ライフサイエンスコーパス: cleavage site

1 enza B virus (IBV) HA possessing a monobasic cleavage site.

2 quences homologous to the targeted gRNA/Cas9 cleavage site.

3 ions (indels) or other rearrangements at the cleavage site.

4 es a pri-miRNA and accurately identifies the cleavage site.

5 ophin release and determined the exact BMP-1 cleavage site.

6 resistance to BVM cluster around the CA-SP1 cleavage site.

7 rotein (gp)41 elements proximal to the furin cleavage site.

8 r-219, 50 amino acids downstream of the BMP1 cleavage site.

9 t overlap or are immediately upstream of the cleavage site.

10 e site, thereby having minimal impact on the cleavage site.

11 catalysis and allow hydrolases to access the cleavage site.

12 e G40 and adenosine A32 close to the G53-U54 cleavage site.

13 leavage peptide and blue light to uncage the cleavage site.

14 nt of the guide or target strands and at the cleavage site.

15 r a modified amide bond at the main protease cleavage site.

16 d inhibitory peptides derived from a cohesin cleavage site.

17 ine teschovirus 1 (PTV-1) 2A autoproteolytic cleavage site.

18 d PAR1 signaling independent of the protease cleavage site.

19 ase in readout of information content at the cleavage site.

20 tation (App(s)), also located near the BACE1-cleavage site.

21 ognizes HS substrate and selects a favorable cleavage site.

22 ucture of S2 proximal to the secondary (S2') cleavage site.

23 the S1/S2 boundary resulting in a furin-like cleavage site.

24 only used to create a single DSB at a unique cleavage site.

25 NH nuclease domain positioning away from the cleavage site.

26 nal changes in VWF that reveal the A2 domain cleavage site.

27 on of protease-specific substrates and their cleavage sites.

28 its precision and wide coverage of different cleavage sites.

29 fferent predictors for the identification of cleavage sites.

30 ursor localize in close proximity to the SSU cleavage sites.

31 h the protease, 32 of which were outside Gag cleavage sites.

32 cleavage is regulated by acetylation of the cleavage sites.

33 dictions of other, distinct target substrate-cleavage sites.

34 tion by trypsin/chymotrypsin by exposing new cleavage sites.

35 es, revealing the hydrophobic nature of Tiki cleavage sites.

36 genes, and binds RNA motifs downstream from cleavage sites.

37 cilitating access of the protease to the Gag cleavage sites.

38 d PAR1 signaling independent of the protease cleavage sites.

39 caspase and matrix metalloprotease substrate-cleavage sites.

40 f the prodomain distant from the proteolytic cleavage sites.

41 genic ancestors via acquisition of polybasic cleavage sites.

42 se proximity to each other and autocatalytic cleavage sites.

43 on of protease-specific substrates and their cleavage sites.

44 etrate regions with a low density of trypsin-cleavage sites.

45 redictor of protease-specific substrates and cleavage sites.

46 ult in the deletion of sequences between the cleavage sites.

47 formed other predictors for calpain-specific cleavage sites.

48 long the translocation coordinate toward the cleavage site, a 4-nucleotide RNA experiences a free ene

49 ncluded the presence of a signal peptidase I cleavage site, a predicted beta-barrel fold, and cross-p

50 te-directed (Arg-to-Ala) mutagenesis of this cleavage site abolished matriptase-mediated APP processi

51 t that SARS-CoV-2 has evolved a unique S1/S2 cleavage site, absent in any previous coronavirus sequen

52 The C62-A63 step at the cleavage site adopts a splayed-apart orientation, with f

53 The determination of important cleavage sites allowed the development of selectively mo

54 the junction of the signal peptidase (Spase) cleavage site along with a well conserved lipobox motif.

55 The smaller conformer of melittin has fewer cleavage sites along the peptide backbone than the large

56 Peptide cleavage site analysis suggested that several, and not o

57 express a TEVp (tobacco etch virus protease) cleavage site and a SpyTag (st) between cMyBP-C domains

58 of the SARS-CoV-2 S glycoprotein, the furin cleavage site and D614G, have evolved to balance virus i

59 the Scc1 substrate that is distinct from the cleavage site and is required for rapid and specific sub

60 protease, activates PAR1 through a distinct cleavage site and promotes anti-inflammatory responses,

61 the spike glycoprotein, including the furin cleavage site and the D614G natural mutation, that modul

62 tracellular site different from the thrombin-cleavage site and thus initiates biased receptor signali

63 specifically bind to the GPIbalpha shedding cleavage site and to inhibit its shedding.

64 orly understood; MMPs have limited access to cleavage sites and are inhibited by tension on the fibri

65 t methods for quantifying on- and off-target cleavage sites and associated deletions remain nascent.

66 We defined the cleavage sites and boundaries between the processed prot

67 e genomes, enriched with eukaryotic protease cleavage sites and combined with additional domains to f

68 ied the exact MMP14-mediated Tie2 ectodomain cleavage sites and could show that pharmacological MMP14

69 ytical methods are required to identify main cleavage sites and degradation products of GalNAc conjug

70 Initial DNA cleavage sites and end trimming varied by nuclease, guid

71 e to a database of experimentally determined cleavage sites and experimentally validated for four epi

72 d peptide substrates on the basis of protein cleavage sites and found similar catalytic efficiencies

73 Broad identification of optimal cleavage sites and natural substrates of proteases is cr

74 Cas1-Cas2 integration and defines the exact cleavage sites and specificity of Cas4.

75 aling from PARs is influenced by alternative cleavage sites and the physical interactions within the

76 cription factor, a LOV domain-caged protease cleavage site, and a calcium-activated TEV protease that

77 influenza viruses is cleaved at a monobasic cleavage site, and a number of proteases have been shown

78 eam and 7 or 8 bp of dsRNA downstream of the cleavage site, and bacterial EndoV binds only 2 or 3 nt

79 region, the loops contiguous to the protease cleavage sites, and the latency-associated structural el

80 peptides, frequency of peptides with missed cleavage sites, and the reproducibility of FASP.

81 on of protease-specific substrates and their cleavage sites, and will facilitate hypothesis-driven fu

82 that residues on the C-terminal side of the cleavage site are most sensitive to changes.

83 ditional experiments reveal that 85% of Cas9 cleavage sites are also found by other in vitro-based me

84 MPP cleavage sites are also present in other mitochondrial f

85 The identified cleavage sites are not at a fixed distance position rela

86 cleavage sites Leu-81 and Leu-148, autolytic cleavage site Arg-122, and restoration of the missing di

87 HPV16 L2 contains two consensus cleavage sites, Arg5 (2RHKR5) and Arg12 (9RTKR12).

88 n, which inserts the segment upstream of the cleavage site as an extra beta-strand in a central beta-

89 Serial truncation mapping identified the cleavage site as Leu(90)/Val(91) in the 95-amino acid AD

90 g a different insertion at the hemagglutinin cleavage site, as well as nine nucleotide differences at

91 express RIPK1(D325A), in which the caspase-8 cleavage site Asp325 had been mutated, died mid-gestatio

92 d to define transcription initiation and RNA cleavage sites associated with all polyadenylated viral

93 ndeed, computational prediction of substrate-cleavage sites associated with MMPs is a challenging pro

94 ediated degradation was due to an additional cleavage site at Leu-148 in the autolysis loop and the l

95 he SARS-CoV-2 S glycoprotein harbors a furin cleavage site at the boundary between the S(1)/S(2) subu

96 The identification of the 3Cpro cleavage site at the C terminus of N supported previous

97 haFXIIa (FXII-R353A), or lacking the 3 known cleavage sites at Arg334, Arg343, and Arg353 (FXII-T, fo

98 ion strategy to introduce artificial tryptic cleavage sites at Cys29 and Cys33 in rhEPO.

99 oughput sequencing technology to define TOP2 cleavage sites at single-base precision, and use the tec

100 582-nucleotide insertion, flanked by 3C(pro) cleavage sites at the 5' and 3' ends, was found in the 2

101 ed to contain conserved thrombin-susceptible cleavage sites based on sequence analysis, and heavy cha

102 rate prior to T1 closure such that the U5-A6 cleavage site becomes embraced to achieve its cleavage c

103 Next, we replace the cleavage site between gp120 and gp41 with various linker

104 introduced a previously developed enzymatic-cleavage site between helices E and F and pulled from th

105 ave an Arg residue at the P4 position of the cleavage site between the nonstructural protein P1 (nsP1

106 centrin deficiency or mutation of a separase cleavage site blocked DNA damage-induced PCM expansion.

107 Mutation of the cleavage site blocks cleavage and inhibits autophagy in

108 Acquisition of the furin cleavage site by the SARS-CoV-2 S glycoprotein decreased

109 hat cells clear trailing chromatids from the cleavage site by undergoing two phases of cell elongatio

110 ncluding processing of 8 of the 13 substrate cleavage sites by dengue virus NS2B/NS3 protease.

111 e findings suggest that RNase E searches for cleavage sites by scanning linearly from the 5'-terminal

112 enzyme has generally been thought to locate cleavage sites by searching freely in three dimensions.

113 strate cleavages so that conservation of the cleavage site can be assessed.

114 ures with Pb(2+) and the modification at the cleavage site captured the pre-catalytic state of the RN

115 The conserved cleavage site, close to the L2 N terminus, confounds obs

116 f the typical six- to eight-residue protease cleavage sites compared to state-of-the-art synthetic pe

117 ospacer-adjacent motif (PAM) near the target cleavage site, constraining the sequences accessible for

118 n HIV-1 subtype-B, specific mutations in Gag cleavage sites (CS) are associated with treatment failur

119 ervations suggest that cleavage at the furin-cleavage site decreases the overall stability of SARS-Co

120 cles pseudotyped with the wild-type or furin cleavage site-deficient S protein of SARS-CoV-2.

121 ts revealed that tandem stem-loops 3' to the cleavage site define optimal, correctly-positioned cleav

122 We find that the distance between two Top1 cleavage sites determines the deletion size and that thi

123 ble in the serum of mice, mutating the furin cleavage site did not alter the stimulation of hepcidin

124 A SARS-CoV-2 mutant with an altered furin cleavage site did not depend on NRP1 for infectivity.

125 this system to examine the role of a caspase cleavage site, DQVD, within the HAZV nucleocapsid protei

126 protease activity both in vitro and at H3NT cleavage sites during osteoclastogenesis.

127 found that, besides the previously reported cleavage site E349 in NEMO, scission by PRRSV nsp4 took

128 ffect, stabilizing mRNA by protecting distal cleavage sites en masse from ribonuclease attack.

129 tem to test the importance of a DQVD caspase cleavage site exposed on the apex of the HAZV nucleocaps

130 Two mutations, one in the fusion (F) protein cleavage site, F117S (F117S), and another in hemagglutin

131 phosphorylates MLL1 proximal to the taspase1 cleavage site, facilitating its cleavage, and pharmacolo

132 ur models stems from the use of high-quality cleavage site features extracted from the substrate sequ

133 In PAM-1/OSX, a cleavage site for furin-like convertases was exposed, ge

134 pr construct, in which 2xCL denotes a tandem cleavage site for the viral protease.

135 The major cleavage sites for all four proteases are found in the C

136 age site within PBS1 can be substituted with cleavage sites for other pathogen proteases, which then

137 e site within PBS1 can be altered to contain cleavage sites for other proteases, enabling RPS5 activa

138 QGAP1 amino acid sequence revealed potential cleavage sites for proteases of the proprotein convertas

139 ght peptides encompassing predicted protease cleavage sites for Serp-1 and NSP were synthesized and t

140 uency analysis to discover the most frequent cleavage sites for similar amide bonds, defined based on

141 ide and residues downstream of the canonical cleavage site form an extended alpha-helix in the ER mem

142 overed that A673V mutation shifted the BACE1 cleavage site from the Glu(11) to the Asp(1) site, resul

143 ith sequences derived from putative ZMPSTE24 cleavage sites from amphibian, bird, and fish prelamin A

144 ) the presence or absence of endonucleolytic cleavage sites, (g) control of intracellular ribonucleas

145 ith single nucleotide resolution, DNA gyrase cleavage sites (GCSs) throughout the Escherichia coli ge

146 e frequently applied to analyze and validate cleavage sites guided by microRNAs (miRNAs).

147 an "immature" Chikungunya virus in which the cleavage site has been mutated to inhibit proteolysis.

148 Sequences closer to the cleavage site have critical but redundant roles in both

149 Three classes of cleavage sites have been identified and characterized: (

150 ck-in mice bearing a mutation of MET caspase cleavage site highlighted that p40MET production is impo

151 esulting in a set of 55 high-confidence gRNA cleavage sites identified by both methods.

152 ated by sequence immediately upstream of the cleavage site, (ii) deletions are predominantly associat

153 The F117S mutation in the F protein cleavage site improved F protein cleavage efficiency whi

154 ase domain adjacent to the target DNA strand cleavage site in a conformation essential for concerted

155 hat cells clear trailing chromatids from the cleavage site in a two-step cell elongation and demonstr

156 ed and optimally positioned to encounter the cleavage site in acyl-CoA.

157 transcription termination downstream of the cleavage site in an XRN2-dependent manner.

158 n collagen cross-linking sites and the MMP-1 cleavage site in collagens I and II.

159 Eliminating the Bmp1/TLD cleavage site in gliomedin or treating myelinating cultu

160 golins, SARS-CoV-2 harbors a polybasic furin cleavage site in its spike (S) glycoprotein.

161 type and mutant SARS-CoV-2 lacking the furin cleavage site in S protein could utilize ACE2 from a bro

162 The absence of the polybasic cleavage site in SARS-CoV-2 did not affect virus replica

163 lts highlight the importance of this caspase cleavage site in the HAZV life cycle but reveal the DQVD

164 o 21-bp direct repeats and a major terminase cleavage site in the phage genome.

165 soschizomer I-BmoI which targets a different cleavage site in the thymidylate synthase gene, recapitu

166 We found that the cleavage site in this 1192-amino-acid-long fragment is l

167 ryotic and eukaryotic type II topoisomerases cleavage sites in a variety of organisms and paves the w

168 P) fragments located between the S1P and S2P cleavage sites in cells exposed to ER stress.

169 ed accessibility of the enzymes to potential cleavage sites in folded proteins.

170 We have identified caspase-3 cleavage sites in GIRK1 ((387)ECLD(390)) and GIRK2 ((349

171 Site-directed mutagenesis of the phytaspase cleavage sites in prosystemin abrogated not only the phy

172 -RNA-seq) revealed ~25,000 RNase E-dependent cleavage sites in Vibrio cholerae, several of which resu

173 ation-free long-read sequencing reveals Cas9 cleavage sites in vitro that would have been difficult t

174 Our analysis of cleavage sites indicates that cleavage requires multiple

175 -terminal gasdermin D region adjacent to the cleavage site, influences gasdermin D recognition by cas

176 at it is processed proteolytically at a WGSS cleavage site into a heterodimer.

177 The cleavage site is 11/9 nucleotides downstream of the A re

178 ither the mRNA polyadenylation signal and/or cleavage site is an efficient strategy to down-regulate

179 ologically relevant on the basis that such a cleavage site is likely to be conserved.

180 rhEPO is compromised, as no natural tryptic cleavage site is located between the glycosylation sites

181 For each VWF monomer, the ADAMTS13 cleavage site is located deeply buried inside the VWF A2

182 The -cleavage site is only one amino acid N-terminal to a Val

183 This should help establish whether or not a cleavage site is physiologically relevant on the basis t

184 the domain immediately downstream of the S2' cleavage site is the FP (amino acids 798-818 SFIEDLLFNKV

185 suggest that host DSB repair at CRISPR/Cas9 cleavage sites is a novel and important pathway that may

186 2 that either directly affect the furin-like cleavage site itself (NSPRRAR) or a flanking sequence (Q

187 -2 that either directly affect the polybasic cleavage site itself (NSPRRAR) or a flanking sequence (Q

188 ructure of the BMV capsid shows four trypsin cleavage sites (K(65), R(103), K(111), and K(165) on the

189 , thermolysin/neutral protease share similar cleavage sites, L( downward arrow)G and P( downward arro

190 s achieved by simultaneous mutations of CTRC cleavage sites Leu-81 and Leu-148, autolytic cleavage si

191 trimental APP mutation at the beta-secretase cleavage site linked to early-onset AD found in a Swedis

192 ensor containing the flavivirus internal NS3 cleavage site linker reported the highest fluorescence a

193 followed by site-directed mutagenesis of the cleavage sites links receptor activation to specific ami

194 ism whereby protease recognizes distinct Gag cleavage sites, located in the intrinsically disordered

195 e PICS (proteomic identification of protease cleavage sites) method are similar for both KLK2 variant

196 guanosine residue 3-nucleotide downstream of cleavage site must not form canonical base pairing for t

197 duction in pericentrin-deficient or separase cleavage site mutant-expressing cells, and an increase i

198 pro-TGF-beta1 with the proprotein convertase cleavage site mutated to mimic the structure of the TGF-

199 ral pocket in proximity to the MMP-9 zymogen cleavage site near Arg-106, which is distinct from the c

200 mains including the lack/excess of enzymatic cleavage sites, nonunique peptide sequences, impaired pe

201 Mutagenesis of the cleavage site nullified the processing event, resulting

202 that the Q193-G194 pair within GSDMD is the cleavage site of 3C.

203 APP mutation, shifted the preferential beta-cleavage site of BACE1 in APP from the Glu(11) site to t

204 nto short CRISPR RNA guides that specify the cleavage site of Cas nucleases in the genome of the inva

205 a matrix metalloproteinase-2 and -9 specific cleavage site of COL6alpha3 (C6Malpha3) and employed in

206 we identified haplotypes with hemagglutinin cleavage site of different lengths.

207 2 (PPPY) as well as the late domain/protease cleavage site of matrix (LYPAL), by mass spectrometry an

208 esidue at position 8 (P8) of the proteolytic cleavage site of MuV F, because this amino acid residue

209 asic amino acids (KGKRTAR/G) at the protease cleavage site of the HA protein, which were previously f

210 ctural features of the 20S pre-rRNA near the cleavage site of the nuclease, Nob1.

211 SVAID contains the beta- and alpha-secretase cleavage sites of APP: proteomic analysis of the interac

212 ding was not observed at the initial epsilon-cleavage sites of C99, subtle changes in hinge flexibili

213 Most peptides were released at the cleavage sites of cathepsins B and D, which thus play an

214 r outside the active site of protease or the cleavage sites of Gag (located within intrinsically diso

215 e synthetic peptides mimicking the predicted cleavage sites of neurotoxin precursors.

216 y bound ligands did not mask any proteolytic cleavage sites of pepsin, trypsin or chymotrypsin.

217 e, were found to be abundant in the specific cleavage sites of the cocoa enzyme.

218 ecting degradation kinetics and preferential cleavage sites of the endolysosomal proteases cathepsin

219 that the mutant VWF gives access to multiple cleavage sites of the VWF multimer at the same time.

220 n of MMP-2, -3, -7, -8, -9 and -12 substrate-cleavage sites on independent tests.

221 downward arrowSAGGSVA, downward arrow shows cleavage site), on phage or coated it onto silver nanopa

222 allowed us to identify 10(4) to 10(5) unique cleavage sites over a 1,000-fold dynamic range of NGS co

223 These potential cleavage sites overlap with known motifs for lysine acet

224 e activity for the preferred residues at the cleavage site (P1, P1') and nearest-neighbor positions (

225 Three protease:cleavage site pairs from Potyvirus are shown to be ortho

226 ularly at the hemagglutinin (HA) proteolytic cleavage site (PCS) that can affect virus activation and

227 sequences surrounding the 12 viral protease cleavage sites (PCSs) provided greater than 80% protecti

228 y threefold in human coding sequences to one cleavage site per approximately 11 bp.

229 otein sequences for the presence of protease cleavage sites, Pfam domains, glycosylation sites, signa

230 termed Proteomic Identification of protease Cleavage Sites (PICS).

231 lacing Arg371 with alanine at the activation cleavage site (PK-R371A, or single-chain PK).

232 elevant features in an effort to improve the cleavage site prediction accuracy.

233 It provides optimized cleavage site prediction models with better prediction p

234 mputational approaches for protease-specific cleavage site prediction to further advance the existing

235 n bioinformatics tools for protease-specific cleavage site prediction.

236 1) APP V717I mutations alter gamma-secretase cleavage site preference.

237 ch differs from the poliovirus 3C proteinase cleavage site previously identified.

238 nce 5-A/CCGGT-3 and cuts it ('/' denotes the cleavage site) producing staggered DNA ends.

239 le the Icelandic APP mutation near the BACE1-cleavage site protects from sporadic dementia, emphasizi

240 , systematic bioinformatics studies of known cleavage sites provide important insights into caspase/g

241 bearing a mutation in the IL-1alpha thrombin cleavage site (R114Q) exhibited defects in efficient wou

242 ) precursor with alterations in the protease cleavage site (R508S/R511S) or by introducing a disulfid

243 structural homogeneity at the signal peptide cleavage site regardless of the native secretory route.

244 pared human FXII variants lacking the Arg353 cleavage site required for conversion to alphaFXIIa (FXI

245 Lastly, we demonstrate that dentilisin cleavage sites reside within critical functional domains

246 t 4 out of 4 and 7 out of 9 of the predicted cleavage sites, respectively.

247 Amino acid substitution at the cleavage site resulted in no renal excretion of AIM.

248 type DNAJC14 affected the NS3/4A and NS4A/2K cleavage sites, resulting in altered NS3-to-NS3-4A ratio

249 lectrophoresis and LC-MS/MS to determine the cleavage site(s) and Asn(347) glycosylation as a functio

250 ed by the OMA1 or YME1L proteases, acting at cleavage sites S1 and S2, respectively, to produce short

251 P673 regulates APP processing, and the BACE1 cleavage site selection is critical for amyloidogenesis

252 PP673 regulates APP processing and the BACE1 cleavage site selection is critical for amyloidogenesis

253 The conjugate containing the enzymatic cleavage site showed high extracellular stability and fa

254 Previous work has identified cleavage site signatures in substrates such as GSDMD, bu

255 nfolding of this domain, thereby leaving the cleavage site solvent-exposed and ready for cleavage.

256 repared independent test data sets with 3641 cleavage sites (specific to 10 proteases).

257 s is difficult to reconcile with the relaxed cleavage site specificity of RNase E, the endonuclease m

258 dering MMPs with few experimentally verified cleavage sites, such as for MMP-2, -3, -7, and -8.

259 e N-termini but strongly enriched at caspase cleavage sites, suggesting roles for the substrate adapt

260 nds are at or near preferred gamma-secretase cleavage sites, suggesting that the sequence of APP and

261 ts 3'-end processing of pre-miRNAs on Drosha cleavage site that correlates with miRNA-offset RNAs (mo

262 s of full-length decorin but also harbored a cleavage site that was not found in atrial appendages fr

263 As by juxtaposing poly(A) signals (PASs) and cleavage sites that are otherwise too far apart.

264 However, S proteins have two distinct cleavage sites that can be activated by a much wider ran

265 in conformation and were associated with the cleavage sites that generate the 50 kb DNA fragments dur

266 ntigenic fragments in CD4 T cells identified cleavage sites that were predictably enhanced, reduced,

267 o acid precursor protein containing multiple cleavage sites that, when cleaved, releases multiple bio

268 alpha2delta constructs containing artificial cleavage sites, that this processing is an essential ste

269 by an increased availability of the ADAMTS13 cleavage site through A2-domain-fold thermodynamic desta

270 a-helix in the ER membrane, which covers the cleavage site, thus preventing cleavage.

271 has a modification at the fusion protein (F) cleavage site to reduce the efficiency of F protein clea

272 distribute CTCF/cohesin occupancy rewire DNA cleavage sites to novel loop anchors.

273 ural explanation of accessibility of the RNA cleavage sites to the peptide with adoption of an 'in-li

274 pecifically, an out membrane protease (OmpT) cleavage site was engineered into the switch loop of RF1

275 -segments and a strategically placed SPase I cleavage site, we determined how targeting and stability

276 s residue is just before the gamma-secretase cleavage site, we then investigated whether the p75(alph

277 locus no longer produces transcripts with S2 cleavage sites, we generated a simplified system to iden

278 Signal peptidase I (SpI) cleavage sites were found in 463 of these putative secre

279 Within its protein core, 18 different cleavage sites were identified.

280 For IgG2, two pepsin cleavage sites were identified; anti-hinge reactivity wa

281 ny of the corresponding substrates and their cleavage sites were not found yet.

282 Alternative MAVS cleavage sites were used to ensure the inactivation of t

283 ssing-alternative splice sites, introns, and cleavage sites-which are often rare and lowly expressed

284 cing error-prone NHEJ events at the nuclease cleavage site, while avoiding the unwanted effects of gl

285 wo canonical sites adjacent to the necessary cleavage site, while CsrD acts by overcoming CsrA-mediat

286 ethod for predicting eight protease-specific cleavage sites, while GPS-CCD and LabCaS outperformed ot

287 Replacing the natural furin cleavage site with a HRV 3C protease site, we show how t

288 id position 5 upstream of the signal peptide cleavage site, with cleavage-inducing glycine (G) result

289 s the 5'-ruler mechanism for defining target cleavage sites, with accessibility of positions -2 to -5

290 onal analysis, we identified the FCV-induced cleavage site within G3BP1, which differs from the polio

291 We have shown that the cleavage site within PBS1 can be altered to contain clea

292 We show that the AvrPphB cleavage site within PBS1 can be substituted with cleava

293 Previous studies identified a caspase-3 cleavage site within the amyloid-beta precursor protein,

294 cleaved the aggrecan core protein at a novel cleavage site within the interglobular domain.

295 all cases the existence of a unique trypsin cleavage site within the membrane domain (out of 16 pote

296 The cleavage site within the S2 subunit responsible for acti

297 Flap closure traps the Gag cleavage sites within the catalytic cleft of protease.

298 ion and limits the accessibility of protease cleavage sites within the prodomain.

299 DAM9, 10, and 17 by meprin beta and identify cleavage sites within their prodomains.

300 of accurate predictors of the substrates and cleavage sites would facilitate understanding of proteas