ライフサイエンスコーパス: clan

1 an chooses a bride in a different lineage or clan).

2 rototypical zinc metallopeptidase (gluzincin clan).

3 y a cytochrome P450 (CYP71D616) of the CYP71 clan.

4 ies and redefine relationships across the CE clan.

5 that SpoIVB is a serine peptidase of the SA clan.

6 ts of the S107 family, a member of the VHIII clan.

7 diversity for both clan 3 and mitochondrial clan.

8 thase and Archaeosine transglycosylase (PUA) clan.

9 energetics of this remarkable metalloenzyme clan.

10 rally differs from the other families in the clan.

11 e relevant to other transporters in the MtN3 clan.

12 ests that these proteins belong to the EsxAB clan.

13 ion modules that together comprise the Tudor clan.

14 ouped into families and in turn grouped into clans.

15 nabled the grouping of related families into clans.

16 s and the homologous families are grouped in clans.

17 ped into a family; families are grouped into clans.

18 s and the homologous families are grouped in clans.

19 contains 758 peptidases, 153 families and 22 clans.

20 Cards describing the individual families and clans.

21 have similar tertiary folds are grouped into clans.

22 were in 9 of the 12 established metazoan CYP clans.

23 lineage between two highly supported 'DPANN' clans.

24 4400 sequence homologs of 92 families and 38 clans.

25 (Pfam 29.0) includes 16 295 entries and 559 clans.

26 partitioning of sperm whales into sympatric clans.

27 nto families, which are in turn grouped into clans.

28 nto families, which are in turn grouped into clans.

29 r of several solitary males, that group into clans.

30 All species had large expansions of clan 2 diversity, with H. vulgaris having reduced divers

31 . vulgaris having reduced diversity for both clan 3 and mitochondrial clan.

32 ions, decreases social centrality within the clan, 5) increases aggression in cohabiting subordinate

33 Clan 71, 72, and 85 remain the largest CYP clans and inc

34 ubtilisin-like and alpha/beta-hydrolase fold clans according to phylogenetic lineages, and indicate t

35 One group (the CYP71 clan) after an early trigger to diversification, has kep

36 e-rich repeat, and NACHT-containing protein (CLAN), also known as ICE protease-activating factor, bel

37 include two cytochromes P450 from the CYP71 clan and an alcohol dehydrogenase (ADH).

38 The identification of GH-A clan and GH2 specific residues in the active site of BtM

39 ge of d3GHR carriers among this unique Druze clan and underscores the importance of genotype-environm

40 identical to the howardite-eucrite-diogenite clan and, like them, are probably derived from the aster

41 beta3 integrin antibodies, however, induced CLANs and actually enhanced CLAN formation in cells spre

42 n of the microdissected tissue revealed that CLANs and CLAN-like structures were a common finding in

43 ased on the MEROPS nomenclature of peptidase clans and families, is incorporated into the Plant Prote

44 from 19 Adivasi individuals belonging to two clans and from 35 Sinhalese, we find that the Adivasi an

45 Clan 71, 72, and 85 remain the largest CYP clans and include many taxa-specific CYP (sub)families r

46 on of groupings of related RNA families into clans and new developments to the website.

47 was used to identify molecular components of CLANs and quantitate CLAN formation in HTM cells plated

48 tten, concise text annotations for peptidase clans and the small molecule inhibitors that are outside

49 copy was used to identify phalloidin-labeled CLANs and to ascertain the presence of alpha-actinin, PI

50 species (known as a 'holotype'), family and clan, and each protein species, family and clan has its

51 he cloning of a novel human CED-4-like gene, CLAN, and several of its alternatively spliced isoforms.

52 nized into so-called descent groups (tribes, clans, and lineages) and practice exogamous marriages (a

53 ng, thereby eliminating the possibility that CLANs are artifacts of culture conditions, and to determ

54 These clans are defined by sequence homologies primarily in hi

55 Pfam clans are described in detail, together with the new ass

56 in organized TM tissue, which indicates that CLANs are far more common than predicted (even from tiss

57 While the two Adivasi clans are genetically more similar to each other than to

58 green algae and several green algae-specific clans are recognized.

59 CLANs are unique actin-branched networks whose formation

60 by an 18-year empirical study, we show that clans are unlikely products of stochastic processes (gen

61 n boundaries, their classification into Pfam clans, as well as their functional annotation.

62 CLANs associated with either DEX treatment or beta3 inte

63 Identification and analysis of Clan CA (papain) cysteine proteases in primitive protozo

64 Cysteine proteases of the Clan CA (papain) family are the predominant protease gro

65 sources have the hallmarks of a papain-like, Clan CA Cys protease.

66 eal-time PCR, the expression of twenty-seven clan CA cysteine protease genes in the Giardia genome wa

67 asites like Leishmania predominantly express Clan CA cysteine proteases for key life cycle functions.

68 ve and do not show any cross reactivity with clan CA cysteine proteases such as papain, cathepsin B,

69 ine peptidases differ fundamentally from the clan CA enzymes and have been included together in clan

70 and separase, and their differences from the clan CA enzymes are described.

71 f papain-like cysteine proteases (family C1, clan CA) is determined by S2-P2 interactions.

72 e cysteine proteases cathepsin B and papain (clan CA), and legumain (clan CD).

73 Clan CA, family C1 cysteine peptidases (CPs) are importa

74 ificities of papain-like cysteine proteases (clan CA, family C1) papain, bromelain, and human catheps

75 entral domain homologous to the papain-like (clan CA, family C1) protease family.

76 to the group of papain-like enzymes known as clan CA.

77 Caspases are proteases of clan CD and were described for the first time more than

78 It shares core structural elements with clan CD cysteine peptidases but otherwise structurally d

79 Clan CD cysteine peptidases, a structurally related grou

80 le protease inhibitors, are specific for the clan CD cysteine proteases.

81 tors that are highly potent and specific for clan CD cysteine proteases.

82 le protease inhibitors, are specific for the clan CD cysteine proteases.

83 The main characteristics of clan CD enzymes are outlined here, in particular glycosy

84 They belong to clan CD of cysteine peptidases and contain a well-conser

85 r, unlike other well-characterized groups of clan CD peptidases, there are no high-resolution structu

86 rthermore, our inhibition studies with other clan CD proteases suggested that mycocypins may serve as

87 ns may serve as broad-spectrum inhibitors of clan CD proteases.

88 hepsin B and papain (clan CA), and legumain (clan CD).

89 A enzymes and have been included together in clan CD.

90 K7L belongs to protease Clan CE, which includes distantly related cysteine prote

91 on" where we obtained 95.3% accuracy for two clan classes from Dominica and 93.1% for four ETP clan t

92 (ETP) dataset with 16,995 codas; (2) "vocal clan classification" where we obtained 95.3% accuracy fo

93 d SAM-binding riboswitches belong to the SAM clan, comprising three families that share a common SAM-

94 These results indicate that CLAN contributes to several biological processes central

95 To directly investigate the expression of clan-defined supraclonal sets, we exploited the evolutio

96 databases, summary alignments for peptidase clans, displays to show the distribution of peptidases a

97 les form long-lasting social units and vocal clans, distinguished by unique click dialects known as c

98 bserved that the number of protein families, clans, domains, and motifs increases from simple to prog

99 roups whose gene trees support well-resolved clans elsewhere in the animal tree.(16) We find that mos

100 coustic repertoires, mirroring the empirical clans, emerge when whales learn preferentially the most

101 This study showed for the first time that CLANs exist in cells of TM tissues from both normal and

102 rpose of this study was to determine whether CLANs exist within TM cells in situ in tissue unmanipula

103 on of glycoside hydrolase (GH) families into clans expands the utility of information on catalytic me

104 ested that family 26 was related to the GH-A clan (families 1, 2, 5, 10, 30, 35, 39, and 42) of (alph

105 Members of the alpha/beta-knot clan form deep trefoil knots in their native backbone st

106 CLANs form in glaucomatous and steroid-treated TM cells,

107 LY294002 decreased beta1 integrin-mediated CLAN formation by 42%, and PP2 completely blocked it.

108 3766, and Trio siRNA decreased beta3-induced CLAN formation by 72%, 45%, and 67%, respectively, where

109 however, induced CLANs and actually enhanced CLAN formation in cells spread on fibronectin, VCAM-1, t

110 molecular components of CLANs and quantitate CLAN formation in HTM cells plated on coverslips coated

111 Thus, glucocorticoid-induced CLAN formation may involve enhanced beta3 integrin signa

112 retreatment increased beta3 integrin-induced CLAN formation nearly sixfold and the level of alphavbet

113 n or CD47 activation significantly increased CLAN formation over beta1 integrin-induced levels, where

114 egrin overexpression in TM-1 cells increased CLAN formation twofold.

115 was PI-3K dependent, whereas beta3-mediated CLAN formation was CD47 and Rac1/Trio dependent and migh

116 CLAN formation was dependent on the ECM substrate and wa

117 beta1-Mediated CLAN formation was PI-3K dependent, whereas beta3-mediat

118 AP-5, LY294002 did not affect DEX-associated CLAN formation, whereas NSC23766 decreased the percentag

119 -5, both inhibitors decreased DEX-associated CLAN formation.

120 egrin signaling pathways converge to enhance CLAN formation.

121 d porcine VH genes belong to the VH3 family (clan), four of which, VHA, VHB, VHC, and VHE, alone comp

122 cemeteries organized around two matrilineal clans, furthering our understanding of the early evoluti

123 ant analyses, and further exploration of the Clan Genomics hypothesis, there has been a logarithmic e

124 n genome reference build, exploration of the clan genomics hypothesis, understanding human gene and g

125 rare variations in disease and supports the clan genomics hypothesis.

126 e crystal structure of the beta-glycosidase (clan GH-1A, family 1) from the hyperthermophilic archaeo

127 structure, instead they are similar to other clan GH-A enzymes specific for manno-configured substrat

128 ing of glycoside hydrolase families known as clan GH-A, with the catalytic acid/base Glu 139 and nucl

129 s, confirming the mechanistic commonality of clan GH-D members.

130 confirms their predicted classification into clan GH-F together with GH43 alpha-L-arabinofuranosidase

131 Each peptidase, family and clan has a unique identifier.

132 gh the structure of the SAM-I member of this clan has been extensively studied, how the alternative p

133 w the relationship between families within a clan has been improved by the introduction of a new tool

134 d clan, and each protein species, family and clan has its own unique identifier.

135 ile the number of new peptidase families and clans has only grown slowly the number of complete genom

136 Enzymes of this clan have now been identified in parasitic protozoa.

137 CLANs have been observed in steroid-treated and glaucoma

138 y scored more remotely related Pfams in Pfam clans higher than closely related Pfams, thus, leading t

139 vely charged CDR2 sequences, whereas high IF clan I J558 CDR2 sequences are diverse.

140 election, that it may operate differently in clan I versus II/III V(H)s, and that it has a lasting in

141 se odors within the colony obscures separate clan identities.

142 VH3 clan IgG from S. aureus-infected or SpA-treated animals

143 High IF clan II/III V(H)s share more positively charged CDR2 seq

144 ncoded by variable region heavy chain (V(H)) clan III genes via a V region framework surface that has

145 phage display, to derive Abs diagnostic for clan III Ig.

146 t avian single chain Fv Abs specific for the clan III products, including those from the human VH3 fa

147 e with a model B cell superantigen induced a clan III-restricted clonal deletion.

148 nal set of susceptible B cells that includes clan III/V(H) S107 family-expressing lymphocytes.

149 itative analysis showed that there were more CLANs in glaucoma TM specimens than normal TM specimens,

150 cale redistributions of sperm whale cultural clans in the Pacific have likely changed mitochondrial g

151 t of which could be classified into a single clan, indicating a single evolutionary source for the ma

152 n family domains (Pfams), Pfam functions and clan information, we develop a deep learning method e-De

153 The 11 conserved CYP clans known from vascular plants are all present in gree

154 CLANs lacked Arp3 and cortactin.

155 ocus group discussions (FGDs) were held with clan leaders, traditional cutters, and their assistants

156 icrodissected tissue revealed that CLANs and CLAN-like structures were a common finding in the TM cel

157 tamate-specific metallocarboxypeptidase from clan MC to be identified and characterized.

158 idase with sequence similarity to enzymes of clan MC, but with a novel predicted specificity towards

159 sequence exhibits features characteristic of clan ME family M16 metallopeptidases, including an "inve

160 at mediates interactions between other Tudor clan members and their substrates.

161 We analyzed DNA samples from 14 clan members with different GHR genotypes, finding a sig

162 Among the 73 clan members, 8.2% carried the d3GHR isoform, with nearl

163 a hydrophobic cavity that is common to Tudor clan members, disrupts chromatin binding and virus infec

164 ular basis regulating specificity among GH-J clan members, which represent an interesting target for

165 inal Phe or Lys) or methotrexate, cleaved by clan MH glutamate carboxypeptidases.

166 We expressed and assayed CYP3 clan midgut P450s and demonstrated that CYP9Q1, CYP9Q2,

167 pproaches, we demonstrate in this study that CLAN modulates endogenous caspase-1 activation and subse

168 n of two members of the phycobilin lyase E/F clan, MpeW and MpeQ, in Synechococcus sp. strain A15-62

169 ispositions of 759 individuals spanning nine clans nested within four pastoral ethnic groups of Kenya

170 The CYP71 clan now represents more than half of all CYPs in higher

171 Clan-O formed by families GH88 and GH105 was singular in

172 c, we performed the same analysis on the P53 clan, obtaining comparable results.

173 Separase is a member of the CD clan of cysteine proteases, which also includes the pro-

174 As for all the clan of GH-A enzymes, the two catalytic glutamate residu

175 teins, all of which belong to the pfam EsxAB clan of mycobacterial T7SS.

176 many proteins belonging to the Transthyretin clan of Pfam.

177 from families 7, 13 and 43, appear to form a clan of related structures with identical catalytic appa

178 The At3g26430 protein belongs to the SGNH clan of serine hydrolases, and more specifically to the

179 ers and reminiscent of the SA (chymotrypsin) clan of serine proteases.

180 evel society with an upper level composed of clans of individuals communicating using similar pattern

181 sin, aminopeptidase, and dipeptidylpeptidase clans of MPs.

182 A common theme among these three unrelated clans of serine proteases is the development or maintena

183 to fall into two evolutionarily independent clans of serine proteases, herpesvirus assemblin-like an

184 se, although it has little homology to other clans of serine proteases.

185 Evolution of the Ab system has yielded three clans of VH region genes that are represented in almost

186 In 22 clans of wild meerkats (Suricata suricatta), we show tha

187 ublished tertiary structures for a peptidase clan or family, and search for peptidase specificity dat

188 ding serine proteases of the subtilisin-like clan, or subtilases, have been identified.

189 Some Druze clans, particularly those with exceptional long-lived fa

190 whereas NSC23766 decreased the percentage of CLAN-positive cells by 80%.

191 It also provides quantitative data on CLAN prevalence in organized TM tissue, which indicates

192 CE clan proteases, specific hydrolases for ubiquitin-like m

193 The CARD of the CLAN proteins binds a number of other CARD-containing pr

194 e their physiologic functions are uncovered, CLAN proteins may prove to be valuable therapeutic targe

195 tional adaptations observed among diverse CE clan proteins.

196 roteins represent an ancient metalloprotease clan regulating cellular communications across biologica

197 med that jellypin was an inhibitor of the S1 clan SA family of serine proteinases.

198 The subtilisin protease (SUB; Clan SB, family S8) of Leishmania donovani was cloned an

199 nounced PREP specificity within the group of Clan SC proteases was generally observed.

200 ectrometry identified oligopeptidase B (OPB; Clan SC, family S9A) as the responsible enzyme.

201 CLAN size and phenotype were variable, with the same var

202 type, LJ-26, was demonstrated to recognize a clan-specific surface expressed in diverse mammalian, an

203 ication that our approach was unlikely to be clan-specific, we performed the same analysis on the P53

204 sly published datasets violate incontestable clans, suggesting that hidden paralogy and low phylogene

205 some noticeable exceptions that reflect the clan system of community organization that has historica

206 ing enzyme (ICE)-like subfamily, and a large clan that does not cluster with any of the vertebrate ca

207 These clans then come together with solitary bachelor males to

208 The mean number of CLANs/TM cell in our glaucoma tissue was estimated to be

209 classes from Dominica and 93.1% for four ETP clan types; and (3) "individual whale identification" wh

210 ls, organized strictly according to maternal clans, underscore a strong sense of social cohesion and

211 CLAN vertices contained the actin-binding proteins alpha

212 Fcgamma binding activity, which retains the clan VHIII Fab binding specificity.

213 CLAN was also found to mediate a direct antibacterial ef

214 Substantial endogamy in the Scythian clan was found.

215 CLANs were induced by plating cells on fibronectin (a be

216 DEX-associated CLANs were structurally similar to those induced by mAb

217 hown to contain cross-linked actin networks (CLANs) when exposed to dexamethasone, as have TM culture

218 orbed beta1 integrin antibodies also induced CLANs, whereas adsorbed beta3 or alpha2beta1 integrin an

219 carbohydrate active enzyme) classes and Pfam clans, which attested its usefulness in the phylogenetic

220 an electrolyte additive (chloroacetonitrile, ClAN) with these advantages enabled the redox coupling o