ライフサイエンスコーパス: circumvent

1 fects set practical constraints difficult to circumvent.

2 rroneous merging of axially aligned RyRs was circumvented.

3 its up-dip swarm migration but ultimately is circumvented.

4 EJC deposition by antisense oligonucleotides circumvents aberrant NMD promoted by mutant SRSF2, resto

5 n in drug discovery as a validated method to circumvent acquired resistance in oncology.

6 n depletion confers additional advantages to circumvent acquired resistance to Trabectedin, a chemoth

7 Here, we circumvent aforementioned genetic screening limitations

8 To circumvent ambiguities associated with acyl migration or

9 This proposal attempts to circumvent amperometric detection limitations and provid

10 te a metabolic strategy used by S. aureus to circumvent antibiotic and immune attack and provide cruc

11 otic-treatment, and MDR-Mtb as mechanisms to circumvent antibiotic effects.

12 g expression of AR and AR splice variants to circumvent AR reactivation.

13 e historically chosen for genome analysis to circumvent assembly issues caused by haplotype variation

14 egarding how blockage caused by 1-MCP may be circumvented at the metabolic level, thus opening avenue

15 sufficient for autophagy-dependent cells to circumvent ATG7 KO and maintain protein homeostasis.

16 an one hour after 40 s of stimulation, while circumventing auditory confounds.

17 t is unknown if or how such cancer cells can circumvent autophagy inhibition.

18 acks of non-traditional approaches intent on circumventing bacterial drug resistance.

19 biofilm formation, and thus are promising in circumventing bacterial infections.

20 as photocatalysis and in photodetectors that circumvent bandgap limitations.

21 y automated machine learning algorithm could circumvent border detection and instead would estimate t

22 Grazing on zoospores may circumvent bottlenecks in carbon transfer imposed by the

23 eting of PALB2 to DNA breaks in mutant cells circumvents BRCA1 haploinsufficiency.

24 systems should be useful to those looking to circumvent BSL-3 work with SARS-CoV-2 yet study the mech

25 Here we show that this problem can be circumvented by assembling a functional ribozyme by the

26 These drawbacks can be circumvented by CAR-T cells targeting tumour-specific dr

27 ios can lead to aggregation, but this can be circumvented by coating instead with an oligolysine-PEG

28 This process is circumvented by deleting the gene encoding cytochrome c

29 Unwanted evaporation of bioassay liquids was circumvented by employing mineral oil droplets.

30 This can be circumvented by liver-specific delivery of a rho kinase

31 The molecular barrier effect can be circumvented by placing water or human sweat as molecula

32 s imposed by polyphenol-rich diet seem to be circumvented by the C. cumulans gut, ensuring efficiency

33 al reduction of ECm during RNA synthesis was circumvented by the protection of the nitroxide as a ben

34 The aforementioned obstacle is circumvented by using a two-step germline substitution p

35 Importantly, a targeted strategy to circumvent CAF-induced resistance has yet to be identifi

36 py and rationally designed nanostructures to circumvent cancer immunotherapy failures, (2) bioenginee

37 rk allows users to protect their privacy and circumvent censorship restrictions but also shields thos

38 to their use as immunotherapeutics that can circumvent central tolerance and limit graft-versus-host

39 belled proteins, ideal but unaffordable, and circumvent certain limitations of traditionally used syn

40 ck approach for perturbing gene function and circumvents certain limitations of standard GEMM develop

41 gest a mechanism for lipid mobilization that circumvents challenges in processing insoluble metabolit

42 Our results show how directed evolution circumvents challenges inherent to enzyme design by shif

43 VAs can help circumvent challenging surgical situations.

44 This circumvents chances of re-bleed if standard bronchial ar

45 signing novel mechanism-based treatments for circumventing chemotherapy-induced metastasis.

46 alenses in the visible have been proposed to circumvent chromatic aberration but their throughput eff

47 This circumvents common issues associated with light scatteri

48 adaptation of assays to the point-of-care by circumventing complex data processing.

49 In this work, we have opened a route to circumvent complicated multiconjugation schemes using en

50 To circumvent complications associated with dynein studies

51 paralogous sensor duo, ScuR and SarF, which circumvents ComR in order to disconnect these two physio

52 ation to recruit a STAT3-activating complex, circumventing cytokine receptor activation.

53 foreign targets with multiple mutations but circumvent damage to the host genome.

54 tive conditions appears very promising as it circumvents deep oxidation of CH(4) to CO(2) and does no

55 constraints imposed by this principle could circumvent deleterious effects that limit the performanc

56 strointestinal bacterial reference sequences circumvents dependence on de novo assembly of metagenome

57 on, and how vegetative desiccation tolerance circumvents destructive, stress-induced cell senescence.

58 se of a borohydride and preformed C(4) -unit circumvents difficulties in product isolation and closin

59 R) spectroscopy is a contactless method that circumvents diffraction limitations by using changes in

60 eal devices are analyzed, and strategies for circumventing dissolution are suggested.

61 To circumvent DON's toxicity, we synthesized a series of tu

62 ecology, as they are likely more capable of circumventing ecological or evolutionary barriers to inf

63 ly the administration of an oligonucleotide, circumvents ectopic expression of proteins, and represen

64 for antimicrobial resistance and potentially circumventing efforts to contain resistance through rest

65 verted to another cell type, can potentially circumvent epigenetic changes and proliferative stages r

66 We circumvented epistasis constraints among them using a co

67 ar to have recognized the ways such research circumvents ethical standards by putting people, includi

68 t are effective through a novel mechanism to circumvent existing side effects.

69 s may help pathogenic gram-negative bacteria circumvent FAS inhibition.

70 Here, through a combination of a redundancy-circumventing genetic screen and biochemical analyses, w

71 te a proteolytic surface that GAS employs to circumvent host innate immunity.

72 mouse CMV utilizes the m153 glycoprotein to circumvent host-mediated Clr-b downregulation, in order

73 ved replicative mobilization strategies that circumvented hosts' epigenetic silencing.

74 more, treatment with the MSC secretome could circumvent hurdles associated with cellular therapy, inc

75 h developmental cheating may be difficult to circumvent; hypothetical "choosy floc" that avoid exploi

76 by reducing the number of projections and to circumvent image degradation by adding deep-learning-gen

77 ses have evolved sophisticated strategies to circumvent immune cell recognition.

78 lifelong infection facilitated, in part, by circumventing immune defenses mediated by tumor necrosis

79 localization from three different channels, circumventing impractical 4D Fourier Transforms of the e

80 and mTORC1, which are coordinated by HRI to circumvent ineffective erythropoiesis (IE).

81 gulation pathways, eIF2alphaP and mTORC1, to circumvent ineffective erythropoiesis, highlighting heme

82 ere, we study the capacity of macrophages to circumvent inhibitory activity mediated by CD47 on cance

83 methodology to analyze efficacy trials that circumvents it, leveraging a combination of compartmenta

84 In order to circumvent limitations imposed by the normally harsh rea

85 This reaction manifold circumvents limitations in present-day technologies for

86 y autophagy-dependent cancer cells evolve to circumvent loss of autophagy by upregulating NRF2, which

87 eine from a therapeutic lead is desirable to circumvent manufacturing difficulties resulting from oxi

88 Dried blood spots (DBSs) could circumvent many logistical challenges at the cost of inc

89 ecule with an inserted hydrophilic domain to circumvent membrane rigidity caused by defective palmito

90 f DNA translocations, this is achieved while circumventing most allelic and non-allelic mutations and

91 nd pathogenesis.IMPORTANCE How herpesviruses circumvent mucosal defenses to promote infection of new

92 ovides a fundamentally different strategy to circumvent multiple mechanisms of kinase inhibitor resis

93 (CST) because it is common for seismicity to circumvent nearest-neighbour along-strike faults where c

94 t biofilm-induced persistent inflammation by circumventing nuclear factor kappa B activation and its

95 al pathogens, adaptive prediction helps them circumvent nutritional immunity, protects them against p

96 tive HDAC inhibition is a viable approach to circumvent off-target effects.

97 help to identify therapeutic strategies that circumvent or ameliorate the pathogenesis of ALS.

98 tibody cocktails for prophylaxis or therapy, circumventing or limiting the emergence of viral escape

99 To circumvent P322S/P322S lethality, mice containing a two-

100 rget for therapeutic intervention that could circumvent pain-induced affective disorders.

101 destabilization as a potential mechanism to circumvent PLA2G16.

102 and emerges as an attractive alternative to circumvent poor IM resolution.

103 To circumvent potential compensation, we used short hairpin

104 ablishes a universal correction strategy and circumvents potential toxicity of ectopic glucocerebrosi

105 h Bap1 loss contributing to tumorigenesis by circumventing PRC2-mediated repression of oncogenic targ

106 ential regimens of protein therapeutics that circumvent pre-existing immunity or induced immunity.

107 treating a wide range of solid tumors and to circumvent problems associated with narrow windows of se

108 mploying surface-confined redox-transducers, circumvents problems associated with the use of solution

109 of monomeric E2A-PBX1 to stably bind DNA and circumvents protein interactions that otherwise modulate

110 ds to dampen growth factor stimulation while circumventing RAR-mediated retinoid toxicity.

111 embryos, and uses only bright-field imaging, circumventing requirement for anesthesia or restraint, c

112 ion therapies are now employed to prevent or circumvent resistance pathways; and two, our understandi

113 bility suggesting that targeting IKBKE could circumvent resistance to AR targeting therapies.

114 could be a potential therapeutic approach to circumvent resistance to cisplatin.

115 everal possible targets whose disruption may circumvent resistance.

116 s, and enable phase-matching strategies that circumvent restrictions due to intrinsic material proper

117 hardware and software on mobile devices, and circumvent sample preparation by directly targeting vola

118 mical sensors for dopamine as a strategy for circumventing sensor fouling, which is a persistent prob

119 drug containers is of increasing interest to circumvent several obstacles in drug therapy such as rap

120 This approach circumvents several challenges associated with the analy

121 ) within which ion channels are incorporated circumvents several limitations associated with live-cel

122 erogeneity or to epigenetic transitions that circumvent signaling blockade.

123 facilitates chloride ionization and thereby circumvents simple elimination pathways.

124 brids have recently come to the fore as they circumvent some of the aforementioned shortcomings with

125 article electron cryomicroscopy (cryoEM) can circumvent some of the problems of x-ray crystallography

126 , capable of sampling directly from tissues, circumvent some of these issues but require high-perform

127 To circumvent spin-spin broadening, iron and nickel atoms w

128 asthma exacerbations) have the potential to circumvent steroid sensitivity pathways and decrease muc

129 To circumvent stress-induced translational shutdown, viruse

130 address this problem, we devised a method to circumvent such B cell developmental blocks by expressin

131 atalytic, intermolecular C-H alkylation that circumvents such reactive species via a new elementary s

132 To circumvent that, we used genome editing to generate isog

133 cell antigen receptor transgene was found to circumvent the abnormal B-cell development: haploinsuffi

134 using a combination of methods that together circumvent the biases and limitations of individual appr

135 To circumvent the blood-brain barrier (BBB) and decrease of

136 ds that are ENT1 and ENT2 substrates and can circumvent the blood-testis barrier through this transep

137 are ENT1 and ENT2 substrates and can thereby circumvent the BTB through this transepithelial transpor

138 To circumvent the challenge of the space clamp effect and e

139 iation can serve as an effective strategy to circumvent the CO poisoning and improve the performance

140 XPHOS, thereby providing a means for LSCs to circumvent the cytotoxic effects of ven/aza therapy.

141 single mutation in the ancestral genome can circumvent the detected trade-offs.

142 potential of DNMTi combination treatment to circumvent the development of chemorefractory AML relaps

143 strategy for sequential immunogen design to circumvent the difficult roadblocks in HIV-1 bnAb induct

144 Secondly the method is able to circumvent the effect of non-specific adsorption, a majo

145 Scaled-up synstor circuits could circumvent the fundamental limitations in computers, and

146 Ago2-dependent processing allows miR-451 to circumvent the global repression of canonical miRNAs eli

147 ortant advantage of MSCs is their ability to circumvent the immune system and function as immunomodul

148 latory axis that cancer cells can exploit to circumvent the immune system.

149 e most pervasive strategies tumors employ to circumvent the immune system.

150 To circumvent the inaccessibility of MXene phases derived f

151 strategies that L. monocytogenes employs to circumvent the intestinal epithelial barrier and compare

152 r blood flow kinetic energy assessment could circumvent the issues of the current imaging modalities.

153 To circumvent the limitations in using genetics to understa

154 In our quest to circumvent the limitations of chemotherapy and photodyna

155 including newly emerging flavivirus strains, circumvent the limitations of current diagnostic assays.

156 and immunotherapy an attractive approach to circumvent the limitations of immunotherapy alone.

157 In vivo mRNA display libraries promise to circumvent the limitations of mass spectrometry-based pr

158 Current studies do not circumvent the limitations of removing PCs from their mi

159 To circumvent the limitations of scenario-based life cycle

160 Here we use graph clustering to circumvent the limitations of traditional phylogenetic a

161 etermine that established PEL cell lines can circumvent the loss of IRAK1, IRAK4, and MYD88; however,

162 In trying to circumvent the many challenges associated with water fil

163 In order to circumvent the narcotic effects of Delta(9)-tetrahydroca

164 This approach would circumvent the need for complex synthetic pathways curre

165 from a primary clinical specimen would help circumvent the need for culture and, in the process, sub

166 on, alternative approaches are required that circumvent the need for fitness landscapes.

167 dependent, discerning methods could entirely circumvent the need for forensic laboratory testing.

168 Numerous efforts have been made to circumvent the need for immunosuppression by using vario

169 that a fluoro-pyridine group can be used to circumvent the need for monomer chirality to control the

170 ns, suggesting that combined treatment could circumvent the need for prolonged drug exposure.

171 erconducting (HTS) shim coil prototypes that circumvent the size and strength limitation of our earli

172 tic design of dual-graphite batteries, which circumvent the sluggish ion-desolvation process found in

173 To circumvent the surface oxide, a novel approach is discov

174 This method was evaluated for its ability to circumvent the synthetic bottlenecks encountered in the

175 ates of redox species have been developed to circumvent the technical challenge of direct imaging Li;

176 h active or passive avoidance responses that circumvent the threat.

177 In this work, we provide a template to circumvent the tradeoff between cell viability and speci

178 and long-read Oxford Nanopore sequence data circumvented the expected error rate of the nanopore seq

179 owth, migration, and invasion, and partially circumvented the loss of ERalpha.

180 ely minor cytopathic effects in fibroblasts, circumvented the need of RelA for their propagation.

181 They then crossed/circumvented the Taklamakan Desert and Tian Shan Range t

182 e and restricted to neural progenitors, thus circumventing the aforementioned confounds.

183 in deviance detection while at the same time circumventing the confound of awareness and report by me

184 ndependently reach different optima, thereby circumventing the constraint of a shared autosomal genom

185 ying redox cycling induced oxidative stress, circumventing the experimental difficulties of measuring

186 By circumventing the fundamental limitations of computers,

187 ther it is possible to develop protocols for circumventing the irreversibility of time and if so to p

188 tive two-electron substrate reductions while circumventing the isolation of any unstable superreduced

189 Cs in aqueous solutions and the solid-state, circumventing the laborious procedure of identifying the

190 accelerates the fibrillation rate of CsgA by circumventing the lag phase during nucleation.

191 vation by the catalase peroxidase KatG, thus circumventing the majority of the resistance mechanisms.

192 By circumventing the need for a pure colony, MALDI-TOF mass

193 de nanomaterials for catalytic applications, circumventing the need for complex and expensive atomic

194 r utilizing a graded neutral density filter, circumventing the need for complex beam shaping apparatu

195 nents after disassociation of the MOFs, thus circumventing the need for large organic chromophores.

196 rally tunable and narrowband photoresponses, circumventing the need for separate bandpass filter arra

197 conditions that display high atom-economy by circumventing the need for wasteful stoichiometric activ

198 are wired to the presence of fluoride (i.e. circumventing the need of feeding expensive additives).

199 r tetrapyrrole biliverdin IXalpha (BV), thus circumventing the need to coproduce or supplement optoge

200 sufficient to trigger ASD-like features, and circumventing the NSC stage by direct conversion of ASD

201 ism away from a problematic pathway, thereby circumventing the time-dependent cytochrome P (CYP) 450

202 dase mimetic gold nanoparticles that ensures circumventing the use of antibodies and incorporating en

203 LCM) with low-input genome sequencing, while circumventing the use of whole-genome amplification (WGA

204 -based infrared spectroscopy (AFM-IR), which circumvents the Abbe diffraction limit, allows nanoscale

205 This formulation circumvents the assumption required in existing methods

206 mplifies the subsequent analysis, because it circumvents the complicating temperature dependence of t

207 CALM circumvents the expense, labor, and time required for sy

208 A modular ligand design circumvents the extended linear syntheses typical of bif

209 ketosynthase domain-mediated transacylation circumvents the inability of the condensation domain to

210 solid potassium salt of ferrate (K(2)FeO(4)) circumvents the inherent drawbacks of the instability of

211 election with a single observed network that circumvents the intractability of such likelihoods.

212 th stationary reactant phases, which largely circumvents the limitations of traditional colloidal syn

213 This approach circumvents the need for aligning the imaged region betw

214 exone (XR-naltrexone), administered monthly, circumvents the need for daily pill taking, potentially

215 gand pyrithione is membrane permeable, which circumvents the need to utilize invasive techniques to i

216 noprobes with excellent biocompatibility and circumvents the problem of particle agglomeration.

217 rands, we demonstrate a design paradigm that circumvents the sophisticated routing and size limitatio

218 The approach circumvents the use of air- and moisture-sensitive reduc

219 This method also circumvents the use of moisture-sensitive organometallic

220 ication protocols, the work presented herein circumvents the use of water scavengers and perfluorooct

221 t defences and the parasites that attempt to circumvent them(5-9), but it remains unclear why females

222 cted to arise and highlight the potential to circumvent these by spatially and temporally down-scalin

223 To circumvent these challenges and to address the outstandi

224 Here we show an approach that can circumvent these challenges by collaboratively exploitin

225 In this article, we circumvent these challenges by introducing graphene-base

226 To circumvent these constraints, we realize a paradigm of p

227 Here, we circumvent these difficulties by calculating analyticall

228 To circumvent these drawbacks, we present the first example

229 STICK) nanodelivery strategy is presented to circumvent these important physiological barriers to imp

230 shotgun sequencing (RNA-Seq) can be used to circumvent these issues for hepatitis C virus (HCV) and

231 One way to circumvent these issues is by the use of external energy

232 In an effort to circumvent these issues, different strategies have been

233 To circumvent these issues, this study describes a new way

234 To circumvent these issues, we analyzed 45,334 single-cell

235 To circumvent these issues, we developed a simple algorithm

236 However, computational approaches circumvent these limitations and are a powerful tool to

237 To circumvent these limitations and study the role of patro

238 ional profiling of primary tumor cells could circumvent these limitations, but suitable platforms are

239 To circumvent these limitations, we challenge the adequacy

240 To circumvent these limitations, we screened 14 Cas9/gRNA c

241 -glucose cotransporter-2 inhibitors may help circumvent these limitations.

242 Here we circumvent these problems by modifying a proven, environ

243 ide a user-friendly tool to help researchers circumvent these risks and to assist in the design and p

244 We circumvented these limitations with short hairpin RNA an

245 In this study, we present an approach for circumventing these issues through the application of qu

246 cell-penetrating peptide, termed a pepducin, circumvents these challenges by preventing the receptor

247 an indirect optical trapping platform which circumvents these limitations by using hydrodynamic forc

248 pathway based on [Formula: see text] efflux circumvents these problems and renders the odorant respo

249 A promising alternative that circumvents these shortcomings is the direct delivery of

250 se that regulates MYC Ser62 phosphorylation, circumvents these subtype-specific differences and ubiqu

251 e of the ways viruses can interfere with, or circumvent, these defences.

252 le paths through ecological state-space that circumvent this apparent barrier.

253 To circumvent this barrier, we demonstrate a strategy for r

254 We circumvent this by utilizing capillary forces and microf

255 To circumvent this challenge, a computational approach util

256 Here we present an approach to circumvent this difficulty and show that a pair of funct

257 To circumvent this drawback, we generated an eye-specific D

258 nts of invading fungi, but C. neoformans can circumvent this immunosurveillance mechanism by instead

259 out incurring a cost for photosynthesis must circumvent this inherent coupling of carbon dioxide and

260 One approach to circumvent this is to generate crops with a stable or ev

261 ise optical saturation microscopy (DeSOS) to circumvent this issue and image cells in their native ph

262 To circumvent this issue, here we present a study of develo

263 ttempt to search for a better alternative to circumvent this issue, we developed a second-generation

264 g power instrumentation or derivatization to circumvent this issue.

265 nalytes with SERS substrates are required to circumvent this limitation and expand the sensitivity of

266 Several powerful near-field techniques circumvent this limitation by employing local nanoscale

267 ctionality in vivo and propose a strategy to circumvent this limitation by harnessing gain-of-functio

268 quently as genome-resolved metagenomics, can circumvent this limitation by obtaining metagenome-assem

269 To circumvent this limitation, we derived normal and DNMT3A

270 To circumvent this limitation, we engineered a novel recomb

271 aking the lattice symmetry it is possible to circumvent this limitation.

272 alt screening was performed in an attempt to circumvent this obstacle and successfully delivered grea

273 d pluripotent stem cells (iPSCs) may help to circumvent this obstacle but often harbor genetic and ep

274 An emerging approach to circumvent this obstacle is to utilize the distance betw

275 ittle is known about how enteropathogens may circumvent this physiologic barrier.

276 Here, we circumvent this problem by introducing a lateral flow pl

277 To circumvent this problem, several nucleic acids based on

278 To circumvent this problem, stealth vectors must be generat

279 To circumvent this problem, the behaviour of neighbouring g

280 To circumvent this problem, we demonstrate the application

281 To circumvent this problem, we have used a WASH conditional

282 To circumvent this problem, we target the resynthesis of ph

283 s donor-alt-acceptor conjugated polymers can circumvent this problem; combining a tuneable energy gap

284 Modern plant breeders increasingly seek to circumvent this process to produce doubled haploid indiv

285 To circumvent this restriction, we have utilized hydrogels

286 However, as ablative technologies evolve to circumvent this stalemate, safer, and more effective pul

287 c accuracy provided by PET could potentially circumvent this therapeutic gap.

288 To circumvent this, the mucosal route can be utilized, howe

289 In this study, we have circumvented this problem by designing frustrated varian

290 extended linker can play a critical role in circumventing this unproductive reaction.

291 hieving high strength and ductility, thereby circumventing this well-known trade-off in conventional

292 larized (13)C NMR at natural abundance, that circumvents this limitation.

293 cale CRISPR libraries targeting gene subsets circumvents this problem.

294 We observed that CD40L(+) CAR T cells circumvent tumor immune escape via antigen loss through

295 ication of H1N1 viruses in HeLa cells can be circumvented upon the introduction of H5N1 virus HA and

296 f H1N1, H3N2, and LPAI viruses, which can be circumvented upon the introduction of H5N1 virus NP and

297 le as a high-capacity Li-containing cathode, circumventing use of metallic lithium in constructing ne

298 ures possessing intrinsic catalytic activity circumvent various limitations of natural enzymes and he

299 e current therapeutic approaches designed to circumvent venom variation and deliver next-generation t

300 ngth about iron, odd-electron reactivity was circumvented via increased covalency.