ライフサイエンスコーパス: clavulanic acid

1 zidime) and beta-lactamase inhibitors (e.g., clavulanic acid).

2 lso leads to decreased inhibition potency of clavulanic acid.

3 production of the beta-lactamase inhibitor, clavulanic acid.

4 icrobiome was similar to that of amoxicillin-clavulanic acid.

5 ation with beta-lactamase inhibitors such as clavulanic acid.

6 y of PBP2a for penicillin in the presence of clavulanic acid.

7 ased inactivators tazobactam, sulbactam, and clavulanic acid.

8 ctamase detectable only after induction with clavulanic acid.

9 ases by the similar inhibitors sulbactam and clavulanic acid.

10 biosynthesis of the beta-lactamase inhibitor clavulanic acid.

11 oxacin (750 mg twice daily) plus amoxicillin/clavulanic acid (1,000 mg twice daily).

12 , per os (PO), every 24 h (q24), amoxicillin-clavulanic acid 10 mg/kg, PO, q24, enrofloxacin 10 mg/kg

13 ofloxacin 10 mg/kg combined with amoxicillin-clavulanic acid 10 mg/kg, PO, q24, rifampicin 15 mg/kg,

14 ne compared with the MIC of ceftazidime with clavulanic acid (2 micrograms/ml) to facilitate the reco

15 Cefoxitin (24%) and amoxicillin-clavulanic acid (21%) were most used in the PAP group, w

16 tis and who received 2 g of amoxicillin plus clavulanic acid 3 times a day while in the hospital befo

17 Antibiotic disks with and without clavulanic acid, 3-aminophenylboronic acid, or EDTA were

18 irical systemic antibiotics (amoxicillin and clavulanic acid, 375 mg, to be taken 3 times a day for 1

19 high for ampicillin (66.7%) and amoxicillin-clavulanic acid (40.0%).

20 ide (600 mg orally every 8 h) or amoxicillin-clavulanic acid (500 mg amoxicillin and 125 mg clavulani

21 c acid and enrofloxacin (62.4%), amoxicillin-clavulanic acid (58.2%), rifampicin (45.5%), and clarith

22 imum of 5 days, after which oral amoxicillin/clavulanic acid (875/125 mg every 12 h) could be given f

23 s ampicillin-sulbactam (A/S) and amoxicillin-clavulanic acid (A/C) for 100 consecutive isolates of Ac

24 iated with reduced resistance to amoxicillin-clavulanic acid (adjusted odds ratio 0.58 [95% CI 0.35-0

25 ts treated with an active BLBLI (amoxicillin-clavulanic acid [AMC] and piperacillin-tazobactam [PTZ])

26 ovill and AMR genes (relevant to amoxicillin-clavulanic acid, ampicillin, ceftriaxone, ciprofloxacin,

27 mide (a novel carbapenem) and by amoxicillin-clavulanic acid (an orally administered beta-lactam-beta

28 SHV results in resistance to amoxicillin and clavulanic acid, an important clinical beta-lactam-beta-

29 technical difficulties were solved by using clavulanic acid, an irreversible inhibitor of beta-lacta

30 of S130G and SHV-1 differed by only 17% for clavulanic acid and 40% for tazobactam.

31 -spectrum beta-lactam antibiotic amoxicillin/clavulanic acid and a first-generation cephalosporin cef

32 udy extend the biosynthetic gene cluster for clavulanic acid and attest to the importance of analyzin

33 Clavulanic acid and avibactam are clinically deployed se

34 ation disk diffusion tests (ceftazidime with clavulanic acid and cefotaxime with clavulanic acid) for

35 lowed by the combination therapy amoxicillin-clavulanic acid and enrofloxacin (62.4%), amoxicillin-cl

36 all cultures were susceptible to amoxicillin-clavulanic acid and gentamicin and 99% (one with interme

37 Although clavulanic acid and penicillin share marked structural s

38 olyl groups that distinguish tazobactam from clavulanic acid and sulbactam, respectively.

39 conclude that tazobactam is superior to both clavulanic acid and sulbactam.

40 -based antibiotics (amoxicillin, amoxicillin/clavulanic acid) and levofloxacin (a fluoroquinolone ant

41 ime), quinolones, penicillins (amoxicillin + clavulanic acid), and macrolides (azithromycin) was most

42 signed to treatment: 1719 to amoxicillin and clavulanic acid, and 1708 to placebo.

43 0G SHV inhibited with tazobactam, sulbactam, clavulanic acid, and 2'-glutaroxy penem sulfone (SA2-13)

44 penicillins, penicillin V and amoxicillin + clavulanic acid, and appears to be very safe in patients

45 o trimethoprim-sulfamethoxazole, amoxicillin/clavulanic acid, and ciprofloxacin.

46 evant inhibitors, tazobactam, sulbactam, and clavulanic acid, and SHV beta-lactamase (EC 3.5.2.6) hav

47 mase crystals are soaked in 5 mM tazobactam, clavulanic acid, and sulbactam solutions, respectively.

48 lations at 10, 22, and 29 min for sulbactam, clavulanic acid, and tazobactam, respectively.

49 activation by the beta-lactamase inhibitors, clavulanic acid, and tazobactam.

50 Cefalexin, amoxicillin-clavulanic acid, and trimethoprim were the most commonly

51 illin-based (amoxicillin or amoxicillin with clavulanic acid) antibiotic treatment.

52 nd the inhibitors tazobactam, sulbactam, and clavulanic acid are followed in single crystals of the e

53 Tazobactam, sulbactam, and clavulanic acid are the only beta-lactamase inhibitors i

54 urrently employed in medical practice (e.g., clavulanic acid) are significantly more effective agains

55 ta-lactams, and the beta-lactamase inhibitor clavulanic acid as well as resistance to tetracycline, s

56 ed PEN (36%), amoxicillin (AX) (32%), and AX-clavulanic acid (AX-CLV) (31%); and the symptoms maculop

57 ntibiotic episodes (amoxicillin, amoxicillin clavulanic acid, azithromycin, cefuroxime, cephalexin, c

58 orf11 (fd), and orf12, that are required for clavulanic acid biosynthesis as indicated by gene replac

59 treptomyces clavuligerus were sufficient for clavulanic acid biosynthesis, because they allowed produ

60 ly demonstrated to catalyze an early step in clavulanic acid biosynthesis, the ATP/Mg(2+)-dependent i

61 m synthetase (beta-LS), which is involved in clavulanic acid biosynthesis.

62 The orf6 gene of the clavulanic acid biosynthetic gene cluster in S. clavulig

63 the beta-lactamase inhibitors sulbactam and clavulanic acid bound to the deacylation-deficient E166A

64 Based on growth inhibition by clavulanic acid by disk and MIC test methods, 18 (9.5%)

65 ESBL screen test) were further tested for a clavulanic acid (CA) effect by BMD and the disk diffusio

66 Initially, 117 (84%) isolates demonstrated a clavulanic acid (CA) effect by disk diffusion (i.e., an

67 y >/=3 doubling dilutions in the presence of clavulanic acid (CA) or the disk diffusion zone diameter

68 The levels of enamine from tazobactam and clavulanic acid can be increased by increasing the conce

69 t, while results for ampicillin, amoxicillin-clavulanic acid, cefdinir, cefixime, ceftriaxone, and cl

70 eta-lactams compound, aztreonam, amoxicillin/clavulanic acid, cefoxitin, ceftazidime and piperacillin

71 Ceftazidime disks with and without clavulanic acid (CLAV) were also tested to confirm exten

72 in (AX), which is often prescribed alongside clavulanic acid (Clav), is the most common elicitor.

73 esponses have been reported with amoxicillin/clavulanic acid, clindamycin, metronidazole, and the com

74 ted directly downstream of orf9 (cad) in the clavulanic acid cluster.

75 e main culprit was AX (70.1%) followed by AX-clavulanic acid (CLV) (26.8%) and the main symptoms macu

76 Selective reactions to clavulanic acid (CLV) account for around 30% of immediat

77 iate selective hypersensitivity reactions to clavulanic acid (CLV) and amoxicillin (AX), probably due

78 e drug hypersensitivity reactions (IDHRs) to clavulanic acid (CLV) have increased in the last decades

79 Amoxicillin (AX) combined or not with clavulanic acid (CLV) is frequently involved in IgE-medi

80 zole (ESM), cefixime (CFIX), and amoxicillin-clavulanic acid (CVA-AMPC), 21.2% were confirmed to be a

81 y > 2 log2 dilution steps in the presence of clavulanic acid) defined a group of 92 probable ESBL-pos

82 ostoperative treatment with amoxicillin plus clavulanic acid did not result in a greater incidence of

83 rger population of enamine than sulbactam or clavulanic acid does and that tazobactam's intermediate

84 he overall use of quinolones and amoxicillin-clavulanic acid dropped by 52.2% (P = .001) and 42.5% (P

85 veloping increased resistance to amoxicillin/clavulanic acid during long-term in vitro exposure to th

86 fect the amount of trans-enamine formed with clavulanic acid during the critical early time period of

87 ons (microg/ml) and IC(50) concentrations to clavulanic acid for the Met69Ile, Leu, and Val substitut

88 (imipenem for noncarbapenemase B-lactamases, clavulanic acid for type A carbapenemases, and EDTA for

89 ime with clavulanic acid and cefotaxime with clavulanic acid) for ESBL confirmatory testing.

90 ecreased during treatment in the amoxicillin-clavulanic acid group (day 4, p=0.030) and the tebipenem

91 ithdrew, leaving 1715 in the amoxicillin and clavulanic acid group and 1705 in the placebo groups.

92 on days 4-10 (p<=0.0011) in the amoxicillin-clavulanic acid group and on days 4-14 (p<=0.0019) in th

93 romide group and 15 (50%) to the amoxicillin-clavulanic acid group.

94 tly fewer women allocated to amoxicillin and clavulanic acid had a confirmed or suspected infection (

95 the use of either norfloxacin or amoxicillin-clavulanic acid in the treatment of small bowel overgrow

96 single beta-lactamase drug (ceftazidime with clavulanic acid) in combination disk diffusion tests for

97 d susceptibility to coamoxiclav (amoxicillin-clavulanic acid) induced DILI.

98 We conclude that the clavulanic acid inhibition of the S130G beta-lactamase m

99 y for carbenicillin and the ability to evade clavulanic acid inhibition.

100 Band broadening in the sulbactam and clavulanic acid inter-mediates reflected a heterogeneous

101 the Raman and x-ray data indicated that the clavulanic acid intermediate is decarboxylated.

102 Clavulanic acid is a potent inhibitor of beta-lactamase

103 Clavulanic acid is a potent inhibitor of beta-lactamases

104 Clavulanic acid is a potent mechanism-based inhibitor of

105 Clavulanic acid is a widely used beta-lactamase inhibito

106 nicillin N, the critical beta-lactam ring of clavulanic acid is demonstrated to form by intramolecula

107 The clinically used beta-lactamase inhibitor clavulanic acid is produced by fermentation of Streptomy

108 -lactamase inhibitors such as tazobactam and clavulanic acid is the expression of variant beta-lactam

109 ble agreement was also found for amoxicillin-clavulanic acid, linezolid, minocycline, and tobramycin.

110 azithromycin < metronidazole < amoxicillin + clavulanic acid < clarithromycin < penicillin V < clinda

111 amycin, piperacillin-tazobactam, ticarcillin-clavulanic acid, metronidazole, cefotetan, ampicillin, a

112 e inhibitors and cephalosporins (amoxicillin/clavulanic acid MIC >= 256 mug/mL; ceftriaxone MIC >= 8

113 e inhibitors and cephalosporins (amoxicillin/clavulanic acid MIC 256 ug/mL; ceftriaxone MIC 8 ug/L).

114 co-amoxiclav (250 mg amoxicillin plus 125 mg clavulanic acid; n=1212), both (n=1192), or placebo (n=1

115 co-amoxiclav (250 mg amoxicillin and 125 mg clavulanic acid; n=1550), both (n=1565), or placebo (n=1

116 line antibiotics consist of oral amoxicillin/clavulanic acid or cefalexin with metronidazole.

117 und between the residents taking amoxicillin/clavulanic acid or ciprofloxacin.

118 r, AmpC beta-lactamases are not inhibited by clavulanic acid or other similar compounds.

119 sence of bla(TEM-1) variants and amoxicillin-clavulanic acid or piperacillin-tazobactam resistance, a

120 a single dose of intravenous amoxicillin and clavulanic acid or placebo (saline) following operative

121 bat these enzymes, agents that inhibit (e.g. clavulanic acid) or evade (e.g. aztreonam) beta-lactamas

122 avulanic acid (500 mg amoxicillin and 125 mg clavulanic acid orally every 8 h).

123 up B showed higher resistance to amoxicillin-clavulanic acid (P = .03), trimethoprim-sulfamethoxazole

124 t not penicillin hydrolysis, we suggest that clavulanic acid paired with an oxyimino-cephalosporin ra

125 es clavuligerus resulted in complete loss of clavulanic acid production and the accumulation of N2-(c

126 Similarly, in amoxicillin-clavulanic acid recipients, significant changes were obs

127 in rash and two women in the amoxicillin and clavulanic acid reported other allergic reactions, one o

128 ting revealed that ampicillin and ampicillin/clavulanic acid resistance was observed only for the S13

129 Unfortunately, the emergence of clavulanic acid-resistant variants of TEM-1 and SHV-1 be

130 In summary, enrofloxacin and amoxicillin-clavulanic acid show promising properties for the treatm

131 onstant for the preacylation complex, KI, of clavulanic acid (SHV-1, 0.14 microm; S130G, 46.5 microm)

132 that single-dose treatment with amoxicillin/clavulanic acid significantly reduces methicillin-resist

133 With clavulanic acid, slightly smaller amounts of enamine are

134 Comparative inhibitory activities of clavulanic acid, sulbactam, and tazobactam against clini

135 m the CTX-M-9 S130G variant that reacts with clavulanic acid, sulbactam, and tazobactam in solution,

136 can be inhibited by the clinical inhibitors (clavulanic acid, sulbactam, and tazobactam), but the pre

137 he expected product of the beta-LS, restored clavulanic acid synthesis.

138 bserved in children treated with ticarcillin-clavulanic acid (T/C), we conducted a study to determine

139 nd ribitol and susceptibility to amoxicillin-clavulanic acid, the 58 isolates were separable into fou

140 The first committed biosynthetic step toward clavulanic acid, the clinically important beta-lactamase

141 For tazobactam and clavulanic acid, the correctly oriented encounter comple

142 ligands, such as tazobactam, sulbactam, and clavulanic acid, the positioning of the lactam ring in t

143 Clavulanic acid, the therapeutically important inhibitor

144 resistance in S. maltophilia because, unlike clavulanic acid, they do not induce L1 production.

145 ARGs; this ranged from 75.1% for amoxicillin-clavulanic acid to 3.4% for ciprofloxacin.

146 ns tested in combination with 4 microg/mL of clavulanic acid was used to confirm ESBL status.

147 Amoxicillin alone or combined to clavulanic acid were the most commonly involved BL excep

148 s much enamine intermediate as sulbactam and clavulanic acid, which correlates with its superior perf

149 ated with decreased potency of the inhibitor clavulanic acid, which is used in combination with amoxi

150 he presence of penicillin but the absence of clavulanic acid, which suggests that penicillin/beta-lac

151 acillin and the combination of oxacillin and clavulanic acid with the Vitek GPS-SA card, the referenc