ライフサイエンスコーパス: chromosome instability

1 atid recombination events leading to rampant chromosome instability.

2 ad spectrum of early-onset cancers caused by chromosome instability.

3 totic spindle, and centrosomal defects cause chromosome instability.

4 developed malignant tumors with evidence of chromosome instability.

5 ads to sister chromatid cohesion defects and chromosome instability.

6 mage-induced point mutagenesis and extensive chromosome instability.

7 the formation of micronuclei, a hallmark of chromosome instability.

8 of endogenous MCAK/Kif2C similarly increased chromosome instability.

9 ave an increased probability of resulting in chromosome instability.

10 t are temperature sensitive and exhibit high chromosome instability.

11 mean level to achieve maximal suppression of chromosome instability.

12 large target for ionizing radiation-induced chromosome instability.

13 bout accusations of a different type of CIN, chromosome instability.

14 altered checkpoint responses, and increased chromosome instability.

15 on cancer are microsatellite instability and chromosome instability.

16 we show that compromised autophagy promoted chromosome instability.

17 he interface cause checkpoint deficiency and chromosome instability.

18 persistence of under-replicated regions and chromosome instability.

19 assembly, endoreduplication and significant chromosome instability.

20 s of methylation may provide the basis for X-chromosome instability.

21 me (ChrVII) can undergo remarkable cycles of chromosome instability.

22 rad1 yeast, but at the same time exacerbated chromosome instability.

23 onal and can exhibit a neoplastic nature and chromosome instability.

24 ch as severe growth retardation and enhanced chromosome instability.

25 elomerase activity, correlate with increased chromosome instability.

26 cancer development through the generation of chromosome instability.

27 a in situ lesions for centrosome defects and chromosome instability.

28 or of cdc28(CST) temperature sensitivity and chromosome instability.

29 ion of wild-type BUB1 or MAD3 genes leads to chromosome instability.

30 aryotype and, hence, precise quantitation of chromosome instability.

31 XRCC3 mutation causes severe chromosome instability.

32 ss-linking agent mitomycin-C and spontaneous chromosome instability.

33 many malignancies as part of a signature of chromosome instability.

34 of cell cycle control, but not by increased chromosome instability.

35 ication, which leads to aberrant mitosis and chromosome instability.

36 a cellular phenotype that includes increased chromosome instability.

37 vel 20q13.2 amplification is associated with chromosome instability.

38 tulated to be a driver of malignancy through chromosome instability.

39 oteotoxicity, replication stress, and severe chromosome instability.

40 x, which reduce aneuploidy by suppression of chromosome instability.

41 umerous human malignancies, and is linked to chromosome instability.

42 po IIalpha-deficient cells and a hallmark of chromosome instability.

43 functions of R loops and ATR in suppressing chromosome instability.

44 S: Many different types of cancer cells have chromosome instability.

45 sDNA), sensitivity to replication drugs, and chromosome instability.

46 t YAP cooperates with FOXM1 to contribute to chromosome instability.

47 abnormal large-scale chromatin structure and chromosome instability.

48 T-cell lymphoma samples, indicating ongoing chromosome instability.

49 ns with 18 deletion mutations known to cause chromosome instability.

50 escape, abnormal chromosome segregation, and chromosome instability.

51 tly missegregate at mitosis, driving further chromosome instability.

52 plication complexes, replication stress, and chromosome instability.

53 her mutant to H3T3ph during mitosis promotes chromosome instability.

54 or malignant progression by promoting whole chromosome instability.

55 ain of 1q12, 1q21, and Xq13.1 without global chromosome instability.

56 t, chromosome congression defects, and whole-chromosome instability.

57 both spindle poles [1], is a major cause of chromosome instability [2], which is commonly observed i

58 bility, and deletions of NAT1 and SBA1 cause chromosome instability, a phenotype not previously assoc

59 re, we report that p53 suppresses structural chromosome instability after mitotic arrest in human cel

60 tic response is the prevention of structural chromosome instability after prolonged activation of the

61 The lymphoma cells demonstrated chromosome instability along with upregulation of severa

62 brids and misincorporated ribonucleotides to chromosome instability also was uncertain.

63 rative tissues such as skin and bone marrow, chromosome instability and a predisposition to develop c

64 the abp1 null strain displays marked mitotic chromosome instability and a pronounced meiotic defect.

65 and telomere dysfunction are associated with chromosome instability and an increased risk of cancer.

66 Chromosome instability and aneuploidy are hallmarks of c

67 hese events correlated with the induction of chromosome instability and aneuploidy in nonmalignant Ma

68 ng cascade, as a means to selectively induce chromosome instability and aneuploidy in the epidermis o

69 called the spindle checkpoint contribute to chromosome instability and aneuploidy.

70 ll cycle, thus preventing repeated cycles of chromosome instability and aneuploidy.

71 nts irs1 and irs1SF exhibit high spontaneous chromosome instability and broad-spectrum mutagen sensit

72 ication in response to DNA damage, and cause chromosome instability and cancer in humans.

73 be a novel role for PinX1 and telomerase in chromosome instability and cancer initiation and suggest

74 the significance of telomerase activation in chromosome instability and cancer initiation.

75 n mitosis, dysregulation of which results in chromosome instability and cancer predisposition.

76 ble-strand breaks containing such termini on chromosome instability and cancer.

77 s and anti-tumor therapy on the one hand and chromosome instability and carcinogenesis on the other.

78 leads to DNA damage in mitosis, and promotes chromosome instability and cell death.

79 Here we show that chromosome instability and changes in chromosome content

80 h this, a human PICH(-/-) cell line exhibits chromosome instability and chromosome condensation and d

81 t centrosome defects occur concurrently with chromosome instability and cytologic changes in the earl

82 lomeres, these defects may contribute to the chromosome instability and disease associated with NBS p

83 tion leads to cell death in yeast and causes chromosome instability and embryonic lethality in mammal

84 Breakage-fusion-bridge cycles contribute to chromosome instability and generate large DNA palindrome

85 an msc1 mutant, a pht1 mutant also exhibits chromosome instability and genetic interactions with kin

86 ve or therapeutic effects in arsenic-induced chromosome instability and genotoxicity.

87 nt cells from patients exhibited spontaneous chromosome instability and impaired DNA repair that was

88 amplification is a phenotype-causing form of chromosome instability and is initiated by DNA double-st

89 , centrosome defects have been implicated in chromosome instability and loss of cell cycle control in

90 Disruption of POT1 function leads to chromosome instability and loss of cellular viability.

91 e, and zebrafish models are characterized by chromosome instability and low survivin expression.

92 alterations in MT assembly rates that affect chromosome instability and mitotic spindle function, but

93 lian cells induces centrosome amplification, chromosome instability and oncogenic transformation, a p

94 ctopic kinetochore assembly led to increased chromosome instability and partial aneuploidy of the tar

95 cers, results in abnormal mitoses leading to chromosome instability and possibly tumorigenesis.

96 argeting microtubule poleward flux to modify chromosome instability and provide insight into the mech

97 stinct networks that safeguard against whole chromosome instability and reveal the differential impor

98 Nbs1 inhibited DNA break repair, leading to chromosome instability and subsequent transformation tha

99 re, the deletion of RCY1 is tied to enhanced chromosome instability and temperature-sensitive cell gr

100 de important insights into the mechanisms of chromosome instability and the development of novel appr

101 genetic factors might influence the onset of chromosome instability and the role of chromosomal insta

102 roviding insights into their contribution to chromosome instability and therefore, to genomic variati

103 s with higher FGC scores are associated with chromosome instability and TP53 mutations, and a worse p

104 when expressing telomerase, contributing to chromosome instability and tumor cell progression.

105 a prominent protooncogene that causes whole chromosome instability and tumor formation over a wide g

106 t AD and CVD also share a cell cycle defect: chromosome instability and up to 30% aneuploidy-in neuro

107 Chromosome 1q gain, associated with chromosome instability and upregulated mitochondrial fun

108 rom illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregat

109 Abro1 deficiency results in increased chromosome instability, and Abro1-null mice are tumor-pr

110 -induced oxidative stress, telomere erosion, chromosome instability, and apoptosis, suggesting that i

111 urred together with mitotic spindle defects, chromosome instability, and high cytologic grade.

112 Chromosome breakage syndromes are defined by chromosome instability, and individuals with these disea

113 ulation can induce centrosome amplification, chromosome instability, and oncogenesis.

114 temperature undergo G2/M arrest, progressive chromosome instability, and subsequent cell death.

115 ensitive to double-strand breaks, leading to chromosome instability, and that this instability can be

116 tical role in preventing replication stress, chromosome instability, and tumorigenesis.

117 Aneuploidy and chromosome instability are common abnormalities in human

118 finding that supports the potential value of chromosome instability as a prognostic predictor.

119 ility genes using the surrogate biomarker of chromosome instability as a screen.

120 We found that all tumors exhibit chromosome instability as evidenced by structural chromo

121 onstrate that genotoxic carcinogens increase chromosome instability, as evidenced by a significant in

122 a defined interstitial telomere sequence on chromosome instability, as well as other aspects of DNA

123 n genetic syndrome associated with increased chromosome instability at fragile sites following replic

124 Spindle defects are not only an impetus of chromosome instability but are also a cause of developme

125 in cell lines derived from colon tumors with chromosome instability, but not in cells from colon tumo

126 Here we show that induction of chromosome instability by overexpression of the mitotic

127 d a sensitive method to examine the level of chromosome instability by using retrovirus carrying both

128 Gene expression patterns associated with chromosome instability, called CIN25 and CIN70, were det

129 These results demonstrate how chromosome instability can arise as a by-product of defe

130 is a human genetic disease characterized by chromosome instability, cancer predisposition, and cellu

131 tion deficiency (HRD), which we attribute to chromosome instability caused by unrepaired DNA gaps at

132 inverted repeats was followed by a period of chromosome instability, characterized by amplification o

133 curs at secondary structures associated with chromosome instability, chromosome remodelling, viral re

134 Chromosome instability (CIN) and aneuploidy are hallmark

135 centrosomes, which has been associated with chromosome instability (CIN) and aneuploidy.

136 er is categorized into two distinct classes: chromosome instability (CIN) and microsatellite instabil

137 Aneuploidy and chromosome instability (CIN) are hallmarks of the majori

138 sociates significantly with the induction of chromosome instability (CIN) by the likely human lung ca

139 nd further correlated with the levels of the chromosome instability (CIN) genes MAD2 and CDC20.

140 Chromosome instability (CIN) has been detected in pNETs

141 Whole chromosome instability (CIN) is a common feature of canc

142 Chromosome instability (CIN) is a common feature of tumo

143 Chromosome instability (CIN) is a common property of can

144 Chromosome instability (CIN) is deleterious to normal ce

145 Chromosome instability (CIN) is frequently observed in m

146 Chromosome instability (CIN) is observed in 80% to 90% o

147 Chromosome instability (CIN) is one of the most importan

148 Chromosome instability (CIN) is the most common form of

149 Chromosome instability (CIN) is the most striking featur

150 mors are aneuploid because of the underlying chromosome instability (CIN) phenotype, in which a defec

151 Chromosome instability (CIN), a common feature of solid

152 on cancer: microsatellite instability (MSI), chromosome instability (CIN), and chromosome translocati

153 Cancer cells exhibit high levels of chromosome instability (CIN), and considerable interest

154 h the majority of colorectal cancers exhibit chromosome instability (CIN), only a few genes that migh

155 Chromosome instability (CIN), pulmonary dysplasia, sonic

156 One form of chromosome instability (CIN), the recurrent missegregati

157 determine the role of gene overexpression on chromosome instability (CIN), we performed genome-wide s

158 t elevated chromosome mis-segregation termed chromosome instability (CIN), which is likely to be a po

159 Chromosome instability (CIN), which is often mutually ex

160 One of the hallmarks of cancer is chromosome instability (CIN), which leads to aneuploidy,

161 l chromosome segregation, thereby preventing chromosome instability (CIN).

162 characterised by TP53 mutation and extensive chromosome instability (CIN).

163 urs in human cancers and is a major cause of chromosome instability (CIN).

164 and human breast epithelial cells results in chromosome instability (CIN).

165 is characterised by poor outcome and extreme chromosome instability (CIN).

166 tion of human cleavage-stage embryos exhibit chromosome instability (CIN).

167 fective cell cycle exit and the emergence of chromosome instability (CIN).

168 rize the causes underlying the high rates of chromosome instability (CIN+) observed in colorectal tum

169 e function is an important mechanism for the chromosome instability commonly found in cancer.

170 Trp53(YC/YC) fibroblasts exhibited increased chromosome instability compared to Trp53(-/-) cells.

171 kpoint control leads to more subtle rates of chromosome instability compatible with cell viability re

172 Dramatic genome dynamics, such as chromosome instability, contribute to the remarkable gen

173 Chromosome instability contributes to the multistep onco

174 ity increased and when telomeres lengthened, chromosome instability decreased.

175 past few years, study of the rare inherited chromosome instability disorder, Fanconi Anemia (FA), ha

176 ene mutated in Nijmegen breakage syndrome, a chromosome instability disorder, has been identified and

177 tardation, male infertility, immune defects, chromosome instability, DNA repair defects, and radiatio

178 high levels of copy number heterogeneity in chromosome instability-driven murine T-cell lymphoma sam

179 e a source for both numerical and structural chromosome instability during HPV-associated carcinogene

180 nst highly aneuploid blastomeres to overcome chromosome instability during preimplantation developmen

181 A genome-wide increase in chromosome instability (gains and losses) within genes a

182 els of nuclear YAP correlated with increased chromosome instability gene expression patterns and aneu

183 ibiting FOXM1 with thiostrepton, reduced the chromosome instability gene expression patterns.

184 We conclude that chromosome instability generates the necessary chromosom

185 hese simulations lead us to suspect that the chromosome instability genes cause cell-cycle perturbati

186 between retroelements, DNA methylation, and chromosome instability has yet been identified.

187 lmark of cancer cells, few mutations causing chromosome instability have been identified in cancer ge

188 weight isoforms (LMW-E) of cyclin E induces chromosome instability; however, the degree to which the

189 ifferently and leads to different degrees of chromosome instability in a breast cancer model system.

190 one deleterious hot-spot mutation increased chromosome instability in a wild-type (WT) background, s

191 igating aneuploidy in human cancers, rate of chromosome instability in aneuploidy tumor cells, and ge

192 multiple DNA repair processes to potentiate chromosome instability in both monocytes and hepatocytes

193 Here, we show that Akt1 promotes chromosome instability in Brca1-deficent cells.

194 ssue fragility, defective cell migration and chromosome instability in Caenorhabditis elegans.

195 ene-induced replication stress, but promotes chromosome instability in cancer cells that lack cell cy

196 le elongation forces might be used to reduce chromosome instability in cancer cells.

197 r, is the major cause of mitotic defects and chromosome instability in cancer cells.

198 es is the major cause of mitotic defects and chromosome instability in cancer cells.

199 consequential mitotic defects contribute to chromosome instability in cancers.

200 8 and spt4 delta strains exhibit synergistic chromosome instability in combination with CEN DNA mutat

201 3, induced centrosome hyperamplification and chromosome instability in cultured cells.

202 We found that Wwox loss is followed by mild chromosome instability in genomes of mouse embryo fibrob

203 tic mutations may represent a major cause of chromosome instability in human cancers.

204 ons and altered function with aneuploidy and chromosome instability in human lymphocytes and in Droso

205 e the relationship between telomere loss and chromosome instability in mammalian cells, we investigat

206 nstitutes a previously overlooked source for chromosome instability in mitosis and meiosis.

207 Cdk2 abrogates centrosome amplification and chromosome instability in p53-null MEFs.

208 orks leads to increases in recombination and chromosome instability in Saccharomyces cerevisiae and c

209 ly, Merit40 mutation exacerbated ICL-induced chromosome instability in the context of concomitant Brc

210 tify 19 genes that when over-expressed cause chromosome instability in the yeast Saccharomyces cerevi

211 xcess centrosomes can lead to aneuploidy and chromosome instability in tumor cells, how untransformed

212 oint signaling system that may contribute to chromosome instability in tumors.

213 Thus, chromosome instability in vivo may be associated with ab

214 n this issue of Cell, Lemoine et al. monitor chromosome instability in yeast cells with reduced level

215 Lastly, we show that TSI is associated with chromosome instabilities including chromosome loss, micr

216 rstrand cross-links, and exhibited extensive chromosome instability including aneuploidy, chromosome

217 As a result, KSHV-infected cells manifest chromosome instability, including chromosomal misalignme

218 notypes, such that when telomeres shortened, chromosome instability increased and when telomeres leng

219 Moreover, we show that the chromosome instability induced by the loss of p53 is gre

220 This study examined the extent of chromosome instability induced in cultured human colon c

221 Chromosome instability is a critical event in cancer pro

222 Chromosome instability is a prevalent vulnerability of c

223 mong the diploid nuclei, which suggests that chromosome instability is a result of altered genetic co

224 Volumes of data indicate that chromosome instability is an early event of carcinogenes

225 We not only demonstrate that chromosome instability is conserved between bovine and h

226 ction, the significance of APC in regulating chromosome instability is less well established.

227 The induced chromosome instability is linked to an evolutionarily co

228 The increased chromosome instability is observed irrespective of cellu

229 This suggests that chromosome instability is somehow suppressed in the aneu

230 Chromosome instability is thought to be a major contribu

231 Despite the observed chromosome instabilities, Ku80-/- mice have only a sligh

232 Chromosome instability leading to aneuploidy and accumul

233 Aneuploidy-chromosome instability leading to incorrect chromosome n

234 AD2+/-cells enter anaphase early and display chromosome instability, leading to the formation of lung

235 Chromosome instability leads to aneuploidy, a state in w

236 Exemplified by chromosome instability-mediated carcinogenicity, we disc

237 bility, microsatellite instability (MSI) and chromosome instability (microsatellite stable; MSS), are

238 e genetic features that lead to sporadic CRC-chromosome instability, microsatellite instability, and

239 well as the effects of defective DNA repair, chromosome instability, microsatellite instability, and

240 As chromosome instability might drive tumour evolution, kar

241 y identified in a phenotype-based screen for chromosome instability mutants in mice.

242 ed a phenotype-driven mutagenesis screen for chromosome instability mutants using a flow cytometric p

243 Here, we report that the mouse chromosome instability mutation Chaos3 (chromosome aberr

244 est exhibited neither significant structural chromosome instability nor p53-dependent cell cycle arre

245 plication provides a potential mechanism for chromosome instability observed as a consequence of cycl

246 Chromosome instability of cbf1Delta cells is suppressed

247 inker, mitomycin C (MMC), thus mimicking the chromosome instability of FA cells.

248 Our work suggests the chromosome instability of human embryos could be mitigat

249 s normal yeast chromosome may be relevant to chromosome instability of mammalian fragile sites and of

250 suppressed both the frequency and structural chromosome instability of spontaneous polyploids in HCT1

251 to suppress the proliferation and structural chromosome instability of the resulting polyploid cells.

252 ls and is a primary mechanism preventing the chromosome instability often seen in aneuploid human tum

253 Bloom syndrome (BS) are clinically distinct, chromosome instability (or breakage) disorders.

254 tion-induced gene expression, DNA repair and chromosome instability, oxidative damage, cell cycle arr

255 with high-grade invasive carcinomas and with chromosome instability, particularly gains of chromosome

256 light on the initial molecular events in the chromosome instability phenotype.

257 ctions (G2/M), which may explain some of the chromosome instability phenotypes attributed to loss of

258 mere length and fluctuations in the rates of chromosome instability phenotypes, such that when telome

259 chromosomes are distinct forms of structural chromosome instability precipitated by replication inhib

260 e characterized by congenital abnormalities, chromosome instability, progressive bone marrow failure

261 stress conditions can induce an increase in chromosome instability, proteotoxic stress, caused by tr

262 ome (NBS) is a rare human disease displaying chromosome instability, radiosensitivity, cancer predisp

263 transient Mad2 overexpression and consequent chromosome instability recur at markedly elevated rates.

264 Telomere shortening can lead to chromosome instability, replicative senescence, and apop

265 Sister chromatid fusion is followed by chromosome instability resulting from breakage-fusion-br

266 the sites of DSBs, a mechanism that prevents chromosome instability resulting from DSBs near telomere

267 in a human tumor cell line, suggesting that chromosome instability resulting from telomere loss play

268 ithin a single tissue respond differently to chromosome instability: some proliferating cell lineages

269 sting a link between centromere alterations, chromosome instability, SSc autoimmunity, and fibrosis.

270 that increased genetic variation, including chromosome instability, starts at the initiation stage o

271 There are two types of chromosome instability, structural and numerical, and th

272 oticeable for the suppression of spontaneous chromosome instability such as micronuclei and 53BP1 nuc

273 FA is a chromosome instability syndrome characterized by childho

274 Fanconi anemia (FA) is a chromosome instability syndrome characterized by increas

275 anconi anemia (FA) is an autosomal recessive chromosome instability syndrome characterized by progres

276 Fanconi anemia (FA) is a chromosome instability syndrome of children caused by in

277 proteins and responsible proteins for other chromosome instability syndromes (BLM, NBS1, MRE11, ATM,

278 erm line DDR alterations underlie hereditary chromosome instability syndromes by promoting the acquis

279 ion, in events that may ultimately drive the chromosome instabilities that underpin early-onset cance

280 taining two centromeres (dicentrics) trigger chromosome instability that is avoided by the enigmatic

281 This suggests ongoing chromosome instability that other platforms fail to dete

282 Chromosome instability, the process that gives rise to a

283 been reported to display an elevated rate of chromosome instability, thereby indicating that aneuploi

284 This chromosome instability, therefore, is a consequence of m

285 inactivation of p53 has been shown to induce chromosome instability through centrosome hyperamplifica

286 lication stress and minimizing its impact on chromosome instability, thus preventing diseases, includ

287 inhibition or heat shock, markedly increased chromosome instability to produce a cell population with

288 enerates multipolar mitoses, aneuploidy, and chromosome instability to promote cancer biogenesis.

289 CA promotes cell invasion and chromosome instability, two hallmarks of cancer.

290 cells and provides a rationale to understand chromosome instability typical of polyploid cancer cells

291 oduces extracellular superoxide and promotes chromosome instability via macrophage-induced bystander

292 ysis of these models has revealed that whole chromosome instability (W-CIN) can cause, inhibit or hav

293 To determine the consequences of whole chromosome instability (W-CIN) we down-regulated the spi

294 Intratumor heterogeneity mediated through chromosome instability was associated with an increased

295 adult tissue, we engineered a mouse in which chromosome instability was selectively induced in T cell

296 y, parameters for cell cycle progression and chromosome instability were analysed in deltabetaRII tum

297 A double-strand-break (DSB) repair can cause chromosome instability, which may result in cancer.

298 onset to S-phase and mitosis, and increased chromosome instability, which was enhanced by ionizing r

299 in conjunction with increased DNA damage and chromosome instability, while decreasing heterochromatin

300 urrent knowledge regarding radiation-induced chromosome instability with the emerging molecular infor