ライフサイエンスコーパス: cleavage by

1 , provide insights into the mechanism of DNA cleavage by 1.

2 ~1-2 kcal mol(-1) and the following H-H bond cleavage by ~10 kcal mol(-1), respectively.

3 increase the RPR's apparent rate of correct cleavage by 11,140-fold, compared to only 480-fold for m

4 es have been identified for catalysis of RNA cleavage by 2'-hydroxyl transesterification, forming 2',

5 Studies on the mechanism of cleavage by 3-finger ZFNs established that the preferred

6 )-derived protein that fluoresces only after cleavage by 3CL(pro) This experimentally optimized repor

7 o group I introns, the LC ribozyme catalyzes cleavage by a 2',5' branching reaction, leaving the 3' p

8 eptide ending in a dibasic motif, suggesting cleavage by a furin-like proprotein convertase (PC).

9 Most of these coupled sites underwent cleavage by a mechanism described previously by the Povi

10 preparing the substrate for subsequent ring cleavage by a meta-cleaving enzyme.

11 g by Fe.BLM leads to increased double-strand cleavage by a novel mechanism and identify a specific DN

12 or base and involves rate-limiting B-N bond cleavage by a small water cluster, (H2O)n.

13 Ectodomain cleavage by A-disintegrin and -metalloproteases (ADAMs)

14 endothelial cells can promote CgA C-terminal cleavage by activating the plasminogen activator/plasmin

15 Here we show that receptor cleavage by ADAM (A Disintegrin And Metalloprotease) met

16 restingly, the reaction rate of pro-TNFalpha cleavage by Adam 17 was also reduced by a small molecule

17 on and diminished protein half-life, whereas cleavage by ADAM proteases was not modified.

18 a-119 downward arrowVal-120, with additional cleavage by ADAM10 at Gly-227 downward arrowArg-228 near

19 Surprisingly, we not only found cleavage by ADAM10, ADAM17, and BACE1 C-terminal to the

20 Additional cleavage by ADAM8 was observed at the previously propose

21 emolytic-uremic syndrome) or with inadequate cleavage by ADAMTS-13 of ULVWF multimeric strings secret

22 6 scissile bond within the VWF A2 domain for cleavage by ADAMTS13.

23 a key protective determinant against FL-VWF cleavage by ADAMTS13.

24 Blockade of APP cleavage by AEP in mice alleviates pathological and beha

25 ll interfering RNAs that guide transgene RNA cleavage by AGO1.

26 Unlike AGO2, target cleavage by AGO3 requires both 5'- and 3'-flanking regio

27 ta-elimination mechanism for glycolytic bond cleavage by Alg17c are similar to those observed for fam

28 it is essential for irreversible ether lipid cleavage by alkylglycerol monooxygenase.

29 ions of the TL strongly impair intrinsic RNA cleavage by all three RNAPs and eliminate the interspeci

30 APP cleavage by alpha-secretase produces potentially neurotr

31 uire allosteric changes induced via receptor cleavage by alpha-thrombin to mediate heterodimer format

32 ared reaction mechanism that catalyzes their cleavage by an elaborated variant of the two-metal, in-l

33 ively, and no consequences for stability and cleavage by an endonuclease (EcoRI).

34 ) that releases a downstream activator after cleavage by an upstream DNAzyme.

35 rom the tRNA halves or from independent tRNA cleavage by ANG.

36 These data indicate that PAR3 cleavage by APC at Arg41 can initiate distinctive APC-li

37 We also mapped the cleavage by Arg-specific gingipains to the reactive site

38 Here, we report that RNA cleavage by Argonaute3 initiates production of most Piwi

39 mune evasion mechanisms associated with NEMO cleavage by arterivirus nsp4 and describes a novel subst

40 four new pbs1 alleles, two of which blocked cleavage by AvrPphB.

41 protein (APP) through sequential proteolytic cleavage by BACE1 and gamma-secretase.

42 o dissociate protein cis-dimers required for cleavage by BACE1 at low pH values.

43 ies, we confirm that A673T APP shows reduced cleavage by BACE1 in transfected mouse primary neurons a

44 ion makes APP a less favorable substrate for cleavage by BACE1.

45 Symmetric cleavage by BCO1 yields retinoids (beta-15'-apocarotenoi

46 We also show that a stepwise cleavage by BCO2 and BCO1 with APO10ol as an intermediat

47 -15'-apocarotenoids, C20), whereas eccentric cleavage by BCO2 produces long-chain (>C20) apocarotenoi

48 y promotes APP distribution in endosomes and cleavage by beta secretase.

49 otein is an important step in its subsequent cleavage by beta-secretase (BACE1).

50 the amyloid-beta precursor protein (APP) via cleavages by beta- and gamma-secretase.

51 CsrA stabilizes CsrB against RNase E cleavage by binding to two canonical sites adjacent to t

52 omain (Toc159G) of pea (Pisum sativum) using cleavage by bound preproteins conjugated with the artifi

53 nds complement component C5 and prevents its cleavage by C5 convertases, inhibiting release of both t

54 ave investigated the mechanism of C1-C2 bond cleavage by cAD using a fatty aldehyde that incorporates

55 Moreover, stimulation of NRG1 cleavage by calcyon was recapitulated in HEK 293 cells s

56 We show that proteolytic cleavage by CalpA generates Cactus fragments lacking an

57 Full IL-1alpha activity required cleavage by calpain after necrosis, which increased its

58 that are produced in these complexes through cleavages by calpains or other nonprocessive proteases.

59 ions was achieved by prodrugs susceptible to cleavage by carboxylesterase 1.

60 e S-peptide can protect its s10 part against cleavage by carboxypeptidase Y (CPY).

61 Double-stranded DNA (dsDNA) cleavage by Cas9 is a hallmark of type II CRISPR-Cas imm

62 DNA unwinding is a checkpoint before cleavage by Cas9, and was shown to be made more sensitiv

63 ease-specific types of proteolytic cleavage, cleavages by casapses/granzyme B are considered as essen

64 on activation following cell cycle dependent cleavage by caspase 7; knock-down of caspase 7 phenocopi

65 Additionally, TRIF cleavage by caspase-1 diminished NLRP3 inflammasome acti

66 Preventing TRIF cleavage by caspase-1 in an in vivo model of P. aerugino

67 Gasdermin D (GSDMD) cleavage by caspase-1 or caspase-11 inflammasomes trigge

68 a is a complex process involving proteolytic cleavage by caspase-1.

69 to form homo- and heterodimers, but feedback cleavage by caspase-3 at Asp-330 removed the linker enti

70 Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N domain, whic

71 d mechanistic studies, we show that upon DDD cleavage by caspase-3 the resulting DEVD-T peptide acts

72 ppressor of cytokine responses; reveal N4BP1 cleavage by caspase-8 as a point of signal integration d

73 LD proteins that had been mutated to prevent cleavage by caspase-8.

74 pH approximately 12) and reductive C-Cl bond cleavage by cast zerovalent iron, Fe(0).

75 Intramembrane cleavage by catalytically active SPP provided the primar

76 ly enhanced thermostability while inhibiting cleavage by cathepsin S, an endosomal protease essential

77 Indeed, cleavage by cathepsins is required for native TLR3 to si

78 bon limitation via the disruption of sucrose cleavage by cell wall invertases in developing ovaries.

79 oselectivity of aliphatic carbon-carbon bond cleavage by changes involving an intermediate in the rea

80 then extended from simple binding to direct cleavage by conjugation to bleomycin A5 in a manner that

81 mechanisms to protect their genomes from R-M cleavage by covalent modifications, such as the hydroxym

82 ide mechanistic insights into RNA-guided DNA cleavage by Cpf1 and establish a framework for rational

83 We found that cleavage by CRISPR-Cas was more efficient than cleavage

84 understanding of target DNA recognition and cleavage by CRISPR-Cas9 nucleases, methods to determine

85 ogen, is thermodynamically stable, such that cleavage by CTRC leads to an equilibrium mixture contain

86 of in vivo RNA secondary structure in miRNA cleavage by developing the new CAP-STRUCTURE-seq method

87 maximum rate (Vmax) of pre-microRNA (miRNA) cleavage by Dicer and facilitates loading of miRNA onto

88 In vitro, Loqs-PD enhances the rate of dsRNA cleavage by Dicer-2 and also enables processing of subst

89 le than the corresponding oxopeptides toward cleavage by dipeptidyl peptidase 4, the principal regula

90 cretin hormones are terminated via enzymatic cleavage by dipeptidyl peptidase-4 (DPP-4) and through r

91 ucleotides within a 5' flap are resistant to cleavage by DNA2, and extended RNA:DNA hybrids inhibit b

92 omic DNA, we show that the intrinsic rate of cleavage by DNase I closely tracks the width of the mino

93 quence in Uc.283+A, which prevents pri-miRNA cleavage by Drosha.

94 self-cyclization, rather than by intrachain cleavage by endogenous thiols.

95 ed viral protease or fusion to ubiquitin and cleavage by endogenous ubiquitin proteases.

96 addition, mutant TREM2 becomes sensitive to cleavage by endoglycosidase D under conditions that inhi

97 ion strongly depended upon MMP-dependent ECM cleavage by enlarging matrix pore diameters, and integri

98 The structural basis for branch-specific cleavage by ERManI and GMIA was explored by replacing an

99 plex strongly promotes transcript hydrolytic cleavage by establishing a network of interactions that

100 vating proteases, nor were they sensitive to cleavage by exogenous trypsin.

101 hat the ATXalpha insertion is susceptible to cleavage by extracellular furin-like endoproteases, but

102 DNA cleavage by fCas9 requires association of two fCas9 mono

103 ynthesis acts in concert with alternate flap cleavage by flap endonuclease 1 (FEN1) to mediate CAG re

104 lycan did not affect the kinetics of proBDNF cleavage by furin in vitro, indicating that effects othe

105 domain shedding and subsequent intramembrane cleavage by gamma-secretase leads to release of a solubl

106 Transmembrane cleavage by gamma-secretase occurs at three gamma-sites

107 The proteolytic cleavage by gamma-secretase of its C-terminal fragment p

108 t of APP (C99), when delivered to the ER for cleavage by gamma-secretase, acts as a lipid-sensing pep

109 into the observed dependence of C99 protein cleavage by gamma-secretase, critical to the formation o

110 ations alter amyloid precursor protein (APP) cleavage by gamma-secretase, increasing the proportion o

111 Initial cleavage by GlpG or Rhom7 allows subsequent degradation

112 za virus hemagglutinin (HA) glycoprotein via cleavage by host cell proteases is essential for viral i

113 The coronavirus (CoV) S protein requires cleavage by host cell proteases to mediate virus-cell an

114 1-kDa fragment (TCP96), are produced through cleavage by human neutrophil elastase and aggregate lipo

115 estigated the ability of DNA to catalyze RNA cleavage by hydrolysis rather than transesterification,

116 tivity of HOIL-1-generated oxyester bonds to cleavage by hydroxylamine, and macrophages from knock-in

117 utilization of three DSBR pathways following cleavage by I-SceI or CRISPR/Cas9 nucleases.

118 IgG-selective cleavage by IdeS thus neutralizes NMO-IgG pathogenicity,

119 eactions; DNA 13 underwent double-strand DNA cleavage by independent single-strand cleavages at all f

120 e immune receptor signaling and maturational cleavage by inflammasomes.

121 We demonstrate that NusG slows RNA cleavage by inhibiting backtracking.

122 all-molecule inhibitors that attenuated PARP cleavage by inhibiting gamma-H2AX, which in turn inhibit

123 e continually produced through nonprocessive cleavages by intracellular, intramembrane, and extracell

124 e we report that ceramide stimulates CREB3L1 cleavage by inverting the orientation of TM4SF20 in memb

125 n the human reproductive system produced via cleavage by kallikrein-related peptidase 3 (KLK3), aka p

126 Here, Xu et al discover NLRP1 cleavage by lethal toxin induces the N-end rule, which t

127 combination was also protective against MEK2 cleavage by lethal toxin or adenylyl cyclase activity by

128 n and exhibits a kinetic effect on substrate cleavage by LF.

129 beta-HSDH could regulate cortisol side-chain cleavage by limiting pro-androgen formation in bacteria

130 Regulation of ADAM17-mediated Neogenin cleavage by Lrig2 is required for neurite growth inhibit

131 rocessing and turnover requires knowledge of cleavages by major endoribonucleases within a living cel

132 Identification of the sites of cleavage by mass spectrometry allowed us to test the fun

133 ied by cross-linking, bridging proteins, and cleavage by matrix degrading enzymes.

134 ha was shed by keratinocytes via proteolytic cleavage by matrix metalloproteinases upon stimulation w

135 e depletion of ORP2 resulting in proteolytic cleavage by matrix metalloproteinases, and reduced activ

136 of heparin enhanced the rate of procollagen cleavage by matrix-bound BMP-1.

137 of the MazF dimer prevents mRNA binding and cleavage by MazF.

138 Indeed, prodomain cleavage by meprin beta caused increased ADAM protease a

139 in, which is further matured via proteolytic cleavage by metalloproteases such as ADAM17, a process k

140 rategy in which antibody-targeted controlled cleavage by micrococcal nuclease releases specific prote

141 n factors, including SPL13, are targeted for cleavage by miR156.

142 otease and a second inefficient or regulated cleavage by mitochondrial intermediate protease.

143 cleavage during import, involving efficient cleavage by mitochondrial processing protease and a seco

144 collagen type I and type IV are resistant to cleavage by MMP-1, MMP-2, MMP-9, and MMP-13, whereas non

145 phaIIbbeta3 is a necessary cofactor for PAR1 cleavage by MMP-2 by binding the MMP-2 hemopexin domain,

146 protect both SLRPs and collagen fibrils from cleavage by MMPs.

147 A is protected from restriction endonuclease cleavage by modifying the DNA using a DNA methyltransfer

148 ytic sites of PEDV nsp5 probably impact NEMO cleavage by modulating potential interactions of nsp5 wi

149 he inhibitory effect of RAD51 on 3'-flap DNA cleavage by MUS81-EME1 through its RAD51 filament disrup

150 tion forks at CFSs and hence facilitates CFS cleavage by MUS81-EME1.

151 The cleavage by NE results in dissociation of the FRET fluor

152 Cleavage by NEIL3 is the primary unhooking mechanism for

153 The nanosensors shed volatile reporters upon cleavage by neutrophil elastase, an inflammation-associa

154 Cleavage by NS3-4A occurs at Cys 11, removing the cytoso

155 ctivation of Riplet but does not affect MAVS cleavage by NS3-NS4A.

156 ally using kinetic isotope effects show that cleavage by oxidative addition of an O-H bond in H2O is

157 and the two IGFBP-4 fragments generated upon cleavage by PAPP-A were all decreased following treatmen

158 hia coli, cell elongation requires crosslink cleavage by PG endopeptidases to make space for the inco

159 ent to target a protein for export, and that cleavage by plasmepsin V is not coupled directly to the

160 These FXII mutants rapidly activate after cleavage by plasmin, escape from inhibition through C1 e

161 ce new sites that are sensitive to enzymatic cleavage by plasmin.

162 ion procedure or primed by limited selective cleavage by plasmin.

163 Inositol cleavage by PLCgamma1 simultaneously triggers both endop

164 ed greater susceptibility to redox-dependent cleavage by proteases present in serum.

165 bitrary DNA sequences could be addressed for cleavage by protein engineering, ushering in the breakth

166 ases, and the dependence of S. aureus on L27 cleavage by Prp validates the enzyme as a target for pot

167 phosphorylation by c-Abl affects galectin-3 cleavage by PSA.

168 We show that ATP-dependent DNA cleavage by R-proteins occurs at fixed positions (6-7 nu

169 /monomer) are required for site-specific DNA cleavage by R-proteins.

170 s in vivo and in vitro, and enhances 3' tail cleavage by Rad1/Rad10 in a purified system in vitro.

171 The susceptibility of gene segments to cleavage by RAG is associated with gene transcription an

172 The susceptibility of gene segments to cleavage by RAG is associated with histone modifications

173 ue (K233) results in a large increase of DNA cleavage by RAG1/2.

174 hat the Dsc E3 ligase acts on SREBP prior to cleavage by Rbd2.

175 based reporters that become fluorescent upon cleavage by recombinant DENV-2/ZIKV proteases in vitro A

176 ations in DSP-PP(240) had similar effects on cleavage by recombinant human BMP1, a candidate physiolo

177 mparts RNA-selective cleavage or to indirect cleavage by recruiting an endogenous nuclease, or a ribo

178 (20beta-HSDH) regulates cortisol side-chain cleavage by reducing the C-20 carboxyl group on cortisol

179 sylated proteins in the ER, controlled Msb2p cleavage by regulating transcriptional induction of Yps1

180 EME1 for replication fork and flap structure cleavage by relaxing substrate specificity.

181 strategies as (i) bisulfite treatment, (ii) cleavage by restriction endonucleases, and (iii) immuno/

182 to an unusual mechanism of PT-dependent DNA cleavage by restriction enzymes in the face of partial P

183 in IRTT, rendering the sequence resistant to cleavage by RgpB.

184 that the most important determinant for mRNA cleavage by ribosome-dependent toxins is interaction wit

185 cules: the light-regulation of catalytic RNA cleavage by RISC and the light-regulation of seed region

186 RNA cleavage by RNA polymerase (RNAP) is the central step in

187 iversal bacterial factor that stimulates RNA cleavage by RNA polymerase (RNAP), the functions of line

188 efficiently inhibits unstimulated transcript cleavage by RNAPII.

189 domain protein, CsrD, which targets them for cleavage by RNase E.

190 NA, GcvB, and the protein, Hfq, which reduce cleavage by RNase E.

191 re ASOs, 3'-SpSpRp, that promotes target RNA cleavage by RNase H1 in vitro and provides a more durabl

192 ng, which immediately triggered cellular RNA cleavage by RNase L and arrested host protein synthesis.

193 replication; however, the RNAs targeted for cleavage by RNase L under these conditions have not been

194 ion initiation factor eIF2 and stimulate RNA cleavage by RNase L.

195 suggests that viral RNPs are susceptible to cleavage by RNase L.

196 mRNA is a substrate for endoribonucleolytic cleavage by RNase mitochondrial RNA processing (MRP) and

197 d signaling enzymes, and myofilament protein cleavage by ROS-activated proteases) that have been impl

198 the mechanisms underlying symmetrical strand cleavages by RuvC, we performed crystallographic and bio

199 seudomonas sp. strain DCA1) versus C-Cl bond cleavage by S(N)2 reaction (Xanthobacter autotrophicus G

200 y establishes atomic mechanisms of substrate cleavage by separase and suggests competitive inhibition

201 Our results suggest that rapid cohesin cleavage by separase requires a substrate docking intera

202 ing S and destroyed at anaphase through Scc1 cleavage by separase.

203 receptor that is activated after proteolytic cleavage by serine proteases, including mast cell trypta

204 -length 135-kDa precursor though proteolytic cleavage by serine proteases.

205 Simulations of DNA cleavage by SgrAI uncover the origins of the kinetic adv

206 ellular fragment of ODZ1 through proteolytic cleavage by signal peptide peptidase-like 2a.

207 ns were also shown to be prone to hydrolytic cleavage by SIRT1-3 and SIRT6, supporting recent finding

208 endoplasmic reticulum (ER) to the Golgi for cleavage by site-1 and site-2 proteases.

209 ease-targeted chimeras, RIBOTACs) and direct cleavage by small molecules have also been developed.

210 We investigated whether blocking BCMA cleavage by small-molecule GS inhibitors (GSIs) could au

211 RNA cleavage by some endoribonucleases and self-cleaving rib

212 (UTR) that renders it directly refractory to cleavage by SOX.

213 ichia coli, the d-Ala-mDAP cross-links whose cleavage by specialized endopeptidases is crucial for ex

214 ATP level was not necessary for Pro-sigma(K) cleavage by SpoIVFB, based on analysis of mutants that b

215 idate features of Pro-sigma(K) important for cleavage by SpoIVFB, coexpression of the two proteins in

216 wise unreactive amide bond towards sigma N-C cleavage by switchable coordination.

217 nstead serve as activators that stimulate PG cleavage by target enzymes called amidases to promote ce

218 nation of mtDNA copies that results from its cleavage by targeted nucleases, with broad implications

219 ulation of the stability of MLL1 through its cleavage by taspase1, which can be harnessed for targete

220 this context, in further support of a direct cleavage by TF/FVIIa.

221 ay-selective PAR2 mutant resistant to direct cleavage by TF:FVIIa and FXa was activated by these prot

222 ibility to ubiquitin-independent ("default") cleavage by the 20S core proteasome was unchanged.

223 o show that eIF4E promotes the rate of eIF4G cleavage by the 2A protease.

224 omponent C3/C3b/C3c and potently inhibits C3 cleavage by the alternative pathway.

225 NLRP1B inflammasome is activated upon direct cleavage by the anthrax lethal toxin protease.

226 ate guide RNAs that direct site-specific DNA cleavage by the Cas9 endonuclease in cultured cells.

227 e SMN pre-mRNA by specifically inhibiting 3' cleavage by the cleavage and polyadenylation specificity

228 found that the target RNA per se induces DNA cleavage by the Cmr complex in vitro.

229 OS-1 cells is exclusively dependent on prior cleavage by the convertases, because both R198A and R221

230 nding of the PAM-dependent, crRNA-guided DNA cleavage by the Cpf1 family nucleases.

231 ey are generated following transcription and cleavage by the DROSHA/DGCR8 and DICER/TRBP/PACT complex

232 The major cleavage by the endonuclease activity occurs at a positi

233 The AAA+ GTPase McrB powers DNA cleavage by the endonuclease McrC.

234 Premature termination requires RNA cleavage by the endonuclease subunit of Integrator, but

235 slocated MLL1 is a substrate for proteolytic cleavage by the endopeptidase threonine aspartase 1 (tas

236 In metazoans, cleavage by the endoribonuclease SMG6 is often the first

237 virus F must undergo endocytic recycling and cleavage by the endosomal/lysosomal protease cathepsin L

238 itiated events, mutations reflect sequential cleavage by the enzyme.

239 ion that the sequence context influences the cleavage by the enzymes can be interpreted as a hint for

240 ein products generated from intramembraneous cleavage by the gamma-secretase complex is not well defi

241 In stationary phase, surface M1 protein cleavage by the GAS cysteine protease SpeB eliminated Fg

242 n cells and are activated through sequential cleavage by the Golgi-localized Site-1 and Site-2 protea

243 e ribonuclease Csm6, rather than through DNA cleavage by the HD domain.

244 xylation of the olefin with oxone, oxidative cleavage by the in situ-generated 3,4,5,6-tetramethyl-2-

245 Mature IL-1beta secretion requires cleavage by the inflammasome.

246 ansmembrane macrophage proteins subjected to cleavage by the inflammation-responsive protease ADAM17.

247 ediator of innate immune defense because its cleavage by the inflammatory caspases 1, 4, 5, and 11 yi

248 d bilayer of the inner membrane, followed by cleavage by the inner membrane peptidase.

249 ther intramembrane proteolysis, specifically cleavage by the intramembrane-cleaving aspartyl protease

250 on or that the glycans are desulfated before cleavage by the lyases.

251 cts the peptidoglycan of dividing cells from cleavage by the major autolysin LytA and occurs at the s

252 In analyzing site-specific DNA cleavage by the mammalian RAG1-RAG2 recombinase, which i

253 of A2E photodegradation resulted in reduced cleavage by the matrix metalloproteinases MMP2 and MMP9.

254 posite precursor protein Atp25 upon internal cleavage by the matrix processing peptidase MPP, and in

255 P binding by the CBS domain and Pro-sigma(K) cleavage by the membrane domain.

256 the result of an increased susceptibility to cleavage by the metalloprotease ADAM10.

257 d TA-dinucleotide repeats are susceptible to cleavage by the MUS81 nuclease, leading to massive chrom

258 MutSgamma directly stimulates DNA cleavage by the MutLgamma endonuclease.

259 tically, the Abs also bound and inhibited C3 cleavage by the nephritic factor-stabilized convertase.

260 unodominant peptide of MOG is susceptible to cleavage by the NOX2-controlled cysteine cathepsins L an

261 tructure of cellular pre-mRNA to promote its cleavage by the PA subunit.

262 a unique phenomenon of PEDV nucleocapsid (N) cleavage by the PEDV-encoded 3C-like protease (3Cpro) du

263 that the N terminus of LapA is required for cleavage by the periplasmic cysteine protease LapG and r

264 e p15NC must interact with RNA for efficient cleavage by the PR.

265 are necessary for efficient RNA binding and cleavage by the proteins associated with the two major s

266 precursor protein (APP) endoproteolysis and cleavage by the rate-limiting beta-site enzyme 1 (BACE1)

267 s, thus allowing activation upon proteolytic cleavage by the respective proteases.

268 fied that interact with APP and modulate its cleavage by the secretases.

269 NPTAB activity is dependent upon proteolytic cleavage by the SKI-1/S1P protease.

270 In particular, we detected 5'splice site cleavage by the spliceosome, showing that cleaved upstre

271 force synapsis of the transposon ends before cleavage by the transposase occurs.

272 structure in positioning each DNA strand for cleavage by the two Cas9 nuclease domains is unknown.

273 DNA cleavage by the Type III restriction enzymes requires lo

274 Following cleavage by the unknown protease, the N-terminal portion

275 Cleavage by the wild-type enzyme is not activated by unr

276 d some of the linkages that are resistant to cleavage by the wild-type enzyme.

277 This accelerated site-specific DNA cleavage by the zinc-finger nuclease, without enhancing

278 cellular proteases, we show that proteolytic cleavage by these enzymes is not a prerequisite for TapA

279 luence the rate of 5'-monophosphate-assisted cleavage by these two ribonucleases.

280 however, the biological significance of MLL1 cleavage by this endopeptidase remains unclear.

281 flammatory activity modulated by proteolytic cleavage by thrombin and plasma carboxypeptidase B2 (CPB

282 Water-soluble fibrinogen, following cleavage by thrombin, self-polymerize to form water-inso

283 Upon cleavage by thrombin, the B-domain and the associated PE

284 NAD(+) cleavage by TIR domains is therefore a conserved feature

285 ered allele that is susceptible to inducible cleavage by tobacco etch virus protease.

286 MPs blocking interaction with receptors, and cleavage by tolloid proteinases is thought to relieve th

287 Our data suggest that increased cadherin cleavage by transgenic MMP20 in the WT background releas

288 PAR-2 is activated via proteolytic cleavage by trypsin-like serine proteases, including kal

289 Cleavage by Tsp occurs in the periplasmic domain of TcpP

290 We detected cleavage by two out of three transcription activator-lik

291 Upon transcript binding, DNA cleavage by type III effector complexes is activated.

292 endent enzymes enhance the rate of C-Co bond cleavage by up to approximately 10(12)-fold to generate

293 to monitor the kinetics and products of RNA cleavage, by use of a program designed to mass-match obs

294 ; (ii) the LnmJ-SH domain catalyzes C-S bond cleavage by using l-cysteine and l-cysteine S-modified a

295 h a thrombospondin type 1 motif, member 13), cleavage by which in the VWF A2 domain is dependent on e

296 In the absence of Ca(2+), S-2288 cleavage by wild-type HABP2 was Na(+)-dependent, with Km

297 GreA factors activate RNA cleavage by wild-type RNAPs to similar levels.

298 a classical competitive inhibitor of PF-3688 cleavage by Xase.

299 yme and the 5' end created from an endolytic cleavage by yeast at a site distinct from where potato e

300 Constitutive OPA1 cleavage by YME1L and OMA1 at two distinct sites leads t