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1 g (approximately 50 differentially expressed circular RNAs).
2  and ligates the processed ends to produce a circular RNA.
3 tracellular SAM dynamics when expressed as a circular RNA.
4 -state output of protein-coding genes toward circular RNAs.
5  drug doxorubicin and their interaction with circular RNAs.
6 ets are a major source of miRNAs, YRNAs, and circular RNAs.
7 ffect of doxorubicin via regulating a set of circular RNAs.
8 native splicing can lead to the formation of circular RNAs.
9 able methods recently used to identify human circular RNAs.
10 uctured 3' UTRs as well as highly structured circular RNAs.
11  genes are noncanonically spliced to produce circular RNAs.
12 uch as long non-coding RNAs, pseudogenes and circular RNAs.
13 g covalently modified RNAs, edited RNAs, and circular RNAs.
14 nerates an RNA pool consisting of lariat and circular RNAs.
15 ously described cases of scrambled exons and circular RNAs.
16 pliced transcripts and the formation of more circular RNAs.
17 via a custom pipeline optimized for handling circular RNAs.
18 encing of small RNAs including microRNAs and circular RNAs.
19 ein-coding genes are able to generate exonic circular RNAs.
20 e alternatively spliced region of linear and circular RNAs.
21 l RNA-seq, our method is also able to detect circular RNAs.
22 anding the function of viral long ncRNAs and circular RNAs.
23                                              Circular RNAs, a family of covalently circularized RNAs
24                                              Circular RNAs, a new class of noncoding RNAs, are implic
25 t the first cell type-specific expression of circular RNAs-a neuron-specific and nuclear-enriched RNA
26 le plasma cells have uniquely high levels of circular-RNAs accounted for by and reflecting the combin
27 , including short microRNAs, long ncRNAs and circular RNAs, across various heart diseases indicates t
28 ogy, such as the functions of enhancer RNAs, circular RNAs and chemical modifications to RNA in cellu
29 e new strategy for the in vitro synthesis of circular RNAs and hairpin ribozymes is described.
30 mFISH), we selectively identified and imaged circular RNAs and their linear counterparts derived from
31 mputational methods to discover and quantify circular RNA are essential.
32                                              Circular RNAs are an increasingly important class of RNA
33 vidence that virus-derived, protein-encoding circular RNAs are biologically functional and linked to
34                                              Circular RNAs are covalently closed RNA transcripts that
35                                In metazoans, circular RNAs are expressed in a tissue-specific manner,
36                                              Circular RNAs are found in a wide range of organisms and
37                             In addition, the circular RNAs are found in complexes with proteins requi
38                                              Circular RNAs are garnering increasing interest as poten
39 but the underlying mechanisms by which these circular RNAs are generated are largely unknown.
40                                              Circular RNAs are generated at low levels from many prot
41                                              Circular RNAs are generated from many protein-coding gen
42                        Upon viral infection, circular RNAs are globally degraded to release PKR, whic
43                                              Circular RNAs are important for many cellular processes
44                                      Whether circular RNAs are involved in the modulation of miRNA ac
45                                Also, because circular RNAs are not primary substrates for exonuclease
46 eover, discovering biological contexts where circular RNAs are regulated will shed light on potential
47                                              Circular RNAs are regulatory RNAs that show promise as b
48 verged eukaryotes, but the functions of most circular RNAs are still unknown.
49 irus (HDV) RNA, it is generally assumed that circular RNAs are the only templates.
50 genome, with potential biogenesis factors of circular RNA as the features of the training data.
51 ments to the current methods used to isolate circular RNAs as well as a way to reveal RNA structures
52           Concurrent existence of lncRNA and circular RNA at both nucleus and cytosol within a cell a
53 y of minor spliceosome donors to splice into circular RNA at un-annotated, rather than annotated, exo
54 G islands within the flanking regions of the circular RNA back-spliced junction sites.
55  gene encodes an abundant linear and several circular RNAs believed to perform noncoding functions du
56          Our results uncover a mechanism for circular RNA biogenesis that may account for circulariza
57 standing of the mechanisms and regulation of circular RNA biogenesis, the impact that circRNA generat
58 in between the repeats can sometimes inhibit circular RNA biogenesis.
59 y eukaryotic genes generate linear mRNAs and circular RNAs, but it is largely unknown how the ratio o
60                                Prediction of circular RNA can be achieved in three steps: distinguish
61 evealed an increasingly detailed view of how circular RNAs can be generated and function.
62                                              Circular RNA circPABPN1 blocked HuR binding to Atg16l1 m
63                                              Circular RNA (circR)-284 is a potential inhibitor of miR
64 entification of competing endogenous RNA and circular RNA (circRNA) as important regulators of miRNA
65                      The modulation of Oprm1 circular RNA (circRNA) expression by morphine, coupled w
66 in Bank (MSBB)) AD RNA-seq dataset, cortical circular RNA (circRNA) expression was quantified in the
67 expression emerged: ubiquitous expression of circular RNA (circRNA) from genes traditionally thought
68                                              Circular RNA (circRNA) has recently gained attention for
69                                              Circular RNA (circRNA) is a candidate for next-generatio
70                                              Circular RNA (circRNA) is a class of noncoding RNA whose
71                                              Circular RNA (circRNA) is a class of noncoding RNA with
72                                              Circular RNA (circRNA) is a class of RNA molecules that
73                                              Circular RNA (circRNA) is a novel class of long non-codi
74                                              Circular RNA (circRNA) is an emerging class of vaccines
75                                              Circular RNA (circRNA) is covalently closed, single-stra
76  controls back-splicing reactions leading to circular RNA (circRNA) production.
77                                     Finally, circular RNA (circRNA) sequencing revealed that the flan
78 2, however, a surprising discovery was made: circular RNA (circRNA) was shown to be a transcriptional
79                                              Circular RNA (circRNA), a subclass of non-coding RNA, pl
80 1-5p reduces LUSC metastasis by inhibiting a circular RNA (circRNA), CDR1as.
81 g RNAs (e.g., mRNA) in the form of linear or circular RNA (circRNA).
82 zed rather than linear transcripts, known as circular RNA (circRNA).
83 sed ubiquitination, DNA methylation, and the circular RNA (circRNA)/long noncoding RNA (lncRNA)-miRNA
84 ing endogenous RNAs (ceRNA) including mRNAs, circular RNAs (circRNA) and long noncoding RNAs (lncRNA)
85                                              Circular RNAs (circRNA) are a recently described class o
86                                              Circular RNAs (circRNA) are covalently closed molecules
87                                              Circular RNAs (circRNA) are known to function as competi
88                    In recent years, multiple circular RNAs (circRNA) biogenesis mechanisms have been
89 the overall profile of miRNA target sites in circular RNAs (circRNA) generated by alternative back sp
90            Here, we investigated the role of circular RNAs (circRNA) in metastasis, using melanoma as
91                                              Circular RNAs (circRNA) is a class of natural (biogenic)
92                                              Circular RNAs (circRNAs or circ) have emerged as potenti
93                                              Circular RNAs (circRNAs) act as gene expression regulato
94                                  A subset of circular RNAs (circRNAs) and linear RNAs have been propo
95                                              Circular RNAs (circRNAs) are a class of endogenous nonco
96                                              Circular RNAs (circRNAs) are a class of non-coding RNAs
97                                              Circular RNAs (circRNAs) are a class of noncoding RNAs p
98                                              Circular RNAs (circRNAs) are a class of RNAs commonly fo
99                                              Circular RNAs (circRNAs) are a class of RNAs generated f
100                                              Circular RNAs (circRNAs) are a class of RNAs that is und
101                                              Circular RNAs (circRNAs) are a class of single-stranded
102                                              Circular RNAs (circRNAs) are a covalently closed subclas
103                                              Circular RNAs (circRNAs) are a distinct category of sing
104                                              Circular RNAs (circRNAs) are a diverse class of RNAs wit
105                                              Circular RNAs (circRNAs) are a large class of noncoding
106                                              Circular RNAs (circRNAs) are a new class of endogenous R
107                                              Circular RNAs (circRNAs) are a newly appreciated class o
108                                              Circular RNAs (circRNAs) are a newly discovered class of
109 nal linear RNAs (containing 5' and 3' ends), circular RNAs (circRNAs) are a special type of RNAs that
110                                              Circular RNAs (circRNAs) are a unique class of covalentl
111                                              Circular RNAs (circRNAs) are abundant and accumulate wit
112               Recent studies have shown that circular RNAs (circRNAs) are abundant, widely expressed
113                                              Circular RNAs (circRNAs) are an intriguing class of RNA
114                                              Circular RNAs (circRNAs) are associated with crucial hal
115                                              Circular RNAs (circRNAs) are broadly expressed in eukary
116                                              Circular RNAs (circRNAs) are covalently closed non-codin
117                                              Circular RNAs (circRNAs) are covalently closed RNA molec
118                                       Exonic circular RNAs (circRNAs) are covalently closed RNA molec
119                                              Circular RNAs (circRNAs) are covalently closed RNAs deri
120                                              Circular RNAs (circRNAs) are covalently closed RNAs that
121                                              Circular RNAs (circRNAs) are emerging as important regul
122                                              Circular RNAs (circRNAs) are endogenous RNAs.
123                                              Circular RNAs (circRNAs) are enriched in the mammalian b
124                                     Although circular RNAs (circRNAs) are enriched in the mammalian b
125                                              Circular RNAs (circRNAs) are formed in all domains of li
126                                              Circular RNAs (circRNAs) are found across eukaryotes and
127                                              Circular RNAs (circRNAs) are generated by back splicing
128                                              Circular RNAs (circRNAs) are highly expressed in the bra
129                                              Circular RNAs (circRNAs) are implicated in various biolo
130                                              Circular RNAs (circRNAs) are noncoding RNAs generated by
131                                              Circular RNAs (circRNAs) are prevalent in eukaryotic cel
132                                           As circular RNAs (circRNAs) are resistant to degradation by
133                                              Circular RNAs (circRNAs) are reverse-spliced and covalen
134                                              Circular RNAs (circRNAs) are single-stranded RNAs that a
135                                              Circular RNAs (circRNAs) are stable and prevalent RNAs i
136                                              Circular RNAs (circRNAs) are stable RNAs present in cell
137                                              Circular RNAs (circRNAs) are widely expressed in human c
138             Numerous evidences indicate that Circular RNAs (circRNAs) are widely involved in the occu
139                                              Circular RNAs (circRNAs) as biomarkers for cancer detect
140                                  The role of circular RNAs (circRNAs) as biomarkers remains poorly ch
141 e expression patterns of several circulating circular RNAs (circRNAs) as potential biomarkers in pati
142  (miRNAs), long non-coding RNAs (lncRNAs) or circular RNAs (circRNAs) can be selectively targeted via
143               Recent studies have identified circular RNAs (circRNAs) expressed from the Epstein-Barr
144 -coding RNAs is limited, and their impact on circular RNAs (circRNAs) has not been explored.
145                                              Circular RNAs (circRNAs) have emerged as an important cl
146                                              Circular RNAs (circRNAs) have emerged as key regulators
147                               Although these circular RNAs (circRNAs) have garnered considerable atte
148                                              Circular RNAs (circRNAs) have recently emerged as a larg
149 Blood, Alhasan et al report the existence of circular RNAs (circRNAs) in circulating human platelets,
150                  The pervasive expression of circular RNAs (circRNAs) is a recently discovered featur
151                    Deregulated expression of circular RNAs (circRNAs) is associated with various huma
152 ecent evidence suggests that many endogenous circular RNAs (circRNAs) may play roles in biological pr
153                                              Circular RNAs (circRNAs) perform diverse functions, incl
154                                              Circular RNAs (circRNAs) play important roles in the reg
155                                       Exonic circular RNAs (circRNAs) produce predominantly non-codin
156                                              Circular RNAs (circRNAs) produced from back-splicing of
157                                              Circular RNAs (circRNAs) represent a class of endogenous
158                                              Circular RNAs (circRNAs) represent a new type of regulat
159                                              Circular RNAs (circRNAs) represent an abundant and conse
160 V) has been recently found to generate novel circular RNAs (circRNAs) through backsplicing.
161 utational methods estimate the expression of circular RNAs (circRNAs) using the number of sequencing
162 ression profiles; 43 microRNAs (miRNAs), 125 circular RNAs (circRNAs), 366 long noncoding RNAs (lncRN
163                                              Circular RNAs (circRNAs), a class of long noncoding RNAs
164                                              Circular RNAs (circRNAs), a class of non-coding RNAs gen
165 sized an important role for RBM20 in forming circular RNAs (circRNAs), a novel class of noncoding RNA
166                                              Circular RNAs (circRNAs), a novel class of poorly conser
167 RNAs (ncRNAs), including microRNAs (miRNAs), circular RNAs (circRNAs), and long noncoding RNAs (lncRN
168 ity is elevated further by the production of circular RNAs (circRNAs), another class of mature RNA th
169                              Single-stranded circular RNAs (circRNAs), generated through 'backsplicin
170                                              Circular RNAs (circRNAs), highly expressed in the centra
171                                              Circular RNAs (circRNAs), known to act as epigenetic reg
172  including long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs).
173 and long noncoding RNAs (lncRNAs), including circular RNAs (circRNAs).
174 ion, with the average tumor expressing 7,232 circular RNAs (circRNAs).
175 ) have probed the putative immunogenicity of circular RNAs (circRNAs).
176 CV orthologues of the latency-associated EBV circular RNAs circRPMS1_E4_E3a and circEBNA_U.
177 agues identify a new class of intron-derived circular RNAs (ciRNAs) and show that they have the poten
178        Particularly, the recently identified circular RNA, ciRS-7, which acts as a designated miR-7 i
179 e experiments demonstrate utilization of the circular RNA class of RNAs across 4 members of the gamma
180  Total RNA isolated from cells producing the circular RNA contained ribozyme activity.
181 ort that insulin secretion is regulated by a circular RNA containing the lariat sequence of the secon
182                              A 48 nucleotide circular RNA containing the stem, bulge and loop of the
183 s unique gene, splicing, polyadenylation and circular RNA defects that differ from RBM20 KO.
184 , and used a custom pipeline to characterize circular RNAs derived from coding exons.
185           We also detected approximately 250 circular RNAs derived from single or multiple exons.
186  identified regulated expression of specific circular RNAs derived from Ttn (Titin), Fhod3 (Formin ho
187 increases the sensitivity and specificity of circular RNA detection by discovering and quantifying ci
188  expression profiling revealed more than 476 circular RNAs differentially expressed in control brain
189 lic di-guanosine monophosphate (di-GMP) is a circular RNA dinucleotide that functions as a second mes
190                   Here, we demonstrated that circular RNA DYM (circDYM) levels were significantly dec
191 encing and bioinformatics identified several circular RNAs enriched in VSMCs; however, only one, poss
192 for exploring the functional consequences of circular RNA expression across eukaryotes.
193 ogy to determine confidence in prediction of circular RNA expression, our algorithm uses a statistica
194 sed of multiple genes, termed fusion-derived circular RNAs (fcircRNAs), represent a class of potentia
195 on model trained to predict the formation of circular RNA from a random genomic locus on human genome
196 ntly closed structure to further distinguish circular RNA from linear RNA following in vitro synthesi
197 ep learning framework, circDeep, to classify circular RNA from other lncRNA.
198  than 80 percent accurate for distinguishing circular RNAs from other lncRNAs due to difficulty of cl
199 hort and long non-coding RNAs and predicting circular RNAs from other long non-coding RNAs (lncRNAs).
200                                         This circular RNA gemmed from alternative splicing of Lrp6 (l
201                                              Circular RNAs generated by splicing are devoid of flanki
202                               Both the small circular RNA genome and its complement, the antigenome,
203 capsid, which consists of a single-stranded, circular RNA genome complexed with delta antigen, the vi
204                                     Both the circular RNA genome of HDV and its complementary antigen
205                                     Both the circular RNA genome of HDV and its complementary antigen
206                                          The circular RNA genome of hepatitis delta virus (HDV) can f
207            Hepatitis delta virus (HDV) has a circular RNA genome that replicates by a double rolling-
208   Hepatitis delta virus (HDV) replicates its circular RNA genome via a rolling circle mechanism.
209 of HDV replication: (i) the 1,679-nucleotide circular RNA genome, (ii) its exact complement, the anti
210 e(s) to transcribe its 1,679-nucleotide (nt) circular RNA genome.
211 d suggests that ligation may be used to form circular RNA genomes.
212 igns such as Dicer-substrate RNA, shRNA, and circular RNA have been evaluated in vitro and in preclin
213  such as microRNAs, long non-coding RNAs and circular RNAs have been assessed as potential therapeuti
214                                              Circular RNAs have great stability and can sequester pro
215                  The study of this and other circular RNAs helps understanding beta-cell dysfunction
216 uences, and (ii) thousands of novel intronic circular RNAs (IcircRNAs) are expressed in cells.
217 er RNAs, microRNAs, long noncoding RNAs, and circular RNAs (ie, regRNAs) in heart failure.
218 nucleotide from its helical complex with the circular RNA in an ATP-dependent reaction.
219 s suggest a potentially significant role for circular RNA in human development.
220                   Silencing of this intronic circular RNA in pancreatic islets leads to a decrease in
221 tion of splicing intermediates, we show that circular RNA in Schizosaccharomyces pombe is generated t
222 omarkers in various diseases but the role of circular RNAs in CP is beginning to be understood.
223 tions of microRNAs, long non-coding RNAs and circular RNAs in joint tissues and biofluids has increas
224 tudies have revealed thousands of endogenous circular RNAs in mammalian cells, some of which are high
225 le and useful strategy for the generation of circular RNAs in preparative amounts; and (iii) that sel
226 Seq), we compared the expression patterns of circular RNAs in proliferating (early-passage) and senes
227 s the branch sites confirmed lariat RNAs and circular RNAs in the pool generated by constitutive and
228                  A global down-regulation of circular RNAs in tumors relative to normal tissues was o
229 ing induction of general and tissue-specific circular RNAs, including in the heart and lung, during h
230  regulate the expression of other Drosophila circular RNAs, including Plexin A (PlexA), suggesting a
231          Moreover, inhibition of Ttn-derived circular RNA increased the susceptibility of cardiomyocy
232 harmacologically, the steady-state levels of circular RNAs increased while expression of their associ
233                         We aimed to identify circular RNAs interacting with miRNAs enriched in VSMCs
234                      Pervasive expression of circular RNA is a recently discovered feature of eukaryo
235                  The pervasive expression of circular RNA is a recently discovered feature of gene ex
236 H and 2',3'-cyclic phosphate termini to form circular RNA is an essential step in the life cycle of t
237 s largely unknown how the ratio of linear to circular RNA is controlled or modulated.
238                            The effect of the circular RNA is exerted at the transcriptional level and
239                  Therefore, the detection of circular RNAs is vital to understanding their biogenesis
240 As, which considers the specific features of circular RNA, is essential to the development of systema
241 rtex, with marked enrichment for genes where circular RNA isoforms are dominant.
242  places box C/D RNAs among the extremely few circular RNAs known to exist in nature.
243 n for its biogenesis, we found that Laccase2 circular RNA levels are not controlled by Mbl or the Lac
244           It is now clear that modulation of circular RNA levels can result in a variety of molecular
245 n of the cleavage/polyadenylation machinery, circular RNA levels were similarly increased.
246 ti et al. (2017) demonstrate that endogenous circular RNAs may generate proteins, thereby expanding t
247 in genome methylation, long non-coding RNAs, circular RNAs, micro-RNAs and fruit metabolites revealed
248 ntial as biomarkers and disease targets, and circular RNA mimics are being explored for use as therap
249 ingle-strand RNA to form a covalently closed circular RNA molecule through ligase-adenylylate and RNA
250 e data also demonstrate the utility of small circular RNA molecules as tools for biochemical studies.
251 ssing facilitated accurate quantification of circular RNA molecules in individual cells.
252              CircRNAs are covalently closed, circular RNA molecules that typically comprise exonic se
253 RNA and creates highly stable and functional circular RNA molecules.
254 epatitis delta virus (HDV), which contains a circular RNA of 1.7 kilobases, is nonetheless able to re
255                   The HDV genome is a closed circular RNA of about 1,700 bases which is replicated th
256 xons) or catalyses back-splicing to generate circular RNA (on long exons).
257                                          The circular RNA population is also defined and shown to inc
258 containing minimal repeats (<40 nt) generate circular RNAs predominately after 3' end processing.
259 he first examples of developmentally induced circular RNAs processed by the minor spliceosome, and an
260 he past two decades, a circular form of RNA (circular RNA), produced through alternative splicing, ha
261                         The vast majority of circular RNA production occurs at major spliceosome spli
262 ected into alternative pathways that lead to circular RNA production.
263 with previous knowledge that Cdr1as (ciRS-7) circular RNA protects miR-7 from Cyrano-mediated TDMD, w
264 processing, and the functions carried out by circular RNAs remains limited.
265                                              Circular RNAs represent a class of endogenous RNAs that
266                                              Circular RNAs require internal ribosome entry sites (IRE
267 99 401 and 114 574 AS events from linear and circular RNAs, respectively.
268 d probes against the negative strands of the circular RNA sequence, absent in the cell.
269            Additionally, using the low-error circular RNA sequencing technique, we identified novel c
270 larization of an exon of the PVT1 gene, as a circular RNA showing markedly reduced levels in senescen
271  This was not due to an inability to cut any circular RNA, since Vhs cuts circular mRNAs containing a
272 crease HCC cell invasion via suppressing the circular RNA-SMG1.72 (circRNA-SMG1.72) expression via tr
273 g and long noncoding transcripts, as well as circular RNA species that were also experimentally valid
274 encing have allowed comprehensive studies of circular RNA species.
275 ty of blocking the microRNA let-7 by using a circular RNA sponge.
276 e transcriptomes, but many issues related to circular RNAs still need to be clarified.
277 ditionally, GEMORNA's versatility extends to circular RNA, substantially enhancing circular EPO expre
278                       Mixtures of linear and circular RNAs synthesized in vitro and containing 225-11
279                                              Circular RNA templates were found to be at least several
280 ) is a 1,679-nucleotide (nt) single-stranded circular RNA that is predicted to fold into an unbranche
281 tis delta virus (HDV) contains a viroid-like circular RNA that is presumed to replicate via a rolling
282 tis delta virus (HDV) contains a viroid-like circular RNA that replicates via a double rolling circle
283 e utility of orthogonal analytical tests for circular RNA that take advantage of its covalently close
284  of eukaryotic protein-coding genes generate circular RNAs that have covalently linked ends and are r
285 e non-translatable, autonomously replicating circular RNAs that infect only plants.
286                            Covalently closed circular RNA transcripts are prevalent in eukaryotes and
287                                              Circular RNA transcripts were first identified in the ea
288 oding species such as long noncoding RNA and circular RNA transcripts whose presence had not been pre
289                                Biogenesis of circular RNA usually involves a backsplicing reaction wh
290 tion of single-stranded RNA to form a closed circular RNA via covalent ligase-AMP and RNA-adenylylate
291 ne deaminase acting on RNA (ADAR)-recruiting circular RNAs, we find that guided A>I snRNAs consistent
292                                        These circular RNAs were rare and stochastic, although a few b
293 on of yeast EFM5 or HMRA1 can be chased into circular RNA when the exon is sufficiently long.
294       Hepatitis delta virus (HDV) contains a circular RNA which encodes a single protein, hepatitis d
295 s were molecular precursors in biogenesis of circular RNA which occurred through catalytic role of so
296 e previously characterized Muscleblind (Mbl) circular RNA, which requires the Mbl protein for its bio
297 ne learning method for the identification of circular RNAs, which considers the specific features of
298 g sequences, making linear mRNA as stable as circular RNA while achieving higher translation efficien
299                                         This circular RNA with no noncoding sequences is a unique nat
300                 Other noncoding RNAs such as circular RNAs, YRNAs, or long noncoding RNAs are current

 
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