ライフサイエンスコーパス: clathrin

1 ARF-binding protein), clathrin adaptors, and clathrin.

2 e receptor accounted for colocalization with clathrin.

3 ginations of the plasma membrane capped with clathrin.

4 postsynaptic Bin1 shows colocalization with clathrin, a major endocytic protein, it also colocalizes

5 Clathrin accumulated in the cytoplasmic virus assembly c

6 Pan1 proteins recruit TPC and AP-2 subunits, clathrin, actin and ARP2/3 proteins to autophagosomes.

7 at isoform mixing influences tissue-specific clathrin activity in neurons, which requires their funct

8 dentified the medium subunit (micro1) of the clathrin adaptor AP-1 as a top hit.

9 lencing of clathrin or the gamma1 subunit of clathrin adaptor AP-1 by RNA interference in MDCK cells

10 ian immunodeficiency virus (SIV) engages the clathrin adaptor AP-2 to downregulate tetherin via its D

11 ndependent of 1) endocytosis mediated by the clathrin adaptor AP2; 2) Tf, which was suggested to faci

12 ptor (IR) endocytosis through recruiting the clathrin adaptor complex AP2 to IR.

13 membrane proteins is orchestrated by the AP2 clathrin adaptor complex.

14 Irc6 and p34 bind to clathrin adaptor complexes AP-1 and AP-2 and are members

15 The Arabidopsis (Arabidopsis thaliana) clathrin adaptor EPSIN1 (EPS1) is implicated in clathrin

16 We show that clathrin adaptor interaction sites on clathrin heavy cha

17 The epithelial cell-specific clathrin adaptor protein (AP)-1B has a well-established

18 2) and the phosphorylated active form of the clathrin adaptor protein 2 (AP2) at clathrin-coated pits

19 ellular membrane trafficking mediated by the clathrin adaptor protein complex-1 (AP-1) is important f

20 Silencing of clathrin adaptor proteins (AP) AP-1A, AP-1B, or both cau

21 156 of the mu2 subunit of the main endocytic clathrin adaptor, AP2.

22 The yeast clathrin adaptor-interacting protein Irc6 is an ortholog

23 This work uncovers a novel role of clathrin adaptor-type interactions to stabilize nonkinet

24 are structurally conserved between COPI and clathrin/adaptor proteins.

25 ence, here we study the role of clathrin and clathrin adaptors in megalin's apical localization and t

26 Previous work implicated clathrin and clathrin adaptors in the polarized trafficking of fast r

27 Clathrin adaptors play central roles orchestrating assem

28 gamma-ear-containing, ARF-binding protein), clathrin adaptors, and clathrin.

29 affic of the vacuolar cargo requires the GGA clathrin adaptors, which arrive during the early-to-late

30 Our experiments demonstrate that clathrin and AP-1 control the sorting of an apical trans

31 ic reticulum-retained chimera, revealed that clathrin and AP-1 silencing disrupted apical sorting of

32 RI1) undergoes endocytosis, which depends on clathrin and AP-2.

33 ndocytic accessory proteins collaborate with clathrin and AP2 to drive CCV formation.

34 Hence, here we study the role of clathrin and clathrin adaptors in megalin's apical local

35 Previous work implicated clathrin and clathrin adaptors in the polarized traffick

36 ell surface endogenously expressed CB1Rs was clathrin and dynamin dependent and could be modeled as a

37 e cytosol is found to be transported through clathrin and dynamin mediated endocytic pathways.

38 Inhibitors of clathrin and dynamin prevented CLR endocytosis and activ

39 are CME hotspots, and that key CME proteins, clathrin and dynamin, show a strong preference towards p

40 esult of Arf6-mediated reduction in gyrating clathrin and increased lysosomal targeting of the recept

41 NECAP arrival at CCPs parallels that of clathrin and increases with mu2Thr156 phosphorylation.

42 Clathrin and other proteins assemble into small invagina

43 teracted physically with proteins related to clathrin and other vesicle-related proteins, raising the

44 ting as limiting scaffold protein organizing clathrin and TACC3 complex crosslinking K-fibers.

45 ases, a pool of DrICE that co-localizes with Clathrin, and a mechanism by which the Hippo Network con

46 Clathrin- and actin-mediated endocytosis is essential in

47 receptor from the cell surface by hijacking clathrin- and adaptor protein complex 2 (AP2)-dependent

48 e pH-responsive nanoparticles enter cells by clathrin- and dynamin-dependent endocytosis and accumula

49 We show both virion types enter by clathrin- and dynamin-dependent endocytosis, facilitated

50 ndocytic machinery, including beta-arrestin, clathrin, AP2, and dynamin, significantly reduced JCPyV

51 Together, these findings uncover AP-2 and clathrin as players in Slack channel regulation.

52 In the absence of Hsc70 function, clathrin assembles into pits but fails to enrich cargo.

53 at adaptor protein 2 (AP2) complexes trigger clathrin assembly on the plasma membrane, and biochemica

54 ocytosis (CME) begins with the nucleation of clathrin assembly on the plasma membrane, followed by st

55 of rs3851179 in phosphatidylinositol binding clathrin assembly protein with borderline significance (

56 clusterin, and phosphatidylinositol binding clathrin assembly protein.

57 Coordinated clathrin assembly provides the earliest spatial cue for

58 These data reveal a universal mode of clathrin assembly that allows variable cage architecture

59 ase that functions as a key regulator of the clathrin-associated host adaptor proteins and regulates

60 y report the phosphoinositide composition of clathrin-associated structures, and the use of these sen

61 results suggest that the dynamic exchange of clathrin, at the cost of the reduced overall assembly ra

62 veal that these sites interact directly with clathrin-box motifs on GTSE1.

63 e, we report cryo-EM maps for five different clathrin cage architectures.

64 tein 1 (ACAP1) functions as an adaptor for a clathrin coat complex that has a function in endocytic r

65 cant spatiotemporal alterations in endocytic clathrin coat dynamics.

66 l-free reconstitution system, we report that clathrin coat formation and cargo sorting can be uncoupl

67 Besides AP-2 and clathrin triskelia, clathrin coat inception depends on a group of early-arri

68 This combined approach has strong effects on clathrin coat structure and function by dictating the st

69 cteristic helical structures around necks of clathrin-coated membrane buds.

70 or protein 2 (AP2) complexes, which initiate clathrin-coated pit (CCP) assembly, are activated by con

71 ighly sensitive and quantitative analysis of clathrin-coated pit (CCP) dynamics, we have evaluated th

72 hat this phosphorylation event starts during clathrin-coated pit (CCP) initiation and increases throu

73 , exhibit increased rates of CME and altered clathrin-coated pit dynamics.

74 activity of neutral sphingomyelinase but not clathrin-coated pit maturation.

75 When and where a clathrin-coated pit will form and what cargo it will con

76 r size increases beyond the size of a single clathrin-coated pit, B cells retrieve receptor clusters

77 ations affect the morphology and kinetics of clathrin-coated pits (CCPs) by directly following their

78 guishing abortive coats (ACs) from bona fide clathrin-coated pits (CCPs) is required but unaccomplish

79 ed by stabilization and growth/maturation of clathrin-coated pits (CCPs) that eventually pinch off an

80 iated endocytosis occurs via the assembly of clathrin-coated pits (CCPs) that invaginate and pinch of

81 ing structures at the plasma membrane termed clathrin-coated pits (CCPs) that mediate vesicle formati

82 e formation of clathrin-coated vesicles from clathrin-coated pits (CCPs).

83 d bilayer, accompanied by an accumulation of clathrin-coated pits and caveolae.

84 ns unclear whether the cargos in the growing clathrin-coated pits are actively monitored by the coat

85 ation of EETI-II-positive macropinosomes and clathrin-coated pits at early time points after treatmen

86 Without MYO7B or actin filaments, many clathrin-coated pits fail to be severed from the membran

87 inositol 3-kinase C2alpha at plasma membrane clathrin-coated pits is spatially segregated from its hy

88 tosis depends on the formation of functional clathrin-coated pits that recruit cargos and mediate the

89 Superresolution imaging of microtubules and clathrin-coated pits was demonstrated, under both modes.

90 s, focal adhesions, primary cilia, caveolae, clathrin-coated pits, and plaques play additional key ro

91 st partially defined by the cytoskeleton and clathrin-coated pits, in which receptors and G proteins

92 molecules via endocytic components, such as clathrin-coated pits, vacuoles, and micropinocytic vesic

93 these proteins are essential for fission of clathrin-coated pits.

94 place throughout the lifetime of the growing clathrin-coated pits.

95 m of the clathrin adaptor protein 2 (AP2) at clathrin-coated pits.

96 endocytosis and is undetectable in endocytic clathrin-coated pits.

97 the nanoscale structural dynamics of single clathrin-coated sites.

98 Yet, in living cells, EH domains gathered at clathrin-coated structures are poorly accessible, indica

99 Recruitment of receptors into clathrin-coated structures is essential to signal transd

100 ration of the weakly recruited receptor into clathrin-coated structures.

101 hages resulted in the binding of mu1A of the clathrin-coated vesicle AP-1 complex.

102 ion of myosin VI and Hip1R in actin-mediated clathrin-coated vesicle budding.

103 thrin adaptor EPSIN1 (EPS1) is implicated in clathrin-coated vesicle formation at the trans-Golgi net

104 ovides novel insight into the TGN-associated clathrin-coated vesicle trafficking machinery that impac

105 athways include effector endocytosis through clathrin-coated vesicle trafficking, defense signaling t

106 Clathrin-coated vesicles (CCVs) that form at the PM and

107 (CCPs) that invaginate and pinch off to form clathrin-coated vesicles (CCVs).

108 lattices and the transition to highly curved clathrin-coated vesicles - are adaptable and can follow

109 AuNPs were also abundant inside the cells in clathrin-coated vesicles and endosomes.

110 strate that REEP6 is detected in a subset of Clathrin-coated vesicles and interacts with the t-SNARE,

111 ody revealed that TBC1D24 is associated with clathrin-coated vesicles and synapses of hippocampal neu

112 ndocytosis (CME) occurs via the formation of clathrin-coated vesicles from clathrin-coated pits (CCPs

113 We previously showed that clathrin-coated vesicles have a dynamic phosphoinositide

114 Clathrin-coated vesicles lose their clathrin lattice wit

115 EEP6 in trafficking of cargo via a subset of Clathrin-coated vesicles to selected membrane sites in r

116 are important components for the cleavage of clathrin-coated vesicles, phagosomes, and mitochondria.

117 ns (CLCa and CLCb) are major constituents of clathrin-coated vesicles.

118 t solute uptake occurs in both caveolae- and clathrin-coated vesicles.

119 that eventually pinch off and internalize as clathrin-coated vesicles.

120 Clathrin coats drive transport vesicle formation from th

121 play central roles orchestrating assembly of clathrin coats.

122 characterized the biophysical properties of clathrin comprising individual CLC variants for correlat

123 the membrane, causing accumulation of large clathrin-containing "scars" on the cell surface.

124 microscopy to be modified and to have higher clathrin content than those of cells not exposed to elev

125 ant as tools to investigate the effects that clathrin defects have on secretion pathways and plant gr

126 The endocytosis was clathrin dependent and partially dependent on beta-arres

127 level, we observed a striking impairment of clathrin-dependent and -independent endocytosis in proxi

128 Moreover, these two effectors decrease clathrin-dependent and -independent endocytosis.

129 aled to regulate CD22 surface expression and clathrin-dependent CD22 internalization after BCR stimul

130 ed outcome of neuronal injury with disrupted clathrin-dependent endocytosis and impaired receptor des

131 namin is a GTPase that plays a vital role in clathrin-dependent endocytosis and other vesicular traff

132 rected endocytosis that is distinct from the clathrin-dependent endocytosis of invasive pathogens.

133 We further show that P4 induces clathrin-dependent endocytosis of mPRbeta into signaling

134 phatase-activating protein that functions in clathrin-dependent endocytosis, and beta-1,3-glucoronylt

135 Ligand stimulation of IGF1R promotes its clathrin-dependent endocytosis, mediated by two distinct

136 pling of cell surface GLP-1R activation with clathrin-dependent endocytosis, the SNXs were found to c

137 docytosis through an adaptor protein 2 (AP2)/clathrin-dependent mechanism, attenuated morphine-induce

138 that the enhanced uptake of nanomaterials is clathrin-dependent using chemical inhibitors and silenci

139 Secretion assays revealed that clathrin depletion causes a near-complete block in secre

140 on of ClaH corroborated the observation that clathrin does not play an important role in endocytosis

141 t the ATPase Hsc70 and a dynamic exchange of clathrin during assembly are required for this checkpoin

142 that CS causes CFTR to be internalized in a clathrin/dynamin-dependent fashion.

143 signaling was blocked in cells treated with clathrin endocytosis inhibitor.

144 oteins in the conjugation of LC3 to Rab5(+), clathrin(+) endosomes containing beta-amyloid in a proce

145 dherin is cleaved by calpain upon entry into clathrin-enriched domains.

146 Clathrin ensures mitotic spindle stability and efficient

147 ome clear that the structure and dynamics of clathrin - flat clathrin lattices and the transition to

148 Clathrin forms diverse lattice and cage structures that

149 Inhibitors of CME that interfere with clathrin function have been described, but their specifi

150 d how this CLC diversity influences neuronal clathrin function, we characterized the biophysical prop

151 w that clathrin adaptor interaction sites on clathrin heavy chain (CHC) are repurposed during mitosis

152 have previously shown that mESCs lacking the clathrin heavy chain (Cltc), an essential component for

153 protein zeta/delta, annexin A1/A3/A4/A5/A6, clathrin heavy chain 1, glyceraldehyde-3-phosphate dehyd

154 ies of ERICH3 interacting proteins including clathrin heavy chain which are known to play a role in v

155 ith an inducible short hairpin RNA targeting clathrin heavy chain, resulting in approximately 85% pro

156 clathrin light chain-binding domain nor the clathrin heavy chain-binding motif were needed for virus

157 eolin-1 (CAV-1) and dynamin-2 (DNM2) but not clathrin heavy chain.

158 , which has a stomatal function defect, as a clathrin heavy chain1 (CHC1) mutant allele and show that

159 To investigate the role of clathrin in DCV biogenesis, we stably transduced PC12 ce

160 Golgi-derived carrier that is vesicular, yet clathrin independent.

161 which is partially dynamin-dependent, but is clathrin-independent and does not associate with sorting

162 tosis, a clear requirement for actomyosin in clathrin-independent endocytosis (CIE) has not been demo

163 TDD overexpression does not affect clathrin-independent endocytosis or, surprisingly, AP1-d

164 Macropinocytosis is an actin-driven form of clathrin-independent endocytosis that generates an enlar

165 spergillus nidulans, we show that AP-2 has a clathrin-independent essential role in polarity maintena

166 d, in the course of evolution, a specialized clathrin-independent function necessary for fungal polar

167 OA2), a BAR-domain protein that orchestrates CLATHRIN-independent internalization, as a critical medi

168 wing engulfment into a membrane vesicle by a clathrin-independent process.

169 olin-1 and that internalization proceeds via clathrin-independent, lipid raft-mediated endocytosis.

170 inhibits CME and CCP dynamics by perturbing clathrin interactions with AP2 and SNX9.

171 2 and AP2A1/2 reduced IGF1R association with clathrin, internalization, and pathway activation by mor

172 Clathrin is recruited to CCPs through interactions betwe

173 T4 traffic pathway in humans, which involves clathrin isoform CHC22.

174 raffic, notably the participation of a novel clathrin isoform, CHC22, in humans but not rodents.

175 LC splice variants differentially influenced clathrin knee conformation within assemblies, and clathr

176 Clathrin-coated vesicles lose their clathrin lattice within seconds of pinching off, through

177 eractions that stabilize key elements of the clathrin lattice, namely, between adjacent heavy chains,

178 he structure and dynamics of clathrin - flat clathrin lattices and the transition to highly curved cl

179 We discuss the structure of lattices, how clathrin lattices form, and which proteins or biophysica

180 redistribution of integrin alphaVbeta5 from clathrin lattices to focal adhesions.

181 Clathrin light chain (CLC) subunits in vertebrates are e

182 LatB decreased AFL1-Clathrin Light Chain colocalization, further indicating

183 isms, as well as Retinitis Pigmentosa Type 2-Clathrin Light Chain, a membrane protein with a novel do

184 HIPR-1 mutants demonstrated that neither the clathrin light chain-binding domain nor the clathrin hea

185 Clathrin light chains (CLCa and CLCb) are major constitu

186 Sodium channel and clathrin linker 1 (SCLT1) mutations were associated with

187 Although clathrin localizes to the mitotic spindle and kinetochor

188 In plants, clathrin mediated endocytosis (CME) represents the major

189 galin is a transmembrane protein involved in clathrin-mediated endocytic processes, and is expressed

190 sarcoidosis, including phagosome maturation, clathrin-mediated endocytic signaling and redox balance.

191 ive combined immune deficiency with impaired clathrin-mediated endocytosis

192 The robustness of processes like clathrin-mediated endocytosis (CME) across a diverse ran

193 Clathrin-mediated endocytosis (CME) and its core endocyt

194 otein complex 2 (AP-2), which is involved in clathrin-mediated endocytosis (CME) and synaptic vesicle

195 Clathrin-mediated endocytosis (CME) begins with the nucl

196 ptor, in particular, plays a central role in clathrin-mediated endocytosis (CME) by recruiting cargo

197 Clathrin-mediated endocytosis (CME) constitutes the majo

198 Clathrin-mediated endocytosis (CME) in mammalian cells i

199 rcome the cell's high turgor pressure during clathrin-mediated endocytosis (CME) in yeast, but precis

200 Clathrin-mediated endocytosis (CME) is key to maintainin

201 Clathrin-mediated endocytosis (CME) is the primary mecha

202 Dyn2) are indispensable proteins of the core clathrin-mediated endocytosis (CME) machinery.

203 Clathrin-mediated endocytosis (CME) occurs via the forma

204 lective autophagy pathway in yeast for early clathrin-mediated endocytosis (CME) proteins facilitated

205 avy chain (Cltc), an essential component for clathrin-mediated endocytosis (CME), display a loss of p

206 During clathrin-mediated endocytosis (CME), endocytic-site matu

207 activity of RTKs are governed mainly through clathrin-mediated endocytosis (CME), endosomal recycling

208 During clathrin-mediated endocytosis (CME), over 50 different p

209 docytosis of transferrin as an indicator for clathrin-mediated endocytosis (CME), we find that alpha-

210 Conserved proteins drive clathrin-mediated endocytosis (CME), which from yeast to

211 5-HT(2)Rs), and entry is thought to occur by clathrin-mediated endocytosis (CME).

212 ase dynamin mediates membrane fission during clathrin-mediated endocytosis (CME).

213 DYCRV) that is an internalization signal for clathrin-mediated endocytosis and a determinant of NF-ka

214 ces AQP2 membrane accumulation by inhibiting clathrin-mediated endocytosis and increasing exocytosis.

215 onse to the needs of eukaryotic cells during clathrin-mediated endocytosis and intracellular traffick

216 We observed that INPP4A is dispensable for clathrin-mediated endocytosis and is undetectable in end

217 Thus, XLalphas restricts clathrin-mediated endocytosis and plays a critical role

218 c7 inhibitor H3 (SecinH3), and inhibitors of clathrin-mediated endocytosis but was unaffected by chlo

219 of dynamin-dependent endocytosis, including clathrin-mediated endocytosis by caveoli.

220 dendritic spines and regulates postsynaptic clathrin-mediated endocytosis by positioning the endocyt

221 Clathrin-mediated endocytosis depends on the formation o

222 Disruption of clathrin-mediated endocytosis did not affect accumulatio

223 either fusion pore closure (kiss-and-run) or clathrin-mediated endocytosis directly from the plasma m

224 Clathrin-mediated endocytosis in budding yeast requires

225 t ~200 Arp2/3 complexes assemble at sites of clathrin-mediated endocytosis in human cells.

226 d paralogs remain elusive, and their role in clathrin-mediated endocytosis in mammalian cells is deba

227 Treatment with the clathrin-mediated endocytosis inhibitor, Dyngo-4a, re-st

228 Clathrin-mediated endocytosis is likely the main uptake

229 components, but is rich in components of the clathrin-mediated endocytosis machinery.

230 Clathrin-mediated endocytosis occurs via the assembly of

231 nhibition increased exocytosis and inhibited clathrin-mediated endocytosis of AQP2, but exerted its e

232 ns illuminate key host factors that regulate clathrin-mediated endocytosis of JCPyV, which is necessa

233 hese manipulations was without effect on the clathrin-mediated endocytosis of transferrin receptor (T

234 further characterize how JCPyV utilizes the clathrin-mediated endocytosis pathway to invade host cel

235 lfate and was internalized by LRP1, LRP2 and clathrin-mediated endocytosis to be gathered in Rab11 ve

236 kdown or knockout of essential components of clathrin-mediated endocytosis with quantitative assessme

237 tomyosin cytoskeleton has been implicated in clathrin-mediated endocytosis, a clear requirement for a

238 g the concurrent activation of caveolae- and clathrin-mediated endocytosis, alongside macropinocytosi

239 ced interferon signaling or an inhibition of clathrin-mediated endocytosis, and PKD inhibitors do not

240 xin-9 (SNX9) and dynamins, key components of clathrin-mediated endocytosis, as binding partners of XL

241 en alpha-Syn-bearing fibrils enter cells via clathrin-mediated endocytosis, but the underlying mechan

242 During clathrin-mediated endocytosis, F-actin assembly initiate

243 Rather than clathrin-mediated endocytosis, macropinosomes encapsulat

244 diated endocytosis but not macropinocytosis, clathrin-mediated endocytosis, or glycosphingolipid-enri

245 pathways, particularly flotillin-dependent, clathrin-mediated endocytosis, provide a new avenue for

246 of the dynamin helix is a critical stage in clathrin-mediated endocytosis, the mechanism for this re

247 e, we demonstrate high-resolution imaging of clathrin-mediated endocytosis, vimentin, the endoplasmic

248 Applying NERDSS to steps in clathrin-mediated endocytosis, we design multicomponent

249 single-cell analysis of protein-folding and clathrin-mediated endocytosis, we show that both chapero

250 This process is contributed to by clathrin-mediated endocytosis, with a positive role of R

251 coordination of intracellular signaling and clathrin-mediated endocytosis.

252 l inhibited LGR5 internalization by blocking clathrin-mediated endocytosis.

253 carried out by adaptor protein-2 (AP-2) via clathrin-mediated endocytosis.

254 tion of tissues through mechanoregulation of clathrin-mediated endocytosis.

255 rus G rapidly recycles from the membrane via clathrin-mediated endocytosis.

256 ans, and they are known to be key factors in clathrin-mediated endocytosis.

257 is A virus (HAV)-infected cells (exo-HAV) by clathrin-mediated endocytosis.

258 internalize small BCR clusters by classical clathrin-mediated endocytosis.

259 nocytosis, without affecting phagocytosis or clathrin-mediated endocytosis.

260 mparable uptake kinetics and a predominantly clathrin-mediated endocytotic mechanism, irrespective of

261 igh-throughput assay to measure the rates of clathrin-mediated FAP-EGFR endocytosis stimulated with p

262 Mechanistically, TCR ligation leads to clathrin-mediated internalization of the TCR-CD3zeta com

263 inase-dependent and blocked by inhibitors of clathrin-mediated internalization; and EGFR activity was

264 regulate its retrieval as well as functional clathrin-mediated vesicle trafficking were essential for

265 tion of coated vesicle size and shape during clathrin-mediated vesicular trafficking or endocytosis.

266 o bind the cargo alpha(2B)-AR and to recruit clathrin onto the trans-Golgi network.

267 Inhibition of clathrin or beta-arrestin specifically reduced JCPyV int

268 Targeted silencing of clathrin or the gamma1 subunit of clathrin adaptor AP-1

269 functional CRIB domain localizes normally at clathrin pits during endocytosis, and activates Arp2/3 c

270 Depletion of clathrin plaque and branched actin components causes acc

271 st a novel paradigm in cell biology, wherein clathrin plaques act as platforms capable of recruiting

272 centronuclear myopathy (CNM), regulates both clathrin plaques and surrounding branched actin filament

273 Here, we show that clathrin plaques and surrounding branched actin filament

274 Clathrin plaques are stable features of the plasma membr

275 CHC22 clathrin plays a key role in intracellular membrane traf

276 ure and molecular model of assembled porcine clathrin, providing insights into interactions that stab

277 terpart and to inhibit cargo interaction and clathrin recruitment to form specialized transport vesic

278 a more classical pathway involving dynamin, clathrin, sorting endosomes and Golgi trafficking where

279 asymmetric immune response is driven by the clathrin-sorting adaptor AP-1B, which mediates the polar

280 microtubule bundles, the mechanisms by which clathrin stabilizes microtubules are unclear.

281 GTSE1 recruited to the spindle by clathrin stabilizes microtubules by inhibiting the micro

282 ated link between the adhesion machinery and clathrin structures at the plasma membrane.

283 nt reduction in synaptojanin1 recruitment to clathrin structures, indicating broad control of CCP ass

284 R and TfR were recruited to largely distinct clathrin structures.

285 These findings suggest that clathrin supports specific functions in multiple cell ty

286 n pharmacological inhibition of dynamin-2 or clathrin terminal domain (TD) ligand association, these

287 taarr1 complex can efficiently interact with clathrin terminal domain and ERK2 MAPK in vitro.

288 ponded to an increase in colocalization with clathrin, the increase in colocalization was present in

289 ed endocytosis (CME) by recruiting cargo and clathrin to endocytic sites.

290 Besides AP-2 and clathrin triskelia, clathrin coat inception depends on a

291 a phosphoinositide phosphatase, important in clathrin uncoating during endocytosis of presynaptic ves

292 eolar lipid rafts and the AP2A1/2 complex in clathrin vesicles.

293 Surprisingly, the onset of clathrin waves, but not individual endocytic events, req

294 In the lipid-stressed cells, MC4R and clathrin were redistributed to the plasma membrane where

295 ined the paralogous CLTC gene encoding CHC17 clathrin, which mediates endocytosis.

296 ion factor 6) GTPase activating proteins and clathrin, while CLIC4 overexpression affected protein re

297 rin knee conformation within assemblies, and clathrin with neuronal CLC mixtures was more effective i

298 Flot-1-clathrin with Rab4, but IGF1R-AP2A1/2-clathrin with Rab11, implicates Flot-1 as the adaptor fo

299 Selective association of IGF1R-Flot-1-clathrin with Rab4, but IGF1R-AP2A1/2-clathrin with Rab1

300 more effective in membrane deformation than clathrin with single neuronal isoforms nCLCa or nCLCb.