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1 cells of a patient with a t(2;11)(q22.1;q21) chromosomal translocation.
2 factor is associated with risk of a specific chromosomal translocation.
3 multiple myeloma due to a recurrent t(4;14) chromosomal translocation.
4 ffects in ALL with the t(12;21)/(ETV6-RUNX1) chromosomal translocation.
5 (PML)/RARalpha, which is generated in APL by chromosomal translocation.
6 f PAX5 in cells with and without the t(8;21) chromosomal translocation.
7 s formed as the result of a disease-specific chromosomal translocation.
8 me expansion, chromosomal rearrangement, and chromosomal translocation.
9 R1- (EWS) fusion genes that are derived from chromosomal translocation.
10 ociated with a balanced t(1;11)(q42.1;q14.3) chromosomal translocation.
11 ous end-joining (Alt-NHEJ) events, including chromosomal translocations.
12 nst DNA damage, and reduces the frequency of chromosomal translocations.
13 ements, including deletions, inversions, and chromosomal translocations.
14 for the formation of AID-dependent Igh-cMyc chromosomal translocations.
15 territories favors DSB formation, leading to chromosomal translocations.
16 d with mutations, altered gene expression or chromosomal translocations.
17 2 (FGFR2) fusion proteins (FFs) generated by chromosomal translocations.
18 rrangement and the role of ATM in preventing chromosomal translocations.
19 ed due to involvement in leukemia-associated chromosomal translocations.
20 ollicular lymphoma is one of the most common chromosomal translocations.
21 mplicated in joining DSBs found in oncogenic chromosomal translocations.
22 repair activity, but at the cost of frequent chromosomal translocations.
23 from GC B cells and frequently involves MYC chromosomal translocations.
24 quence identity that can potentially mediate chromosomal translocations.
25 tion of signal ends as potentially oncogenic chromosomal translocations.
26 reater potential than SIT, but depended upon chromosomal translocations.
27 yndrome (DS-ALL) patients, lacking recurring chromosomal translocations.
28 e NHEJ, an error-prone pathway implicated in chromosomal translocations.
29 s that can serve as substrates for oncogenic chromosomal translocations.
30 type marginal zone (MZ) lymphomas because of chromosomal translocations.
31 s, rather than breakpoints in trans, forming chromosomal translocations.
32 dily detected circulating disease or canonic chromosomal translocations.
33 onsequences including off-target editing and chromosomal translocations.
34 icated in cancer-associated gene fusions and chromosomal translocations.
35 hub of RAG-mediated V(D)J recombination and chromosomal translocations.
36 arranged in a number of different cancers by chromosomal translocations.
37 stic leukemia through its involvement in the chromosomal translocation 1;19 and consequent expression
38 ia 1 (DISC1) gene is disrupted by a balanced chromosomal translocation (1; 11) (q42; q14.3) in a Scot
41 riants in NR2F2 including a de novo balanced chromosomal translocation, a de novo substitution disrup
42 a snoRNA overexpressed as a consequence of a chromosomal translocation, a potent driving force of the
43 ich premalignant B cells carrying a t(14;18) chromosomal translocation accumulate additional genetic
46 ange in gene sequences and thus suggest that chromosomal translocations alone may play an underapprec
47 dly develop thymic lymphomas bearing complex chromosomal translocations, amplifications and deletions
48 M-dependent DNA damage responses, leading to chromosomal translocation and defective G(2)/M checkpoin
49 ful platform for understanding the effect of chromosomal translocation and for the development of new
50 iple myeloma (MM) as a result of the t(4;14) chromosomal translocation and in a broad variety of othe
51 Two of these driving loci are linked by a chromosomal translocation and thus constitute a novel ty
52 in originally identified as the product of a chromosomal translocation and which associates with both
54 Ls that respond poorly to current therapies, chromosomal translocations and amplification lead to con
55 re involved in recurrent leukemia-associated chromosomal translocations and are key regulators of cel
56 ps with an alternative breakpoint region for chromosomal translocations and contains a GC-specific no
58 promotes lymphocyte malignancies by causing chromosomal translocations and DNA deletions at cancer g
59 ressive pro-B cell lymphomas bearing complex chromosomal translocations and gene amplifications invol
61 neage leukemia (MLL) fusion genes arise from chromosomal translocations and induce acute myeloid leuk
62 ia/lymphoma 1 (TCL1) oncogene is a target of chromosomal translocations and inversions at 14q31.2, an
63 ic development and its dysregulation through chromosomal translocations and loss-of-function mutation
64 genomic instability by initiating oncogenic chromosomal translocations and mutations involved in the
66 data define PARP1 as a critical mediator of chromosomal translocations and raise the possibility tha
67 in GSI-resistant human tumor cell lines with chromosomal translocations and rearrangements in Notch g
68 anscription factors associated with balanced chromosomal translocations and salivary gland tumors.
69 homologous end joining, which contributes to chromosomal translocations and telomere fusions, but the
71 int mutations, amplifications/deletions, and chromosomal translocations, and how these aberrant event
83 ) is a proto-oncogene frequently involved in chromosomal translocations associated with acute leukemi
85 g it suitable for discovering and cataloging chromosomal translocations associated with specific grou
86 ndicated that T-DNA insertion lines can have chromosomal translocations associated with the T-DNA ins
88 ), is the premier model of cancer-associated chromosomal translocations because it is the only transl
89 ressive soft tissue tumor characterized by a chromosomal translocation between chromosome 18 and X, g
90 EWS-ATF1, the fusion product of a balanced chromosomal translocation between chromosomes 22 and 12,
91 identification of the genes associated with chromosomal translocation breakpoints has fundamentally
92 We examine a set of clinically important chromosomal translocation breakpoints that occur at long
93 was not seen in conjunction with established chromosomal translocations but 6 (12%) cases had high hy
94 only for the repair of pathologic DSBs as in chromosomal translocations, but also for the repair of p
95 t of ESC-based cellular and animal models of chromosomal translocation by CRISPR/Cas9 provides a powe
96 nd frequency of DNA damage in the genesis of chromosomal translocations by measuring these parameters
100 210(BCR-ABL), the fusion product of a (9;22) chromosomal translocation causative for chronic myeloid
103 ription factor c-Myc, e.g. caused by t(8;14) chromosomal translocation commonly found in Burkitt lymp
105 osa, we determined that dosage variation and chromosomal translocations consistent with homoeologous
106 leotide substitutions, insertions/deletions, chromosomal translocations, copy number abnormalities, a
107 Over 80% of aRMSs are characterized by a chromosomal translocation-derived fusion transcription f
108 tly driven by genetic abnormalities, such as chromosomal translocations directly involving the MYC lo
110 netic-epigenetic interplay at breakpoints of chromosomal translocations disrupting CG-rich loci, we q
112 by a single amino acid substitution or by a chromosomal translocation [e.g., t(8;21)], is linked to
114 Many sarcomas and leukemias carry nonrandom chromosomal translocations encoding tumor-specific mutan
115 DNA sequencing data, we developed Fusion And Chromosomal Translocation Enumeration and Recovery Algor
118 hese domains would be lost or disrupted by a chromosomal translocation event after amino acid 597, wh
119 The FUS and EWSR1 genes are also prone to chromosomal translocation events, which result in aberra
120 om DNA-PKcs (5A/5A) B cells reveal increased chromosomal translocations, extensive use of distal swit
121 nalysis identified a pattern of paired intra-chromosomal translocations flanking focal amplifications
122 vement of interchromosomal LCRs in recurrent chromosomal translocation formation, we performed comput
124 AID and increased somatic hypermutation and chromosomal translocation frequency to the Igh locus and
125 OZ (MYST3, KAT6A) is the target of recurrent chromosomal translocations fusing the MOZ gene to CBP, p
126 ypes via various direct mechanisms including chromosomal translocations, gene amplification or deleti
127 essive soft-tissue malignancies that express chromosomal translocation-generated fusion genes, SS18-S
128 and can lead to rDNA transcriptional arrest, chromosomal translocations, genomic losses, and cell dea
129 show that well-established cancer-associated chromosomal translocations give rise to fusion circRNAs
132 two defined loci can produce stable balanced chromosomal translocations, however, a single engineered
133 The lack of cellular and animal models for chromosomal translocations, however, has hampered our ab
135 contribute to oncogenic activation, when in chromosomal translocations Ig enhancer elements and onco
136 PARP1 protein expression strongly repressed chromosomal translocations, implying that PARP1 is essen
138 transcriptionally as a result of the t(4;14) chromosomal translocation in a subset of patients with M
139 s a fusion oncoprotein generated by the 2;13 chromosomal translocation in alveolar rhabdomyosarcoma (
140 ression, suggesting that its deregulation by chromosomal translocation in BL leads to miR-28 suppress
141 ncogenic fusion gene EWS-WT1 is the defining chromosomal translocation in desmoplastic small round-ce
142 ic myelogenous leukemia (CML) results from a chromosomal translocation in hematopoietic stem or early
144 s created by the recurrent t(11;18)(q21;q21) chromosomal translocation in mucosa-associated lymphoid
145 as a proto-oncogene resulting from a t(6;14) chromosomal translocation in multiple myeloma and its ex
147 asked whether PARP1 inhibition could prevent chromosomal translocations in 3 translocation reporter s
148 disposes to thymic lymphomas associated with chromosomal translocations in a p53 mutant background, a
149 anscription factor, is overexpressed through chromosomal translocations in a subset of B cell lymphom
150 rand breaks, inverted duplications and intra-chromosomal translocations in a wide spectrum of organis
152 transcription factor is converted by t(1;19) chromosomal translocations in acute leukemia into the ch
153 ation genes (MTGs), originally identified as chromosomal translocations in acute myelogenous leukemia
154 MTG16 (CBFA2T3) are identified as targets of chromosomal translocations in acute myeloid leukemia (AM
155 enetic links to cancer with the discovery of chromosomal translocations in association with many hema
160 advances toward understanding the origin of chromosomal translocations in incipient lymphoid cancers
162 t for the formation of the most common human chromosomal translocations in lymphoid malignancies, yet
163 ome non-consensus RSS, frequently present at chromosomal translocations in lymphoid neoplasms, may pr
168 wn as EVI1) proto-oncogene is deregulated by chromosomal translocations in some cases of acute myeloi
172 ther V(D)J recombination or CSR can initiate chromosomal translocations, including oncogenic IgH locu
173 genomic instability has been associated with chromosomal translocations, including the recurrent t(11
174 o an oncoantigen resulting from an oncogenic chromosomal translocation inhibits lymphoma disseminatio
175 A variety of genetic lesions, including chromosomal translocations, internal tandem duplications
176 cells express oncogenic ALK resulting from a chromosomal translocation involved in lymphomagenesis.
178 ymphoid malignancies characterized by clonal chromosomal translocations involving antigen receptor ge
181 alterations of GNA13, CREBBP, and EZH2, and chromosomal translocations involving IgH and either BCL2
182 ator of normal hematopoietic development and chromosomal translocations involving MLL are one of the
183 xpression in leukemic cells, suggesting that chromosomal translocations involving MLL could lead to t
191 subset of acute myeloid leukemias (AML) with chromosomal translocations involving the MLL gene have a
194 y harbored RAG-dependent reciprocal t(14:15) chromosomal translocations involving the T cell receptor
197 ytosis, has been identified in two recurring chromosomal translocations, involving either MLL or MLLT
199 al organization of the genome contributes to chromosomal translocations is an important question in c
200 rors in CSR can lead to dangerous, oncogenic chromosomal translocations it is important to identify t
205 is a member of the nuclear pore complex, the chromosomal translocations leading to NUP98 gene fusions
207 are frequently altered in leukaemia through chromosomal translocation, mutation or aberrant expressi
209 In this regard, major RAG off-targets in chromosomal translocations occur as convergent RSS pairs
210 dominant-negative truncation that models the chromosomal translocation of human DISC1 in schizophreni
211 rying both a deletion of FcgammaRIIB and the chromosomal translocation of Y-linked autoimmune acceler
212 ) is frequently associated with mutations or chromosomal translocations of genes encoding transcripti
213 g of cells that have acquired cancer-causing chromosomal translocations of great relevance for humans
218 ns and targeted somatic engineering of inter-chromosomal translocations, offering multifaceted opport
219 etically altered by mutation, amplification, chromosomal translocation or inversion, has been shown t
221 sing proteins, such as those expressed after chromosomal translocations or from point mutations, are
222 ia (MLL) gene is also frequently involved in chromosomal translocations or partial tandem duplication
224 ally as a consequence of gene amplification, chromosomal translocations, or posttranslational mechani
225 actors are commonly deregulated in cancer by chromosomal translocation, overexpression or post-transl
227 hronic phase, this sole genetic abnormality (chromosomal translocation Ph(+): t(9;22)(q34;q11)) at th
228 cluding castration resistance and subsequent chromosomal translocations, play key roles in prostate c
229 expression, transcriptional activity, or by chromosomal translocation plays a critical role in carci
230 actor complex that is frequently involved in chromosomal translocations, point mutations, or deletion
234 or protein tyrosine kinase, is involved in a chromosomal translocation resulting in expression of a B
235 MLL1 gene is a frequent target for recurrent chromosomal translocations, resulting in transformation
236 several recent reports, we demonstrate that chromosomal translocation risk is causally unrelated to
237 te lymphoblastic leukemia (ALL), the t(1,19) chromosomal translocation specifically targets the E2A g
238 e location of genes involved in carcinogenic chromosomal translocations, suggesting their role in can
241 AML2 fusion oncogene, encoded by a recurring chromosomal translocation t(11;19)(q14-21;p12-13), is a
242 g sarcomas are characterized by the in-frame chromosomal translocation t(11;22) generating the EWS-FL
243 FLI1 is a fusion gene product generated by a chromosomal translocation t(11;22)(q24;q12) found in Ewi
244 E2A-PBX1 fusion oncogene, which results from chromosomal translocation t(1;19) and is present in 5% t
246 e fusion protein NUP98-HOXD13 (NHD13) of the chromosomal translocation t(2;11)(q31;p15) is expressed
247 th acute myeloid leukemia characterized by a chromosomal translocation t(7;12)-HLXB9/TEL and concomit
248 skin tumor associated with a characteristic chromosomal translocation (t[17;22][q22;q13]) resulting
249 ients, 2 of which were associated with known chromosomal translocations (t(1;19)(TCF3-PBX1) or MLL),
250 y identified at the breakpoint of a balanced chromosomal translocation, t(1;11) (q42.1;14.3), in a fa
251 illness through its disruption by a balanced chromosomal translocation, t(1;11)(q42.1;q14.3), that co
254 acute myeloid leukemias (AMLs), a recurring chromosomal translocation, termed t(8;21), generates the
255 are 100- to 1,000-fold more prone to undergo chromosomal translocation than the adjacent regions.
256 (PML) was originally identified as part of a chromosomal translocation that contributes to the develo
257 is characterized by the t(15;17)(q22;q11.2) chromosomal translocation that creates the promyelocytic
258 hypotonia that harbored a de novo, balanced chromosomal translocation that disrupts the CAPZB gene.
259 Ewing's sarcoma contain the (11;22)(q24;q12) chromosomal translocation that encodes the EWS/FLI oncop
260 hyroid carcinomas contains a t(2;3)(q13;p25) chromosomal translocation that fuses paired box gene 8 (
261 3 gene cause Waardenburg syndrome, whereas a chromosomal translocation that generates a PAX3-FOXO1 fu
262 oft tissue malignancy initiated by a t(X;18) chromosomal translocation that generates an SS18-SSX fus
263 sarcoma is characterized by a pathognomonic chromosomal translocation that generates the EWSR1-FLI1
264 ), an indolent neoplasm caused by a t(14;18) chromosomal translocation that juxtaposes the BCL2 gene
265 ALL) harbor a fusion oncogene results from a chromosomal translocation that juxtaposes the mixed-line
267 cells, BCR expression is retained despite a chromosomal translocation that links the antiapoptotic g
268 osarcoma is characterized by a pathognomonic chromosomal translocation that results in an oncogenic f
272 EJ) in the generation of large deletions and chromosomal translocations that are frequently observed
273 xpressed at the transcriptional level due to chromosomal translocations that bring the MYC gene under
274 but improper regulation of DSBs can lead to chromosomal translocations that can result in B cell lym
275 he MLL gene is involved in a large number of chromosomal translocations that create chimeric proteins
276 K expression in nonneural cells results from chromosomal translocations that create novel fusion prot
278 ; 3 of 97 tumors examined) harbors oncogenic chromosomal translocations that fuse in-frame the tyrosi
279 promyelocytic leukemia is causally linked to chromosomal translocations that generate chimeric retino
282 l carcinomas (TFE-fusion RCCs) are caused by chromosomal translocations that lead to overexpression o
283 Ewing sarcoma family tumors (ESFTs) exhibit chromosomal translocations that lead to the creation of
284 vere forms of DNA damage and responsible for chromosomal translocations that may lead to gene fusions
286 acterized by simple karyotypes and recurrent chromosomal translocations, the mechanisms driving cytog
287 this approach in three patients with complex chromosomal translocations: The first had craniofacial a
293 eover, a BCAM-AKT2 fusion gene generated via chromosomal translocation using the CRISPR/Cas9 system l
294 AML1 function and its direct involvement in chromosomal translocation, we demonstrate that both the
299 ces the risk for aberrant recombinations and chromosomal translocations when exposed to DNA damage, i
300 promyelocytic leukemia (APL) is driven by a chromosomal translocation whose product, the PML/retinoi