ライフサイエンスコーパス: circadian

1 Circadian (~24 hour) clocks have a fundamental role in r

2 t varies between day and night, to determine circadian adaptation and behaviours.

3 workers, as compared to when they were under circadian alignment (interaction of "circadian alignment

4 oughout days of misalignment, as compared to circadian alignment (interaction of "circadian alignment

5 e under circadian alignment (interaction of "circadian alignment condition" vs. "day", mood: p < 0.00

6 ared to circadian alignment (interaction of "circadian alignment condition" vs. "day", mood: p = 0.00

7 T2D patients contain clocks with diminished circadian amplitudes and reduced in vitro synchronizatio

8 a feedforward circuit with inputs from both circadian and diel cycles.

9 ut RNA-Seq approach, we examined genome-wide circadian and diurnal control of the Arabidopsis transcr

10 he clock, suggesting that the integration of circadian and light signals is important for the fitness

11 chanistic and intervention studies examining circadian and sleep health in these patients are warrant

12 Circadian and ultradian characteristics of rest-activity

13 ess severity with concomitant disturbance of circadian and ultradian rest-activity rhythms and loss o

14 el suggested that seizure pathways change on circadian and/or slower timescales in the majority of pa

15 processed at each rush hour regulated by the circadian and/or tissue-specific pathways.

16 Circadian (approximately daily) rhythms of physiology an

17 Circadian (approximately daily) rhythms pervade mammalia

18 eus (SCN) acts as a master pacemaker driving circadian behavior and physiology.

19 her changes in nucleotide metabolism control circadian behavioral and genomic rhythms remains unknown

20 Measuring circadian behavioral and SCN rhythmicity in these tempor

21 ells by deletion of Bmal1 severely disrupted circadian behavioral rhythms and compromised TTFL time-k

22 , and hence for the temporal coordination of circadian behaviors.SIGNIFICANCE STATEMENT Ion channels

23 l responses to light and their regulation by circadian circuit and molecular mechanisms.

24 ntial differences and demonstrating that the circadian clock affects posttranscriptional regulation.

25 e state in cyanobacteria is regulated by the circadian clock and can adapt to seasonal changes of day

26 Dissociation between the output of the circadian clock and external environmental cues is a maj

27 ransferase activity of SPY in modulating the circadian clock and implicate that O-glycosylation might

28 The circadian clock and physical activity are both required

29 eptor REVERBalpha is a core component of the circadian clock and proposed to be a dominant regulator

30 cation across kingdoms, is influenced by the circadian clock and the light-dark (diel) cycle in an op

31 ations in light sensitivity in the mammalian circadian clock are interrelated.

32 Some of the genes controlled by the circadian clock are oncogenes or tumor suppressors.

33 Whether pathogens modulate host circadian clock as a potential strategy to suppress host

34 Disabling the circadian clock causes abnormal collagen fibrils and col

35 odulatory signaling peptide produced only by circadian clock circuit neurons.

36 on and high nighttime expression of the core circadian clock component CRYPTOCHROME (CRY) in the NAc.

37 RESPONSE REGULATOR 5 (PRR5), one of the core circadian clock components, as a new SPY-interacting pro

38 The mammalian circadian clock consists of a transcription-translation

39 HC class II-IL-10-epithelial barrier axis by circadian clock disarrangement, alterations in feeding t

40 Compared to control mice, circadian clock disruption significantly exacerbated pos

41 The mammalian circadian clock encodes time via rhythmic action potenti

42 ke behavior (helplessness), we found altered circadian clock function and high nighttime expression o

43 We then focus on emerging data tying circadian clock function to immunologic activities withi

44 utilizing the self-assembling properties of circadian clock gene 2 hydrophobin chimera and homogenei

45 brain-dead donors show marked differences in circadian clock gene expression patterns, suggesting fun

46 The 5 known circadian clock gene transcripts showed a strong circadi

47 he question about whether enhancement of the circadian clock in beta-cells will confer protection aga

48 cts of Myc mutation or overproduction on the circadian clock in comparison to their effects on cell c

49 w-dimensional macroscopic model for the core circadian clock in mammals.

50 The circadian clock in plants temporally coordinates biologi

51 cise has been proposed as a time cue for the circadian clock in rodents and humans.

52 t difference in the sensitivity of the major circadian clock in the suprachiasmatic nucleus to a low

53 The circadian clock is an intrinsic oscillator that imparts

54 The mammalian cell-autonomous circadian clock is built around a self-sustaining transc

55 The circadian clock itself has the potential for use as a ta

56 In conclusion, our study has identified a circadian clock mechanism of protein homeostasis wherein

57 a tissue-dependent manner led to intertissue circadian clock misalignment.

58 illations in protein expression levels for a circadian clock model, we illustrate the adaptability of

59 We conclude that the Arabidopsis circadian clock not only controls transcription of genes

60 pathways to the accessory medulla (AME), the circadian clock of the Madeira cockroach.

61 The circadian clock orchestrates biological processes so tha

62 Whether such variations are dependent on the circadian clock per se or are secondary to circadian dif

63 exercise, are sufficient to shift the muscle circadian clock phase, likely through changes in core cl

64 ions during the night-time when the internal circadian clock promotes sleep, in many cases resulting

65 Here, we show circadian clock regulation of endoplasmic reticulum-to-p

66 stems-level control mechanisms involving the circadian clock set rates of nighttime starch mobilizati

67 lutionarily conserved role in modulating the circadian clock system, via O-GlcNAcylation in mammals,

68 hour clock exists in addition to the 24-hour circadian clock to coordinate metabolic and stress rhyth

69 y understood mechanisms to synchronize their circadian clock to light.

70 ence indicates that metabolic control by the circadian clock underpins specific hallmarks of cancer m

71 ns link thermosensory PNs in the lACA to the circadian clock via the accessory medulla.

72 w how the molecular workings of the cellular circadian clock work as building blocks of those propert

73 alling hub and a core component of the plant circadian clock(2,3).

74 us mammalian 12-h clock independent from the circadian clock, but its function and mechanism of regul

75 ickness is a fatal disease that disrupts the circadian clock, causes disordered temperature regulatio

76 tions in two key elements of the Arabidopsis circadian clock, GIGANTEA (GI) and ZEITLUPE (ZTL), which

77 al role of O-GlcNAc in regulating the animal circadian clock, here we report that nuclear-localized S

78 ation of the 12-hour clock, but not the core circadian clock, is associated with the onset and progre

79 components of the negative limbs of the core circadian clock, most notably REV-ERBalpha.

80 feeding, which affects the phase of the skin circadian clock, reverses the diurnal rhythm of IMQ-indu

81 Hence, circadian clock-pituitary epigenetic pathway interaction

82 ically modulates the pace of the Arabidopsis circadian clock.

83 n endogenous timekeeping system known as the circadian clock.

84 interactions between the light-signaling and circadian-clock networks, focusing on the role of light

85 An intimate link exists between circadian clocks and metabolism with nearly every metabo

86 tural light-dark conditions is a function of circadian clocks and photic input pathways, but a mechan

87 Studies show that beta-cell circadian clocks are important regulators of GSIS and gl

88 Light-entrained circadian clocks confer rhythmic dynamics of cellular an

89 Circadian clocks in fungi and animals are driven by a fu

90 genes and molecular mechanisms underpinning circadian clocks in multicellular organisms are well und

91 Circadian clocks keep time via ~ 24 h transcriptional fe

92 the biophysical mechanisms linking molecular circadian clocks to cardiac arrhythmogenesis are not ful

93 Honey bees are highly dependent on circadian clocks to regulate critical behaviors, such as

94 eg, neurohumoral factors) and intrinsic (eg, circadian clocks) to cells.

95 BMAL1 is a core component of the mammalian circadian clockwork.

96 in SCN slices recorded ex vivo Abrogation of circadian competence in VPAC2 cells by deletion of Bmal1

97 ction, and there is an emerging role for the circadian components in regulating viral replication.

98 ns at clock-controlled genes (ccg) revealing circadian control of genome-wide chromatin states.

99 brain sites raises the possibility of local circadian control of neural activity and function.

100 rhabdoms remained narrow, indicating strong circadian control on the process.

101 d expression of PER1 (a key gene involved in circadian control) in agreement with sleep anomalies in

102 tabolic pathway in the mammalian liver under circadian control.

103 Pulmonary inflammatory responses lie under circadian control; however, the importance of circadian

104 and reduced when either CRY is bound to the circadian corepressor PERIOD2.

105 ional spatial version of this model across a circadian cycle.

106 y of cortisol secretion mechanisms and their circadian cycles as well as environmental factors that a

107 n by the receptor CXCR2 and by regulators of circadian cycles.

108 e circadian clock per se or are secondary to circadian differences in physical activity and feeding p

109 appropriate model for studying light-induced circadian disruption and that exacerbated dyslipidemia m

110 Yet, circadian disruption has become increasingly prevalent w

111 disruption of the circadian system, known as circadian dysrhythmia, is increasingly common.

112 tion of adequate sleep patterns coupled with circadian entrainment.

113 by the parasite, possibly to anticipate its circadian environment.

114 At least 5 ion channels show a circadian expression pattern in the ventricles of failin

115 adian clock gene transcripts showed a strong circadian expression pattern.

116 eart ventricles have not been examined for a circadian expression pattern.

117 These properties can be exploited to impose circadian expression, which is asymmetric and varies in

118 erns, suggesting fundamental deviations from circadian expression.

119 he hope is that recognition of paracrine and circadian factors can be considered more deeply in the f

120 food scarcity and time-of-day dependence of circadian food anticipation.

121 understand key factors that impact sleep and circadian function for young adults of differing races a

122 ing system and may enable the enhancement of circadian functions through related input pathways.

123 adian rhythms (activity and temperature) and circadian gene expression in female and male mice, respe

124 ck mechanism but leads to a reprogramming of circadian gene expression in the liver in analogy to wha

125 tration of cocaine triggers reprogramming in circadian gene expression in the striatum, an area invol

126 denylation in regulating poly(A) rhythms and circadian gene expression.

127 an period, suggesting non-redundant roles in circadian gene regulation.

128 However, with an increasing number of circadian genes being discovered, there is a pressing ne

129 This is largely because circadian genes operate in virtually every cell type in

130 Toward this, in this study, we consider the circadian genes' omics profile, such as copy number chan

131 stablish a key role for microbiome-dependent circadian GLP-1 secretion in the maintenance of 24-h met

132 e good); (2) the pathological consequence of circadian governance impairment (ie, the bad); and (3) w

133 Here, we focus on circadian governance of 6 fundamentally important proces

134 n part reliant on melatonin orchestration of circadian homeostatic activities.

135 ) for 24 h, but not for 48 h, and there is a circadian increase in PHep over the day.

136 and (3) whether persistence/augmentation of circadian influences contribute to pathogenesis during d

137 a previously underestimated critical role in circadian influences on long-term retinal health and pre

138 Removal of circadian input by exposure to either permanent darkness

139 We predict 27 potential circadian kinases to participate in phosphorylating thes

140 ircadian regulator, the transcription factor circadian locomotor output cycles kaput (CLOCK).

141 ircadian control; however, the importance of circadian mechanisms in the underlying fibrotic phenotyp

142 Circadian misalignment adversely impacted emotional stat

143 that DST-transition-associated, preventable circadian misalignment and sleep deprivation might under

144 throughout 4 days of continuous exposure to circadian misalignment in non-shift workers, as compared

145 which is thought to induce higher levels of circadian misalignment in the west than in the east ("ti

146 t-lag paradigms, which showed that long-term circadian misalignment induced significant early mortali

147 Persisting circadian misalignment leads to deleterious effects on h

148 quences, we investigated whether exposure to circadian misalignment underpins mood vulnerability in s

149 s circadian pacemaker and sleep/wake cycles (circadian misalignment), while environmental conditions

150 Circadian modifications to histones are important for tr

151 n paclitaxel-treated rats exhibited a robust circadian oscillation, reaching the nadir during the day

152 vantage of clear phenotypic heterogeneity of circadian oscillations in clonal cell populations to inv

153 Circadian oscillations in spontaneous action potential f

154 gnalling, in addition to its role in driving circadian oscillations of [Ca(2+) ] in the cytosol and c

155 omponent of the clock pathway that regulates circadian oscillations of gene expression.

156 gulators in the nucleus that are part of the circadian oscillator demonstrates a new role for the cir

157 The Arabidopsis circadian oscillator is a gene network which orchestrate

158 Circadian oscillator proteins are known to regulate the

159 We also established that the circadian oscillator within guard cells can contribute t

160 ntegrate these time cues to drive a coherent circadian output(1-3).

161 ther ipRGC function in DR is associated with circadian outputs and sleep/wake behavior.

162 induce a misalignment between the endogenous circadian pacemaker and sleep/wake cycles (circadian mis

163 s define a connection between the reward and circadian pathways in the regulation of pathological cal

164 hils infiltrated the mouse liver following a circadian pattern and regulated hepatocyte clock-genes b

165 In our simulations, we found that there is a circadian pattern in the occurrence of early afterdepola

166 yarrhythmias and sudden cardiac death show a circadian pattern of occurrence in patients with heart f

167 f failing human hearts, which may underlie a circadian pattern of ventricular tachyarrhythmia/sudden

168 In addition, we evaluated the circadian pattern of wrist temperature (internal circadi

169 he influence of these variables on sleep and circadian patterns for young adults are not well known.

170 focus on sleep, physical/motor activity, or circadian patterns to identify common biologic pathways

171 ption of ck-1a regulation is consistent with circadian period being exquisitely sensitive to levels o

172 The finding that circadian period defects in two classically derived Neur

173 ochastic generation of variation in cellular circadian period explain important adaptive features of

174 Here we showed that heterogeneity in circadian period is heritable and used a multi-omics app

175 These findings suggest that circadian period may be used as an indicator of cellular

176 It also increased the variability of the circadian period of bioluminescent TTFL rhythms in SCN s

177 examining the molecular basis for the short circadian period of upf-1(prd-6) mutants, we uncovered a

178 of DNMT1 and DNMT3A had opposite effects on circadian period, suggesting non-redundant roles in circ

179 , and reducing Nipped-A expression lengthens circadian period.

180 nistic sites in PERIOD that directly control circadian period.

181 in PDF clock neurons dramatically lengthens circadian period.

182 DNA methylation as an important regulator of circadian periodicity.

183 rs are established drug targets for aligning circadian phase to this cycle in disorders of sleep(5,6)

184 At three time points ~ 1 month apart, circadian phase was determined during an overnight in-la

185 ain important adaptive features of entrained circadian phase.

186 and its effect is dependent on the patient's circadian phenotype.

187 ivity of both the pupillary light reflex and circadian photoentrainment, thereby shifting the dynamic

188 hanges in ambient light intensity, including circadian photoentrainment.

189 h typical day and night resulting in varying circadian preferences called chronotypes.

190 processes-a sleep homeostatic process and a circadian process.

191 re lacking despite considerable focus on how circadian processes, which have a central role in regula

192 erepressed target gene enrichment limited to circadian processes.

193 breathing movements, and from baroreflex and circadian processes.

194 Weight, adiposity, energy expenditure, and circadian profiles of hormones and metabolites were asse

195 er mice that are Cre dependent, allowing the circadian properties of genetically defined populations

196 These results defined a distinctive group of circadian psychiatric phenotypes that we propose to desi

197 Our results reveal a feeding- and circadian-regulated dynamic neuroimmune circuit in the i

198 These results demonstrate that circadian-regulated intestinal mitochondrial uncoupling

199 Here, we investigated the involvement of circadian regulation in long-term WUE in Arabidopsis (Ar

200 ed with defects in circadian rhythm, loss of circadian regulation is thought to be pathogenic and con

201 our data suggest that its basic role in the circadian regulation of arousal is conserved.

202 ation, adding another layer of complexity to circadian regulation of gene expression.

203 Circadian regulation of metabolism is largely driven by

204 scuss (1) the physiological significance for circadian regulation of these processes (ie, the good);

205 MicroRNAs are important coordinators of circadian regulation that mediate the fine-tuning of gen

206 molecules that specifically bind to the core circadian regulator, the transcription factor circadian

207 Here we develop bioluminescent circadian reporter mice that are Cre dependent, allowing

208 roblasts with longer periods displayed muted circadian responses to lithium as well as to other chron

209 Circadian rest-activity rhythm fragmentation and attenua

210 ified Rbfox2-regulated genes associated with circadian rhythm and entrainment, glutamatergic/choliner

211 ethod was used to investigate the effects of circadian rhythm and food intake on several metabolite c

212 ses suggest that genetic factors controlling circadian rhythm and pigmentation are also involved in t

213 analysis, we found a novel regulation of the circadian rhythm and sleep by the miR-375-timeless inter

214 viously described and to the disturbances in circadian rhythm and sleep reported in PD patients.

215 e l-LNv neurons, where miR-375 modulated the circadian rhythm and sleep via targeting timeless.

216 ential Organ Failure Assessment, and central circadian rhythm by melatonin profile.

217 CLK8 enhances the amplitude of the cellular circadian rhythm by stabilizing the negative arm of the

218 nin is not a reliable measure of the central circadian rhythm in critically ill patients.

219 disease (PD), but the molecular role of the circadian rhythm in PD is unclear.

220 n two-hybrid system, real-time monitoring of circadian rhythm in U2OS cells, and various biochemical

221 Dysfunction of the circadian rhythm is one of most common nonmotor symptoms

222 adian pattern of wrist temperature (internal circadian rhythm marker).

223 ors of objective and self-reported sleep and circadian rhythm measures.

224 The central circadian rhythm rapidly dampens with onset of critical

225 lusters in pathways involving metabolism and circadian rhythm were noted in insulin-responsive tissue

226 bility linked to respiration, locomotion and circadian rhythm(4-10).

227 immunity, chronic inflammation, cell cycle, circadian rhythm, and olfactory functions.

228 ecause old age is associated with defects in circadian rhythm, loss of circadian regulation is though

229 ating the mammalian locomotor activity (LMA) circadian rhythm.

230 s physiological activities often adhere to a circadian rhythm.

231 Circadian rhythmicity demonstrated phase alignment withi

232 ticoid activity, as evidenced by the lack of circadian rhythmicity in GR-deficient B cell counts norm

233 Circadian rhythmicity is created endogenously by genetic

234 d alternative polyadenylation (APA), display circadian rhythmicity resulting from oscillation in the

235 Although variation due to circadian rhythmicity was not a significant source of va

236 ondrial form of NOC possesses high-amplitude circadian rhythmicity with peak expression level during

237 ee-quarters of the expressed genes exhibited circadian rhythmicity.

238 Further, LAN significantly altered circadian rhythms (activity and temperature) and circadi

239 uential Organ Failure Assessment score), and circadian rhythms (profiles of serum melatonin and its u

240 s here the relevance of glia for maintaining circadian rhythms and also for serving functions of slee

241 l DEGs, suggesting reciprocal interaction of circadian rhythms and chemotherapy.

242 Altered circadian rhythms and CRY expression were also observed

243 Shift work has been shown to disrupt circadian rhythms and is associated with several adverse

244 The neuromodulator melatonin synchronizes circadian rhythms and related physiological functions th

245 Disrupted sleep-wake and molecular circadian rhythms are a feature of aging associated with

246 s to anticipate daily environmental changes, circadian rhythms are also important for orchestrating c

247 Circadian rhythms are daily cycles in biological functio

248 Circadian rhythms are endogenous 24-h oscillations which

249 Circadian rhythms are generated by interlocked transcrip

250 We next induced severe disruption of circadian rhythms by exposing ApoE(-/-) mice to constant

251 t, compared to controls, mice that had their circadian rhythms disrupted (ECD) had higher Chlamydia l

252 at compared to controls, mice that had their circadian rhythms disrupted in this ECD model will have

253 Historically, fetal circadian rhythms have been considered irrelevant owing

254 igate whether lithium differentially impacts circadian rhythms in bipolar patient cell lines and cruc

255 vident than in the respiratory system, where circadian rhythms in inflammatory lung disease have been

256 t much more common and chronic disruption of circadian rhythms in the general population than shift w

257 dopamine reward circuit, exhibits disturbed circadian rhythms in the postmortem brains of depressed

258 Circadian rhythms influence many of these phenomena.

259 scoordination between central and peripheral circadian rhythms is a core feature of nearly every gene

260 We first characterized circadian rhythms of behavior, light responsiveness, and

261 Growing evidence demonstrates circadian rhythms of pain hypersensitivity in various ch

262 The cardiovascular system exhibits strong circadian rhythms to maintain normal functioning.

263 temperature changes due to menstruation, and circadian rhythms were controlled for in the experimenta

264 abuse disorders are linked to alteration of circadian rhythms, although the molecular and neuronal p

265 tion, many noncanonical genes have intrinsic circadian rhythms, especially within the liver and kidne

266 se studies establish a regulatory link among circadian rhythms, hypoxia response, fatty acid uptake,

267 recent discoveries of the interplay between circadian rhythms, proliferative metabolism and cancer,

268 screen to uncover ion channels with roles in circadian rhythms, we have identified the I(h) channel a

269 ) can synchronize the central and peripheral circadian rhythms, which in turn can prevent or even tre

270 take is associated with adiposity and robust circadian rhythms.

271 iologic regulation to create this subtype of circadian rhythms.

272 regulation of sleep and biological (diurnal, circadian) rhythms, suggesting common pathophysiologies

273 w SCN cells interact to generate an ensemble circadian signal.

274 In the UK Biobank, circadian strain markers (sleep length, chronotype, and

275 The circadian system affects physiological, psychological, a

276 istribution across the population in how the circadian system aligns with typical day and night resul

277 rs experience a 'misalignment' between their circadian system and daily sleep-wake behaviors, with ne

278 ologies to gain insight into the role of the circadian system and patterns of sleep and motor activit

279 Disruption of the circadian system caused by disordered exposure to light

280 show that lithium differentially impacts the circadian system in a patient-specific manner and its ef

281 n oscillator demonstrates a new role for the circadian system in subcellular Ca(2+) signalling, in ad

282 The circadian system modulates many important physiologic pr

283 veal effects of NAD(+) on metabolism and the circadian system with aging through the spatiotemporal c

284 n mice were phenocopied by modulation of the circadian system with drugs that target the clock, and t

285 Cell-autonomous circadian system, consisting of core clock genes, genera

286 th the metabolic syndrome, disruption of the circadian system, known as circadian dysrhythmia, is inc

287 Characterization of circadian systems at the organism level-a top-down appro

288 Circadian systems share the three properties of entrainm

289 s (SCN) of the hypothalamus is the principal circadian timekeeper of mammals.

290 ified, at least two of them are critical for circadian timekeeping as mutants expressing non-phosphor

291 Networks of circadian timekeeping in the brain display marked daily

292 e thirst-controlling sCVOs possess intrinsic circadian timekeeping properties and raise the possibili

293 ork promises to advance understanding of the circadian timekeeping system and may enable the enhancem

294 artially under the control of the endogenous circadian timekeeping system.

295 eying morning and evening information to the circadian timing system in the brain.

296 nstrate a novel tumor-suppressor role of the circadian transcription factor BMAL1 in triple-negative

297 in mammals that long photoperiods induce the circadian transcription factor BMAL2, in the pars tubera

298 n importance, characterized the seasonal and circadian use, and identified snow cover as the most imp

299 favor subsequent alertness prior to dawn (a circadian "wake maintenance zone").

300 ivity, creating stereotypical spatiotemporal circadian waves of cellular activation across the circui