ライフサイエンスコーパス: class I gene

1 recisely and definitively mapped to the L(d) class I gene.

2 geneic donor-derived swine leukocyte antigen class I gene.

3 element and downstream core promoter of the class I gene.

4 allogeneic major histocompatibility complex class-I gene.

5 lular major histocompatibility complex (MHC) class I genes.

6 ilies, M1 and M10, distinct from other mouse class I genes.

7 species-specific expansion of paralogous Mhc class I genes.

8 iple of a primordial class I region with few class I genes.

9 The 6p21.3 minimal deletion spans HLA class I genes.

10 itive/retroviral elements not flanking other class I genes.

11 ducts differ considerably from classical HLA class I genes.

12 l block or may express only nonclassical MHC class I genes.

13 othelial cells stably transfected with human class I genes.

14 nscription of major histocompatibility (MHC) class I genes.

15 TR) and 131 different alleles encoded by HLA class I genes.

16 equences of major histocompatibility complex class I genes.

17 ved in the promoters of human and murine MHC class I genes.

18 eam of the betaGAP sequence are nonclassical class I genes.

19 LA-E gene is distinct from that of other MHC class I genes.

20 macaques have an expanded repertoire of MHC class I genes.

21 NLRC5, which regulates the expression of MHC class I genes.

22 number of proteins compared to classical HLA class I genes.

23 highlights three independent associations to class I genes.

24 ologs of the six fixed, functional human MHC class I genes.

25 reduced expression of half of the 131 intact class I genes.

26 identified transcriptional regulator of MHC class I genes.

27 NLRC5, as a transcriptional regulator of MHC class I genes.

28 ates with and activates the promoters of MHC class I genes.

29 ], is a key transcription coactivator of MHC class I genes.

30 ng the overall sequence similarity among the Class I genes.

31 eles from 57 major lineages of classical HLA class I genes.

32 , this cis-element is found 5' of 20 primate class I genes (15 human genes), seven of which are known

33 There were 453 class I genes, 258 class II genes, and 83 class III gene

34 Nineteen gene mutations, including 8 class I genes, 4 class II genes, WT1 and TP53 (class III

35 X1 box, to be involved in NLRC5-mediated MHC class I gene activation.

36 differences in the mechanisms repressing RSL class I gene activity between members of the Poaceae and

37 Strikingly, nearby tap2 and MHC class I genes also retain ancient sequence lineages, ind

38 transactivates the proximal promoters of MHC class I genes, although the molecular mechanism of trans

39 e last 50 kb of the H2-T region, including 2 class I genes and 3 class I pseudogenes, and includes th

40 500-kb stretch of the H2-M region contains 9 class I genes and 4 pseudogenes, which fall into two sub

41 nstrates an important role for all three HLA class I genes and a complex and heterogeneous pattern of

42 Recent work has shown that MHC class I genes and CD3zeta, an obligate component of T ce

43 athogenesis, possible contributions from MHC class I genes and CD8(+) T cells are controversial.

44 the first direct evidence incriminating MHC class I genes and CD8(+) T cells in the pathogenesis of

45 ined by combinations of variable KIR and HLA class I genes and conserved CD94:NKG2 genes.

46 pression of major-histocompatibility-complex class I genes and nuclear factor-kappaB target genes.

47 In addition to Class I genes and pseudogenes, we describe over 63 genes

48 Partial loss of several HLA class I genes and subsequent reduced presentation of min

49 essential element for the expression of HLA class I genes and that its transcriptional activity depe

50 take into account both the HLA class II and class I genes and use even larger samples.

51 acy rate of 100% at two-field resolution for Class I genes, and over 99.7% for Class II.

52 c determinants of HIV-1 disease, and the HLA class I genes appear to be highly influential in this re

53 Furthermore, we discovered that RSL class I genes are also required for the development of m

54 Class I genes are constitutively expressed and include t

55 at HLA class I-recognizing receptors and HLA class I genes are genetic risk determinants that modulat

56 The major histocompatibility complex (MHC) class I genes are induced synergistically by interferons

57 Class I genes are maximally expressed in the subjective

58 the expanded CMZ phenotype, suggesting that Class I genes are more likely to affect the stem cells a

59 However, given that RSL class I genes are not sufficient for root hair developme

60 ne coevolving with TAP transporters, whereas class I genes are poorly expressed.

61 ough understanding of the mechanism by which Class I genes are regulated.

62 The prevailing model stipulates that Class I genes are repressed and Class II genes are activ

63 Major histocompatibility complex class I genes are ubiquitously expressed and governed by

64 e genomic regions containing the KIR and HLA class I genes are unlinked, structurally complex, and hi

65 These findings identify MHC class I genes as direct targets of Foxp3 whose expressio

66 n, 4 Mb telomeric of human leukocyte antigen class I genes, at 6p22.1.

67 bidopsis thaliana homeodomain-leucine zipper class I genes; ATHB7 and ATHB12, both strongly induced b

68 Mutations in class I genes (AtTPS1-AtTPS4) indicate a role in regulat

69 unique to MHCII genes, because previous MHC class I gene-based therapies failed to produce Tregs.

70 products of certain nonclassical MHC-linked class I genes bind peptides in a similar way.

71 ed to the expressed cotton-top tamarin's MHC class I genes, but does show some similarity to So-N1, a

72 ss II odorant receptor (OR) genes to that of class I genes, but not in other vertebrate gene families

73 ates of ASFV increased the expression of MHC class I genes, but there was no parallel increase in MHC

74 ducks predominantly use UAA, one of five MHC class I genes, but whether biased expression is also tru

75 eric H2-T and the telomeric H2-M4, -5 and -6 class I genes by "nonclass I genes".

76 anscriptional mechanism of regulation of MHC class I genes by IFN-gamma.

77 IFNs regulate most MHC class I genes by stimulating transcription initiation.

78 The major histocompatibility complex (MHC) class I gene cAMP response element (CRE)-like site, -107

79 rphisms in the human leukocyte antigen (HLA) class I genes can cause the rejection of pluripotent ste

80 Patr-AL is an expressed, non-polymorphic MHC class I gene carried by approximately 50% of chimpanzee

81 letion of a local cis-acting enhancer in the class I gene cluster.

82 This M1/M10 class I gene-cluster is separated from the centromeric H

83 Class I genes code for structural proteins that effect c

84 biased expression of a single classical MHC class I gene coevolving with TAP transporters, whereas c

85 The cloning of shark class I genes completes the identification of molecules

86 r results show that the expansion of the MHC class I gene complex, as well as increased selection for

87 The HLA-A*24 class I gene confers significant risk of disease and ear

88 The promoters of MHC class I genes contain a well-conserved core module, the

89 The data argue that class I gene conversion mutations dramatically affect bo

90 e key substrate for the natural selection of class I gene conversion variants is the diversity in imm

91 In contrast, a nonclassical MHC class I gene discovered in the chimpanzee is not present

92 These findings demonstrate that the self MHC class I gene dosage may regulate the extent of CD8(+) T

93 ional major histocompatibility complex (MHC) class I genes encode molecules that present intracellula

94 The major histocompatibility complex class I gene enhancer binding proteins MBP1 and MBP2 are

95 infection, the human leukocyte antigen (HLA) class I genes exhibit the strongest and most consistent

96 ls showed an up-regulation of FOXP3, (2) MHC class I genes exhibited long-term suppression, and (3) i

97 ombinatorial fine-tuning of the level of MHC class I gene expression in response to intrinsic and ext

98 could explain the repression of IFN-beta and class I gene expression in virus-infected cells.

99 CIITA also up-regulates MHC class I gene expression in vitro.

100 Tight regulation of MHC class I gene expression is critical for CD8 T cell activ

101 In this report, we demonstrate that MHC class I gene expression is enhanced by the T cell enhanc

102 Locus-specific down-regulation of MHC class I gene expression is frequently observed in human

103 Therefore, characterization of MHC class I gene expression of Papio subspecies is a prerequ

104 while higher levels restrict the domains of Class I gene expression to intermediate positions of the

105 pling a cell surface readout of bivalent MHC class I gene expression with whole-genome CRISPR-Cas9 sc

106 Major histocompatibility complex class I gene expression, which also is regulated by TTF-

107 er involved in tissue-specific regulation of class I gene expression.

108 lower major histocompatibility complex (MHC) class I gene expression.

109 s, shuttles to the nucleus and activates MHC class I gene expression.

110 family transcription factors, to promote MHC class I gene expression.

111 to explain lung phenotype variation; (2) HLA class I genes, extending previous GWAS findings in the H

112 scribe two highly divergent nonclassical MHC class I genes found in the chicken (Gallus gallus) that

113 Class I gene fragments are amplified by the polymerase c

114 Amplified class I gene fragments can then be subcloned into the ex

115 CTL epitopes, we sequenced and expressed MHC class I genes from three ELA-A1 horses.

116 ne marrow transduced with the allogeneic MHC class I gene H-2K(b) led to long-term expression of K(b)

117 recombinant murine genes composed of the MHC class I gene H-2L(d) and the Fc portion of immunoglobuli

118 cination is performed with an allogeneic MHC class I gene (H-2 Kd)-modified tumor, the T cells obtain

119 duced major histocompatibility complex (MHC) class I gene (H-2K(b)) in bone marrow (BM)-derived cells

120 human major histocompatibility complex (MHC) class I genes has been shown previously to increase at t

121 Therefore RSL class I genes have been conserved since O. sativa and A.

122 These findings suggest that KIR and MHC class I genes have coevolved as an interacting system.

123 Suprisingly, however, class I genes have not been identified unambiguously in

124 ta gene loci and the human leukocyte antigen class I gene HLA-A*02:01 and are deficient for the corre

125 sm of IFN-gamma stimulation of the human MHC class I gene HLA-A2, several human tumor cell lines were

126 Rats transgenic for the human MHC class I gene HLA-B27 are susceptible to a spontaneous mu

127 genotyped, combining anonymous loci with the class I genes HLA-B and -C distributed across a genetic

128 o pinpoint disease susceptibility to the MHC class I genes HLA-B and HLA-A (risk ratios >1.5; P(combi

129 All expressed human MHC class I genes (HLA-A, -B, -C, -E, -F, and -G) have funct

130 uding major histocompatibility complex (MHC) class I genes (HLA-A, HLA-B and B2M with p = 0.0001, p =

131 DQA1) whereas TAK was mostly associated with class I genes (HLA-B/MICA).

132 The human MHC class I gene, HLA-B27, is a strong risk factor for susce

133 gamma-induced transcription of the human MHC class I gene, HLA-E.

134 ass II genes, HLA-DRB1 and HLA-DQB1, and the class I genes, HLA-A and HLA-B, with type 1 diabetes (T1

135 The HLA class I genes, HLA-A, -B, and -C, contain an inverted CC

136 three major histocompatibility complex (MHC) class I genes (human leukocyte antigen A [HLA-A], -B, an

137 ar run-on assays revealed that, unlike other class I genes, IFN-gamma stimulation of HLA-A mRNA accum

138 ion of a retrovirally encoded allogeneic MHC class I gene in bone marrow-derived cells can be used to

139 of a retrovirally transduced allogeneic MHC class I gene in bone marrow-derived cells from recombina

140 -CCAAT, TATAA-like, Sp1BS, and Inr-of an MHC class I gene in primary B-cells during both basal and ac

141 ion of the RUNX1-containing complex with the class I gene in vivo.

142 e three codominantly expressed classical MHC class I genes in humans and mice.

143 A major expansion of from six class I genes in humans to as many as 22 active MHC clas

144 We show that there are three RSL class I genes in O. sativa and that each is expressed in

145 We characterized the function of class I genes in Oryza sativa root development.

146 res that are similar to certain nonclassical class I genes in other vertebrates, and, unlike polymorp

147 One of the hallmarks of MHC class I genes in outbred populations is their extraordin

148 to all other classical and nonclassical MHC class I genes in primates, the rate of synonymous nucleo

149 genes in humans to as many as 22 active MHC class I genes in rhesus and levels of sequence divergenc

150 The limited variability of MHC class I genes in the Callitrichinae is likely the result

151 HC class I, UAA, although they have five MHC class I genes in the complex, arranged TAP1-TAP2-UAA-UBA

152 he human HC locus and implicate nonclassical class I genes in the control of iron absorption.

153 es, and a translocation and expansion of the class I genes in the mammalian lineage.

154 he role of the human leukocyte antigen (HLA) class I genes in this biological process.

155 ovine major histocompatibility complex (MHC) class I genes in transfected mouse Ltk- cells.

156 allogeneic major histocompatibility complex class-I genes in the absence of host T-cell depletion an

157 Tight linkage of proteasome and class I genes, in comparison with gene organizations of

158 era exhibit limited variability of their MHC class I genes, in contrast to the high variability displ

159 The rhesus monkey's complement of MHC class I genes includes the products of at least one expr

160 LCL 721.221 cells transfected with certain class I genes, including HLA-G, were also sufficient to

161 Cytokine induction of the MHC class I genes increases the nascent molecules available

162 his article, we show that NLRC5-mediated MHC class I gene induction requires the W/S and X1, X2 cis-r

163 y that is necessary for transcription of MHC class I genes: inhibition of the AT activity represses t

164 ate that a single mutational event in an HLA class I gene is sufficient for loss of the corresponding

165 ork on the Xenopus MHC, the single classical class I gene is tightly linked to immunoproteasome and t

166 pression of major histocompatibility complex class I genes is determined by a series of upstream regu

167 We show that expression of the MHC class I genes is downregulated in HPV-positive keratinoc

168 erozygosity of Human leukocyte antigen (HLA) class I genes is linked to beneficial outcomes after HIV

169 on of major histocompatibility complex (MHC) class I genes is regulated by both tissue-specific (basa

170 The expression of several MHC class I genes is up-regulated at the transcriptional lev

171 essed major histocompatibility complex (MHC) class I genes isolated from a range of equid species and

172 s-infected, major histocompatibility complex class I gene knockout mice compared with no deaths for w

173 MHC class I gene knockout mice were the most susceptible, mo

174 n another individual due to variation in HLA class I genes, loci central to the immune response.

175 MHC class I gene loss and dramatic reduction in functional d

176 Biased expression of one MHC class I gene may make viral escape within an individual

177 s, but with the non-conventional MHC encoded class I gene, MICA (MHC class I chain-related gene A).

178 Two highly divergent human MHC class I genes, MICA and MICB, are regulated by promoter

179 ence of class I loci or a failure to express class I genes might explain some of the relatively "weak

180 cal in the 5'-regulatory region of 12 rodent class I genes, nine of which have been shown to be funct

181 In addition to MHC class I genes, NLRC5 also induced the expression of beta

182 have cloned and characterized classical MHC class I genes of pig-tailed macaques and have identified

183 ily, termed H2-Mv, representing nonclassical class I genes of the major histocompatibility complex.

184 The MHC class I genes of the New World primate, the cotton-top t

185 ese findings reveal a novel influence of MHC class I genes on CD4(+) T-cell responses to viral infect

186 DAF-16 directly regulates class I genes only, through the DAF-16-binding element (

187 may be transfer of gene segments among shark class I genes over evolutionary time.

188 r than repressing, the expression of several Class I genes (Pax6, Dbx1, Dbx2).

189 The MHC class I gene, PD1, has neither functional TATAA nor Init

190 lanoma cell line expressed a mutated HLA-A11 class I gene product that was recognized by the bulk tum

191 Thus, HLA class I gene products not only mediate HIV-1 pathogenesi

192 e the major histocompatibility complex (MHC) class I gene products, interferon-induced genes, and the

193 d that mice which have altered expression of class I gene products, the beta2-microglobulin knockout

194 ) with self-major histocompatibility complex class I gene products.

195 ported to express distinct but undefined MHC class I gene products.

196 redominantly at the level of the TCR and MHC class I gene products.

197 Although CIITA also transactivates MHC class I gene promoters, loss of CIITA in humans and mice

198 At least one of these nonclassical class I genes, Q2, is expressed in the gastrointestinal

199 roles of NLRC5/class I transactivator in MHC class I gene regulation and host defense by CD8(+) T cel

200 ion of the products of this nonclassical MHC class I gene remains unknown.

201 echanism to ensure that the transcription of class I genes remains tightly repressed under various ph

202 y polymorphic, but co-evolution with TAP and class I genes remains unclear.

203 An in-depth analysis of the MHC class I gene repertoire in the two orangutan species, Po

204 omoter of a major histocompatibility complex class I gene requires TAF(II)250.

205 In gene trees of primate MHC class I genes, sequences from the Callitrichinae cluster

206 Overall, we find that the Class I gene subfamily is evolving much more quickly tha

207 Class I genes, such as those encoding the v-cyclin, late

208 nus, therefore, expresses its own set of MHC class I genes, suggesting that an unusually high rate of

209 CIITA also modulates the expression of MHC class I genes, suggesting that it may have a more global

210 basal and activated transcriptions of an MHC class I gene target distinct core promoter domains, nucl

211 may represent a remnant of a once active MHC class I gene that is no longer functional in the cotton-

212 lso well conserved in Xenopus, excluding the class I genes themselves.

213 The ability of MHC class I genes to facilitate CD4(+) Th1 development could

214 e sequenced introns 2, 3, and 8 of all three Class I genes (total>15.0 kb) for five non-human primate

215 to inhibit nuclear translocation of the MHC class I gene transactivator, NLRC5, and orchestrate its

216 example of a locus-specific repressor of MHC class I gene transcription in human tumor cells.

217 lls were treated with TNF-alpha or IL-1beta, class I gene transcription substantially increased when

218 whereby low levels of Shh signaling initiate Class I gene transcription, while higher levels restrict

219 ng that FlhG acts as a negative regulator of class I gene transcription.

220 I and class I-like genes, only two classical class I genes, two CD1 genes and some non-classical Rfp-

221 Another nonclassical class I gene (UAA-NC1) was detected that is linked neith

222 Three duck MHC class I genes (UBA, UCA, and UEA) are predicted to be pa

223 The Shh dependent activation of Class I genes was mediated, in part, by Gli2.

224 se data demonstrate that the function of RSL class I genes was to control the development of structur

225 n 6p21.32-p21.33, which included several HLA class I genes, was detected.

226 f the major histocompatibility complex (MHC) class I gene, we determined nucleosome occupancy and pos

227 three putative nonclassical full-length MHC class I genes were found.

228 s were presented by different molecules, MHC class I genes were identified in cDNA clones from Arabia

229 smid clones bearing the MHC-linked classical class I genes were isolated and shown to contain proteas

230 Class I genes were regulated primarily by unliganded ERb

231 "Class I" genes were uniformly induced by p53 in all cell

232 AP1 binding sites were more enriched in class I genes, whereas ERE, NFkappaB1, and SP1 sites wer

233 est a dual role for Shh in the regulation of Class I genes, whereby low levels of Shh signaling initi

234 e mammals have a third family of NKG2DL-like class I genes which we named MILL (MHC class I-like loca

235 DH classes I-V, the human cluster contains 3 class I genes while the mouse cluster has two class V ge

236 es, are transcribed from PEP promoters only (Class I genes), while in some instances (e.g. accD) gene