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1 a acetyl-CoA synthetase) or citrate (via ATP citrate lyase).
2 d genes, such as fatty acid synthase and ATP-citrate lyase.
3 e protein 3 and 4, apolipoprotein V, and ATP citrate lyase.
4 ibitors of the recombinant human form of ATP-citrate lyase.
5 observed with mammalian, yeast, and mold ATP-citrate lyase.
6  cytosolic enzyme of citrate metabolism, ATP citrate lyase.
7  the reductive tricarboxylic acid cycle, ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase,
8                                 Lowering ATP citrate lyase 88% did not inhibit glucose-induced insuli
9  these biosynthetic genes, which include ATP citrate lyase, ACC, FAS, and stearoyl-CoA desaturase.
10                                   Acetylated citrate lyase, acetate:CoA ligase (AMP forming), and pho
11 s been previously shown to modulate both ATP-citrate lyase (ACL) and AMP-activated protein kinase (AM
12                                          ATP citrate lyase (ACL) catalyzes an ATP-dependent biosynthe
13                                      The ATP citrate lyase (ACL) inhibitor, bempedoic acid, reduces l
14                                          ATP-citrate lyase (ACL) is an essential enzyme of the reduct
15 NIP-H/Caytaxin links kinesin-1 (KLC1) to ATP citrate lyase (ACL), a key enzyme for ACh synthesis, and
16 nhibitory activities (IC(50) s <5 uM) of ATP-citrate lyase (ACL), a new drug target for the treatment
17                      Here we showed that ATP-citrate lyase (ACL), an enzyme converting citrate to ace
18 is dependent on adenosine triphosphate (ATP)-citrate lyase (ACL), the enzyme that converts glucose-de
19  A (acetyl-CoA) production by the enzyme ATP-citrate lyase (ACL).
20  concentration, and nuclear functions of ATP-citrate lyase (ACL).
21 ia-derived citrate through the action of ATP citrate lyase (ACL).
22  the amino and carboxy portions of human ATP-citrate lyase (ACL).
23 A synthetase 2 (ACSS2) while maintaining ATP-citrate lyase (ACLY) activity.
24 te, which are processed to acetyl-CoA by ATP-citrate lyase (ACLY) and acyl-CoA synthetase short-chain
25 nesis (DNL), is produced from citrate by ATP-citrate lyase (ACLY) and from acetate through AcCoA synt
26 inherited variants in the genes encoding ATP citrate lyase (ACLY) and HMGCR to create instruments tha
27 cs and metabolite profiling, we identify ATP-citrate lyase (ACLY) as a distinctly mTORC2-sensitive AK
28 l pyruvate uptake and adenosine triphosphate-citrate lyase (ACLY) enzymatic activity.
29                                      The ATP citrate lyase (ACLY) enzyme cleaves cytosolic citrate to
30 olic acetyl CoA (Ac-CoA), is produced by ATP-citrate lyase (ACLY) from mitochondria-derived citrate o
31 methylglutaryl-CoA reductase (HMGCR) and ATP-citrate lyase (ACLY) in a TGF-beta receptor/PI3K/protein
32 etate, which can be blocked by silencing ATP citrate lyase (ACLY) in CAFs.
33      We investigated the requirement for ATP citrate lyase (ACLY) in NK cell function using an induci
34                                          ATP-citrate lyase (ACLY) is a central metabolic enzyme and c
35                                          ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyze
36                       Adenosine triphosphate citrate lyase (ACLY) is a key regulatory enzyme of gluco
37                                          ATP-citrate lyase (ACLY) is a major source of nucleocytosoli
38                       Here, we show that ATP-citrate lyase (Acly) is enriched in vesicles and provide
39                                          ATP-citrate lyase (Acly) is one of two cytosolic enzymes tha
40    In this study, we report that nuclear ATP-citrate lyase (ACLY) is phosphorylated at S455 downstrea
41                                          ATP citrate lyase (ACLY) is the predominant nucleocytosolic
42                                          ATP-citrate lyase (ACLY) is upregulated or activated in seve
43                    Inhibition of hepatic ATP-citrate lyase (ACLY) is widely accepted as the main medi
44                                          ATP-citrate lyase (ACLY) links carbohydrate and lipid metabo
45                                          ATP citrate lyase (ACLY) links substrate availability and mi
46                                          ATP citrate lyase (Acly) plays a pivotal role in chromatin m
47                                          ATP-citrate lyase (ACLY) synthesizes cytosolic acetyl coenzy
48                            Here, we show ATP citrate lyase (Acly) to be activated in inflammatory mac
49 phate kinase-mediated phosphorylation of ATP-citrate lyase (ACLY) which enhances the ACLY activity.
50                                          ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis,
51 sregulation is mediated by activation of ATP-citrate lyase (ACLY), a key enzyme that generates acetyl
52 n stimulates the S455 phosphorylation of ATP citrate lyase (ACLY), a pivotal enzyme that links citrat
53 luding citrate/isocitrate carrier (CIC), ATP-citrate lyase (ACLY), acetyl-CoA carboxylase (ACC) and f
54 g proteins in breast cancer, identifying ATP-citrate lyase (ACLY), an enzyme in the de novo lipogenes
55              Six2Cre-mediated removal of ATP-citrate lyase (Acly), an enzyme that converts citrate to
56  leads to increased levels of endogenous ATP-citrate lyase (ACLY), and this is accompanied by increas
57 rt that the acetyl-CoA-producing enzyme, ATP citrate lyase (ACLY), is a key regulator of macropinocyt
58 ry is controlled by the metabolic enzyme ATP-citrate lyase (ACLY), which produces acetyl coenzyme A (
59 n intracellular pool of acetyl CoA in an ATP-citrate lyase (ACLY)-dependent manner.
60 t on oxidative energy metabolism and the ATP-citrate lyase (ACLY).
61 -CoA derived from citrate via the enzyme ATP citrate lyase (ACLY).
62  lines deficient in these mitochondrial [ATP-citrate lyase (ACLY)]-, cytosolic [acetyl-CoA synthetase
63 se (FASN), acetyl-CoA carboxylase (ACC), ATP citrate lyase (ACLY)].
64 boxylase (ACCalpha), and increased FASN, ATP citrate lyase(ACLY), and malic enzyme (ME) protein expre
65 idosis is associated with an increase in ATP citrate lyase activity and protein abundance, and is par
66 ocitraturia and increased renal cortical ATP citrate lyase activity by 28%.
67 ria in rats and increased renal cortical ATP citrate lyase activity by 67% after 7 d.
68  showed that nucleocytosolic citrate and ATP-citrate lyase activity drove IL1B, IL10, and IL23A expre
69                              Thus, human ATP:citrate lyase activity is regulated in vitro allosterica
70                                              Citrate lyase activity was higher than ATP citrate synth
71 feeding was associated with no change in ATP citrate lyase activity.
72 anner involving fatty acid oxidation and ATP-citrate lyase activity.
73 ight loss, is a competitive inhibitor of ATP-citrate lyase, an extramitochondrial enzyme involved in
74 ngth HCV RNAs express elevated levels of ATP citrate lyase and acetyl-CoA synthetase genes, both of w
75               Because adenosine triphosphate-citrate lyase and adenosine monophosphate-activated prot
76                      These data suggest that citrate lyase and AMP-forming acetate:CoA ligase, but no
77  elongation in tumour cells by targeting ATP citrate lyase and fatty acid elongase 6, as well as impa
78 lation of citrate and the stimulation of ATP citrate lyase and fatty-acid synthase leading to de novo
79 ession by RNAi inhibits up-regulation of ATP citrate lyase and fatty-acid synthase.
80  both cases, lower levels of acetyl-CoA, ATP-citrate lyase and mitochondrial membrane potential were
81 lly deubiquitinates and thus upregulates ATP citrate lyase and oxoglutarate dehydrogenase, two key en
82 ydrogenase phosphatase, while repressing ATP citrate lyase and short-chain acyl-CoA synthetase gene e
83 its catalytic histidine to histidines on ATP-citrate lyase and succinic thiokinase.
84  to the inhibition of adenosine triphosphate-citrate lyase and the activation of adenosine monophosph
85  completed for bempedoic acid (targeting ATP-citrate lyase) and inclisiran (an interference RNA-based
86 y-acid synthase, acetyl-CoA carboxylase, ATP citrate lyase, and Glut-1 were significantly increased t
87 oteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.
88                    Induction of spot 14, ATP citrate-lyase, and fatty acid synthase polypeptides, but
89 dentified an important metabolic enzyme, ATP-citrate lyase, as a novel PTPN2 substrate.
90 the 3-D crystal structure of M. tuberculosis citrate lyase beta-subunit (CitE), which as annotated sh
91  biosynthesis that is analogous to bacterial citrate lyase but producing acetyl-CoA rather than a pro
92          The rates of phosphorylation of ATP-citrate lyase by nm23-H1(S120G) and nm23-H1(P96S) were s
93 esis of fatty acids from glucose include ATP-citrate lyase (CL) and fatty acid synthase (FAS).
94                             Flux through ATP-citrate lyase, combined with malic enzyme activity, cont
95 encoding the alpha- and beta-subunits of ATP citrate lyase could be amplified from both organisms.
96 ept directly, we used acetate-dependent, ATP citrate lyase-deficient mouse embryonic fibroblasts (Acl
97 situation observed for other prokaryotic ATP-citrate lyase enzymes, the C. tepidum enzyme was not abl
98 io of ATP/ADP, phospholipid content, and ATP citrate lyase expression.
99 of FAS, acetyl-CoA carboxylase-alpha and ATP-citrate lyase, fails to activate caspase-8 or to elicit
100  coding for key lipogenic (malic enzyme, ATP citrate-lyase, fatty acid synthase), glycolytic (pyruvat
101 nduction of mRNAs encoding malic enzyme, ATP citrate-lyase, fatty acid synthase, liver-type pyruvate
102 peron and is implicated in the regulation of citrate lyase genes (citCDEFG); (2) YgfI (tentatively re
103     Both forms of RuBisCO, together with ATP citrate lyase genes in the rTCA cycle, increase with dis
104  genes, including SCD1, FAS, ACC1, ACC2, ATP-citrate lyase, glycerol kinase, and HMG-CoA reductase.
105  hypothesis that compounds which inhibit ATP-citrate lyase have the potential to be a novel class of
106 se results suggest an important role for ATP citrate lyase in proximal tubular citrate metabolism.
107 pyruvate through the citrate shuttle and ATP citrate lyase in the cytosol.
108  and fumarase and activate the cytosolic ATP-citrate lyase in vivo, acting as a direct regulator of c
109 ate transporter Slc25A1, and the nuclear ATP-citrate lyase, in association with intracellular accumul
110 icant differences from other prokaryotic ATP-citrate lyases, including the enzyme from the closely re
111  the CRM hydroxycitrate, an inhibitor of ATP citrate lyase, induced the depletion of regulatory T cel
112 re bempedoic acid, an adenosine triphosphate-citrate lyase inhibitor that reduces cholesterol synthes
113                       Bempedoic acid, an ATP citrate lyase inhibitor, reduces low-density lipoprotein
114        ETC-1002 is an adenosine triphosphate-citrate lyase inhibitor/adenosine monophosphate-activate
115 ate instruments that mimic the effect of ATP citrate lyase inhibitors and HMGCR inhibitors (statins),
116 enetic variants that mimic the effect of ATP citrate lyase inhibitors and statins appeared to lower p
117                          While the bacterial citrate lyase is a complex with three subunits, the M. t
118                                          ATP citrate lyase is an enzyme in the cholesterol-biosynthes
119                                          ATP-citrate lyase is an epigenetic regulator to promote obes
120        Whether the genetic inhibition of ATP citrate lyase is associated with deleterious outcomes an
121         Interestingly, the expression of ATP-citrate lyase is increased in Nat8l-silenced adipocytes
122 e show that acetyl-CoA synthase, rather than citrate lyase, is essential for acetyl-CoA synthesis in
123           Fatty acid synthase (FASN) and ATP-citrate lyase, key enzymes of de novo lipogenesis, are s
124 tion, both processes being attenuated by ATP-citrate lyase knockdown.
125 fat diet (HFD) results in suppression of ATP citrate-lyase levels in tissues such as adipose and live
126 c gene loci via citrate accumulation and ATP-citrate lyase-mediated generation of acetyl CoA.
127   Neither lifelong genetic inhibition of ATP citrate lyase nor lifelong genetic inhibition of HMGCR w
128            Phosphorylation of C. tepidum ATP-citrate lyase occurred, presumably on a histidine residu
129 er that transcribes genes having homology to citrate lyase operon genes, citC, citD and citE, of Kleb
130           Manipulating the expression of ATP citrate lyase or the canonical TCA-cycle enzyme aconitas
131  acid synthase (FAS), and phosphorylated ATP-citrate lyase (pACL).
132 ing sites in several proteins, including apo-citrate lyase phosphoribosyl-dephospho-CoA transferase c
133                                          ATP citrate-lyase produces acetyl-CoA in the nucleus and cyt
134                           Renal cortical ATP citrate lyase protein abundance increased by 29% after 3
135 own that bempedoic acid, an inhibitor of ATP citrate lyase, reduces levels of low-density lipoprotein
136 ose bisphosphate carboxylase (Calvin cycle), citrate lyase (reverse citric acid cycle), and malyl coe
137 , the catalytic properties of C. tepidum ATP-citrate lyase showed marked similarities to the eukaryot
138 ude FA synthase, acetyl-CoA carboxylase, ATP citrate lyase, stearoyl-CoA desaturase 1, cluster of dif
139 dies we show that the levels of mRNA for ATP citrate lyase, the enzyme that produces acetyl-CoA, are
140                  Bempedoic acid inhibits ATP citrate lyase, the enzyme upstream of HMG-CoA reductase
141 orted to the cytoplasm is metabolized by ATP citrate lyase, ultimately regenerating mitochondrial oxa
142            Recombinantly expressed human ATP:citrate lyase was purified from E. coli, and its kinetic
143                  One of the key enzymes, ATP-citrate lyase, was purified to apparent homogeneity from
144 ochondrial citrate/malate antiporter and ATP citrate lyase, which converts cytosolic citrate into ace
145 MyD88 and TRIF resulted in activation of ATP-citrate lyase, which in turn facilitated the induction o
146                  Activity and protein of ATP citrate lyase, which uses anaplerotic products in the cy
147 yltransferase 1A and adenosine tri-phosphate citrate lyase, which, together, impart macrophages with
148                              Two cytosol ATP-citrate lyases, which take part in the cycle of citrate
149                            Inhibition of ATP citrate lyase with the competitive inhibitor, 4S-hydroxy

 
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