ライフサイエンスコーパス: circumsporozoite

1 Circumsporozoite, a predominant surface protein, is invo

2 nete micronemal proteins chitinase (PgCHT1), circumsporozoite and TRAP-related protein (CTRP), and vo

3 the first microneme protein of the ookinete: circumsporozoite- and TRAP-related protein (CTRP).

4 seasonal booster doses were tested for anti-circumsporozoite antibodies using enzyme-linked immunoso

5 01, 99.7% of children were positive for anti-circumsporozoite antibodies, with a geometric mean titer

6 ozoite antibody titres using a model of anti-circumsporozoite antibody dynamics and the natural acqui

7 A strong anti-circumsporozoite antibody response to 3 priming doses of

8 Here, we report on the anti-circumsporozoite antibody response to seasonal RTS,S/AS0

9 n a 0, 8, and 23-week schedule elicited anti-circumsporozoite antibody responses comparable in magnit

10 immunogenic, with trends toward higher anti-circumsporozoite antibody titers in participants protect

11 An anti-circumsporozoite antibody titre of 121 EU/mL (98-153) wa

12 We assessed the association between anti-circumsporozoite antibody titres and the magnitude and d

13 Anti-circumsporozoite antibody titres are a surrogate of prot

14 Waning anti-circumsporozoite antibody titres predict the duration of

15 n the incidence of clinical malaria and anti-circumsporozoite antibody titres using a model of anti-c

16 RTS,S/AS01-induced anti-circumsporozoite antibody titres were greater in childre

17 s to P. falciparum schizonts and recombinant circumsporozoite antigen, MSP-1(19), MSP-2, AMA-1, and P

18 cles carrying a recombinant Plasmodium vivax circumsporozoite antigen, VMP001, both entrapped in the

19 After initial successful evaluation of the circumsporozoite-based vaccine RTS,S/SBAS2, developed by

20 isplay two epitopes (MAL1 and MAL2) from the circumsporozoite CS proteins of Plasmodium falciparum an

21 WA-1 isolate) or full-length surface protein circumsporozoite (CS) of Plasmodium yoelii (Py).

22 ubcutaneously injected Plasmodium falciparum circumsporozoite (CS) peptides elicited strong parasite-

23 denovirus expressing a major malaria Ag, the circumsporozoite (CS) protein (AdPyCS), was determined u

24 The Plasmodium falciparum circumsporozoite (CS) protein (CSP) is a major vaccine t

25 ell epitope derived from a Plasmodium yoelii circumsporozoite (CS) protein (referred to as the PyCS-B

26 ke particle containing Plasmodium falciparum circumsporozoite (CS) protein epitopes, was shown to eli

27 dium uses a PEXEL/VTS motif to introduce the circumsporozoite (CS) protein into the hepatocyte cytopl

28 Circumsporozoite (CS) protein is a predominant surface a

29 Circumsporozoite (CS) protein is the major surface compo

30 The circumsporozoite (CS) protein of malaria parasites (Plas

31 ective recombinant adenovirus expressing the circumsporozoite (CS) protein of Plasmodium yoelii (AdPy

32 viruses expressing selected sequences of the circumsporozoite (CS) protein of the human malaria paras

33 are known to target the repeat region of the circumsporozoite (CS) protein on the parasite surface.

34 rozoites of Plasmodium predominantly express circumsporozoite (CS) protein on their surface, which bi

35 Plasmodium sporozoites display circumsporozoite (CS) protein on their surface, which is

36 Two circumsporozoite (CS) protein T cell epitopes, previousl

37 response to the Plasmodium berghei malarial circumsporozoite (CS) protein was severely impaired in C

38 echanism and the specific interaction of the circumsporozoite (CS) protein with liver-specific hepara

39 Native Plasmodium circumsporozoite (CS) protein, translocated by sporozoit

40 arget for malaria vaccine development is the circumsporozoite (CS) protein, which is expressed on the

41 patitis B surface Ag (HBs) and P. falciparum circumsporozoite (CS) protein-among Tanzanian children i

42 The Plasmodium falciparum circumsporozoite (CS) protein-based pre-erythrocytic sta

43 e focus on improving the immunogenicity of a circumsporozoite (CS) protein-based vaccine.

44 t, we use an adoptive transfer strategy with circumsporozoite (CS) protein-specific transgenic T cell

45 pecific for the repeat region of the surface circumsporozoite (CS) protein.

46 inimal epitopes of the Plasmodium falciparum circumsporozoite (CS) protein.

47 e repeat sequence of the gene coding for the circumsporozoite (CSP) protein from the AF54087 gene.

48 arly induction of functional IL-21-secreting circumsporozoite (CSP)-specific pTfh cells, together wit

49 anti-repeat Abs that reacted with the native circumsporozoite on P. falciparum sporozoites.

50 s had a striking resemblance to the malarial circumsporozoite precipitate (CSP) reaction.

51 ng monoclonal antibody 3E2 which elicits the circumsporozoite precipitate (CSP)-like reaction and pas

52 phocyte epitope on the Plasmodium falciparum circumsporozoite protein (3D7; amino acids 310 to 319 [E

53 in life and subsequent levels of antibody to circumsporozoite protein (a marker of sporozoite-stage r

54 After immunization, anti-Pf circumsporozoite protein (anti-PfCSP) (isotype and IgG s

55 ) in BALB/c mice required Plasmodium berghei circumsporozoite protein (CS(252-260))-specific memory C

56 denovirus serotype 35 (Ad35) vector encoding circumsporozoite protein (CS) (Ad35.CS), followed by boo

57 The circumsporozoite protein (CS) and the sporozoite surface

58 Circumsporozoite protein (CS) is the antigenic target fo

59 T-cell responses directed against the circumsporozoite protein (CS) of Plasmodium falciparum c

60 multiple-epitope string ME (ME-TRAP) or the circumsporozoite protein (CS) of Plasmodium falciparum.

61 ed the H-2K(d)-restricted CTL epitope of the circumsporozoite protein (CS) of Plasmodium yoelii betwe

62 onkeys and humans by eliciting antibodies to circumsporozoite protein (CS) that inhibit sporozoite in

63 The sporozoite's surface is covered by the circumsporozoite protein (CS), and its region II-plus ha

64 The circumsporozoite protein (CS), one of the major proteins

65 Despite extensive genetic diversity of circumsporozoite protein (CS), the most successful malar

66 The malaria circumsporozoite protein (CS), thrombospondin (TSP), and

67 The circumsporozoite protein (CS), which covers the surface

68 on the major sporozoite surface protein, the circumsporozoite protein (CS).

69 related adhesion protein (TRAP) 130-138-, or circumsporozoite protein (CSP) 252-260-derived epitopes

70 against the repeat-region of the Plasmodium circumsporozoite protein (CSP) abrogate sporozoite infec

71 gh antibody titers against the P. falciparum circumsporozoite protein (CSP) and a moderate CD4(+) T c

72 rongly against the pre-erythrocytic antigens circumsporozoite protein (CSP) and liver stage antigen 1

73 obulin G (IgG) antibodies to preerythrocytic circumsporozoite protein (CSP) and liver-stage antigen 1

74 ne constructs based on the Plasmodium yoelii circumsporozoite protein (CSP) and P. yoelii merozoite s

75 tested for the presence of antibodies to the circumsporozoite protein (CSP) and the 42-kDa fragment o

76 ticle that presents a designed P. falciparum circumsporozoite protein (CSP) and the Plasmodium vivax

77 rized sporozoite-specific genes encoding the circumsporozoite protein (CSP) and thrombospondin-relate

78 ncies and median levels of IgG antibodies to circumsporozoite protein (CSP) and thrombospondin-relate

79 or clonotypes and recognizing the Pf-derived circumsporozoite protein (CSP) antigen are found in the

80 g the carboxy- and the amino-terminal of the circumsporozoite protein (CSP) antigen without the centr

81 ns a top priority, and vaccines based on the circumsporozoite protein (CSP) are among the lead candid

82 The Plasmodium circumsporozoite protein (CSP) binds to salivary glands

83 The circumsporozoite protein (CSP) builds up the surface coa

84 nduced shedding of the major surface protein circumsporozoite protein (CSP) exposed the SSP3 ectodoma

85 Here, we have investigated the circumsporozoite protein (CSP) for the presence of a GPI

86 d a distinction in the repeat lengths of the circumsporozoite protein (CSP) gene sequences between P.

87 ency correlates positively with both anti-Pf circumsporozoite protein (CSP) IgG and CD8 + CD69+ effec

88 a plasmid expressing Plasmodium yoelii (Py) circumsporozoite protein (CSP) induces H-2Kd-restricted

89 ral repeat of the Plasmodium falciparum (Pf) circumsporozoite protein (CSP) inhibit parasite activity

90 The circumsporozoite protein (CSP) is a target for effector

91 The extended rod-like Plasmodium falciparum circumsporozoite protein (CSP) is comprised of three pri

92 The Plasmodium falciparum circumsporozoite protein (CSP) is critical for sporozoit

93 The circumsporozoite protein (CSP) is one of the most studie

94 The circumsporozoite protein (CSP) is the major surface prot

95 The Plasmodium circumsporozoite protein (CSP) is the major surface prot

96 Circumsporozoite protein (CSP) is the most abundant prot

97 on the central and C-terminal regions of the circumsporozoite protein (CSP) of P. falciparum.

98 ic recombinant protein, VMP001, based on the circumsporozoite protein (CSP) of P. vivax.

99 t of the FLAG epitope with an epitope of the circumsporozoite protein (CSP) of Plasmodium falciparum

100 nant that displays a B-cell epitope from the circumsporozoite protein (CSP) of Plasmodium falciparum

101 The circumsporozoite protein (CSP) of Plasmodium has several

102 The circumsporozoite protein (CSP) on the sporozoite surface

103 Plasmodium sporozoites express circumsporozoite protein (CSP) on their surface, an esse

104 IL-5 circumsporozoite protein (CSP) ratios, a helper T cell t

105 nd minor repeat of the Plasmodium falciparum circumsporozoite protein (CSP) respectively.

106 omain (Pfs230-Pro) and a short 36-amino acid circumsporozoite protein (CSP) sequence.

107 markers and diversity in the vaccine target circumsporozoite protein (csp) using nanopore sequencing

108 Circumsporozoite protein (CSP) variants of P. vivax, bes

109 d vaccinia virus recombinants expressing the circumsporozoite protein (CSP) were evaluated in the Pla

110 Several epitopes in the circumsporozoite protein (CSP) were identified as target

111 e combines DNA priming against the P. yoelii circumsporozoite protein (CSP) with a subsequent intrave

112 The circumsporozoite protein (CSP), a major surface antigen

113 alaria is based on the Plasmodium falciparum circumsporozoite protein (CSP), a major surface protein

114 Circumsporozoite protein (CSP), a predominant surface an

115 ein 2 (LISP2), liver-stage antigen 3 (LSA3), circumsporozoite protein (CSP), and a Plasmodium berghei

116 mbospondin-related anonymous protein (TRAP), circumsporozoite protein (CSP), and export protein 1 (Ex

117 RTS,S malaria vaccine, which is based on the circumsporozoite protein (CSP), demonstrated an increase

118 e sporozoites using a combination of surface circumsporozoite protein (CSP), deoxyribonucleic acid, a

119 including apical membrane antigen 1 (AMA-1), circumsporozoite protein (CSP), erythrocyte binding anti

120 The sporozoite's major surface protein, circumsporozoite protein (CSP), is a multifunctional pro

121 The P. vivax circumsporozoite protein (CSP), is considered the leadin

122 ch that targets four P. falciparum antigens: circumsporozoite protein (CSP), liver stage antigen 1 (L

123 udy sought to determine if antibodies to the circumsporozoite protein (CSP), liver-stage antigen 1 (L

124 Levels of IgG antibodies to circumsporozoite protein (CSP), liver-stage antigen type

125 ation of P. falciparum antigens, such as the circumsporozoite protein (CSP), the basis for the RTS, S

126 Antibodies against the NANP repeat of circumsporozoite protein (CSP), the major surface antige

127 n can be prevented by antibodies against the circumsporozoite protein (CSP), the major surface protei

128 Circumsporozoite protein (CSP), the most abundant sporoz

129 Unlike CTL responses to the circumsporozoite protein (CSP), the population of L3-spe

130 he C-terminal region of the vaccine antigen, circumsporozoite protein (CSP), were associated with a r

131 irected against the NANP tetrapeptide of the circumsporozoite protein (CSP), which comprises the vacc

132 e, RTS,S, based on the Plasmodium falciparum circumsporozoite protein (CSP), will likely be the first

133 eading malaria vaccine in development is the circumsporozoite protein (CSP)-based particle vaccine, R

134 inical efficacy of the Plasmodium falciparum circumsporozoite protein (CSP)-based RTS,S/AS01(E) vacci

135 t leading candidate, RTS,S, is a recombinant circumsporozoite protein (CSP)-based vaccine against Pla

136 Circumsporozoite protein (CSP)-specific antibody titers,

137 Tetramer staining for the immunodominant circumsporozoite protein (CSP)-specific CD8(+) T cell ep

138 challenge, the RTS,S/AS01B group had greater circumsporozoite protein (CSP)-specific immune responses

139 odium falciparum sporozoite surface antigen, circumsporozoite protein (CSP).

140 ytic malaria antigen, the Plasmodium berghei circumsporozoite protein (CSP).

141 Ag (RESA), and the dominant B epitope of the circumsporozoite protein (CSP).

142 ination with antibody against the Plasmodium circumsporozoite protein (CSP).

143 The most promising antibody target is circumsporozoite protein (CSP).

144 well-characterized vaccine candidate is the circumsporozoite protein (CSP).

145 NPNA repeat and the C-terminal region of the circumsporozoite protein (CSP).

146 ntly based on targeting antigens such as the circumsporozoite protein (CSP).

147 tibodies and CD4(+) T cells specific for the circumsporozoite protein (CSP).

148 bearing the type I repeat region of P. vivax circumsporozoite protein (CSP).

149 es and sulfatide-binding recombinant malaria circumsporozoite protein (MCSP) inhibit this adhesion.

150 istinct regions on the Plasmodium falciparum circumsporozoite protein (PfCSP) and are highly effectiv

151 body CIS43 targets the Plasmodium falciparum circumsporozoite protein (PfCSP) and prevents malaria in

152 Immunization induces 18-fold higher anti-Pf circumsporozoite protein (PfCSP) antibody levels in prot

153 humans, a recombinant Plasmodium falciparum circumsporozoite protein (PfCSP) candidate vaccine, RTS,

154 The Plasmodium falciparum circumsporozoite protein (PfCSP) is a sporozoite surface

155 on, as well as the C-terminal domain, of the circumsporozoite protein (PfCSP) of the malaria parasite

156 s (mAbs) targeting the Plasmodium falciparum circumsporozoite protein (PfCSP) on sporozoites (SPZ) an

157 t vaccines elicit antibody responses against circumsporozoite protein (PfCSP) that prevent the infect

158 cination was tested for IgG antibodies to Pf circumsporozoite protein (PfCSP) using enzyme-linked imm

159 immunoglobulin G antibodies to P. falciparum circumsporozoite protein (PfCSP) using enzyme-linked imm

160 f proteins, previously described only for Pf circumsporozoite protein (PfCSP), extends to other repea

161 e repeat region of the Plasmodium falciparum circumsporozoite protein (PfCSP), plateaued after two im

162 body responses to Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP), the primary surface an

163 antigens, such as the Plasmodium falciparum circumsporozoite protein (PfCSP), use both sequence dege

164 accine is based on the Plasmodium falciparum circumsporozoite protein (PfCSP), which is O-fucosylated

165 d sequences within the Plasmodium falciparum circumsporozoite protein (PfCSP).

166 ells, specific for the Plasmodium falciparum circumsporozoite protein (PfCSP).

167 response against Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP).

168 ding two preerythrocytic-stage antigens, the circumsporozoite protein (PkCSP) and sporozoite surface

169 The geometric mean anti-P. knowlesi circumsporozoite protein (PkCSP) titers ranged from 1,76

170 DNA plasmid expressing the Plasmodium yoelii circumsporozoite protein (pPyCSP) protects mice against

171 cine which simultaneously expresses P. vivax circumsporozoite protein (PvCSP) and P25 (Pvs25) protein

172 f a pre-erythrocytic vaccine is the P. vivax circumsporozoite protein (PvCSP).

173 studies indicated that the Plasmodium yoelii circumsporozoite protein (PyCSP) 57-70 region elicits T

174 cine plasmids encoding the Plasmodium yoelii circumsporozoite protein (PyCSP) and murine granulocyte-

175 sly shown that a DNA plasmid encoding the Py circumsporozoite protein (PyCSP) can protect mice agains

176 s neonates (7 days) with a Plasmodium yoelii circumsporozoite protein (PyCSP) DNA vaccine mixed with

177 The circumsporozoite protein (PyCSP) of Plasmodium yoelii wa

178 CTL responses against the Plasmodium yoelii circumsporozoite protein (PyCSP), BALB/c mice were immun

179 gimen: one inducing high-titer antibodies to circumsporozoite protein (RTS,S/AS01B) and the other ind

180 antigen-175; liver-stage antigen-1 [LSA-1], circumsporozoite protein [CSP], merozoite surface protei

181 The responses to one antigen (P. falciparum circumsporozoite protein [PfCSP]) were similar among vol

182 y against malaria parasites with the matched circumsporozoite protein allele than against mismatched

183 s showed that age-related antibody levels to Circumsporozoite Protein and 10 merozoite proteins incre

184 A recombinant vaccine based on fusion of the circumsporozoite protein and HBsAg plus a potent adjuvan

185 cine comprising nanoparticles, formed from a circumsporozoite protein and hepatitis B surface antigen

186 composed of a fusion protein of the malaria circumsporozoite protein and hepatitis B surface antigen

187 d based on t1/2, the antibody titers against circumsporozoite protein and merozoite surface protein 1

188 investigations of how antibodies bind to the circumsporozoite protein and neutralize sporozoites.

189 r the last dose, antibodies to P. falciparum circumsporozoite protein and PfSPZ were higher in protec

190 iparum antigens derived from the sporozoite (circumsporozoite protein and sporozoite surface protein

191 epitope overlaps a polymorphic region of the circumsporozoite protein and strain cross-reactivity of

192 cell epitopes and sequences derived from the circumsporozoite protein and the merozoite surface prote

193 All regions of the circumsporozoite protein are targets of functional antib

194 ria and identifies the amino terminus of the circumsporozoite protein as a target of functional antib

195 parasites matched the vaccine in the entire circumsporozoite protein C-terminal (139 infections), as

196 g T3-T1 and a potent B-cell epitope from the circumsporozoite protein central repeat region were test

197 al Asn-Ala-Asn-Pro (NANP) repeat sequence of circumsporozoite protein correlated with vaccine efficac

198 ibody specific for the Plasmodium falciparum circumsporozoite protein expressed on sporozoites.

199 elieved to be responsible for binding to the circumsporozoite protein found on the surface of the Pla

200 he antigen consists of a hybrid in which the circumsporozoite protein fused to hepatitis B surface an

201 positions and haplotypic regions within the circumsporozoite protein had on vaccine efficacy against

202 induced production of IL-2, INF-gamma, anti-circumsporozoite protein IgG, and proliferative T cells.

203 ombinant adenovirus expressing the P. yoelii circumsporozoite protein in mice.

204 Humoral immunity to Plasmodium falciparum circumsporozoite protein is partly mediated by a polymor

205 pecific to certain parasite genotypes at the circumsporozoite protein locus.

206 A plasmid DNA vaccine encoding the circumsporozoite protein of malaria (pCSP) induces toler

207 genetically fused to the minimally truncated circumsporozoite protein of P. falciparum (MCSP) elicits

208 sted with a DNA vaccine plasmid encoding the circumsporozoite protein of P. relictum exhibited a mode

209 The RTS,S/AS01 vaccine targets the circumsporozoite protein of Plasmodium falciparum and ha

210 We developed a vaccine based on the circumsporozoite protein of Plasmodium falciparum that i

211 -4R)-deficient CD8+ T cells specific for the circumsporozoite protein of Plasmodium yoelii develop a

212 Similar results were obtained when the circumsporozoite protein of Plasmodium yoelii was delive

213 hown that a plasmid DNA vaccine encoding the circumsporozoite protein of the malaria parasite elicits

214 high-quality antibody responses against the circumsporozoite protein of the malaria parasite, Plasmo

215 lonal antibodies targeting the P. falciparum circumsporozoite protein on sporozoites, the infective f

216 icted 9-mer epitope of the Plasmodium yoelii circumsporozoite protein or the nucleoprotein of influen

217 ibody responses to the NANP repeat region of circumsporozoite protein peaked after the third dose of

218 region (amino acids 27-117) of P. falciparum circumsporozoite protein plays a critical role in the in

219 rom samples from 4985 participants to survey circumsporozoite protein polymorphisms.

220 derstanding how monoclonal antibodies to the circumsporozoite protein prevent malaria and highlight e

221 optimal dose of an antibody that targets the circumsporozoite protein prior to challenge with P. viva

222 Mice challenged with exogenous circumsporozoite protein produced antibodies against a d

223 h plasmid DNA encoding the plasmodium yoelii circumsporozoite protein protected one of five strains o

224 linear peptide chimeras (LPCs) based on the circumsporozoite protein protects against experimental c

225 accines containing the Plasmodium falciparum Circumsporozoite protein repeat domain are undergoing hu

226 ine containing minimal Plasmodium falciparum circumsporozoite protein repeat epitopes was assessed fo

227 nt P. berghei parasite bearing P. falciparum Circumsporozoite protein repeats.

228 The protective epitopes on the circumsporozoite protein targeted by monoclonal antibodi

229 The circumsporozoite protein that covers the surface of Plas

230 B cell epitopes of the Plasmodium falciparum circumsporozoite protein to compare these with previousl

231 Finally, we amplified gene encoding the circumsporozoite protein to determinate their Plasmodium

232 We conclude that the binding of the circumsporozoite protein to hepatic heparan sulfate prot

233 smodium berghei expressing the P. falciparum circumsporozoite protein to mice.

234 n phase 1 study of a full-length recombinant circumsporozoite protein vaccine (rCSP) administered wit

235 have analyzed the DNA sequences of the Csp (circumsporozoite protein) gene in 24 geographically repr

236 with epitopes from the Plasmodium falciparum circumsporozoite protein, also was localized in the tran

237 surface protein of malaria sporozoites, the circumsporozoite protein, binds to heparan sulfate prote

238 The RTS,S/AS01 malaria vaccine targets the circumsporozoite protein, inducing antibodies associated

239 We measured IgG responses to P. falciparum circumsporozoite protein, liver-stage antigen 1, apical-

240 Humoral responses to the malarial antigens circumsporozoite protein, liver-stage antigen-1, apical

241 rasite chitinase, the 25 kDa protein and the circumsporozoite protein, respectively.

242 s against four of the P.falciparum antigens (circumsporozoite protein, sporozoite surface protein 2,

243 te isolated from the whole mosquito binds to circumsporozoite protein, suggesting a role within the m

244 e in the amino terminus of the P. falciparum circumsporozoite protein, the dominant protein on the sp

245 ting that sequences in Plasmodium falciparum circumsporozoite protein, the target antigen in RTS,S/AS

246 s specific for a conserved sequence from the circumsporozoite protein, which binds to many human leuk

247 The most advanced P. falciparum circumsporozoite protein-based malaria vaccine, RTS,S/AS

248 ed, controlled, phase 2b trial, the low-dose circumsporozoite protein-based vaccine R21, with two dif

249 gammadelta T cells were not required for circumsporozoite protein-specific Ab responses, and gamm

250 Circumsporozoite protein-specific antibodies correlate p

251 baseline) circumsporozoite protein-specific CD4(+) T-cell response

252 of protective CD8(+) T-cell responses to the circumsporozoite protein.

253 zed protective plasmid encoding P. y. yoelii circumsporozoite protein.

254 T cell epitope of the Plasmodium falciparum circumsporozoite protein.

255 coding for the highly polymorphic antigenic circumsporozoite protein.

256 antibody titers targeting the P. falciparum circumsporozoite protein.

257 adenovirus 35 (Ad35) (ARR) vector expressing circumsporozoite protein.

258 l infected hepatocytes that were pulsed with circumsporozoite protein.

259 D of the malaria parasite Plasmodium berghei circumsporozoite protein.

260 g the L. lactis system for the production of circumsporozoite proteins for preclinical and clinical a

261 rotein-1 (PfExp-1), also called antigen 5.1, circumsporozoite related antigen, or QF116.

262 Here, we describe a model of circumsporozoite-specific memory CD8 T cell generation t

263 We show that P. berghei circumsporozoite-specific memory CD8 T cells underwent s

264 ell epitopes present in native P. falciparum circumsporozoite surface protein (PfCSP), were fused in

265 a truncated version of Plasmodium falciparum circumsporozoite surface protein (tCSP) fused to Salmone

266 Anti-circumsporozoite titres wane according to a biphasic exp

267 Pre-vaccination anti-circumsporozoite titres were associated with lower immun