ライフサイエンスコーパス: chromosomal region

1 DOCK4 as a pathogenic gene located on the 7q chromosomal region.

2 deficiency complementation analysis on this chromosomal region.

3 es and it maps the mutated gene to a defined chromosomal region.

4 and horn length is attributable to the same chromosomal region.

5 the cell, a position characteristic of that chromosomal region.

6 esence of a tumor suppressor gene(s) in this chromosomal region.

7 ytokines that have genes located in the same chromosomal region.

8 s flanking genes, diverged from a duplicated chromosomal region.

9 aternally expressed gene(s) in the 15q11-q13 chromosomal region.

10 rther suppresses DSBs within the surrounding chromosomal region.

11 stances on randomly selected non-centromeric chromosomal regions.

12 transcribed parents and reside in gene-rich chromosomal regions.

13 ptional "hot spots" that represent activated chromosomal regions.

14 ortionately fewer copies of late-replicating chromosomal regions.

15 tes frequently involves interactions between chromosomal regions.

16 which recruits more MRN to the DSB-flanking chromosomal regions.

17 ogaster heterochromatic sequence to specific chromosomal regions.

18 were preferentially targeted to transcribed chromosomal regions.

19 syndromes and with common variants from 3-5 chromosomal regions.

20 significant evidence of linkage to specific chromosomal regions.

21 ogenes and tumor suppressors) found in those chromosomal regions.

22 ential loss of methylated TEs from gene-rich chromosomal regions.

23 will help to penetrate the core of apomixis chromosomal regions.

24 ession of genes located in amplified/deleted chromosomal regions.

25 hin the silent-mating-type loci and telomere chromosomal regions.

26 telomeric sequence insertion (TSI) at intra-chromosomal regions.

27 nt loci met this threshold in eight distinct chromosomal regions.

28 ting regulatory interactions across discrete chromosomal regions.

29 ecialist ancestry were concentrated in a few chromosomal regions.

30 genomic stability tunes plasticity of these chromosomal regions.

31 ial genomes to allow cotransfer of disparate chromosomal regions.

32 e proximity to NUP-1, the NPCs and telomeric chromosomal regions.

33 partition system highly correlate with dense chromosomal regions.

34 ervation of gene arrangement (synteny) along chromosomal regions.

35 r the maintenance of mating-type determining chromosomal regions.

36 ng seven independent glioma risk loci in six chromosomal regions.

37 Chromosomal region 1-1/1-1-3 was found to influence the

38 Linkage to chromosomal regions 10q22 and 6q23 with maximum logarith

39 Genetic variants at chromosomal region 11q23.3, near the gene ETS1, have bee

40 nding protein 2 (NAB2) and STAT6, located at chromosomal region 12q13, have been recently identified

41 fied two susceptibility loci: for lobar ICH, chromosomal region 12q21.1 (rs11179580, odds ratio [OR]

42 factor with typical ZNF and KRAB domains, in chromosomal region 13q12.11 (beta = 0.14 SD, P = 3.5 x 1

43 Deletion of chromosomal region 13q14 represents the most common gene

44 A common variant on chromosomal region 15q24-25.1, marked by rs1051730, was

45 Recurrent deletions and duplications at chromosomal region 16p11.2 are a major genetic contribut

46 Copy number variations of human chromosomal region 16p11.2 are genetically linked to 1%

47 Deletion of the recurrent ~600 kb BP4-BP5 chromosomal region 16p11.2 has been associated with a wi

48 cleotide polymorphisms (SNPs) located in the chromosomal region 16p13.13 have been previously associa

49 c hearing impairment (ARNSHI), was mapped to chromosomal region 16q21-q23.2 in three unrelated, consa

50 c Acid Induced 1 gene (RAI1), located in the chromosomal region 17p11.2.

51 The chromosomal region 17q23 containing the RPS6KB1 gene is

52 CYGB is assigned to chromosomal region 17q25, which is frequently lost in mu

53 TOC locus to a small genomic interval within chromosomal region 17q25.

54 PSORS2 (psoriasis susceptibility locus 2) to chromosomal region 17q25.3-qter after a genome-wide link

55 tors encoded in the immune response locus in chromosomal region 1p36.

56 56, p = 7.0 x 10(-8)); and for nonlobar ICH, chromosomal region 1q22 (rs2984613, OR = 1.44, p = 1.6 x

57 Bone morphogenetic protein 2 (BMP2) in chromosomal region 20p12 belongs to a gene superfamily e

58 CK1; gene, PCK1 orthologous/homologous human chromosomal region 20q13.31) at 0.9 gestation (G).

59 inct constitutional microdeletions involving chromosomal region 21q22.12.

60 ll as new mutator candidates PPP2R2A and the chromosomal region 22q13.33.

61 ovel risk loci for nsCL/P are identified (at chromosomal regions 2p21, 14q22, 15q24 and 19p13).

62 e a large cohort with genetic alterations of chromosomal region 2q23.1 and acquired 65 subjects with

63 Microdeletions of chromosomal region 2q23.1 that disrupt MBD5 (methyl-CpG-

64 are risk locus for ASD and language delay at chromosomal region 2q24 (implicating NR4A2) and another

65 its identified local African ancestry at the chromosomal region 2q37 as genome-wide significantly ass

66 ied a recurrent focal amplification on mouse chromosomal region 2qB, which contains the LIM-homeodoma

67 Tyrosine Phosphatase N23 (PTPN23) resides in chromosomal region 3p21.3, which is hemizygously or homo

68 order to a approximately 16.8 cM interval in chromosomal region 3q22-24, and by sequencing candidate

69 s are identified (these include deletions in chromosomal regions 3q27, 3p13, and 3p26 and duplication

70 tic locus for atrial fibrillation (AF) is in chromosomal region 4q25, where four independent associat

71 Amplification of chromosomal region 5q31-5q35.3 has been used to predict

72 tors expressed by myeloid cells 2 (TREM2) in chromosomal region 6p21 (p = 10(-10)).

73 ophila hindgut development; (b) it lies in a chromosomal region (6p22.1) amplified in colorectal canc

74 7q11.23) and deletion (Williams syndrome) of chromosomal region 7q11.23 cause neurodevelopmental diso

75 cant associations for several markers in the chromosomal region 7q21.12 harbouring both the ABCB1 and

76 C1 (10q24), ATP11A (13q34), DPP9 (19p13) and chromosomal regions 7q22 and 15q14-15.

77 Mtss1 is located within chromosomal region 8q23-24, which is one of the three mo

78 at the long sought after ALS/FTD mutation on chromosomal region 9p is a hexanucleotide expansion in C

79 the DMS-MFH tumor-suppressing-gene locus to chromosomal region 9p21-22 but failed to identify mutati

80 n lymphoma (cHL), in which copy gains of the chromosomal region (9p24.1) containing the programmed de

81 The chromosomal regions across the human orthologous were in

82 Genovese and colleagues examined large chromosomal regions adjacent to MYH9 using genome-wide a

83 ed expression levels were located within the chromosomal regions affected by the segmental aneuploidy

84 A total of 22 chromosomal regions, all containing putative TP0092-bind

85 ules, including the identification of shared chromosomal regions among affected family members, prior

86 Mendelian inheritance or identifying shared chromosomal regions among affected family members.

87 istic coevolution between two tightly linked chromosomal regions: an inducer region that initiates re

88 in the bulk of association between the 10q26 chromosomal region and AMD.

89 methylated promoters tend to cluster by both chromosomal region and gene function.

90 s in multiple cancer samples across the same chromosomal region and has greater implication in tumori

91 We mapped the disease to the 2q34-q36.1 chromosomal region and identified a homozygous splice mu

92 report refined mapping of Idd4.1 to a 1.1-Mb chromosomal region and provide genomic sequence analysis

93 uperfamily (IgSF) genes in the human 1q21-23 chromosomal region and revealed significant diversity fo

94 markers to estimate genetic ancestry in each chromosomal region and then tested the association betwe

95 are encoded in a single contiguous gene-rich chromosomal region and VCBP3 is encoded in a separate lo

96 DnaA also binds to other chromosomal regions and functions as a transcription fac

97 al profiling identified several dysregulated chromosomal regions and genes representing an enriched s

98 t findings that demonstrate the movements of chromosomal regions and genomic loci in association with

99 sion, as well as for fluorescence tagging of chromosomal regions and individual mRNAs to track their

100 s (TSF) are variable, being dependent on the chromosomal regions and potential competition with endog

101 rent papillomaviruses interact with distinct chromosomal regions and targets.

102 We demonstrate that pairing involves larger chromosomal regions and that the two chromosome territor

103 Web-based system to find and align syntenic chromosomal regions and visualize the output in an intui

104 ch confine centromere activity to a discrete chromosomal region, and holocentric organisms, which dis

105 a sequence-based physical map for a complex chromosomal region, and we raise the possibility of poly

106 mes in order to identify putative homologous chromosomal regions, and align these regions using genes

107 calize SlmA DNA sites near membrane-tethered chromosomal regions, and cellular studies show that SlmA

108 are found in both intergenic and intragenic chromosomal regions, and contain an array of diverse mot

109 positions of euchromatic and heterochromatic chromosomal regions, and manifests as striking bimodal p

110 Three chromosomal regions are associated with a significant di

111 but it is not the only actor and particular chromosomal regions are known to facilitate the meiotic

112 that some chromosomes, chromosomal arms and chromosomal regions are more affected by IDH1/2 mutation

113 is process works and how it impacts flanking chromosomal regions are poorly understood.

114 ting that the mechanisms of how heterologous chromosomal regions are silenced involves, at some stage

115 n genes, which lie in a relatively gene-poor chromosomal region, are not bound by this complex in non

116 ted in cis tend to be located in polymorphic chromosomal regions, are preferentially associated with

117 We recently identified Mpdz within this chromosomal region as a gene that influences alcohol and

118 The gene maps to the same chromosomal region as the maximum peak we observed in a

119 tortions are present at multiple scales, and chromosomal regions as broad as 5 Mb show a significant

120 Here, we used excision of chromosomal regions as circular "loop outs" to convert s

121 European population have identified multiple chromosomal regions associated with blood pressure, and

122 Genome-wide studies can determine chromosomal regions associated with IBK susceptibility.

123 The present study was conducted to identify chromosomal regions associated with thylakoid membrane d

124 recurrent genomic rearrangements affecting a chromosomal region at 5p15.33 proximal of the telomerase

125 es reveal that TAF3 localizes to a subset of chromosomal regions bound by CTCF/cohesin that are selec

126 ve helicase, are associated with many of the chromosomal regions bound by DnaA in Bacillus subtilis.

127 aD associates with DnaA at oriC and at other chromosomal regions bound by DnaA.

128 The silencing of large chromosomal regions by epigenetic mechanisms has been re

129 pruning, including 2 genes within implicated chromosomal regions: C1qa and Mfge8.

130 ked locus, alr1, has been mapped to the same chromosomal region, called the allorecognition complex (

131 been impeded by a low efficiency (0.5-2%) of chromosomal region capture during yeast transformants wh

132 DNA and to tailor nucleosome composition in chromosomal regions, cells have evolved a set of special

133 Although originally thought to be silent chromosomal regions, centromeres are instead actively tr

134 MiR-125b-1 maps at 11q24, a chromosomal region close to the epicenter of 11q23 delet

135 a large-scale rearrangement that shifts many chromosomal regions closer to the nuclear envelope.

136 PX-RICS is located in the chromosomal region commonly deleted in JBS patients with

137 We performed MDiGS capture for three chromosomal regions consisting of approximately 550 kb o

138 We found that genes located on contiguous chromosomal regions contain similar motifs in the promot

139 eport expression and epigenetic changes in a chromosomal region containing the MIR172b locus in the a

140 In contrast the chromosomal region containing TRM is not well conserved

141 eres are positioned within specific megabase chromosomal regions containing alpha-satellite DNA repea

142 Increasing evidence suggests that chromosomal regions containing microRNAs are functionall

143 too short reads to unambiguously reconstruct chromosomal regions containing repetitive DNA sequences.

144 This chromosomal region contains HYPERMETHYLATED IN CANCER 1

145 Remarkably, a single chromosomal region contains the highest effect size QTL

146 This chromosomal region contains the modifier of tubby hearin

147 ies support the hypothesis that the 15q13-14 chromosomal region contributes to the etiology of schizo

148 We show that MvaT and MvaU bind the same chromosomal regions, coregulating the expression of appr

149 r panel, genotyped in families to search for chromosomal regions correlated with acrophobia.

150 g to generate mice harboring deletion of the chromosomal region corresponding to 16p11.2, as well as

151 In vivo Aire interactions with chromosomal regions depleted of H3K4me3 were dependent o

152 (sialic acid binding Ig-like lectin 5) and a chromosomal region downstream of the DEFA1A3 locus (defe

153 me segregation, but associate with different chromosomal regions during mitosis and meiosis.

154 The two linked chromosomal regions each harbor functional candidate gen

155 Twenty-nine distinct loci mapping to three chromosomal regions encode receptor-type structures poss

156 this recombination event, which replaces the chromosomal region encoding secreted NADase and streptol

157 ition by horizontal gene transfer of a large chromosomal region encoding secreted toxins NAD(+)-glyco

158 The chromosomal region encoding the nuclear NAD(+) synthesis

159 uted along chromosomes and are suppressed in chromosomal regions encompassing compact, hypermethylate

160 ic copy number alterations (SCNAs) involving chromosomal regions enriched for genes in known and prev

161 e on both broad and fine scales and that few chromosomal regions escape selection-induced distortions

162 ur focal genes, At1g67140 and At3g03700, all chromosomal regions exhibited extreme variation in the p

163 screened to obtain a clone with the desired chromosomal region, extensive experience with yeast is n

164 The method isolates haploid chromosomal regions flanking targeted SNPs by hybridizin

165 the differential segregation of polymorphic chromosomal regions following the backcross and single-s

166 leprosy per se, we investigated the TNFSF15 chromosomal region for a possible contribution to suscep

167 In this study, we compare orthologous chromosomal regions for which the human locus establishe

168 or suppressor gene that localizes to 6p23, a chromosomal region frequently associated with loss of he

169 tations/nucleotide/generation for the same Y-chromosomal region from published human-chimpanzee compa

170 congenic strain approach to determine which chromosomal regions from 129Sl/SvImJ provide protection

171 In particular, the data suggest that chromosomal regions from chicken chromosomes (GGA) Z and

172 lence of interactions between pairs of short chromosomal regions from one species (Solanum habrochait

173 mbiotic mesorhizobia received three separate chromosomal regions from the donor Mesorhizobium ciceri

174 nces) shotgun sequencing to assemble the six chromosomal regions from the Non-Stiff Stalk maize inbre

175 ion about the genetic context of SNPs (gene, chromosomal region, functional location, haplotypes tags

176 Thus, these chromosomal regions harbor genes implicated in cell cycl

177 We sought to identify chromosomal regions harboring quantitative trait loci th

178 entified four transcriptional "hot spots" at chromosomal regions harboring statistically increased nu

179 Gain' of supernumerary copies of the 8q24.21 chromosomal region has been shown to be common in many h

180 r or within the COL5A1 gene, at 9q34.2-q34.3 chromosomal region have been reported in association wit

181 Some chromosomal regions have a significant excess of eQTL ov

182 ver six loci spanning between 30- and 500-kb chromosomal regions have been described in two Iowa Stif

183 Several genes and chromosomal regions have been implicated in the genetic

184 otably, differential methylation analysis of chromosomal regions identified three locations containin

185 tion to select only gene-centric SNPs from a chromosomal region in an automated fashion.

186 By considering a long chromosomal region in human T-cells during interphase, w

187 ciation between genetic variants in the 9p21 chromosomal region in humans and the presence of cardiov

188 We evaluated 16 SNPs from five chromosomal regions in a Swedish population (2893 subjec

189 Estimates of the ancestry of specific chromosomal regions in admixed individuals are useful fo

190 absence of group Q homologs on the syntenic chromosomal regions in Arabidopsis thaliana (Brassicales

191 nal organization of chromosomes and specific chromosomal regions in C. elegans.

192 Somatic homozygous deletions of chromosomal regions in cancer, while not necessarily onc

193 lular transport of various cargos, including chromosomal regions in Caulobacter crescentus.

194 plicon, one of the most frequently amplified chromosomal regions in human cancer, but its functional

195 or two of the three most strongly associated chromosomal regions in the Ferreira study, CACNA1C (rs10

196 n changes are preferentially associated with chromosomal regions in which histone H3 lysine residues

197 ultiple, noncontiguous genes encoded in this chromosomal region, in concert with modulatory impacts o

198 tect 56 genome-wide significant SNPs in five chromosomal regions including previously reported risk l

199 lation changes in 187 gene loci at different chromosomal regions including promoters, coding exons, i

200 Amplification of the 8p11-12 chromosomal region is a common genetic event in many epi

201 10 Idd9 congenic mice, in which the NOD Idd9 chromosomal region is replaced by the Idd9 from T1D-resi

202 resulted in loss of heterozygosity, where a chromosomal region is represented by the genotype of onl

203 One example of an affected chromosomal region is the gene coding for Nup214, a nucl

204 contrast to previous studies of a different chromosomal region, IS1236 was involved in 86% of these

205 8 known pneumococcal capsule types, are in a chromosomal region known as the cps locus.

206 signation, which constrains PLK-2 to special chromosomal regions known as pairing centers to ensure p

207 revious finding of BFB as well as identify a chromosomal region likely rearranged by BFB cycles, demo

208 ed out a genomewide linkage scan to identify chromosomal regions likely to contain genes that contrib

209 Chromosomal region maintenance 1 (CRM1) is a nuclear exp

210 Chromosomal region maintenance 1 (CRM1) mediates p53 nuc

211 tion modulated the interaction of ErbB4 with chromosomal region maintenance 1 (CRM1), the major nucle

212 r export mediated by the karyopherin protein chromosomal region maintenance 1 (CRM1).

213 tural attribute of the murine version of the chromosomal region maintenance 1 (mCRM1) nuclear export

214 regulatory elements and to a transcript-poor chromosomal region, markedly decreasing expression.

215 spatial distributions of highly-transcribed chromosomal regions matching recent experimental measure

216 Chromosomal regions meeting genome-wide suggestive crite

217 We found that the chromosomal region most tightly linked to this locus con

218 ntation was assessed in situ by labeling two chromosomal regions, no specific pattern was detected.

219 ng aberrant Pkhd1, but lacking the c3 and c4 chromosomal regions (NOD.Abd3), reproduces the immunopat

220 refZ and RBM mutants capture chromosomal regions normally excluded from the forespore

221 Additionally, we identify chromosomal regions not previously associated with lupus

222 nd secondary AML tended to affect particular chromosomal regions, occurred more frequently in Alu-poo

223 Consequently, meiotic progression in distal chromosomal regions occurs in coordination with the chro

224 rs the allocation of cytosine methylation in chromosomal regions of 50 kb to 2 Mb and, in addition, l

225 We conducted high-resolution scans for chromosomal regions of extreme divergence between these

226 Chromosomal regions of identical or nearly identical DNA

227 h-quality sequence assemblies of orthologous chromosomal regions of interest from multiple species.

228 SNP array analysis has also identified chromosomal regions of somatic uniparental disomy (UPD)

229 Alignment of respective chromosomal regions of these species via conserved genes

230 ber variations (deletion or duplication of a chromosomal region) of synaptic genes have been recently

231 The H19 gene, which localizes within a chromosomal region on human chromosome 11p15 that is com

232 owing to either microdeletion of the entire chromosomal region or ELN point mutations.

233 mmonly include gains or losses of particular chromosomal regions, or mutations in certain cancer-asso

234 SNPs in five chromosomal regions plus a family history of prostate ca

235 discrete genes, but it can also affect large chromosomal regions, potentially leading to LRES.

236 Centromeres are the chromosomal regions promoting kinetochore assembly for c

237 s, which can be identified by the absence of chromosomal region RD1(mic).

238 Two chromosomal regions reached genome-wide significance lev

239 To evaluate candidate genes present within chromosomal regions recurrently deleted in human cancers

240 s, indicating that spatial regulation across chromosomal regions reduces risky crossover events.

241 as a result of epigenetic silencing of large chromosomal regions, referred to as long-range epigeneti

242 al sequence is centrally located at the 1q42 chromosomal region relative to microsatellites previousl

243 gators targeting 129/Sv genes mapping within chromosomal regions reported herein or elsewhere in the

244 Centromeres are essential chromosomal regions required for kinetochore assembly an

245 entified were subsequently overlaid with the chromosomal regions shared among 5 affected family membe

246 everal higher eukaryotes where the outermost chromosomal regions show increased crossing over.

247 Two chromosomal regions showed significant evidence of linka

248 s of the joint effects of changes in the six chromosomal regions showed that six signatures, includin

249 nome-wide association study, we identified 3 chromosomal regions significantly associated with serum

250 roidal glycoalkaloid mQTL was localized to a chromosomal region spanning 14 genes, including a previo

251 Deletion of the chromosomal region spanning the ISL1 gene has been found

252 his study was to determine whether there are chromosomal regions specifically linked to compulsive ho

253 Chromosomal regions such as subtelomeres that show defec

254 family are proteins that associate with the chromosomal region surrounding the centromere (the peric

255 of nucleotide polymorphism and divergence in chromosomal regions surrounding four low-diversity loci.

256 resents a recombination hot spot at the 1q42 chromosomal region that influences the development and d

257 1 in each 4000 new-borns), in which the same chromosomal region that is duplicated in Dup22q11.2 is d

258 study focused on amplification events in two chromosomal regions that are near one of six copies of t

259 Centromeres, chromosomal regions that become physically linked to the

260 in situ hybridization (FISH), we identified chromosomal regions that colocalize frequently with the

261 ent study is to delineate additional non-MHC chromosomal regions that control susceptibility to EAU,

262 w-resolution associations, identifying large chromosomal regions that encompass hundreds of genes, on

263 Common fragile sites (CFS) are chromosomal regions that exhibit instability during DNA

264 a genome-wide linkage analysis to search for chromosomal regions that harbor genetic variants conferr

265 zebrafish-specific genes on chromosome 4 and chromosomal regions that influence sex determination.

266 re numerous candidate genes and QTL in these chromosomal regions that may indicate shared genetic reg

267 Centromeres are essential chromosomal regions that mediate kinetochore assembly an

268 he sites of sister chromatid cohesion to the chromosomal regions that mediate spindle attachment (the

269 ngle-nucleotide polymorphisms (SNPs) in five chromosomal regions--three at 8q24 and one each at 17q12

270 umulation of COs in recombination-suppressed chromosomal regions through intermating and the potentia

271 ively mapped long-range associations between chromosomal regions throughout the fission yeast genome

272 However, progressing from a chromosomal region to the actual causal gene remains cha

273 ocal cross, and sex interacted with numerous chromosomal regions to affect growth traits.

274 enome and exome sequencing and mapped shared chromosomal regions to identify genetic predisposition i

275 -immunoFISH, we demonstrate repositioning of chromosomal regions to the nuclear lamina that is depend

276 ntromeric determinants localized to a single chromosomal region) to holocentricity (centromeric deter

277 Of the six newly identified chromosomal regions, two were associated with LDL choles

278 has been a powerful tool for localizing the chromosomal regions underlying complex traits, systemati

279 actor (protein) or small RNA molecule to the chromosomal region upstream of a regulated gene.

280 PML NBs coordinate chromosomal regions via modification of nuclear proteins

281 omolog-directed interactions at interstitial chromosomal regions was ambiguous, perhaps as a conseque

282 Results for changes in six chromosomal regions were analyzed using univariate and m

283 assively parallel sequencing (ChIP-seq), 312 chromosomal regions were highly enriched by coimmunoprec

284 -wide association study, 4 SNPs mapping to 3 chromosomal regions were independently associated with c

285 on cohort), 7 independent associations, in 5 chromosomal regions, were associated with IL-18 levels (

286 symbiosis ICEs that exist as three separate chromosomal regions when integrated in their hosts, but

287 nds 15- to 18-nt DNA guides derived from the chromosomal region where replication terminates and asso

288 common feature of eukaryote genomes is large chromosomal regions where recombination is absent or str

289 o known as MUL) gene is located in the 17q23 chromosomal region, which is amplified in up to approxim

290 the position of this event determines which chromosomal regions will undergo cohesion release at ana

291 e different genetic variants within the 6p21 chromosomal region with different non-Hodgkin lymphoma (

292 Both intriguing and perplexing is a distal chromosomal region with the greatest DNA similarity betw

293 3 M genotyped and imputed SNPs resulted in 3 chromosomal regions with association P approximately 10(

294 In this way, large chromosomal regions with atypical features are identifie

295 to eight additional cell lines and find that chromosomal regions with conserved and cell-type specifi

296 oping and using a novel approach to identify chromosomal regions with consistent introgression signal

297 Chromosomal regions with newly acquired cenH3 are coloni

298 In chromosomal regions with suppressed recombination, delet

299 out the genome without bias for a particular chromosomal region, with the exception of a small region

300 Our results reveal the architecture of the chromosomal region within which kinetochores are embedde