82 utionary processes such as genome expansion, chromosomal rearrangement, and chromosomal translocation
83 efine new ALL subtypes, cooperate with known chromosomal rearrangements, and influence prognosis.
84 is that there is an association between CNV, chromosomal rearrangements, and recombination by correla
85 sized B. napus involved aneuploidy and gross chromosomal rearrangements, and that dosage balance mech
86 osome translocation, trans-splicing, complex chromosomal rearrangements, and transcriptional read thr
87 cell lymphomas in humans are associated with chromosomal rearrangements ( approximately 40%) and/or m
97 icarte-Filho and colleagues demonstrate that chromosomal rearrangements are the oncogenic "drivers" i
98 ies are modestly reduced in these cells, and chromosomal rearrangements arise at elevated rates in re
99 vestigated both loss of genetic material and chromosomal rearrangement as possible causes of LMNB1 ov
100 ic factors accumulate, fostering large-scale chromosomal rearrangements as functional reduction proce
101 l features that may point to the presence of chromosomal rearrangements as the primary disease cause.
103 mechanistic insight into the way a balanced chromosomal rearrangement associated with a neurodevelop
104 n a head-to-tail configuration and joined by chromosomal rearrangement at the amphibian-to-reptile ev
105 We defined the genetic landscape of balanced chromosomal rearrangements at nucleotide resolution by s
108 xt-generation DNA sequencing, we developed a chromosomal rearrangement-based approach to differentiat
110 c damage through insertional mutagenesis and chromosomal rearrangements between non-allelic SINEs at
111 nds from single nucleotide variants to large chromosomal rearrangements, but the extent of structural
112 ted in the mapping of 77 breakpoints from 40 chromosomal rearrangements by FISH with BACs and fosmids
114 ts on genome integrity could be critical, as chromosomal rearrangements can lead to reproductive isol
115 In approximately 50% of prostate cancers, chromosomal rearrangements cause the fusion of the promo
117 g most allelic and non-allelic mutations and chromosomal rearrangements characteristic of nuclease-de
118 ormalities in newborns with de novo balanced chromosomal rearrangements, comprehensive interpretation
119 by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to ac
120 acterized their recurrent somatic mutations, chromosomal rearrangements, copy number alterations (CNA
122 mosomal polymorphisms largely resulting from chromosomal rearrangements (CRs) are widely documented i
124 sulted via several other mechanisms, such as chromosomal rearrangements, deletion/insertion, transpos
127 g a cryptic heptamer implicated in oncogenic chromosomal rearrangements, destabilize the PCC, allowin
128 ying the evolutionary forces responsible for chromosomal rearrangements, determining how often prezyg
129 imary 53BP1(-/-) B cells revealed that their chromosomal rearrangements differ from those found in wi
131 challenge the claim that the accumulation of chromosomal rearrangements drive complete reproductive i
132 n easy screen for studying the mechanisms of chromosomal rearrangements during the propagation of a s
135 t an oxidative stress is responsible for the chromosomal rearrangements found in radio-induced papill
136 SGS1 results in a 110-fold increase in gross chromosomal rearrangement frequency during aging of nond
137 creens for mutations causing increased gross chromosomal rearrangement (GCR) rates in Saccharomyces c
138 to DNA replication are known to induce gross chromosomal rearrangements (GCRs) and copy-number variat
140 s, small DNA insertions/deletions, and gross chromosomal rearrangements (GCRs) in sch9Delta mutants i
141 revisiae genetic system that generates gross chromosomal rearrangements (GCRs) mediated by foldback i
144 ommon processes such as suppression of gross chromosomal rearrangements (GCRs), DNA repair, modificat
146 c28 activity results in suppression of gross chromosomal rearrangements (GCRs), indicating that Cdc28
149 own to have a major role in preventing gross chromosomal rearrangements (GCRs); however, relatively l
151 re Sequencing (TC-Seq), a method to document chromosomal rearrangements genome-wide, in primary cells
152 l variations and genetic elements, including chromosomal rearrangements, genomic macrosynteny, gene f
157 int mutations have been extensively studied, chromosomal rearrangements have demonstrated greater tum
158 breakpoints responsible for these structural chromosomal rearrangements have not been comprehensively
159 anges, ranging from point mutations to large chromosomal rearrangements, have been identified in pati
160 are serious genomic insults that can lead to chromosomal rearrangements if repaired incorrectly.
161 gy to successfully generate several types of chromosomal rearrangements implicated as driver events i
162 1 (TEL-AML1) fusion gene, is the most common chromosomal rearrangement in childhood cancer and is exc
163 presence and expression of this significant chromosomal rearrangement in prostate cancer stem cells.
164 tly increased the rate of accumulating gross-chromosomal rearrangements in a dosage-dependent manner
167 Examination of the coordinates of various chromosomal rearrangements in conjunction with the genom
170 riants of uncertain significance, especially chromosomal rearrangements in non-coding regions of the
171 or detection of both balanced and unbalanced chromosomal rearrangements in primary human tumour sampl
172 -generation sequencing techniques to examine chromosomal rearrangements in primary murine B cells and
173 However, somatic alterations predisposing to chromosomal rearrangements in prostate cancer remain lar
176 and evaluate sequencing results of balanced chromosomal rearrangements in ten prenatal subjects with
177 omosome 7A provides insight into the role of chromosomal rearrangements in the evolution of this comp
178 hould be considered as alternatives to gross chromosomal rearrangements in the interpretation of whol
181 cribe an efficient method to induce specific chromosomal rearrangements in vivo using viral-mediated
182 y fuse inverted repeats to generate unstable chromosomal rearrangements in wild-type mouse embryonic
183 edicted to form non-B-form DNA induced gross chromosomal rearrangements in yeast and displayed high i
184 dem duplications, and clinically significant chromosomal rearrangements including MLL translocations
188 -Myc/DNMT3B7 mediastinal lymphomas have more chromosomal rearrangements, increased global DNA methyla
189 is one of the hallmarks of cancer genome via chromosomal rearrangement initiated by DNA double-strand
191 ethanesulfonate-derived mutant shows unusual chromosomal rearrangement instead of a point mutation.
192 d cancer lines, we characterize a variety of chromosomal rearrangements involving acrocentric p-arms
195 g approximate boundaries of intra- and extra-chromosomal rearrangements involving gene orthologs, whi
196 noma, is defined by the presence of acquired chromosomal rearrangements involving NUT, usually BRD4-N
203 standardized characterization of structural chromosomal rearrangements is essential both for researc
204 also identify multiple cases of catastrophic chromosomal rearrangements known as chromoanagenesis, in
208 icronuclei levels, the number of large-scale chromosomal rearrangements (LST), and the status of seve
209 ility by production of unbalanced gametes, a chromosomal rearrangement may also disrupt or dysregulat
210 ansposable element system can generate major chromosomal rearrangements (MCRs), but the underlying me
211 occus species provide evidence that multiple chromosomal rearrangements mediated by intercentromeric
214 nd we identify candidate loci that drive the chromosomal rearrangements observed in evolution of yeas
217 : Mature B-cell lymphomas bearing concurrent chromosomal rearrangement of MYC/8q24 and BCL2/18q21 are
218 resulted in genome plasticity manifested as chromosomal rearrangement of syntenic blocks and DNA ins
219 etected several expected events, including a chromosomal rearrangement of the nonessential arm of chr
221 ystem enables to study mechanisms of massive chromosomal rearrangements of any chromosome and their c
227 The genetic hallmark of most infant B-ALL is chromosomal rearrangements of the mixed-lineage leukemia
229 expression signature predominantly driven by chromosomal rearrangements of the ZNF384 gene with histo
230 FET proteins are of medical interest because chromosomal rearrangements of their genes promote variou
234 Gene fusions result from either structural chromosomal rearrangement or aberrations caused by splic
235 can be generated either through insertional chromosomal rearrangement or by intrachromosomal deletio
236 erent genomic environments suggesting either chromosomal rearrangement or multiple acquisition events
237 ted recombination in hybrids, such as within chromosomal rearrangements or areas adjacent to centrome
238 nongradual, saltatory leaps, driven through chromosomal rearrangements or genome doubling, may be pa
239 athogenic domain disruptions can result from chromosomal rearrangements or perturbation of architectu
240 s (e.g., Down syndrome), a family history of chromosomal rearrangement, or a history of multiple misc
241 able of generating inversions similar to the chromosomal rearrangements present in balancer chromosom
242 palindromic duplications, the major class of chromosomal rearrangements recovered from yeast cells la
243 e B. napus cultivar Stellar, we detected one chromosomal rearrangement relative to the parental karyo
246 loid Camelina genomes were shaped by complex chromosomal rearrangements, resembling those associated
249 re can affect the whole cell and may lead to chromosomal rearrangements resulting in genomic instabil
250 te cancers have been shown to have recurrent chromosomal rearrangements resulting in the fusion of th
251 ly, while others are recurrently involved in chromosomal rearrangement, resulting in breakpoint reuse
252 ed to include DNA gene knock-out, deletions, chromosomal rearrangements, RNA editing and genome-wide
253 f B-ALL incorporating 23 subtypes defined by chromosomal rearrangements, sequence mutations or hetero
257 reads can also be used to delineate complex chromosomal rearrangements, such as those that occur in
258 ously published E. coli construct revealed a chromosomal rearrangement that alleviates replication-tr
260 ation of Robertsonian (Rb) fusions, a common chromosomal rearrangement that joins two telocentric chr
261 en exhibit genomic instability, resulting in chromosomal rearrangements that affect the structure and
263 l proximity within the nucleus can result in chromosomal rearrangements that are important in the pat
264 are aneuploid or harbor recurring structural chromosomal rearrangements that are important initiating
265 tation was disrupted only in the presence of chromosomal rearrangements that break<or=650 kbp from ye
267 unexpected CNV complexities, including inter-chromosomal rearrangements that cannot be resolved by aC
268 dinated epigenetic effects of constitutional chromosomal rearrangements that disrupt genes associated
269 g data and chromatin maps highlight distinct chromosomal rearrangements that juxtapose super-enhancer
271 x interplay between duplicated sequences and chromosomal rearrangements that rapidly alter the cytoge
272 gous recombination, but this can cause gross chromosomal rearrangements that subsequently missegregat
273 tabilize the genome by causing mutations and chromosomal rearrangements, the driving forces for carci
274 D loci onto the same chromosome, and further chromosomal rearrangements then resulted in the 2 MAT lo
276 tgroup comparisons allowed directionality of chromosomal rearrangements to be established, enabling p
279 by Ed Lewis, we generated and characterized chromosomal rearrangements to define a region in cis to
280 thyltransferase gene undergoes many distinct chromosomal rearrangements to yield poor-prognosis leuke
281 solved efficiently to prevent sequence loss, chromosomal rearrangements/translocations, or cell death
282 c1 (also known as Mect1/Torc1) by a t(11;19) chromosomal rearrangement underlies the etiology of mali
283 ated by sensitivity to sex steroids, and the chromosomal rearrangement underlying the polymorphism ha
284 We developed bioinformatic tools to identify chromosomal rearrangements using genome-wide, next-gener
286 entially pathogenic consequences of balanced chromosomal rearrangements, we generated a series of gen
287 all populations are prone to the fixation of chromosomal rearrangements, we speculate that biological
288 s from C. arabica and C. canephora, numerous chromosomal rearrangements were detected, including inve
292 dification, the off-target effects including chromosomal rearrangements were significantly reduced.
293 distribution of heterochromatins, as well as chromosomal rearrangements, were uncovered between the t
294 er is able to accurately reconstruct complex chromosomal rearrangements when compared to well-charact
295 nents, originating from the A complement via chromosomal rearrangements, which follow their own evolu
296 ission, all MRE populations showed extensive chromosomal rearrangements, which we attributed to genet
297 novel gene fusions caused by tumour-specific chromosomal rearrangements, whose oncogenic potential re