ライフサイエンスコーパス: cisternae

1 GORASP2) proteins function in stacking Golgi cisternae.

2 olgi stack, suggesting a loss of trans-Golgi cisternae.

3 loss of membrane tethers on the trans-Golgi cisternae.

4 arity, being most abundant on cis and medial cisternae.

5 endent membrane tethering of analogous Golgi cisternae.

6 hat consists of both tubules and fenestrated cisternae.

7 uclear envelope primarily originates from ER cisternae.

8 s translocation of Sig-1R from the MAM to ER cisternae.

9 GRASP proteins work together to stack Golgi cisternae.

10 rix within large rough endoplasmic reticulum cisternae.

11 ombined with relatively rapid exchange among cisternae.

12 olgi apparatus must be guided to the correct cisternae.

13 ere recruited to the region of nascent Golgi cisternae.

14 ct early (cis, medial) and late (trans, TGN) cisternae.

15 asma membrane from the underlying subsurface cisternae.

16 r enzymes and accumulate abnormal Golgi-like cisternae.

17 There is debate about the nature of these cisternae.

18 transport of Golgi resident proteins between cisternae.

19 e the Golgi by remaining within the maturing cisternae.

20 re confined to the space around these latter cisternae.

21 a membrane, cortical lattice, and subsurface cisternae.

22 ive compartment with the structure of the SR cisternae.

23 zed with Sec7-DsRed, a marker of trans-Golgi cisternae.

24 etween a maturing tapetosome and numerous ER cisternae.

25 proximity to ER exit sites and to cis Golgi cisternae.

26 ent with a primary trans-Golgi origin of the cisternae.

27 than a direct role in the stacking of Golgi cisternae.

28 um (ER)-derived membranes nucleate new Golgi cisternae.

29 the buds that lack ER also lack early Golgi cisternae.

30 the inheritance of both early and late Golgi cisternae.

31 These connections all "bypass" interceding cisternae.

32 ing Golgi compartments to generate new Golgi cisternae.

33 ASP65 is directly involved in stacking Golgi cisternae.

34 l unstack Golgi membranes, generating single cisternae.

35 ernae, but are present in medial through TGN cisternae.

36 mbrane, the cortical lattice, and subsurface cisternae.

37 f small vesicles and bulk retrieval of large cisternae.

38 totic Golgi vesicles and tubules into mature cisternae.

39 ate assembly of COPI coat complexes on Golgi cisternae.

40 arge bulging domains on the three trans-most cisternae.

41 s and alignment with the other stacked Golgi cisternae.

42 ation, and in marked disruption of the Golgi cisternae.

43 e, was not sufficient to maintain enveloping cisternae.

44 ich appear to pinch off from the rims of the cisternae.

45 of the pericentriolarly organized stacks of cisternae.

46 iral and cellular proteins in enveloping TGN cisternae.

47 GIC), and ERGIC elements then generate Golgi cisternae.

48 NARE proteins, Sed5p, present in early Golgi cisternae.

49 nged in successive concentric rings in Golgi cisternae.

50 n indicate that it is present in early Golgi cisternae.

51 actor and the accumulation of abnormal Golgi cisternae.

52 ith its receptors, in stacking p97 generated cisternae.

53 in 3 amino acids and localize to trans Golgi cisternae.

54 tructural organization and function of Golgi cisternae.

55 ) from both the centrosome and the cis-Golgi cisternae.

56 ils, and edematous mitochondria with loss of cisternae.

57 secretory vesicles derived from trans-Golgi cisternae.

58 ator of RyR1 channels within the SR terminal cisternae.

59 e receptor (RyR) channels in the SR terminal cisternae.

60 of tethered stacks of cis, medial, and trans cisternae.

61 2 accumulates on cell bodies atop subsurface cisternae.

62 localize at the interior of the trans-Golgi cisternae.

63 understanding tubules that connect the Golgi cisternae.

64 (ts1) animals converted these pits into bulk cisternae.

65 t retained polymerized ATZ within dilated ER cisternae.

66 d Golgi membranes with a single GRASP on all cisternae.

67 etic vacuolar cargo depart from the maturing cisternae?

68 um (ER), an elaborate network of tubules and cisternae [1], establishes contact sites with the plasma

69 p115-mediated docking of vesicles with Golgi cisternae [12].

70 n expanded rough endoplasmic reticulum (rER) cisternae, a hallmark of PSACH.

71 roblasts from affected individuals showed ER cisternae abnormalities, suspected for increased autopha

72 collapse in the central domain of the trans-cisternae accompanying polysaccharide synthesis with a m

73 Margins of trans-Golgi cisternae accumulate the LM8 xylogalacturonan (XGA) epit

74 r in ARCL2 cells resulted in distended Golgi cisternae, accumulation of abnormal lysosomes and multiv

75 ith microbodies, mitochondria and a membrane cisternae, an arrangement characteristic of the microbod

76 f the golgin GMAP-210 causes a loss of Golgi cisternae and accumulation of numerous vesicles.

77 racellularly with concomitant dilation of ER cisternae and activation of the ER stress response marke

78 bud exclusively from medial- and trans-Golgi cisternae and are confined to the space around these lat

79 ture was comprised of a complex of segmented cisternae and branching canaliculi with clustered mitoch

80 of which are unique to IHCs, implicated the cisternae and complexes in the genesis of the vesicles.

81 o understand the relationship between fusome cisternae and cystoblast differentiation, we have begun

82 etory pathway, causing an accumulation of ER cisternae and dilation of the Golgi complex.

83 , and the mutant has Golgi bodies with fewer cisternae and enlarged vesicles.

84 s cisternae and occupy the space between cis cisternae and ER export sites, whereas the COPIb vesicle

85 etween stacks of sarcoplasmic reticulum (SR) cisternae and extensions of transverse-tubules (TT) that

86 ergo, that induces reversible loss of the ER cisternae and extensive ER tubulation, including formati

87 we observed dense granular aggregates within cisternae and intracisternal filament bundles associated

88 ts, which took the form of complex stackable cisternae and labyrinthine structures adjoining the PM a

89 t protein I (COPI) vesicles arise from Golgi cisternae and mediate the recycling of proteins from the

90 at adding artificial adhesive energy between cisternae and mitochondria by dimerizing rapamycin-bindi

91 COPIa vesicles bud exclusively from cis cisternae and occupy the space between cis cisternae and

92 segregated from each other within the Golgi cisternae and packaged into separate vesicles.

93 ed cells, F13L-GFP was associated with Golgi cisternae and post-Golgi vesicles containing the LAMP 2

94 scent vesicles bud from randomly distributed cisternae and surface membrane infoldings and enter vesi

95 cal features, such as proliferation of trans cisternae and swelling of the trans cisternae and trans-

96 -I (PGA/RG-I) are detected in the trans-most cisternae and TGN compartments.

97 m the Golgi occurs directly from three trans-cisternae and that specialized ER plays a significant ro

98 s revealed that Cdc42 is active at all Golgi cisternae and that this activity is controlled by Tuba a

99 n cargo-laden carriers hopping across stable cisternae and the other on "maturing" cisternae that car

100 ented Golgi elements reformed into flattened cisternae and the re-assembled Golgi supported vesicle r

101 has been implicated in the stacking of Golgi cisternae and the regulation of Golgi disassembly/reasse

102 st that they form at the edges of the medial cisternae and then migrate inward.

103 to locate to ER tubules and the edges of ER cisternae and to induce constrictions in ER tubules when

104 of trans cisternae and swelling of the trans cisternae and trans-Golgi network (TGN) compartments.

105 ontinuous membrane network of interconnected cisternae and tubules spread out throughout the cytosol

106 artmentalized organization of interconnected cisternae and tubules while supporting a continuous flow

107 oteins disperses the Golgi stack into single cisternae and tubulovesicular structures, accelerates pr

108 Golgi fragments showed swollen distal Golgi cisternae and vesicular structures.

109 gous to early (RER and ERGIC), middle (Golgi cisternae), and late (TGN) secretory pathway compartment

110 2) intracellular matrix formation in the rER cisternae, and (3) increased chondrocyte apoptosis.

111 Pa at sarcoplasmic reticulum (SR) junctional cisternae, and apo-GP at Z disk.

112 acts with mitochondria, multiple trans Golgi cisternae, and compartments of the endo-lysosomal system

113 fragmentation, short and improperly aligned cisternae, and delayed Golgi reassembly after nocodazole

114 n I)-coated vesicles and buds, but not Golgi cisternae, and it specifically activates Rab1.

115 ressed in HeLa cells was restricted to Golgi cisternae, and its membrane association was sensitive to

116 3) Late endosomes, cisternae, and multivesicular bodies accumulate in the p

117 OPIb vesicles is limited to medial and trans cisternae, and that diffusion of periGolgi vesicles is r

118 Third, intact TGN cisternae apparently peel off from the Golgi stacks and

119 Cisternae appear to be disk-shaped structures that do no

120 Cisternae appear to contain considerable lipidic and oth

121 abundant in cell bodies, with large, flat ER cisternae apposed to the PM, sometimes with a notably na

122 All cisternae are fenestrated and display coated buds.

123 iffraction limit of light microscopy, as the cisternae are only 10-20 nm thick and closely stacked in

124 The stacks of cisternae are positioned between two types of ER, cis an

125 During telophase, Golgi cisternae are regenerated and stacked from a heterogeneo

126 ransport continue-even when individual Golgi cisternae are separated and "land-locked" between mitoch

127 re entering mitosis, the stacks of the Golgi cisternae are separated from each other, and inhibiting

128 This suggests that while the cisternae are static on the time scale of protein traffi

129 In mammalian cells, these cisternae are stitched together as a perinuclear Golgi r

130 and function of these intranuclear membrane cisternae are unknown.

131 will be continuously present within maturing cisternae as resident Golgi proteins arrive and depart.

132 zes with RabE(RAB11), arriving at late Golgi cisternae as they dissipate into exocytic carriers.

133 o stacking and lateral interactions of Golgi cisternae as well as help it function as a vesicle tethe

134 places within individual cisternae when two cisternae at different levels in the Golgi have fused, m

135 act region across which bridges connect some cisternae at equivalent levels, but none at nonequivalen

136 since its removal allows recovery of the ER cisternae at the expense of the densely packed tubular E

137 We suggest that the cisternae attached to ribbons represent synaptic vesicle

138 l maturation model postulates that transient cisternae biochemically mature to ensure anterograde tra

139 mmunicate via vesicles and another one where cisternae biochemically mature to ensure anterograde tra

140 Second, fenestrae are absent from cis cisternae, but are present in medial through TGN cistern

141 ses in Golgi reassembly: formation of single cisternae by membrane fusion, and restacking.

142 The codistribution of parallel cisternae, canalicular-mitochondrial complexes, and syna

143 In mammalian cells, flat Golgi cisternae closely arrange together to form stacks.

144 compartments model postulates that permanent cisternae communicate through bi-directional vesicles, w

145 ls for intra-Golgi traffic: one where stable cisternae communicate via vesicles and another one where

146 With urine exposure, cisternae communicate with salts in the external solutio

147 At the ministack level, cisternae constrain the size of nanostructures ("quanta"

148 As predicted, cisternae contain the secretory cargo throughout the mat

149 is is because it enables the dilated rims of cisternae (containing the aggregates) to move across the

150 lular mature vaccinia virions are wrapped by cisternae, derived from virus-modified trans-Golgi or en

151 t the total amount of adhesive energy gluing cisternae dictates Golgi cisternal stacking, irrespectiv

152 esis and is primarily localized to the Golgi cisternae distinct from the trans-Golgi network (TGN) in

153 ate both formation and stacking of the Golgi cisternae during post-mitotic reassembly.

154 vers additional secretory cargo molecules to cisternae during the early-to-late Golgi transition.

155 Some parallel cisternae ended with segmentation where they contacted m

156 The heterotypic fusion of cisternae, even transiently, raises important questions

157 The Golgi apparatus consists of stacked cisternae filled with enzymes that facilitate the sequen

158 nuclear envelope assembles directly from ER cisternae followed by membrane-dependent insertion of nu

159 ost readily explained by assuming that Golgi cisternae form at the cis face of the stack, progressive

160 Early Golgi cisternae form near the ER and become loaded with the se

161 lated processes including vesicle transport, cisternae formation, and cisternal stacking.

162 from virus-modified trans-Golgi or endosomal cisternae, forms a loose coat around some intracellular

163 function during cell-free assembly of Golgi cisternae from mitotic Golgi fragments revealed that NSF

164 zER) to automatically extract ER tubules and cisternae from multi-dimensional fluorescence images of

165 of matrix organization was found in multiple cisternae from single chondrocytes and in chondrocytes w

166 ian cells.The different composition of Golgi cisternae gave rise to two different models for intra-Go

167 cubation demonstrated that the stacked Golgi cisternae generated a heterogeneous population of vesicl

168 e presence of TER94 suggests that the fusome cisternae grow by vesicle fusion and are a germ cell mod

169 However, an inability to separate Golgi cisternae has meant that the cisternal distribution of m

170 ctions between stacked endoplasmic reticulum cisternae have a shape well known in classical different

171 ructure, leading to dramatically vesiculated cisternae in a variety of cell types.

172 CS2 antiserum stains medial and trans-Golgi cisternae in all cell types investigated.

173 r endoplasmic/sarcoplasmic reticulum (ER/SR) cisternae in cardiomyocytes remain obscure.

174 ll, and PtdIns4P is elevated on medial Golgi cisternae in cells lacking Vps74 or Sac1, suggesting tha

175 graphs of atrial myocytes show peripheral SR cisternae in close proximity to clusters of caveolae.

176 Although the dilation of some Golgi cisternae in Cog5-deficient cells resembled that observe

177 pressed, but was largely restricted to Golgi cisternae in the absence of F13L-GFP or when the F13L mo

178 microscopy revealed the presence of swollen cisternae in the dorsal spinal cord after SNL.

179 Direct continuity between the membranes of cisternae in the Golgi complex in mammalian cells rarely

180 alized by fluorescence imaging of individual cisternae in the yeast Saccharomyces cerevisiae, but tho

181 is composed of collapsed stacks and bloated cisternae in these cells.

182 hown to play a role in stacking of the Golgi cisternae in vitro.

183 cked structure of closely aligned, flattened cisternae in which Golgi enzymes reside; in mammalian ce

184 aused the buildup of huge membrane-connected cisternae, in contrast to the invaginated pits that accu

185 erved dilation of endoplasmic reticulum (ER) cisternae, increased phosphorylation of eukaryotic initi

186 ab family, Ypt1 and Ypt31, to specific Golgi cisternae interferes with addressing this question in ye

187 that affecting SM homeostasis converted flat cisternae into highly curled membranes with a concomitan

188 In addition, the resolution of endocytic cisternae into synaptic vesicles in response to strong s

189 The stacking of Golgi cisternae involves GRASP65 and GRASP55.

190 biosynthesis occurring in the center of the cisternae, IRX9 and the xylan product are arranged in su

191 This behavior of late Golgi cisternae is consistent with the cisternal maturation mo

192 The order of enzymatic activity across Golgi cisternae is essential for complex molecule biosynthesis

193 is disrupted and vesicle budding from Golgi cisternae is reduced in the tno1 mutant, and these defec

194 ory station composed of stacks of membranous cisternae, is a central yet unsettled issue in membrane

195 has been explained by the movement of Golgi cisternae, known as cisternal maturation.

196 eosins and TAGs, and relatively high-density cisternae-like vesicles, which possessed calreticulin an

197 the familiar reticular network of convolved cisternae linked to tubules.

198 he Golgi apparatus is a network of polarized cisternae localized to the perinuclear region in mammali

199 ance of retrieval-based targeting, few Golgi cisternae-localized proteins have been demonstrated to b

200 Injection of KIR4.1 serum IgG into the cisternae magnae of mice led to a profound loss of KIR4.

201 ubular network capable of morphing into flat cisternae, mainly at three-way junctions, and back to tu

202 ells, the peripheral ER contains cytoplasmic cisternae, many tubules, and a large plasma membrane (PM

203 This approach reveals that individual cisternae mature, and do so at a consistent rate.

204 sanoid products, while the location in Golgi cisternae may also reflect its action as a secreted enzy

205 rough the stack along with cargo, but stable cisternae models do not.

206 Under stable cisternae models, Golgi residents remain in the same cis

207 to vesicular tubular complexes and cis-Golgi cisternae, mostly in brain, atlastin-2 and -3 are locali

208 elate strongly with a proliferation of Golgi cisternae observed in earlier electron microscopy.

209 TGN cisternae of cells infected with VZV mutants lacking gI

210 extending tubules associated with the trans-cisternae of control cells.

211 he usual organelles, including mitochondria, cisternae of endoplasmic reticulum and Golgi complexes.

212 trilin-3 (MATN3), also accumulate in the rER cisternae of PSACH chondrocytes, but it is unknown how m

213 s of six or eight and sets of three parallel cisternae of rough endoplasmic reticulum spanning betwee

214 invagination of plasma membrane and terminal cisternae of sarcoplasmic reticulum (SR) by reduction of

215 les, as well as highly disorganized terminal cisternae of sarcoplasmic reticulum, were common.

216 Interestingly, we observed subsurface cisternae of smooth endoplasmic reticulum at the close a

217 unicate to the nervous system via subsurface cisternae of smooth endoplasmic reticulum in lieu of con

218 Thus, we identified cisternae of the GA in distal perisynaptic and subependy

219 ted on the surface of the middle (or medial) cisternae of the Golgi complex.

220 re selectively deposited within the cis-most cisternae of the Golgi stack following a 15 degrees C bl

221 n the hippocampus identified numerous paired cisternae of the rough endoplasmic reticulum (RER) and o

222 is apparently in alignment with the terminal cisternae of the sarcoplasmic reticulum.

223 ithin nanometer-sized stores (the junctional cisternae of the SR) during elementary Ca(2+) release ev

224 cles could be traced in adjacent sections to cisternae open to the medium.

225 increases the number of cis- and trans-Golgi cisternae per cell, and Ena overexpression also redistri

226 cells had altered Golgi morphology and fewer cisternae per Golgi apparatus relative to wild-type cell

227 In the absence of GRASP65, the number of cisternae per Golgi stack is reduced without affecting t

228 55 or GRASP65 by siRNA reduces the number of cisternae per Golgi stack, whereas simultaneous knockdow

229 ne Kv2.1 clusters are adjacent to subsurface cisternae, placing Kv2.1 in close proximity to sites of

230 APM1 localizes at the margins of Golgi cisternae, plasma membrane, select multivesicular bodies

231 all and large intercellular pools of water ("cisternae") present throughout the stratum corneum, and

232 n the cytosol, and these "free-floating" TGN cisternae produce clathrin-coated vesicles.

233 ke organelle composed of stacks of flattened cisternae punctuated by openings of various sizes.

234 use lacking both GORASPs and find that Golgi cisternae remained stacked.

235 Restacking of the newly formed Golgi cisternae requires dephosphorylation of Golgi stacking p

236 ecifically localized to cis and medial/trans cisternae, respectively, it is unknown whether each GRAS

237 , which localize to the cis and medial-trans cisternae, respectively.

238 rinsed) delivers vesicles via infoldings and cisternae selectively to a reserve pool with a halftime

239 1 x 4 microm3) contains two stacks of seven cisternae separated by a noncompact region across which

240 ities in adult, mainly acting on reducing ER cisternae size and favoring collagen secretion.

241 Thus each GRASP appears to play a direct and cisternae-specific role in linking ministacks into a con

242 y, it is unknown whether each GRASP mediates cisternae-specific tethering and whether such specificit

243 To test the consequence of loss of cisternae-specific tethering, we generated Golgi membran

244 l's lateral membrane and adjacent subsurface cisternae (SSC) could further limit the influence of rec

245 nal coupling of mitochondria with subsurface cisternae (SSC) was affected by aging.

246 We are prone to thinking by analogy-Golgi cisternae stack like pancakes, red blood cells look like

247 tes C1P steady-state levels and alters Golgi cisternae stack morphology.

248 ghout the stratum corneum, and at 24 h these cisternae substantially increase in size.

249 muscle triad junctions (triads) and terminal cisternae (TC) vesicles derived from sarcoplasmic reticu

250 is composed of a stack of cis, medial, trans cisternae that are biochemically distinct.

251 a membrane and presence in the subsurface ER cisternae that are juxtaposed to the plasma membrane in

252 ammalian Golgi apparatus exists as stacks of cisternae that are laterally linked to form a continuous

253 ee types of direct connections between Golgi cisternae that are normally distinct from one another.

254 y-state Golgi resident enzymes among stacked cisternae that are stationary.

255 stable cisternae and the other on "maturing" cisternae that carry cargo forward while progressing thr

256 s a sensor of PtdIns4P level on medial Golgi cisternae that directs Sac1-mediated dephosphosphorylati

257 nected network of narrow tubules and dilated cisternae that enclose a single lumen.

258 mograms revealed structures within the Golgi cisternae that have not been seen before.

259 that secretory proteins transit the Golgi in cisternae that mature by the continuous retrograde trans

260 the initial alignment and docking of single cisternae that may be an important prerequisite for stac

261 narily high density of endoplasmic reticulum cisternae that shadow neuronal, astrocytic, vascular, an

262 end-foot compartment showed high-density ER cisternae that shadow retinal ganglion cell (RGC) somata

263 mposed of interconnected tubules and sheets (cisternae) that forms the first compartment in the secre

264 ted recycling to the ER occurs only from cis cisternae, that retrograde transport of Golgi resident p

265 Within cisternae the lipid structure is disrupted by lamellar d

266 he flattened, stacked central regions of the cisternae, the soluble aggregates are in the dilated rim

267 ting intercisternal fusion among neighboring cisternae, thereby contributing to structural integrity

268 s and soluble aggregates placed in cis-Golgi cisternae therefore have different fates.

269 he narrow central spacing of the trans-Golgi cisternae through zipper-like interactions, thereby forc

270 bind to giantin on vesicles and to GM130 on cisternae, thus acting as a tether holding the two toget

271 ave been implicated in the adhesion of Golgi cisternae to each other to form their characteristic sta

272 e GRASP isoforms specifically link analogous cisternae to ensure Golgi compartmentalization and prope

273 ain and mediate homotypic tethering of Golgi cisternae to form extended Golgi ribbons.

274 virions by modified trans-Golgi or endosomal cisternae to form intracellular enveloped virions is dep

275 ne could be used by trans-Golgi or endosomal cisternae to form new viral envelopes.

276 ng of Golgi by the ectopic adhesion of Golgi cisternae to mitochondria.

277 loit differences in surface charge of intact cisternae to perform separation of early to late Golgi s

278 lus nidulans hyphae, we show that late Golgi cisternae undergo changes in composition to gradually lo

279 The pericentriolar stacks of Golgi cisternae undergo extensive reorganization during mitosi

280 ave been implicated in the stacking of Golgi cisternae, vesicle tethering, and mitotic progression, b

281 at GRASP55 and GRASP65 stack mammalian Golgi cisternae via a common mechanism.

282 GRASP65 links cis-Golgi cisternae via a homotypic, N-terminal PDZ interaction, a

283 gi residents recycle from distal to proximal cisternae via retrograde carriers in synchrony with cist

284 ockdown, the polarized organization of Golgi cisternae was altered, creating glycosylation defects, a

285 With the increased spatial separation of cisternae, we show using three-dimensional live imaging

286 Enveloping membranous TGN cisternae were microscopically identified in cells infec

287 ibbons to become fragmented and dilated, but cisternae were still stacked and located in a juxtanucle

288 enzymes at specific places within individual cisternae when two cisternae at different levels in the

289 t in the ring of the inner margins of medial cisternae where fenestrations are abundant.

290 rotein complex localized on cis/medial Golgi cisternae where it may participate in tethering intra-Go

291 protein localizes to the junctional SR (jSR) cisternae, where it is responsible for the storage of la

292 both Rab11a and Rab8a in collapsed membrane cisternae, whereas dominant-negative Rab11-FIP2(129-512)

293 "matrix." Each stack contains three to four cisternae, which can be classified as cis, medial, trans

294 ture vaccinia virus particles are wrapped by cisternae, which may arise from trans-Golgi or early end

295 he Golgi stack into cis-, medial-, and trans-cisternae, which separate early from late processing ste

296 nging from vesicular ER to markedly expanded cisternae with accumulation of moderate-density content

297 The three cisternae with bulging domains can be identified as tran

298 lls, most of the ER is organized as extended cisternae, with a very small fraction remaining organize

299 rmediate production and consumption by Golgi cisternae, with only a minor contribution of pre-existin

300 a to invade the stack and even replace Golgi cisternae within a few hours.