ライフサイエンスコーパス: cinnamyl

1 Cinnamyl 1-3,4-dihydroxy-alpha-cyanocinnamate (CDC), act

2 -7-chloro-8-hydroxy-3-[4'-(N,N-dimethylamino)cinnamyl]-1-phenyl-2,3,4 ,5 -tetrahydro-1H-3-benzazepine

3 pecific lipoxygenase (LO) pathway inhibitor, cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate (1 mumol/L)

4 ith 12/15-lipoxygenase (12/15-LOX) inhibitor cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate (CDC), ERK1/

5 The 12-lipoxygenase inhibitor, cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate (CDC, 10 mic

6 ECs for 48 h with AdRZ or 4 h with 10 microm cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate significantl

7 12/15LO (AdRZ) or with the 12/15LO inhibitor cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate.

8 ose (HG) with or without the 12-LO inhibitor cinnamyl-3,4-dihydroxy-cyanocinnamate (CDC) or with 5.5

9 Pretreatment of the R15L cells with cinnamyl-3,4-dihydroxycyanocinnamate significantly inhib

10 mGSTP1 indicates that the haloenol lactone 3-cinnamyl-5(E)-bromomethylidenetetrahydro-2-furanone is c

11 Cinnamaldehyde, eugenol, caryophyllene, cinnamyl acetate and cinnamic acid are the major compoun

12 d relies on the Pd-catalyzed dimerization of cinnamyl acetate and provides efficient access to DPH in

13 Both (E)-cinnamyl acetate and vinyl oxirane were efficiently used

14 osed the ultrasound-assisted biosynthesis of cinnamyl acetate using self-made immobilized lipase CSL@

15 alool oxide (furanoid), geranyl acetone, and cinnamyl acetate were identified as other potent odorant

16 e ultrasonic-assisted enzymatic synthesis of cinnamyl acetate, showcasing huge potential for sustaina

17 e, we synthesized a series of 8-(substituted cinnamyl)-adenosine analogues, 5-17, and established a r

18 id (1-5), three coumaric acid (6-8), and two cinnamyl alcohol (9-10) derivatives, eight flavonol glyc

19 s-2-hexenal (a novel sweetener) in human and cinnamyl alcohol (a sweetness inhibitor) in mice.

20 , we studied the functions of members of the cinnamyl alcohol dehydrogenase (CAD) and cinnamoyl-CoA r

21 he enzymes cinnamoyl-CoA reductase (CCR) and cinnamyl alcohol dehydrogenase (CAD) catalyze the two ke

22 Cinnamyl alcohol dehydrogenase (CAD) catalyzes the conve

23 Cinnamyl alcohol dehydrogenase (CAD) catalyzes the final

24 y the thioacidolysis degradative method, for cinnamyl alcohol dehydrogenase (CAD) deficiency in angio

25 Silencing two CINNAMYL ALCOHOL DEHYDROGENASE (CAD) genes in Nicotiana

26 otated in the Arabidopsis genome database as cinnamyl alcohol dehydrogenase (CAD) homologues, an in s

27 alcohol precursors synthesized by the enzyme cinnamyl alcohol dehydrogenase (CAD).

28 Cinnamyl alcohol dehydrogenase (CAD; EC 1.1.1.195) has b

29 L.) in which expression of the gene encoding cinnamyl alcohol dehydrogenase (CAD; EC 1.1.1.195) is se

30 ransferases (CCoAOMT and COMT) and a form of cinnamyl alcohol dehydrogenase (ChCAD4) with preference

31 y pine (Pinus taeda L.) severely depleted in cinnamyl alcohol dehydrogenase (E.C. 1.1.1.195), which c

32 Zea mays CINNAMYL ALCOHOL DEHYDROGENASE 2 (ZmCAD2) is involved in

33 n assays, we identified members of the plant cinnamyl alcohol dehydrogenase 7 (CAD7) subfamily as tar

34 ntly, bmr6 plants were shown to have limited cinnamyl alcohol dehydrogenase activity (CAD; EC 1.1.1.1

35 QTL) analysis, identified and cloned a novel cinnamyl alcohol dehydrogenase allele (SbCAD2) that has

36 Silencing the lignin biosynthetic gene cinnamyl alcohol dehydrogenase enhanced the performance

37 mer biosynthetic cinnamoyl CoA reductase and cinnamyl alcohol dehydrogenase in not only the lignifyin

38 thyltransferase, cinnamoyl-CoA reductase and cinnamyl alcohol dehydrogenase in the presence of increa

39 hyltransferase, cinnamoyl-CoA reductase, and cinnamyl alcohol dehydrogenase were coordinately up-regu

40 ransposons into a gene annotated as encoding cinnamyl alcohol dehydrogenase, here designated M. trunc

41 opulus alba) by specifically down-regulating CINNAMYL ALCOHOL DEHYDROGENASE1 (CAD1) by a hairpin-RNA-

42 n of FaEOBII was silenced, the expression of cinnamyl alcohol dehydrogenase1 and FaEGS2, two structur

43 caffeic acid O-methyltransferase [COMT], and cinnamyl alcohol dehydrogenase6 [CAD6], two mutant allel

44 Although SAD and classical cinnamyl alcohol dehydrogenases (CADs) catalyze the same

45 identification and characterization of four cinnamyl alcohol dehydrogenases (CADs) from cucumber (Cu

46 cluding a protease, a ribosomal protein, two cinnamyl alcohol dehydrogenases, a nitrilase and glyoxal

47 a-beta), biphenyl/dibenzodioxocin (5-5), and cinnamyl alcohol end-group structures.

48 Cinnamyl alcohol is a strong attractant for Diabrotica b

49 In contrast, selectivity to the desired cinnamyl alcohol product is highly structure sensitive,

50 ustrated by the Pd/Pt-catalysed oxidation of cinnamyl alcohol to cinnamic acid.

51 Benzyl alcohol, cinnamyl alcohol, cinnamic acid, p-tolylacetic acid and

52 ed with hydrogenation to the desired product cinnamyl alcohol.

53 onstructs were used to down-regulate tobacco cinnamyl-alcohol dehydrogenase (CAD; EC 1.1.1.195) and c

54 ay as storage and/or transportation forms of cinnamyl alcohols between the cytosol and the lignifying

55 dehydes; cinnamaldehydes are then reduced to cinnamyl alcohols by CAD.

56 uential ortho-cinnamylation of phenols using cinnamyl alcohols catalyzed by Re2O7, followed by an oxi

57 onding SF5- or CF3-acetates of p-substituted cinnamyl alcohols with triethylamine followed by trimeth

58 nes could be alkylated with diarylmethanols, cinnamyl alcohols, and phenyl propargyl alcohols having

59 The products of CAD, cinnamyl alcohols, are the precursors of lignin, a major

60 ycinnamoyl CoA esters to their corresponding cinnamyl aldehydes in monolignol biosynthesis.

61 ]GTP-gamma-S binding, we show that the trans-cinnamyl analogues of (+)-(3R, 4R)-dimethyl-4-(3-hydroxy

62 the optimized catalytic conditions of PdCp(1-cinnamyl) and Xantphos in tetrahydrofuran at 50 degrees

63 Aromatic, cinnamyl, and aliphatic aldehydes are competent dipolaro

64 Aryl, cinnamyl, and aliphatic aldehydes are competent dipolaro

65 -stabilizing N substituents, such as benzyl, cinnamyl, and diarylmethyl, undergo facile homolytic C-N

66 of the 7-borylindole products to 7-aryl-, 7-cinnamyl-, and 7-haloindoles are demonstrated.

67 , a series of (+/-)-3-[4'-(N,N-dimethylamino)cinnamyl]benzazepine analogs was designed and prepared,

68 his series of (+/-)-3-[4'-(N,N-dimethylamino)cinnamyl]benzazepines also appears to be identifying an

69 xcellent diastereoselectivity when employing cinnamyl bromide (>95/5 anti/syn).

70 The use of cinnamyl bromide which led to the formation of a 1,6-eny

71 is of various thieno-fused heterocycles were cinnamyl bromide, 2-bromobenzyl chloride, bromocrotonate

72 bstituted allyl bromides, such as crotyl and cinnamyl bromide, can be used providing moderate enantio

73 tric allylic alkylation of ortho-substituted cinnamyl bromides with Grignard reagents is reported.

74 amenable to intermolecular coupling between cinnamyl bromochlorides and a diverse set of commerciall

75 We report the synthesis of chiral cinnamyl but-2-enanoates and 3,3-diphenylallyl-but-2-eno

76 ccur with electron-neutral, -rich, and -poor cinnamyl carbonates, alkyl and trityloxy-substituted all

77 to be stereoconvergent, as an E/Z mixture of cinnamyl chlorides furnish the anti-chlorocyclopropane p

78 diastereoselective isomerization of acyclic cinnamyl chlorides to strained cyclopropanes.

79 The use of commercially available (SIPr)Pd(cinnamyl)Cl (SIPr = 1,3-bis(2,6-diisopropylphenyl)-4,5-d

80 Pd(IPr)(eta(3)-crotyl)Cl and Pd(IPr)(eta(3)-cinnamyl)Cl precatalysts results in a larger kinetic bar

81 Suzuki-Miyaura reaction using Pd(IPr)(eta(3)-cinnamyl)Cl which are compatible with mild bases.

82 within 2-(4-aminophenyl)ethylamine with [Pd(cinnamyl)Cl](2)/L1 and 4-chlorotoluene (affording 5a); t

83 of the reactivity trends established for [Pd(cinnamyl)Cl](2)/L1 toward the chemoselective synthesis o

84 tion employing a single catalyst system ([Pd(cinnamyl)Cl](2)/L1; L1 = N-(2-(di(1-adamantyl)phosphino)

85 crystallographically characterized; the [Pd(cinnamyl)Cl](2)/L2 catalyst system exhibited divergent r

86 egioisomer (5a') was obtained when using [Pd(cinnamyl)Cl](2)/L2.

87 tonation of the oxyanion of the para-hydroxy-cinnamyl cysteine chromophore as a secondary result of a

88 overexpressed F5H in the low-lignin mutants cinnamyl dehydrogenase c and d (cadc cadd), cinnamoyl-Co

89 e, the poor performance of ortho-substituted cinnamyl electrophiles in the enantioselective cooperati

90 avage of the ester side chain of pentacyclic cinnamyl ester 15.

91 oligomerization of the intermediately formed cinnamyl esters.

92 Either aldehyde or cinnamyl ether products can be selectively extracted fro

93 of photocycloaddition between silyl-tethered cinnamyl groups.

94 th LAQ824 (Novartis Pharmaceutical, Inc.), a cinnamyl hydroxamic acid analogue inhibitor of histone d

95 lyl)(mu-Cl)Pd2(IPr)2 (allyl = allyl, crotyl, cinnamyl; IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2

96 rgent reaction between azaaryl acetamide and cinnamyl methyl carbonate.

97 a(p) and sigma(m)) of the substituent on the cinnamyl moiety.

98 showed that compounds 7-9 bearing the trans-cinnamyl N-substituent most closely reproduced the poten

99 H-indenes via metalloradical activation of o-cinnamyl N-tosyl hydrazones is presented, taking advanta

100 Neither the N-substituted cis-cinnamyl nor the cis-phenylcyclopropylmethyl compounds 1

101 Synthesis of cinnamyl- or coumarinyl-substituted ethanolamide derivat

102 ive from palladium-assisted reactions on the cinnamyl p-hydroxybenzoates resulting in initial beta-et

103 The air-stable palladium complex (eta3-cinnamyl)PdCl.(3a) (5) was also employed successfully in

104 of palladium pai-allyl intermediates, and [(Cinnamyl)PdCl](2)/BINAP is superior to other Pd salt/lig

105 ntramolecular oxidative cyclization of ortho-cinnamyl phenols using [PdCl2(CH3CN)2] as catalyst and b

106 s in heterocyclic rings corresponding to the cinnamyl phenyl ring displayed equal or higher biologica

107 made by introducing nitrogen atoms into the cinnamyl ring and replacing its E-double bond with XCH(2

108 OTf then Et3N) led to oligomerization of the cinnamyl SF5- and CF3-acetates.

109 d with protic acid in anhydrous solvent, the cinnamyl unit migrates from the oxygen of tyrosine to di