ライフサイエンスコーパス: claudin-1

1 electively controlling tight junction CLDN1 (claudin-1).

2 on interactions between HCV and CD81 but not claudin 1.

3 ial cell markers paired box protein PAX2 and claudin-1.

4 function and plasma membrane localisation of Claudin-1.

5 localization, including ZO-1, occludin, and claudin-1.

6 f the barrier-forming tight junction protein claudin-1.

7 In contrast to NRC, Can 10 does not express claudin-1.

8 ger E-box binding homeobox-box1 (ZEB-1) with claudin-1.

9 tion of the tight junction proteins ZO-1 and claudin-1.

10 junction (TJ) proteins occludin, JAM-A, and claudin-1.

11 catalytic function dependent upregulation of Claudin-1.

12 ediated mechanism, independent of effects on claudin-1.

13 cyclin D1, c-Myc, COX-2, MMP-7, MMP-14, and Claudin-1.

14 etween mutant BRAF and the loss of Cdx-2 and claudin-1.

15 en reported in four tight junction proteins (claudin 1, 14, 16, and zona occludens 2), nine gap junct

16 lls possess mRNAs encoding ZO-1, -2, and -3, claudin-1, -2, -4, and -8, occludin, and connexin-32.

17 e microscopy without affecting the levels of claudin-1, -2, or -3, occludin, or ZO-1.

18 ncoding tight junction components [Occludin, Claudin-1, -2, Zona occludens (ZO-1, -2)].

19 r redistribution and increased expression of claudin-1, -3, and -4.

20 the TJ-associated proteins actin, occludin, claudin-1, -3, and -5, and ZO-1 and -2 were analyzed by

21 with vector controls, levels of occludin and claudins 1, 4, and 7 increased.

22 IL, E-cadherin/CDH1, OCLN, VIM, FN1, and the Claudins 1, 4, and 7.

23 K1 cells using small interfering RNA against claudins 1-4 and 7.

24 junction adhesion molecule 1, occludin, and claudin-1/4 with minimal effects on the cytoplasmic plaq

25 ne phosphorylation and its dissociation from claudins 1/5, induces endothelial TJ disruption and its

26 Whereas claudin-1, -6, and -9 function equally well as entry cof

27 ematical modeling shows that the majority of claudin-1 (76 +/- 5%) is stably localized at the tight j

28 ferentiation and effector functions, such as claudin-1, a Cdx-2 target gene encoding a critical tight

29 Claudin-1, a component of tight junctions between liver

30 product has 91% identity to a mouse protein, claudin-1, a tight junction (TJ)-associated protein.

31 ubset tested expressed significant levels of Claudin-1, a tight junction protein needed for HCV infec

32 e selectively required for the expression of claudin-1, a tight junction protein that was recently id

33 We found that claudin-1, a tight junction protein, and small proline-r

34 Expression and cellular distribution of claudin-1, a tight junction protein, is dysregulated in

35 isease caused by mutations of CLDN1 encoding Claudin-1, a tight-junction (TJ) protein.

36 In addition, overexpression of claudin-1 abrogated the TSA-induced inhibition of invasi

37 is speculated that cholestasis is caused by Claudin-1 absence, leading to increased paracellular per

38 Claudin-1 activates Wnt and phosphotidylinositol-3-kinas

39 Claudin-1 and -2 were 2- to 6-fold upregulation on trans

40 tion of the specific tight junction proteins claudin-1 and -3 in adult brain endothelial cells.

41 ression studies, certain claudins, including claudin-1 and -4, are postulated to increase, whereas ot

42 Claudin-1 and -5, which were heterotypically compatible

43 while still retaining the ability to bind to claudin-1 and -5.

44 ht junctional elements, ZO-1, JAM, occludin, claudin-1 and -5.

45 s against tight junction proteins, ZO-1, and claudin-1 and by measuring apical-basolateral movements

46 Claudin-1 and claudin-10b were detected only in subpopul

47 ccludin and enhanced membrane association of claudin-1 and claudin-2 by IL-15 required the presence o

48 t junctions correlated with up-regulation of claudin-1 and claudin-2 gene transcription.

49 Consistent with this, binding of claudin-1 and claudin-2, but not claudin-4, to S408A occ

50 n-7 protein levels overall, accumulations of claudin-1 and claudin-7 in TJ increased.

51 Although EpCAM knockdown decreased claudin-1 and claudin-7 protein levels overall, accumula

52 nts, showed a similar pattern of increase in claudin-1 and HDAC-2 mRNA expression throughout all stag

53 ytology samples revealed decreased levels of claudin-1 and increased levels of claudin-2 mRNAs.

54 y the observation of decreased expression of claudin-1 and nuclear beta-catenin in brain endothelial

55 B member I, and the tight-junction proteins claudin-1 and occludin have been identified as essential

56 our findings provide evidence for a role of claudin-1 and occludin in epidermal regeneration with po

57 Here, we investigated the TJ proteins claudin-1 and occludin in ex vivo skin wound healing mod

58 meability selectively in ileum (up-regulated claudin-1 and occludin) and a significant reduction in B

59 height/crypt depth ratio, and mRNA levels of claudin-1 and occludin, no significant differences were

60 Cldn-1(53-80) associated with both claudin-1 and occludin, suggesting both the direct inter

61 entry factors, the tight junction molecules claudin-1 and occludin.

62 here are small changes in the trafficking of claudin-1 and occludin.

63 s of E-cadherin decreased, whereas levels of claudin-1 and ZEB-1 increased.

64 croscopic analyses confirmed the presence of claudin-1 and ZO-1 in Z310 cells at cell-cell contact si

65 ADAM15 co-localised with Claudin-1 and ZO1 at cell-cell junctions.

66 rmed that tight junction proteins (occludin, claudin-1 and zona occludens-1) are internalized through

67 TJ complex proteins claudin-1 and zonula occludens-1 were upregulated follow

68 localization of the tight junction proteins claudin-1 and, to a lesser degree, occludin.

69 in, p120 and beta-catenins, occludin, JAM-1, claudins 1 and 4, and ZO-1) in T84 epithelial cells.

70 of ZO-1 from its binding partners, occludin, claudin 1, and myosin 1C, coincident with opening of tjs

71 ter 6 hours of treatment with HGF, occludin, claudin-1, and beta-catenin were redistributed from the

72 in exchange, but increases exchange of ZO-1, claudin-1, and claudin-2, thereby causing the mobile fra

73 unction proteins zona occludens-1, occludin, claudin-1, and claudin-4, as well as that of desmosomal

74 icrin, and tight junction proteins occludin, claudin-1, and claudin-4, at mRNA and protein levels.

75 he tight junction proteins zona occludens-1, claudin-1, and claudin-5, which were significantly reduc

76 0 (5HT2a, hc-kit, hTapp1, mTapp2, TARP, NG2, claudin-1, and HPV-18 E6).

77 tion of the TJ proteins, ZO-1, occludin, and claudin-1, and is associated with increased paracellular

78 l intercellular TJ proteins (occludin, ZO-1, claudin-1, and JAM) and subjacent AJ (beta-catenin and E

79 r function, such as filaggrin, occludin, and claudin-1, and mRNA levels of filaggrin, loricrin, and i

80 creases in expression of zonula occludens 1, claudin-1, and occludin in rectosigmoid mucosa; the effe

81 lls were transfected with a plasmid encoding Claudin-1, and stable Claudin-1-expressing clones were i

82 d Madin-Darby canine kidney cells, occludin, claudin-1, and ZO-1 were absent from cell-cell contacts

83 n-activated protein kinase (MAPK), occludin, claudin-1, and ZO-1 were recruited to the cell membrane,

84 ounts of the TJ proteins ZO-1, occludin, and claudin-1; and marked disorganization of the actin cytos

85 Occludin, ZO-1, and ZO-2, but not claudin-1, are components of corneal epithelial TJs.

86 uently found in perineurial cells expressing claudin-1 around nerve bundles.

87 Claudin-1 associated with claudin-7 in co-transfection e

88 f MDA-MB-231 ADAM15A expressing cells showed Claudin-1 at cell-cell junctions, in the cytoplasm and n

89 taining barrier and highlight the HIF-1alpha/claudin-1 axis as a potential therapeutic target for EoE

90 y analysis identified a repressed HIF-1alpha/claudin-1 axis, which was restored via pharmacologic HIF

91 gen metabolism, tissue hypoxia, and impaired claudin-1 barrier via repression of HIF-1alpha/claudin-1

92 thelial cells indicates that aquaporin 1 and claudin-1 both remain normally polarized in all genotype

93 ly suppressed the mRNA and protein levels of claudin-1 but had only minor effects on the expression o

94 ted associations of EpCAM with claudin-7 and claudin-1 but not claudin-2 or claudin-4.

95 f patients with AD (loricrin, filaggrin, and claudin 1) but showed characteristic alterations in lipi

96 cell complex molecules such as annexin-2 and claudin-1, but also focal adhesion components such as DO

97 Because antibodies directed against CD81 and claudin-1, but not antibodies directed against scavenger

98 try factors CD81, scavenger receptor BI, and claudin-1; by interferon; and by reagents that inhibit N

99 A B cell line expressing high levels of Claudin-1, CD81, and scavenger receptor BI remained resi

100 membrane, including claudin-1-claudin-1 and claudin-1-CD81 interactions.

101 bstitutions of these residues did not impair claudin-1 cell surface expression or lateral protein int

102 testinal permeability in vivo and changes in claudin-1, claudin-2, and myosin IXB genes expression, w

103 molecular weight complex containing at least claudin-1, claudin-2, and occludin; the difference in th

104 docytes used as a negative control expressed claudin-1, claudin-2, and protein gene product 9.5, whic

105 This regulation requires occludin, claudin-1, claudin-2, and ZO-1.

106 onstrate that EMT is associated with loss of claudin-1, claudin-2, occludin, and E-cadherin expressio

107 audin-3 were able to heterotypically bind to claudin-1, claudin-3, and claudin-5.

108 n Transwell permeable supports and expressed claudin-1, claudin-4, and claudin-8-key proteins for tig

109 hilic solutes, and the TJ proteins occludin, claudin-1, claudin-4, junctional adhesion molecule, and

110 significantly, whereas no obvious change of claudin-1, claudin-4, zonula occludens protein 1, and zo

111 s in ZO-2 expression, but not with occludin, claudin-1, claudin-5 or ZO-1 expression in ovine cerebra

112 We conclude that claudin-1, claudin-5, ZO-1, and ZO-2 expression exhibit

113 measure the protein expression of occludin, claudin-1, claudin-5, zonula occludens (ZO)-1, and ZO-2,

114 ker Langerin and the tight junction proteins Claudin-1, Claudin-7, and ZO-2.

115 ctions within the plasma membrane, including claudin-1-claudin-1 and claudin-1-CD81 interactions.

116 Claudin-1 (Cld-1), a tight-junction integral protein der

117 The tight junction protein claudin 1 (Cldn-1) has been reported to be down-regulate

118 Claudin-1 (CLDN-1), CLDN8, CLDN11, CXADR-like membrane p

119 enger receptor class B type I (SR-BI), CD81, claudin 1 (CLDN1), and occludin (OCLN).

120 arrier composed of reactive astrocyte TJs of claudin 1 (CLDN1), CLDN4, and junctional adhesion molecu

121 (SR-BI), and the tight-junction (TJ) protein claudin 1 (CLDN1).

122 evels of MIR29A and B, but reduced levels of Claudin-1 (CLDN1) and nuclear factor-kappaB-repressing f

123 d that E-cadherin is closely associated with claudin-1 (CLDN1) and occludin (OCLN) on the cell membra

124 munoprecipitation (ChIP) analysis identified claudin-1 (CLDN1) as a prominent HIF target gene.

125 immunosorbant assay using a recombinant CD81-claudin-1 (CLDN1) fusion protein to detect and quantify

126 alysis implicated the tight junction protein claudin-1 (CLDN1) in melanoma progression.

127 Claudin-1 (CLDN1) is a member of the tight junction prot

128 Claudin-1 (CLDN1), a tight junction (TJ) protein, has re

129 ve expression cloning approach we identified claudin-1 (CLDN1), a tight junction component that is hi

130 include CD81, scavenger receptor B1 (SR-B1), claudin-1 (CLDN1), and occludin (OCLN).

131 ier and increased expression of TJ proteins, claudin-1 (CLDN1), claudin-23 (CLDN23), occludin, and Zo

132 Other cell surface molecules, such as CD81, Claudin-1 (CLDN1), Occludin (OCLN), SR-BI, and low-densi

133 A tight junction (TJ) protein, claudin-1 (CLDN1), was identified recently as a key fact

134 tight junction molecules occludin (OCLN) and claudin-1 (CLDN1).

135 s B type I (SR-BI, also known as SCARB1) and claudin-1 (CLDN1).

136 intestinal epithelial tight junction protein claudin-1 (CLDN1).

137 actors, including the tight junction protein claudin-1 (CLDN1).

138 ass B type I (SCARB-1), occludin (OCLN), and claudin-1 (CLDN1).

139 Live cell imaging demonstrates CD81 and claudin-1 coendocytosis and fusion with Rab5 expressing

140 nhibitory effect of TGF-beta on occludin and claudin-1 content.

141 cence microscopy revealed that claudin-7 and claudin-1 continually trafficked into lysosomes.

142 Expression of claudin-1 correlated with that of ZEB-1 in human colon t

143 signaling is a possible mechanism underlying claudin-1-dependent changes.

144 ors of these pathways to study their role in claudin-1-dependent regulation of ZEB-1.

145 e structural and functional roles of various claudin-1 domains in HCV entry, we applied a mutagenesis

146 Putative functional intracellular claudin-1 domains were not important.

147 Claudin-1 down-regulates E-cadherin expression by up-reg

148 lls (HPNCs) were examined for alterations in claudin-1, E-cadherin, and N-cadherin.

149 audin-1 and a synthetic peptide based on the claudin-1 ECL-2 offered no protection to Caco-2 cells.

150 vivo protection from CPE was afforded by the claudin-1 ECL-2 peptide.

151 However, for claudin-1 effects on scratch wound healing were more pro

152 80), because peptides corresponding to other claudin-1 EL domains failed to influence TJ function.

153 The effects of several claudin-1 EL mimetic peptides on epithelial barrier stru

154 Thus, the identification of a critical claudin-1 EL motif, Cldn-1(53-80), capable of regulating

155 oclonal antibody specific for the TJ protein claudin-1 eliminates chronic HCV infection without detec

156 tibodies and HCV particles increase CD81 and claudin-1 endocytosis, supporting a model wherein HCV st

157 In Claudin-1 expressing Can 10 clones, Claudin-1 was locali

158 ith a plasmid encoding Claudin-1, and stable Claudin-1-expressing clones were isolated.

159 hibitors restore cell-cell junctions, rescue claudin 1 expression, and abrogate growth and disseminat

160 (P<0.05), while there were no differences in claudin 1 expression.

161 1A knockdown suppressed HIF-1alpha-dependent claudin-1 expression and epithelial barrier function, as

162 ckdown of Rab3Gap1 prevented plasma membrane Claudin-1 expression and the formation of a barrier comp

163 urther show a functional correlation between claudin-1 expression and TSA-mediated regulation of inva

164 cells showed a positive correlation between claudin-1 expression and tumor growth and metastasis.

165 Inhibition of claudin-1 expression by HDAC-2-specific small interferin

166 on in T47D cells by shRNA reduced endogenous Claudin-1 expression confirming a role for ADAM15 in reg

167 Claudin-1 expression did not differ among groups.

168 /Akt/mTOR pathway was involved in regulating Claudin-1 expression downstream of ADAM15.

169 Furthermore, we demonstrate that changes in claudin-1 expression have significant effects on growth

170 Genetic manipulations of claudin-1 expression in colon cancer cell lines induced

171 t a novel post-transcriptional regulation of claudin-1 expression in colon cancer cells and further s

172 lecular mechanism(s) underlying dysregulated claudin-1 expression in colon cancer remains poorly unde

173 ver, the mechanisms underlying the increased claudin-1 expression in colorectal cancer remains unknow

174 is issue of Oncogene, Suh et al. reported on claudin-1 expression in hepatocellular carcinoma (HCC),

175 rt an inverse relationship between Smad4 and claudin-1 expression in human colorectal carcinoma tumor

176 ee of C and E isoforms led to an increase in Claudin-1 expression in MDA-MB-231 cells, while ADAM15B

177 t and widely used HDAC inhibitors, inhibited claudin-1 expression in multiple colon cancer cell lines

178 Claudin-1 expression increased in the OB and striatum.

179 Defect in claudin-1 expression increases paracellular permeability

180 thermore, this Smad4-dependent inhibition of claudin-1 expression is independent of TGF-beta signalin

181 hibition of PKC signaling in cells with high claudin-1 expression resulted in decreased claudin-1 exp

182 ry human keratinocytes showed that decreased claudin-1 expression resulted in significantly impaired

183 The decrease in Claudin-1 expression resulting from FASN inhibition was

184 HT29 colon cancer cell lines down-regulates claudin-1 expression through transcriptional repression

185 Claudin-1 expression was evaluated by quantitative rever

186 expressed claudin-1, or SW620 cells in which claudin-1 expression was repressed, to determine the eff

187 Claudin-1 expression was silenced by transfection with s

188 Rab25 knockdown also up-regulated claudin-1 expression, increased transepithelial resistan

189 lular permeability in NRC cells silenced for claudin-1 expression.

190 he major mechanism underlying HDAC-dependent claudin-1 expression.

191 h claudin-1 expression resulted in decreased claudin-1 expression.

192 n confirming a role for ADAM15 in regulating Claudin-1 expression.

193 , ADAM15E was the principal variant inducing Claudin-1 expression.

194 sed to eDHFR) and the C-terminal YV motif of claudin-1 (fused to GFP) in single microscope images at

195 We found that induction of claudin-1 gene expression in mature podocytes caused pro

196 ched controls, we assessed the filaggrin and claudin 1 genotypes, the phenotypes by dermatoscopy, and

197 Silencing of Claudin-1 in Can 10 clones increased paracellular permea

198 e of HDAC-dependent epigenetic regulation of claudin-1 in colon cancer.

199 Here, we confirm the role of claudin-1 in HCV entry.

200 We studied the role of claudin-1 in hepatic paracellular permeability.

201 Here, we report an increased expression of claudin-1 in human primary colon carcinoma and metastasi

202 These data implicate claudin-1 in melanoma progression.Oncogene advance onlin

203 tein kinase C (PKC) can affect expression of claudin-1 in rat choroid plexus cells, and we observed a

204 nd membrane association of claudin-2 but not claudin-1 in T84 cells.

205 n proteins zonula occludens-1, occludin, and claudin-1 in the ileum following CLP.

206 ata establish the function and regulation of claudin-1 in the perineurium as the major sealing compon

207 ue distribution of occludin, ZO-1, ZO-2, and claudin-1 in the rat cornea.

208 of the tight junction proteins occludin and claudin-1 in the small intestine.

209 The appearance of claudin-1 in the TJ complex reduced claudin-5 strands (h

210 also report frequent nuclear localization of claudin-1 in these samples.

211 ulation of a potential metastatic modulator, claudin-1, in a TGF-beta-independent manner.

212 hosphorylation of occludin and ZO-1, but not claudin-1, increased significantly.

213 n endothelial cells and cells overexpressing claudin-1 indicated that newly synthesized claudin-1 was

214 e resolved the ultrastructural change in the claudin-1-induced SD-TJ transition.

215 unolabeling of kidney proteins revealed that claudin-1 induction destabilized the SD protein complex

216 Moreover, claudin-1 induction was associated with an endothelial p

217 Mechanistically, claudin-1 interacted with both nephrin and podocin throu

218 ays, AT1002 decreased ZO-1-occludin and ZO-1-claudin 1 interactions coincident with PKCalpha-dependen

219 tly reported that the tight junction protein claudin-1 is a critical HCV entry cofactor.

220 data suggest Rab3Gap1 mediated exocytosis of Claudin-1 is an important component of epidermal barrier

221 Expression of the tight junction protein claudin-1 is dysregulated in colon tumors and associates

222 sed at the normal blood-brain barrier (BBB), claudin-1 is expressed in pathological conditions.

223 e blood microvessels we have identified that claudin-1 is highly expressed in leaky brain microvessel

224 Our results reveal that claudin-1 is incorporated in BBB tight junction complex,

225 ell as entry cofactors in endothelial cells, claudin-1 is more efficient in hepatoma cells.

226 Given that claudin-1 is widely expressed in epithelia, we further d

227 the expression of a tight junction protein, claudin-1, is increased during colon carcinogenesis and

228 e gene expression of claudins, in particular claudin-1, is markedly upregulated in the podocyte, acco

229 on of other TJ and AJ proteins such as ZO-1, claudin-1, JAM, beta-catenin, and E-cadherin were down-r

230 rearrangement of key TJ proteins: occludin, claudin-1, junctional adhesion molecule-A, and zonula oc

231 Last, we found that claudin-1 knockdown prevented TEER elevation by PKD inhi

232 T pathway was significantly attenuated after claudin-1 knockdown, and protein levels of extracellular

233 Immunofluorescence study revealed that claudin-1 level was markedly reduced and almost disappea

234 Manipulation of claudin-1 levels in colon cancer cells showed a positive

235 Although LC claudin-1 levels were dramatically reduced in the absenc

236 Can 10 cells, this decrease correlating with claudin-1 levels.

237 AM15 in ADAM15 over-expressing cells reduced Claudin-1 levels.

238 This was accompanied by a change of Claudin-1 localisation to the cell surface and interacti

239 key HCV receptor/coreceptor molecules CD81, claudin-1, low-density lipoprotein receptor (LDLr), occl

240 we propose that cell-cell contacts formed by claudin-1 may generate specialized membrane domains that

241 , exhibited upregulated expression levels of claudin-1 mRNA and protein in podocytes.

242 We found significant upregulation of claudin-1 mRNA and protein, a nonspecific claudin for bl

243 Further studies revealed modulation of claudin-1 mRNA stability by its 3'-UTR as the major mech

244 ond to CPE, while transfectants expressing a Claudin-1 mutant with the corresponding ECL-2 residue ch

245 thelial integrity with reduced expression of claudin-1, occludin, and E-cadherin and decreased number

246 dition, expression of cell adhesion proteins claudin-1, occludin, and e-cadherin are also increased.

247 or measurement of CD11c, CD3, CD4, tryptase, claudin-1, occludin, E-cadherin, and vascular endothelia

248 O-1 at the tight junction but did not affect claudin-1, occludin, or actin exchange in vitro.

249 lter the expression or distribution of ZO-1, claudin-1, or claudin-4.

250 SW480 colon cancer cells that overexpressed claudin-1, or SW620 cells in which claudin-1 expression

251 Ninety-five renal biopsies were stained for claudin-1 (PEC marker), CD44 (activated PECs), and LKIV6

252 Targeting claudin-1 with a claudin-1 peptide improves brain endothelial barrier per

253 nexin A3 colocalized with cathepsin B and C, claudin-1, phosphorylated ERK1/2, and CD44, but not with

254 During normal mouse epidermal development, Claudin-1 plasma membrane localisation and Rab3Gap1 cell

255 e expression of Smad4 in Smad4-deficient but claudin-1-positive SW480 or HT29 colon cancer cell lines

256 een HCV E2 and its two co-receptors CD81 and claudin-1 probably triggered the activation of AKT.

257 transcription in 30 min, and an increase in claudin-1 protein by 12 h.

258 947 did not prevent the Smad4 suppression of claudin-1 protein expression in either SW480 or HT29 cel

259 genous occludin protein led to a recovery in claudin-1 protein level, relocation of the zonula occlud

260 kdown resulted in decreases in claudin-7 and claudin-1 proteins that were reversed with lysosome inhi

261 e disruption and mislocalization of ZO-1 and claudin-1 proteins.

262 In VZV-infected HPNCs, claudin-1 redistributed to the nucleus; E-cadherin was l

263 In contrast, ZO-1 and claudin-1 redistribution occurred well after maximal TER

264 Up-regulation of claudin-1 reduces expression of E-cadherin.

265 ZEB-1 mediates claudin-1-regulated changes in cell invasion and anoikis

266 We investigated the mechanisms by which claudin-1 regulates E-cadherin expression and its effect

267 boxyl termini of zona occludens-3 (ZO-3) and claudin 1, respectively.

268 ductions in the expression of E-cadherin and claudin-1, responses that are standard characteristics o

269 ns appeared normal, immunohistochemistry for claudin 1 showed no reduction in protein amounts, and mo

270 audin-1 barrier via repression of HIF-1alpha/claudin-1 signaling, which was restored by transgenic ex

271 pathway, including MMP9 hemopexin domain or claudin-1 siRNA, enables an opioid peptide ([D-Ala2,N-Me

272 complexes of claudin-7, integrin alpha2, and claudin-1 that normally form in epithelial basolateral c

273 proteins (ie, zonula occludens-1, Occludin, Claudin-1) that critically regulate epithelial paracellu

274 In addition to claudin-1, the transcripts for several other isotypes of

275 layer, and a loss of intracellular levels of claudin-1 to -4.

276 Immunofluorescence staining localized claudin-1 to cell membranes in IL-1beta-treated astrocyt

277 ation and recruitment of ZO-1, occludin, and claudin-1 to the TJ during junctional biogenesis.

278 in vivo Here, we report the generation of a claudin-1 transgenic mouse model with doxycycline-induci

279 r2a knockdown cells was sufficient to rescue Claudin-1 transport to the cell surface.

280 Claudin-1 up-regulates the repressor ZEB-1 to reduce exp

281 n protein amounts, and molecular analysis of claudin 1 was unremarkable.

282 The expression of occludin and claudin-1 was downregulated, and the distribution patter

283 Claudin-1 was higher (P<0.05) in fetuses at 60% of gesta

284 In Claudin-1 expressing Can 10 clones, Claudin-1 was localized at the TJ and paracellular perme

285 ll borders of the superficial layer, whereas claudin-1 was localized mainly in the basal and wing cel

286 In Ppp2r2a knockdown cells, Claudin-1 was located to the cytoplasm and its expressio

287 In the NISCH liver, Claudin-1 was not detected in hepatocytes or cholangiocy

288 taining of a tissue microarray revealed that claudin-1 was overexpressed in melanoma, and aberrantly

289 g claudin-1 indicated that newly synthesized claudin-1 was present on the cell membrane (~45%), was i

290 in human melanoma, cells lacking endogenous claudin-1 were treated with 200 nM phorbol myristic acid

291 nteract with the first extracellular loop of Claudin-1, whereas soluble E2 did not.

292 surface and interaction between Occludin and Claudin-1 which are thought to be required for tight jun

293 ion and integrity through down-regulation of claudin-1, which is a key component of tight junctions.

294 Targeting claudin-1 with a claudin-1 peptide improves brain endoth

295 Targeting claudin-1 with a specific C1C2 peptide improved brain en

296 nd claudin-7 was required for association of claudin-1 with EpCAM.

297 n-1beta (IL-1beta) causes rapid induction of claudin-1, with an expression pattern reciprocal to loss

298 and localization of tight junction proteins (claudin-1, ZO-1) were visualized by immunofluorescence.

299 ever, other tight junction proteins, such as claudin-1, ZO-1, and occludin, are unchanged.

300 n 1-fusion proteins of beta-actin, occludin, claudin-1, ZO-1, clathrin light chain A1, and caveolin-1