ライフサイエンスコーパス: chromosome structure

1 y reduced cell division and altered polytene chromosome structure.

2 where retrotransposons have a vital role in chromosome structure.

3 Cohesin mediates higher order chromosome structure.

4 mplex is a key determinant of higher-ordered chromosome structure.

5 ole in the control of higher-order bacterial chromosome structure.

6 or clonal subpopulation with a highly stable chromosome structure.

7 xpression and maintain genomic integrity and chromosome structure.

8 complex that links RBF1 to the regulation of chromosome structure.

9 th its proposed function in promoting normal chromosome structure.

10 c elements and for the study of higher-order chromosome structure.

11 lated to fiber-fiber interactions and global chromosome structure.

12 out severely deforming or damaging the local chromosome structure.

13 he genome, perhaps reflecting some aspect of chromosome structure.

14 role for Nse4 in maintenance of higher order chromosome structure.

15 has been difficult to relate linkage maps to chromosome structure.

16 xpression patterns with base composition and chromosome structure.

17 hysical contig maps with mitotic and meiotic chromosome structure.

18 y forms, including aneuploidy and changes in chromosome structure.

19 ts constrain models for higher order mitotic chromosome structure.

20 s genome reduplication, which alters mitotic chromosome structure.

21 e existence of a novel mechanism controlling chromosome structure.

22 een designed to identify genes important for chromosome structure.

23 and elasticity, and provide new insight into chromosome structure.

24 thways that participate in preserving intact chromosome structure.

25 the postreplicative repair pathway influence chromosome structure.

26 limited by the conservation of the existing chromosome structure.

27 r as replicon clusters, form stable units of chromosome structure.

28 fewer cytogenetically evident alterations of chromosome structure.

29 d in genetic screens for genes important for chromosome structure.

30 wn to be required for maintenance of correct chromosome structure.

31 and combine them to improve the modeling of chromosome structure.

32 can be used as a tool for probing bacterial chromosome structure.

33 hisms in genes affecting recombination or in chromosome structure.

34 are established by higher order features of chromosome structure.

35 ent additional coiling for the final mitotic chromosome structure.

36 while COH-3/4 complexes control higher-order chromosome structure.

37 residual cohesin subunits remain to maintain chromosome structure.

38 ert a general influence on the patterning of chromosome structure.

39 expression, chromatin accessibility, and 3D chromosome structure.

40 has important functions in relation to basic chromosome structure.

41 est in the molecular mechanisms that control chromosome structure.

42 disentanglement, and maintenance of mitotic chromosome structure.

43 been proposed as the backbone of interphase chromosome structure.

44 y and the establishment of a normal polytene chromosome structure.

45 y and mechanisms that determine higher-order chromosome structure.

46 om forests can generate useful insights into chromosome structure.

47 riability in nuclear genome organization and chromosome structure.

48 he interaction between TRF2 and lamin A/C on chromosome structure.

49 evisiae to changes in gene order and overall chromosome structure.

50 ild-type cells and in mutants with disrupted chromosome structure.

51 of cell identity genes and control of local chromosome structure.

52 n of recombination complexes with underlying chromosome structures.

53 g foci that are integrated with higher-order chromosome structures.

54 trained Eulerian paths corresponding to full chromosome structures.

55 chia coli, indicating that the alteration of chromosome structure after DNA damage may be a widesprea

56 We have imaged remodeling of meiotic chromosome structures after pachytene exit in Caenorhabd

57 ybridization under conditions that preserved chromosome structure, allowing identification of stage-d

58 Comparisons of chromosome structure among percomorphs show that chromos

59 Identification of components essential to chromosome structure and behaviour remains a vibrant are

60 stage for exploring the mechanisms that link chromosome structure and biological function.

61 rangements (GCRs) are large scale changes to chromosome structure and can lead to human disease.

62 cate Orc2 protein in chromosome duplication, chromosome structure and centrosome copy number control,

63 Despite many decades of study, mitotic chromosome structure and composition remain poorly chara

64 ase cause dramatic loss of compacted mitotic chromosome structure and conclude that TOP2A is crucial

65 Cohesin also plays roles in chromosome structure and DNA repair.

66 Mitotic chromosome structure and DNA sequence requirements for n

67 Major protein contributors to chromosome structure and dynamics are condensin and cohe

68 ources to gain insight into the questions of chromosome structure and dynamics.

69 DNA topoisomerases are major determinants of chromosome structure and dynamics.

70 rm-line cells for cyst formation, nurse cell chromosome structure and egg maturation.

71 parallel roles for titin in both muscle and chromosome structure and elasticity, and provide new ins

72 mal component provides a molecular basis for chromosome structure and elasticity.

73 that are useful for comparative analysis of chromosome structure and evolution and facilitates compa

74 ow-sorted chromosomes enables an overview of chromosome structure and evolution at a resolution never

75 broad community of scientists focused on sex chromosome structure and evolution.

76 Condensin complexes organize chromosome structure and facilitate chromosome segregati

77 ral variation that can affect recombination, chromosome structure and fitness.

78 d related the findings to various aspects of chromosome structure and function (DNA sequence organiza

79 ms will provide avenues for studies on plant chromosome structure and function and for future develop

80 ercoiling may modulate epigenetic effects on chromosome structure and function and on prophage behavi

81 ificance of replication-timing boundaries to chromosome structure and function and support the replic

82 Chromosome structure and function are influenced by tran

83 that Su(var2-10 controls multiple aspects of chromosome structure and function by establishing/mainta

84 The model of chromosome structure and function in cereals with large

85 al interactions play an important role in 3D chromosome structure and function, but our understanding

86 iagnosis of human diseases caused by altered chromosome structure and function, facilitate developmen

87 To learn more about holocentric chromosome structure and function, we generated a monocl

88 rticipates in several fundamental aspects of chromosome structure and function.

89 pression, introducing mutations, and probing chromosome structure and function.

90 ombination and the impact of mobile genes on chromosome structure and function.

91 condensin's role in both meiotic and mitotic chromosome structure and function.

92 extract systems to characterize higher-order chromosome structure and function.

93 tegy for assessing human gene expression and chromosome structure and function.

94 lement integration into host genomes affects chromosome structure and function.

95 factor appears to have a more global role in chromosome structure and function.

96 ster chromatid cohesion and other aspects of chromosome structure and function.

97 ns and offer a unified model for large-scale chromosome structure and function.

98 egions are organized is a critical aspect of chromosome structure and function; however, the sequence

99 e interrogation of the relationships between chromosome structure and gene control in development and

100 ting a mechanism for DNA tension to regulate chromosome structure and gene expression.

101 dies have shown strong conservation of gross chromosome structure and gene order in mammals.

102 precipitation is providing new insights into chromosome structure and gene regulation and control thr

103 protein plays important roles in maintaining chromosome structure and in partitioning.

104 st silencing protein Sir3p functions in both chromosome structure and in transcriptional regulation.

105 istal enhancers through the establishment of chromosome structure and long-range enhancer-promoter in

106 Mitosis entails global alterations to chromosome structure and nuclear architecture, concomita

107 an exciting era of discovery in the field of chromosome structure and nuclear organization.

108 this Review, we explore the contributions of chromosome structure and nucleoid organization to cell c

109 I argue that the instability in chromosome structure and number provoked by inactivation

110 epithelial cancers, triggers instability in chromosome structure and number, which are thought to ar

111 omic stability by a mechanism that preserves chromosome structure and number.

112 Research into chromosome structure and organization is an old field th

113 ant nonlinear DNA structures that may define chromosome structure and organization, as well as interm

114 tic interactions between mutations affecting chromosome structure and partitioning in Bacillus subtil

115 tative DNA translocase) and smc (involved in chromosome structure and partitioning) caused a syntheti

116 otic counterpart, plays an important role in chromosome structure and partitioning.

117 Mitotic chromosome structure and pathways of mitotic condensatio

118 ly and reversibly induces a complete loss of chromosome structure and prevents the enrichment of cond

119 mmon mechanism for establishing higher order chromosome structure and proper X chromosome gene expres

120 g the influence of two major forces, spatial chromosome structure and purifying (or negative) selecti

121 3's critical regulatory functions in meiotic chromosome structure and recombination.

122 ils DNA in vitro and is required for mitotic chromosome structure and segregation in vivo.

123 nce of Ki-67 and the chromosome periphery in chromosome structure and segregation, but little is know

124 etion of SMC-4/MIX-1 causes aberrant mitotic chromosome structure and segregation, but not dramatic d

125 -box proteins have been shown to function in chromosome structure and segregation.

126 Large-scale chromosome structure and spatial nuclear arrangement hav

127 s been a useful phenomenon by which to study chromosome structure and the genes that modify it.

128 monstrate the importance of transcription in chromosome structure and the plasticity of supercoil dom

129 ed in polyacrylamide to maintain both native chromosome structure and the three dimensionality of the

130 microscopy approaches that directly examine chromosome structure and then on population-averaged bio

131 al domains and how they function to regulate chromosome structure and transcription.

132 e1's pivotal role in regulating higher-order chromosome structure and X-chromosome-wide gene expressi

133 ve chromatin mesh that organizes large-scale chromosome structures and protects the genome from insta

134 Mechanisms establishing higher-order chromosome structures and their roles in gene regulation

135 enter M phase without repair of the aberrant chromosome structures and undergo cell death during mito

136 ing, chromatin modification, organization of chromosome structure, and ATP-dependent nucleosome slidi

137 gene expression, connect gene expression to chromosome structure, and contribute to human disease.

138 e nucleus, where it regulates transcription, chromosome structure, and DNA damage repair.

139 nto the relationships between recombination, chromosome structure, and genome evolution.

140 g how modular organization underlies dynamic chromosome structure, and how this structure is probabil

141 n the control of transcription, development, chromosome structure, and human leukemia.

142 lays several key roles in DNA metabolism and chromosome structure, and it is the primary cytotoxic ta

143 chore positions shift in response to altered chromosome structure, and kinetochore complex numbers ch

144 neral roles of sumoylation in transcription, chromosome structure, and RNA processing.

145 by searching in three dimensions, modifying chromosome structure, and spreading to newly accessible

146 el of regulation that relates transcription, chromosome structure, and the cell's ability to sense ch

147 d for gene silencing, as cellular probes for chromosome structure, and therapeutic applications.

148 Thus, some aspects of chromosome structure appear to be revealed directly with

149 Current models of mitotic chromosome structure are based largely on the examinatio

150 maintain genome integrity and sense altered chromosome structure are invariably subverted in cancer

151 Theory predicts that chromosome structures are fluid and can only be describe

152 In particular, insulated chromosome structures are important for regulatory contr

153 The simulated chromosome structures are largely free of knots.

154 The chromosome structures are similar to those in grains suc

155 By representing each 3D chromosome structure as an undirected graph with edge-we

156 iming and is not accompanied by any peculiar chromosome structure as detectable by Hi-C in this yet p

157 chromosome number, and the same stability of chromosome structure, as the RER colon cancers with wild

158 ong DNA sequence, meiotic recombination, and chromosome structure at a genome-wide scale has been dif

159 Examination of chromosome structure at unrelated clusters in maize, ric

160 gabase scale, but show variable cell-to-cell chromosome structures at larger scales.

161 tion-averaged biochemical methods that infer chromosome structure based on the interaction frequencie

162 arrest followed by repair of these aberrant chromosome structures before entering M phase.

163 To study variation in chromosome structure between different cell types, compu

164 her order folding transitions that stabilize chromosome structure beyond the 30-nm diameter fiber.

165 comparative genomics framework for studying chromosome structure, broadly applicable to other organi

166 dence that the establishment of higher-order chromosome structure by a condensin complex regulates cr

167 major NAP, HU, acting together organize the chromosome structure by establishing multiple DNA-DNA co

168 protein complexes that mediates higher-order chromosome structure by tethering different regions of c

169 nce that the control of key genes depends on chromosome structures called insulated neighborhoods, we

170 This unexpected property of chromosome structure can be portrayed as an operon-like

171 The compact chromosome structure can be preserved and anaphase chrom

172 and provide evidence that defective mitotic chromosome structure can promote tumorigenesis.

173 evolution of mutation rate, genome size, and chromosome structure can therefore be extremely rapid an

174 SB distribution is influenced by large-scale chromosome structures, chromatin, transcription factors,

175 Long considered an intriguing component of chromosome structure, common fragile sites have taken on

176 Long considered an interesting component of chromosome structure, common fragile sites have taken on

177 ic) genes, RED1 and MEK1/MRE4, that encode a chromosome structure component and a protein kinase, res

178 Chromosome structure/condensation defects and hyperdiplo

179 (v) Comparison of chromosome structures confirms the polyploid event that

180 A chromosome structure consistent of many stacked layers o

181 Nucleosomes, the basic unit of eukaryotic chromosome structure, cover most of the DNA in eukaryote

182 meiotic cells, and that features of meiotic chromosome structure determine whether one or the other

183 d to developmental problems or underdominant chromosome structure differences between the parents.

184 These visible alterations in chromosome structure do not affect polarity by altering

185 tosis and meiosis, as well as maintenance of chromosome structure during interphase.

186 to chromatin at anaphase onset and regulates chromosome structure during mitotic exit.

187 stinct chromosomal subdomains and remodeling chromosome structure during prophase.

188 tion requires highly orchestrated changes of chromosome structure during the mitotic cell cycle.

189 eristic size pertinent to the description of chromosome structure, e.g. there does not exist any sing

190 s as a self-limiting system in which meiotic chromosome structures establish an environment that prom

191 current arsenal of techniques used to query chromosome structure, focusing first on single-cell fluo

192 and also indicates the potential of altering chromosome structure for treating human disease.

193 lement recognition allow decoupling of local chromosome structure from transcription initiation.

194 DNA segments called transposable elements to chromosome structure, function, and evolution in virtual

195 to ask otherwise intractable questions about chromosome structure, function, and evolution with a bot

196 ies, most or all of which are connected with chromosome structure/function.

197 ur understanding of the relationship between chromosome structure, gene activity, and recombination.

198 reated during recombination are repaired and chromosome structure has been restored.

199 ery few proteins involved in the assembly of chromosome structure have been discovered.

200 exhibit phenotypic similarities in terms of chromosome structure in both diploid and polyploid cells

201 genome reduplication does not alter mitotic chromosome structure in Drosophila papillar cells.

202 n the evolution of sex determination and sex chromosome structure in eukaryotes.

203 ssociation is a conserved feature of meiotic chromosome structure in eukaryotes.

204 ween chromatin modification and higher-order chromosome structure in long-range regulation of gene ex

205 atment and the role of programmed changes in chromosome structure in replication control are discusse

206 The biological role of higher-order chromosome structure in S. cerevisiae is discussed.

207 ely separated target genes, and organize the chromosome structure in space, thereby likely contributi

208 ial imaging methodology (Hi-M) for observing chromosome structure in the Drosophila blastoderm and fi

209 Our data implicate higher-order chromosome structure in the regulation of CO recombinati

210 quired to establish and maintain a compacted chromosome structure in transcriptionally silent Xenopus

211 We propose a unified model of chromosome structure in which hierarchical levels of chr

212 By comparing chromosome structure in wild-type and DCC-defective embr

213 These somatic changes in chromosome structure include duplication of entire chrom

214 ns not only of chromosome number but also of chromosome structure including chromosomal deletions, in

215 ost extreme differences relate to changes in chromosome structure, including the emergence of African

216 s studies of effects of nucleases on mitotic chromosome structure, indicate that mild proteolysis gra

217 eckpoint, further supporting the notion that chromosome structure influences spindle assembly.

218 tiate recombination in meiosis, we show that chromosome structure influences the choice of proteins t

219 Polytene chromosome structure is a characteristic of some polyplo

220 We propose that met1 chromosome structure is altered, causing centromere-prox

221 The regulation of higher-order chromosome structure is central to cell division and sex

222 Chromosome structure is complex, and many aspects of chr

223 ng late S phase and that nurse cell polytene chromosome structure is controlled by regulating whether

224 Control of chromosome structure is important in the regulation of g

225 Our results indicate that local chromosome structure is more important than DNA sequence

226 Mitotic chromosome structure is pivotal to cell division but dif

227 chromosome, the break point of the chimeric chromosome structure is revealed.

228 We conclude that the chromosome structure is supercoiled locally and elongate

229 opoisomerase II mutant, defective in mitotic chromosome structure, is also due to the retention of co

230 le element shown to have a bona fide role in chromosome structure, maintenance of telomeres in Drosop

231 limited amount of structural data on mitotic chromosome structure makes it impossible to distinguish

232 ity, proximity to centromeric sequences, and chromosome structure may all play a role in low recombin

233 regulating chromosome segregation as well as chromosome structure may be governed by the conserved BR

234 specific genes, establishment of the meiotic chromosome structure, meiosis-specific telomere behavior

235 al work, however, has been focused on single chromosome structures, missing the fact that, in the ful

236 strate that GEM-FISH can outperform previous chromosome structure modeling methods and accurately cap

237 of the plus ends of spindle microtubules to chromosome structures named kinetochores.

238 Beyond being a basic component of chromosome structure, no biological effects of common fr

239 Identifying the relationships between chromosome structures, nuclear bodies, chromatin states

240 ided early insight into the consequences for chromosome structure of an ancient large-scale duplicati

241 ta show a domain organization underlying the chromosome structure of E. coli, where MatP proteins ind

242 Here, we show that the high-order chromosome structure of Fusarium graminearum is sculpted

243 t HCV induces changes in gene expression and chromosome structure of infected cells by modulating coh

244 All three analyzed species share the chromosome structure of six out of seven chromosomes and

245 igenetic modifications and three-dimensional chromosome structure of the gene.

246 ic intake on expression as well as the local chromosome structure of the intact GH1 locus.

247 nd ICRF-193, do not phenocopy the effects on chromosome structure of TOP2A degradation by AID.

248 The subgenomes have largely maintained the chromosome structures of their diploid progenitors.

249 O, we investigated the effects of disrupting chromosome structure on Z-ring positioning.

250 the suggestion that features of higher-order chromosome structure or chromosome dynamics act in a tar

251 ese results suggest that the requirements of chromosome structure place significant constraints on eu

252 Chromatin modification and higher-order chromosome structure play key roles in gene regulation,

253 otspots, including HIS2, suggest that global chromosome structure plays a significant role in recombi

254 There is considerable evidence that chromosome structure plays important roles in gene contr

255 Consistent with the condensation defects, a chromosome structure protein complex, condensin II(7,8),

256 has been recognized for several decades that chromosome structure regulates the capacity of replicati

257 Cohesin has essential roles in chromosome structure, segregation and repair.

258 the cytoplasmic filaments may be involved in chromosome structure, segregation, or the cell division

259 exually reproducing single-cell organisms to chromosome-structured sexually reproducing species.

260 mbles a holocentric chromosome, which is the chromosome structure shared by the closest relatives of

261 ing method for measuring gene expression and chromosome structure simultaneously on single chromosome

262 bination and development of meiosis-specific chromosome structure (SPO11).

263 n Drosophila exhibit disrupted sarcomere and chromosome structure, suggesting that giant proteins may

264 ually fast rate of evolution with respect to chromosome structure, suggesting that this classic case

265 facilitates the formation of a higher-order chromosome structure that could also influence gene expr

266 We present a model for mitotic chromosome structure that incorporates this previously u

267 rposes and for investigations of features of chromosome structure that influence gene expression.

268 ion fork, thereby leading to a disruption in chromosome structure that interferes with the meiotic di

269 identifies an activity critical for mitotic chromosome structure that is inactivated by Repo-Man-PP1

270 ntial tissue or developmental differences in chromosome structure that might be informative for compa

271 enhancer-driven genes generally occur within chromosome structures that are formed by the looping of

272 landscape is locally funneled toward "ideal" chromosome structures that represent hierarchical fibril

273 stribution of meiotic recombination, such as chromosome structure, that influences meiotic recombinat

274 To clarify the role of E(var)3-9 in chromosome structure, the gene has been cloned and its m

275 methylation and chromatin remodeling affect chromosome structure, their impact on meiotic recombinat

276 Cohesin helps orchestrate higher-order chromosome structure, thereby promoting sister chromatid

277 lue of microfluidics as a tool for examining chromosome structure, these results lend support to cert

278 ates Ca2+, Mg2+, Na+, and K+ in higher order chromosome structure through electrostatic neutralizatio

279 erstanding of gene function, gene order, and chromosome structure through the de novo synthesis of ge

280 -associated COH-3/4 cohesin, WAPL-1 controls chromosome structure throughout meiotic prophase.

281 oxygen and nutrient availability with global chromosome structure, thus providing a mechanistic insig

282 mechanism involving changes in higher-order chromosome structure to achieve chromosome-wide effects.

283 es crossover formation, which in turn alters chromosome structure to inhibit other crossovers at addi

284 t the natural stochastic fluctuations of the chromosome structure to map both the spatial and tempora

285 dergoing genome reduplication might regulate chromosome structure to prevent mitotic errors.

286 examined at a scale of less than 100 kb, and chromosome structures to be validated.

287 that EFO1 and EFO2 are targeted to different chromosome structures to help establish or maintain sist

288 ocesses, including DNA repair, regulation of chromosome structure, transcriptional regulation, mitosi

289 Our data reveal that regional alterations in chromosome structure underlie clonal transcriptomic, epi

290 f Su(Hw) causes global defects in nurse cell chromosome structure, we demonstrate that these architec

291 regulators of viral oncogene expression and chromosome structure were identified and validated, reve

292 eas virulence determinants, transposons, and chromosome structure were unaltered.

293 ted a large-scale, 100- to 300-nm interphase chromosome structure, which is present throughout the nu

294 objective function was designed for modeling chromosome structures, which was optimized by a gradient

295 involved in the organization of higher-order chromosome structure-which is essential for accurate chr

296 tive COH-3/4 complexes modulate higher-order chromosome structure, while WAPL-1-refractory REC-8 comp

297 We report a detailed analysis of maize chromosome structure with respect to seven histone H3 me

298 of condensin I in the maintenance of mitotic chromosome structure with unprecedented temporal resolut

299 mbination requires continuity of the meiotic chromosome structure within each of these domains.

300 nd two genes that may influence higher order chromosome structure, ZDS1 and ZDS2.