ライフサイエンスコーパス: circadian rhythm

1 ghout the body, held in phase by the central circadian rhythm.

2 ss the production of melatonin and delay our circadian rhythm.

3 havioural indicator of a person's underlying circadian rhythm.

4 % of genes in T. brucei are expressed with a circadian rhythm.

5 ith altered locomotor activity and distorted circadian rhythm.

6 , the shikimate pathway, the cell cycle, and circadian rhythm.

7 ating the mammalian locomotor activity (LMA) circadian rhythm.

8 s physiological activities often adhere to a circadian rhythm.

9 sm in CRY1 is critical for the regulation of circadian rhythm.

10 first global view of miRNA regulation in the circadian rhythm.

11 take is associated with adiposity and robust circadian rhythms.

12 ergy intake with adiposity and with internal circadian rhythms.

13 ddress this question in the context of human circadian rhythms.

14 and and further manipulate CK1 regulation of circadian rhythms.

15 versely, oncogenic processes directly weaken circadian rhythms.

16 nes strengthens the oscillation amplitude of circadian rhythms.

17 trongly associated with changes in sleep and circadian rhythms.

18 nt systems, from post-dieting weight gain to circadian rhythms.

19 esearch in the development and regulation of circadian rhythms.

20 lary light reflexes, and photoentrainment of circadian rhythms.

21 r pacemakers' because they are essential for circadian rhythms.

22 f parasite genotype-specific effects on host circadian rhythms.

23 tion of physiology and indirect alignment of circadian rhythms.

24 res the use of treatment timed to endogenous circadian rhythms.

25 arding the influence of social zeitgebers on circadian rhythms.

26 risk factors, including disrupted sleep and circadian rhythms.

27 f growth synchronization to light cycles via circadian rhythms.

28 uropeptides play pivotal roles in modulating circadian rhythms.

29 gp substrate to account for sex, feeding and circadian rhythms.

30 nd aging, which are associated with impaired circadian rhythms.

31 on in the compound eye and without affecting circadian rhythms.

32 iologic regulation to create this subtype of circadian rhythms.

33 oded and overlaps with systems that maintain circadian rhythms.

34 role for CT-1 in the regulation of metabolic circadian rhythms.

35 el in blood and IGF-1 signaling demonstrates circadian rhythms.

36 e human master clock and multiple peripheral circadian rhythms.

37 ulation and the role of miRNAs in Drosophila circadian rhythms.

38 nimals affects the CR induced changes in the circadian rhythms.

39 iated that insulin action is closely tied to circadian rhythms.

40 of death was used to test associations with circadian rhythms.

41 , which is involved in photic entrainment of circadian rhythms.

42 ges in photoreceptors regulated by light and circadian rhythms.

43 to manage disorders associated with dampened circadian rhythms.

44 ity 4 (eds4) displays alterations in several circadian rhythms.

45 CK1) plays a key regulatory role in metazoan circadian rhythms.

46 llular matrix (ECM)-receptor interaction and circadian rhythms.

47 anisms as compared to millisecond timing and circadian rhythms.

48 ell groups that contribute to the genesis of circadian rhythms.

49 ongatus is a model organism for the study of circadian rhythms.

50 between environmental cycles and endogenous circadian rhythms.

51 rder (SUD) is associated with disruptions in circadian rhythms.

52 tryptamine) is a neurohormone that maintains circadian rhythms(1) by synchronization to environmental

53 bility linked to respiration, locomotion and circadian rhythm(4-10).

54 ) is a serious mood disorder associated with circadian rhythm abnormalities.

55 where patients present significant sleep and circadian rhythm abnormalities.

56 Disruptions in circadian rhythms across an organism are associated with

57 Further, LAN significantly altered circadian rhythms (activity and temperature) and circadi

58 double inversion contains key photosensory, circadian rhythm, adiposity and sex-related genes and di

59 abuse disorders are linked to alteration of circadian rhythms, although the molecular and neuronal p

60 tool for further studies of CLOCK's role in circadian rhythm amplitude regulation and as a potential

61 gulate multiple cellular processes including circadian rhythm and endocytosis.

62 ified Rbfox2-regulated genes associated with circadian rhythm and entrainment, glutamatergic/choliner

63 ethod was used to investigate the effects of circadian rhythm and food intake on several metabolite c

64 oth receptors for the treatment of insomnia, circadian rhythm and mood disorders, and cancer(3), and

65 ses suggest that genetic factors controlling circadian rhythm and pigmentation are also involved in t

66 wever, essential roles for regulation of the circadian rhythm and reproduction of the CNNM family hav

67 The central circadian rhythm and rest-activity rhythms were profiled

68 argeting ER stress could be used to modulate circadian rhythm and restore collagen homeostasis in dis

69 analysis, we found a novel regulation of the circadian rhythm and sleep by the miR-375-timeless inter

70 pled receptors (GPCRs) that help to regulate circadian rhythm and sleep patterns(3).

71 viously described and to the disturbances in circadian rhythm and sleep reported in PD patients.

72 e l-LNv neurons, where miR-375 modulated the circadian rhythm and sleep via targeting timeless.

73 der, an illness associated with dysregulated circadian rhythms and a high incidence of suicidality.

74 rdiotrophin-1 in the regulation of metabolic circadian rhythms and adipose core clock genes in mice a

75 Psi downregulation shortens the period of circadian rhythms and advances the phase of circadian be

76 s here the relevance of glia for maintaining circadian rhythms and also for serving functions of slee

77 T(1) and MT(2) are involved in synchronizing circadian rhythms and are important targets for treating

78 l DEGs, suggesting reciprocal interaction of circadian rhythms and chemotherapy.

79 that PSI regulates the period of Drosophila circadian rhythms and circadian behavior phase during te

80 Altered circadian rhythms and CRY expression were also observed

81 prompt chlorophyll fluorescence, to measure circadian rhythms and demonstrated that the technique wo

82 on are an attractive strategy to synchronize circadian rhythms and develop zeitgeber hygiene.

83 to our knowledge, to propose a link between circadian rhythms and EAD formation and suggests that th

84 reen the remaining 20 kinases for effects on circadian rhythms and find an additional 3 to be involve

85 we highlight the novel relationship between circadian rhythms and homeostatic processes that governs

86 YROs share features with circadian rhythms and interact with, but are independent

87 Shift work has been shown to disrupt circadian rhythms and is associated with several adverse

88 ction impairment, HD mice also show impaired circadian rhythms and loss of ipRGC.

89 uclear receptors REV-ERBalpha and -beta link circadian rhythms and metabolism.

90 The mechanistic link between circadian rhythms and neurodegeneration is still not ful

91 pathway plays important roles in regulating circadian rhythms and neuronal maintenance in the adult

92 The neuromodulator melatonin synchronizes circadian rhythms and related physiological functions th

93 SST expression in the amygdala and disrupted circadian rhythms and rhythmic peaks of anxiety in BD su

94 Neonicotinoids disrupt honey bee circadian rhythms and sleep, likely by aberrant stimulat

95 chronotype as social zeitgeber on individual circadian rhythms and sleep-wake patterns in adult subje

96 lity at the BBB is dynamically controlled by circadian rhythms and sleep.

97 d for effects of neonicotinoids on honey bee circadian rhythms and sleep.

98 hat the gastrointestinal microbiota exhibits circadian rhythms and that the timing of food consumptio

99 of T2D, suggesting a functional link between circadian rhythms and the microbiome in metabolic diseas

100 We begin with a general introduction to circadian rhythms and the molecular circadian clock that

101 non-image forming visual processes including circadian rhythms and the pupillary light reflex.

102 Here, we assessed endogenous circadian rhythms and wake-dependent changes in plasma m

103 immunity, chronic inflammation, cell cycle, circadian rhythm, and olfactory functions.

104 cal research areas such as cancer, virology, circadian rhythms, and behavioural neuroscience.

105 a suite of genes associated with vision and circadian rhythm are differentially expressed in blood t

106 Circadian rhythms are 24-h rhythms in physiology and beh

107 Disrupted sleep-wake and molecular circadian rhythms are a feature of aging associated with

108 a range of techniques, we have examined how circadian rhythms are affected in higher order pif mutan

109 Sleep and circadian rhythms are affected in many of these conditio

110 s to anticipate daily environmental changes, circadian rhythms are also important for orchestrating c

111 Circadian rhythms are biological oscillations that sched

112 Organismal circadian rhythms are coordinated by behavioral rhythms

113 Circadian rhythms are daily cycles in biological functio

114 Circadian rhythms are driven by a transcription-translat

115 Circadian rhythms are endogenous 24-h oscillations which

116 Circadian rhythms are generated by interlocked transcrip

117 Circadian rhythms are generated by the circadian oscilla

118 Circadian rhythms are generated by the cyclic transcript

119 Circadian rhythms are generated by transcriptional negat

120 cally develop at certain stages of life, and circadian rhythms are important during each stage of lif

121 Circadian rhythms are near 24-h cycles that are primaril

122 Thus, interventions that improve circadian rhythms are prospective entry points to mitiga

123 Although circadian rhythms are widespread among different taxa, t

124 tous artificial lighting can disrupt natural circadian rhythms; as a result, sleep disorders affect a

125 Human sleep/wake cycles follow a stable circadian rhythm associated with hormonal, emotional, an

126 ential Organ Failure Assessment, and central circadian rhythm by melatonin profile.

127 CLK8 enhances the amplitude of the cellular circadian rhythm by stabilizing the negative arm of the

128 We next induced severe disruption of circadian rhythms by exposing ApoE(-/-) mice to constant

129 Preservation of circadian rhythms by the protein folding chaperone, BiP.

130 n reward systems and the impact of sleep and circadian rhythms changes on addiction vulnerability in

131 We hypothesized interplay between circadian rhythm, collagen synthesis, and ER stress in n

132 istic differences in chronotype and cellular circadian rhythms compared to lithium non-responders (Li

133 Here we find that a mammalian circadian rhythm component, Cryptochrome 2 (CRY2), regul

134 Circadian rhythms control organismal physiology througho

135 ers), rest-activity rhythms, and the central circadian rhythm-controlled melatonin secretion profile.

136 However, circadian rhythm data are inconsistent.

137 id eye movement sleep behavior disorder, and circadian rhythm disorders commonly occur at a rate grea

138 he long-term, chronic insufficient sleep and circadian rhythm disorders have been associated with oth

139 imals and provide novel targets for treating circadian rhythm disorders.

140 t, compared to controls, mice that had their circadian rhythms disrupted (ECD) had higher Chlamydia l

141 at compared to controls, mice that had their circadian rhythms disrupted in this ECD model will have

142 Sleep and circadian rhythm disruption (SCRD) is a ubiquitous featu

143 Recent studies suggest that circadian rhythm disruption is a major risk factor for t

144 ostasis and contributes to the disease risk, circadian rhythm disruption is emerging as a new risk fa

145 Circadian rhythm disruption is one of the earliest bioma

146 genetic predisposition, obesogenic diet, and circadian rhythm disruption.

147 nical studies are promising, more studies of circadian rhythm disruptions and its mechanisms are requ

148 common occurrence in ageing adults; however, circadian rhythm disruptions are more severe in people w

149 Manifestations of circadian rhythm disruptions differ according to the typ

150 idence from preliminary studies suggest that circadian rhythm disruptions, in addition to being a sym

151 ), psychological stress, physical stress and circadian rhythm disruptions.

152 Many physiological processes exhibit circadian rhythms driven by cellular clocks composed of

153 rix in vivo, which contributes to a dampened circadian rhythm during ageing.

154 Circadian rhythm dysfunction has been associated with in

155 es necessity of SCN(VIP) neurons for the LMA circadian rhythm, elucidates organization of circadian o

156 Moreover, variables pertaining to circadian rhythm entrainment were activated more strongl

157 tion, many noncanonical genes have intrinsic circadian rhythms, especially within the liver and kidne

158 -wavelength light strongly phase shifts skin circadian rhythms ex vivo via an Opn5-dependent mechanis

159 In summary, in vivo circadian rhythms exist in multiple adipose metabolic pa

160 re are strong associations between disrupted circadian rhythms (for example, sleep-wake cycles) and d

161 ng preference (chronotype) as a dimension of circadian rhythm function in 193 Li-R and Li-NR BD patie

162 Circadian rhythms govern a large array of physiological

163 Circadian rhythms govern multiple aspects of animal meta

164 Circadian rhythms govern physiology and metabolism, lead

165 Night-shift work involving disruption of circadian rhythms has been associated with breast cancer

166 Disruption of circadian rhythms has been recognized as a perturbation

167 Basic research in circadian rhythms has largely focused on the functioning

168 Historically, fetal circadian rhythms have been considered irrelevant owing

169 Circadian rhythms have been extensively studied in Droso

170 Circadian rhythms have been implicated in the pathogenes

171 iles are a large group of organisms in which circadian rhythms have been only poorly characterized an

172 Circadian rhythms have been shown to modulate inflammati

173 se studies establish a regulatory link among circadian rhythms, hypoxia response, fatty acid uptake,

174 regulation of a network of genes involved in circadian rhythm in both tissues and downregulation of t

175 nin is not a reliable measure of the central circadian rhythm in critically ill patients.

176 deposition and produced a greatly augmented circadian rhythm in IL6, a factor previously linked with

177 tional transcription cycles, RBCs maintain a circadian rhythm in membrane electrophysiology through d

178 disease (PD), but the molecular role of the circadian rhythm in PD is unclear.

179 through Dopamine 2 Receptors to entrain the circadian rhythm in PER2::LUC bioluminescence.

180 An endogenous circadian rhythm in the BBB controls transporter functio

181 We identify a daily and circadian rhythm in the inhibition of plant development

182 n two-hybrid system, real-time monitoring of circadian rhythm in U2OS cells, and various biochemical

183 vidual bees, shifts the timing of behavioral circadian rhythms in bees that remain rhythmic, and impa

184 Most organisms on the earth exhibit circadian rhythms in behavior and physiology, which are

185 ion is believed to be crucial for generating circadian rhythms in behavior and physiology.

186 Clock neurons generate circadian rhythms in behavioral activity, but the releva

187 igate whether lithium differentially impacts circadian rhythms in bipolar patient cell lines and cruc

188 Measurements of circadian rhythms in body temperature suggest a biologic

189 e shown that L-type calcium channels exhibit circadian rhythms in both expression and function in gui

190 Such "sickness behaviours" include disrupted circadian rhythms in both locomotor activity and body te

191 sought to characterize acute alterations of circadian rhythms in critically ill patients and to eval

192 rugs identified in the screen did not affect circadian rhythms in cultured cells derived from lumines

193 In the current study, we have analyzed circadian rhythms in daily activity and sleep, and the c

194 EA (GI) is required to sustain Suc-dependent circadian rhythms in darkness.

195 t-dispersing factor (PDF) is critical to the circadian rhythms in Drosophila locomotor activity.

196 sex of animals is an important modulator of circadian rhythms in gene expression and their response

197 we show that fibroblasts with ER stress lack circadian rhythms in gene expression upon clock-synchron

198 ffects the circadian clocks by reprogramming circadian rhythms in gene expression.

199 We reveal that circadian rhythms in host locomotor activity patterns an

200 a neurohormone involved in the regulation of circadian rhythms in humans.

201 horylation, which provides the mechanism for circadian rhythms in IGF signaling in vivo.

202 vident than in the respiratory system, where circadian rhythms in inflammatory lung disease have been

203 Studying circadian rhythms in most human tissues is hampered by d

204 slocation of PER and CRY proteins and impact circadian rhythms in peripheral cells and tissue explant

205 the SCN communicate to neurons to determine circadian rhythms in physiology and in rest activity.

206 m a subset of 59 patient donors, we measured circadian rhythms in skin fibroblasts longitudinally ove

207 t much more common and chronic disruption of circadian rhythms in the general population than shift w

208 In contrast, a few cells show noisy circadian rhythms in the isolated E14.5 SCN and most sho

209 Here, we report circadian rhythms in the levels of endogenous H(2)O(2) i

210 dopamine reward circuit, exhibits disturbed circadian rhythms in the postmortem brains of depressed

211 ust synchronize to each other to drive these circadian rhythms in the rest of the body.

212 Here we reveal circadian rhythms in the transcriptome and metabolic pat

213 al regulator of DNL, acquired high-amplitude circadian rhythms in thermogenic BAT.

214 Circadian rhythms in transcription ultimately result in

215 LUCIFERASE upon Cre recombination, we assess circadian rhythms in two of the major classes of peptide

216 AL1 TAD-independent mechanism for generating circadian rhythms in vivo.

217 en using a luminescent reporter of molecular circadian rhythms in zebrafish larvae.

218 Circadian rhythms influence many of these phenomena.

219 By incorporating the circadian rhythm into our model, we reveal that fAbeta a

220 The circadian rhythm is driven by a master clock within the

221 Dysfunction of the circadian rhythm is one of most common nonmotor symptoms

222 Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adult

223 scoordination between central and peripheral circadian rhythms is a core feature of nearly every gene

224 Our results reveal that disruption of host circadian rhythms is a genetically variable virulence tr

225 It is well known that disruption to circadian rhythms is associated with non-infectious dise

226 d review we examine how emerging research on circadian rhythms is being applied to the study of funda

227 define eating patterns relative to internal circadian rhythms limits the extent of these findings.

228 ecause old age is associated with defects in circadian rhythm, loss of circadian regulation is though

229 tion factor that regulates genes involved in circadian rhythm maintenance and metabolism, effectively

230 HRMs affects the major cellular processes of circadian rhythm maintenance and metabolism.

231 adian pattern of wrist temperature (internal circadian rhythm marker).

232 merous studies have shown that disruption of circadian rhythm may increase risk for malignant, psychi

233 It has been suggested that modifying circadian rhythms may be a means to manipulate crops to

234 ve a circadian component, and disruptions in circadian rhythms may even trigger the development of th

235 We conclude that circadian rhythms may influence response to lithium in m

236 ot alter actigraphic sleep parameters before circadian rhythm measurement.

237 fty-one older and 48 young adults followed a circadian rhythms measurement protocol for up to 5.5 day

238 ors of objective and self-reported sleep and circadian rhythm measures.

239 Circadian rhythms, metabolism, and nutrition are intimat

240 Circadian rhythms modulate growth and development in all

241 meostatic sleep drive takes longer to build, circadian rhythms naturally become delayed, and sensitiv

242 ral light/dark cycles and impairs endogenous circadian rhythms necessary to maintain optimal biologic

243 l network models were trained to predict the circadian rhythm of (i) salivary melatonin on a fixed sl

244 ely, alterations in energy state can disrupt circadian rhythms of behavior and physiology, creating a

245 We first characterized circadian rhythms of behavior, light responsiveness, and

246 We analyzed the circadian rhythms of bipolar patient-derived fibroblasts

247 In the laboratory, C. finmarchicus shows circadian rhythms of DVM, metabolism, and most core circ

248 Moreover, circadian rhythms of host organisms appear to dictate tu

249 sae from transgenic mice revealed endogenous circadian rhythms of P-gp protein expression with a shor

250 Growing evidence demonstrates circadian rhythms of pain hypersensitivity in various ch

251 Although circadian rhythms of Vo2 were conserved in young lean CT

252 These findings suggest that the influence of circadian rhythm on neuroprotection must be considered f

253 se of this study was to define the impact of circadian rhythms on benzo-a-pyrene (BaP) metabolism in

254 es in mediating the effects of disruption of circadian rhythms on human health.

255 We discuss the impact of circadian rhythms on society and the challenges for the

256 SDS reduced stress effects on both sleep and circadian rhythms, or hastened their recovery, and atten

257 We then estimated circadian rhythm parameters (amplitude, period, phase) a

258 hydrate metabolism, secondary metabolism and circadian rhythm pathways were commonly enriched in both

259 tic influx and clearance exhibit endogenous, circadian rhythms peaking during the mid-rest phase of m

260 Animal circadian rhythms persist in constant darkness and are d

261 ve describing the magnitude and direction of circadian rhythm phase shifts, depending on the time of

262 tudy human circadian disorders with unstable circadian rhythm phases.

263 Circadian rhythms play an influential role in nearly all

264 Maintenance of physiological circadian rhythm plays a crucial role in human health.

265 Disruption of the circadian rhythm plays a key role in tumorigenesis and f

266 uential Organ Failure Assessment score), and circadian rhythms (profiles of serum melatonin and its u

267 recent discoveries of the interplay between circadian rhythms, proliferative metabolism and cancer,

268 The central circadian rhythm rapidly dampens with onset of critical

269 supports the involvement of this protein in circadian rhythm regulation.

270 1, which is involved in learning, memory and circadian rhythm regulation.

271 titude of mechanisms, including through host circadian rhythm regulation.

272 ancers, including the super-enhancer for the circadian rhythm repressor Per2.

273 rimitive, yet fundamental functions, such as circadian rhythms, reward, aggression, anxiety, and fear

274 tional categories such as membrane proteins, circadian rhythm, signaling, response to stimulus, regul

275 Diagnosis and treatment of circadian rhythm sleep-wake disorders both require asses

276 ing (SDB), sleep-related movement disorders, circadian rhythm sleep-wake disorders, and insomnia diso

277 ts express behavioural deficits including in circadian rhythms, sleep, anxiety and learning/memory.

278 design of interventions to prevent and treat circadian rhythm-sleep disorders and social jet-lag.

279 Together, our data suggest that circadian rhythm stability is pivotal for the maintenanc

280 lex, Fbxl3, delay CRY1/2 degradation, reduce circadian rhythm strength, and lengthen the circadian pe

281 regulation of sleep and biological (diurnal, circadian) rhythms, suggesting common pathophysiologies

282 nucleus (SCN) of the hypothalamus to entrain circadian rhythms that are generated within the SCN.

283 roduces progressive alterations in sleep and circadian rhythms that resemble features of depression a

284 Use of endpoints, such as sleep and circadian rhythm, that are homologous across species wil

285 tion of its complex varied with time of day (circadian rhythm)-this regulation required NR1D1.

286 f the unfolded protein response in order for circadian rhythms to be maintained.

287 chanistic basis underlying the adjustment of circadian rhythms to changing external conditions, howev

288 Adequate synchronisation of endogenous circadian rhythms to external time is beneficial for hum

289 The cardiovascular system exhibits strong circadian rhythms to maintain normal functioning.

290 a, a metabolite that lengthens the period of circadian rhythms, to understand the regulation of circa

291 nce and arrhythmia of the CAM CO(2) fixation circadian rhythm under constant light and temperature fr

292 screen to uncover ion channels with roles in circadian rhythms, we have identified the I(h) channel a

293 id metabolism, cholesterol biosynthesis, and circadian rhythm were most significantly altered in the

294 lusters in pathways involving metabolism and circadian rhythm were noted in insulin-responsive tissue

295 temperature changes due to menstruation, and circadian rhythms were controlled for in the experimenta

296 After each meal schedule, participants' circadian rhythms were measured in a 37-hr constant rout

297 ) can synchronize the central and peripheral circadian rhythms, which in turn can prevent or even tre

298 nd chronic exposure to drugs of abuse alters circadian rhythms, which may contribute to subsequent SU

299 GLP-1 also exhibits a circadian rhythm, with highest release at the onset of t

300 tion, environmental stimuli that entrain the circadian rhythm (zeitgebers), rest-activity rhythms, an