ライフサイエンスコーパス: click

1 ic illicit drug used by abusers in a single "click".

2 ta according to the presence or absence of a click.

3 performing and visualizing docking in a few clicks.

4 eling, inference and visualization via mouse clicks.

5 nary proficiency in echolocation using mouth-clicks.

6 e can echolocate for example by making mouth clicks.

7 Common clinical symptoms include pain and clicking.

8 on someone else's content), "links clicked" (clicking a link to another site or article), or "status

9 Pyrene click adducts of linear alkynylated nucleosides showed p

10 ed a large increase in ultrasonic, broadband clicks after sciatic nerve injury, which was reversed by

11 In response, their click amplitude is reduced and affords acoustic protecti

12 plementation on the MR scanner, enabling one-click analysis and reporting in a manner comparable to m

13 of molecules, but their use as reactants for click and bio-orthogonal chemistry is quite recent.

14 Click and bio-orthogonal reactions are dominated by cycl

15 s review highlights the similarities between click and DEL reaction design and deployment in combinat

16 e found that shopping via bricks and clicks (click and fulfillment via physical store delivery) most

17 cantly altered their behavior as measured by clicks and purchases.

18 In our first study, we observed that the click-and-drag test was better than the conventional sta

19 We designed a click-and-drag version of the Raven test in which partic

20 mpounds from this family are able to undergo click-and-release reactions, finding interesting applica

21 Dahalo in Kenya, whose language has remnant clicks; and the Sabue in Ethiopia, who speak an unclassi

22 ple dual-wavelength, two-step polymerize and click approach for making combinatorial conjugate librar

23 ocess optimization, a finely tuned, stepwise click approach has emerged as a workable, on-demand stra

24 were prepared through a two-step sequential click approach with a combination of oxime ligation and

25 versity Oriented Clicking (DOC) is a unified click-approach for the modular synthesis of lead-like st

26 We suggest that hums and clicks are produced by either separate muscles or by a c

27 Irradiation of such a "click-armed" photocage with blue light leads to fast and

28 etually; a striated patch in their hind wing clicks as the beating wing rotates and bends.

29 abeled probes to Ebola virus RNA followed by click assembly and analysis of the read sequence by vari

30 chnology, which we call probing enzymes with click-assisted NIMS (PECAN), can detect the activity of

31 click production requires only 50 uL of air/click at 500 m depth increasing gradually to 100 uL at 1

32 Herein, we demonstrate that the use of "click"-based attachment of DNA sequencing libraries onto

33 o overcome this limitation, the gene for the click beetle (Pyrophorus plagiophtalamus) red luciferase

34 zation in cells utilizing the split enhanced click beetle luciferase (Emerald Luc, ELuc) complementat

35 ies, Spondylis buprestoides (L.), and a rare click beetle, Stenagostus rufus (De Geer).

36 We further demonstrated that CB6 click can be used in conjunction with strain-promoted az

37 ks were identified by incorporating multiple click characteristics (spectral shape and inter-click in

38 pair that is conjugated with two fluorogenic click chemicals.

39 abolic labelling combined with bioorthogonal click chemistry (that is, reactions performed in living

40 nt labels and - thanks to recent advances in click chemistry - an incredible versatility.

41 Click chemistry analyses demonstrated increased R-Ras pa

42 Ras was validated as an APT-1 substrate, and click chemistry analyses demonstrated increased R-Ras pa

43 Using click chemistry and a modified antibody array to detect

44 proteins, allowing for their detection using click chemistry and antibody arrays.

45 lly conserved compounds that are amenable to click chemistry and can be used as molecular probes in v

46 of sulfur electrophiles is key for advancing click chemistry and chemical probe discovery.

47 Whole cells are labelled via click chemistry and visualized using super-resolution mi

48 4) and sodium ascorbate independently of the click chemistry approach used (azido-COUPY/alkynyl-pepti

49 oionics an attractive opportunity for future click chemistry development.

50 Click chemistry enables conjugation of an azide molecule

51 Bioorthogonal click chemistry ensures fast and highly selective attach

52 roach is highly versatile, as it (i) enlists click chemistry for flexible protein functionalization;

53 K) that harnesses the power of bioorthogonal click chemistry for remodeling guide RNA to display synt

54 mizing reaction conditions, we converted CB6 click chemistry from a rotaxane synthesis tool into a us

55 itterionic salts, which are prepared through click chemistry from readily accessible alkynes and sulf

56 D chelator capable of direct conjugation via click chemistry has been reported.

57 al amino acid incorporation and cell surface click chemistry in bacteria with high-throughput sorting

58 trate the potential of SOF(4) -derived SuFEx click chemistry in biological applications.

59 tocol and the labeling of DNA-Pt by means of click chemistry in cells.

60 combination of genetics and maleimide-based click chemistry in which a cysteine substitution is made

61 gical and medical sciences by application of click chemistry or classic esterification and amidation.

62 Combining the siloxane crosslinker with click chemistry produces exchangeable LCE (xLCE) with tu

63 By taking advantage of a facile, one-pot click chemistry reaction, we report herein the preparati

64 ive as compared to the engineered enzyme and click chemistry reagents.

65 through the use of single-generation in situ click chemistry screens against large peptide libraries.

66 This review is focused on the emerging click chemistry that uses mesoionic compounds as dipole

67 sists uptake by cells allowing extracellular click chemistry to be performed.

68 Here, we successfully use click chemistry to construct DNA templates for sgRNA exp

69 zed peptides were synthesized by solid phase click chemistry to develop novel, potent, selective MC4R

70 ic modification of PG can be extended to use click chemistry to fluorescently label the mature PG in

71 For this purpose, we developed in situ click chemistry to functionalize SPR sensor chips.

72 Here, we use click chemistry to label viruses with integrase coupled

73 demand (EVOD) chip utilizes a catalyst-free click chemistry to rapidly and specifically isolate EVs

74 SuFEx is a new-generation click chemistry transformation that exploits the unique

75 ), and rapid and efficient radiolabeling via click chemistry with (18)F-labeled trans-cyclooctene ((1

76 diabody A2, and subsequently radiolabeled by click chemistry with (18)F-TCO.

77 with either DML or sCy5 and radiolabeled via click chemistry with (18)F-TCO.

78 can be employed for toxin derivatization by click chemistry with an azide-containing reporter molecu

79 by using fluorescent SABRAC analogues or by click chemistry with an azide-substituted analogue.

80 The merging of click chemistry with discrete photochemical processes ha

81 ght into this dynamic interface, we combined Click chemistry with pulsed stable isotope labelling of

82 ith ease", by combining classic C-C pai-bond click chemistry with recent developments in connective S

83 tes by combining stable isotope labeling and click chemistry with subsequent mass spectrometry analys

84 Herein, we describe a "click chemistry" approach for the synthesis of PROTACs.

85 ng which sulfur(VI) fluoride exchange-based "click chemistry" is currently the most prominent.

86 the most versatile bioorthogonal reactions, "click chemistry", has been exploited to overcome limitat

87 Combining ATRP signal amplification with "Click Chemistry", the optimized DNA biosensor was capabl

88 ymerization (ATRP) signal amplification and "Click Chemistry".

89 synthesized proteins were then labeled via 'click chemistry'.

90 Using click chemistry, Alexa Fluor 647 DIBO Alkyne was conjuga

91 Among the dipoles routinely used for click chemistry, azides, nitrones, isonitriles, and nitr

92 osecond photochemical reaction (nsPCR)-based click chemistry, capable of structural probing of protei

93 orthogonal amino acid using copper-catalyzed click chemistry, either before or after the silk fibers

94 Using click chemistry, PLA-b-PEG400-N(3) and PLA-b-PEG2000 blo

95 Click chemistry, proposed nearly 20 years ago, promised

96 ons via selective-pressure incorporation and click chemistry, respectively, without affecting the Ub

97 ylcyclooctyne (DBCO-Cy5.5) via bioorthogonal click chemistry, resulting in Cy5.5-labeled CTLs (Cy5.5-

98 Using click chemistry, the overexpressed sterol regulatory ele

99 Using click chemistry, we labeled newly synthesized proteins a

100 eloped a robust, high-throughput compatible, click chemistry-based approach to identify small molecul

101 transformation into acyl-CoAs and subsequent click chemistry-based detection, to demonstrate that zDH

102 axolotl salamander tissue using whole-mount click chemistry-based fluorescent staining followed by l

103 A click chemistry-based flux assay reveals that necrocytos

104 g precursor was synthesized and subjected to click chemistry-based radiosynthesis of [(18)F]FGlc-FAPI

105 s as a cellular engagement probe for MPC2 in click chemistry-enabled western blotting or global mass

106 ng and tracking strategy using bioorthogonal click chemistry.

107 matic method using the engineered enzyme and click chemistry.

108 merization modification with triazolinedione click chemistry.

109 (SuFEx) has emerged as the new generation of click chemistry.

110 proteins with a non-canonical amino-acid and click chemistry.

111 hen assembled in a combinatorial fashion via click chemistry.

112 king such functionality available for use in click chemistry.

113 ementary oligonucleotides, and bioorthogonal click chemistry.

114 ovalent cross-linking using copper catalyzed click chemistry.

115 re conjugated to IRDye 800 using copper-free click chemistry.

116 oinitiators, which makes it truly two-photon click chemistry.

117 tach different, large hydrophobic groups via click chemistry.

118 Herein, we report for the first time a "click" chemistry approach to oligonucleotide probe elong

119 hogonality and versatility of the thiol-ene "click" chemistry is expected to allow the a la carte che

120 ino acid side chains, including non-natural 'click' chemistry functionalities, to conjugate moieties

121 t reaction (thiol-acrylate/thiol-ene 'double-click' chemistry) to obtain highly uniform dynamically c

122 Here, combining metabolic labeling, click-chemistry and enzymatic reactions, and mass spectr

123 We recently reported a click-chemistry based method for generating RNAseq libra

124 corporated OP-Puro can be detected through a click-chemistry reaction that links it to a fluorescentl

125 tionally designed and developed via a facile click-chemistry type postfunctionalization, which can fo

126 active scaffolds was synthesized by means of click-chemistry under non-conventional microwave heating

127 cancer associated surface proteins into the click-chemistry, we were able to selectively recover can

128 Here we develop a click-chemistry-based enrichment strategy, DIMEN (deep i

129 sulfonates can be further functionalized via click-chemistry-based post-polymerization modification.

130 ia, enabling in vivo photo-cross-linking and click-chemistry-mediated analysis of mycolate-interactin

131 erns and directly on microelectrodes with UV-click-chemistry.

132 en explore the translational potential of EV Click Chips using 158 plasma samples of HCC patients and

133 elop an HCC EV purification system (i.e., EV Click Chips) by synergistically integrating covalent che

134 effective for rapid, unsupervised delphinid click classification across large datasets in which the

135 San, the latter of whom speak languages with clicks classified as Khoisan.

136 andawe in Tanzania, who speak languages with clicks classified as Khoisan; the Dahalo in Kenya, whose

137 We found that shopping via bricks and clicks (click and fulfillment via physical store deliver

138 Additionally, a ' click&click' procedure has been also developed, by seque

139 e, a 1-standard-deviation increase in "likes clicked" (clicking "like" on someone else's content), "l

140 ng "like" on someone else's content), "links clicked" (clicking a link to another site or article), o

141 A two-step synthesis of a Cu-click compatible alkynyl oxoaldehyde probe (AlkMGO) via

142 prosthetic group, followed by a copper-free click conjugation to a modified adnectin to generate (18

143 Here, we describe a split-and-click convergent chemical route to individual or pools o

144 dendrimer synthesis entails straightforward click coupling followed by an amidation reaction, and th

145 ly new bifunctional HBED chelator for direct click coupling.

146 ctions with pathway-dependent, hierarchical 'click' covalent assembly to produce hybrid synthetic pep

147 ng (e.g., free radical chain polymerization, click cross-linking, cross-linking due to oxidation of p

148 uch as a dependency-free, browser-based, one click, cross-platform install and better navigation inte

149 ovides a dependency-free, browser-based, one click, cross-platform solution for creating MS1 ground t

150 formation or a Cu(I)-catalyzed azide-alkyne click (CuAAC) reaction for labeling an octreotide peptid

151 e hub in concert with a diverse selection of click-cycloaddition processes.

152 modification was made possible through SuFEx click derivatization of the pendant sulfonyl fluoride gr

153 ethod was applied to a dataset of 52 million clicks detected across five monitoring sites over two ye

154 le species identification were compared with clicks detected on sea-surface towed hydrophone arrays i

155 etric platform was developed for the "lab-on-click" detection of illicit drugs in nonpretreated oral

156 underwater-recorded odontocete echolocation click detections, DetEdit can be adapted to almost any s

157 The click detector achieved 99.5% accuracy in classifying 65

158 Networks (CNNs) to construct an echolocation click detector designed to classify spectrograms generat

159 assembly of oligonucleotides into a gene by click-DNA ligation.

160 Diversity Oriented Clicking (DOC) is a unified click-approach for the modul

161 ults, make corrective edits efficiently (one-click editing of an entire nanowell video sequence in 5-

162 ent report, we collected a large database of click emissions with three blind people expertly trained

163 We demonstrate that click-ExM is applicable in cell culture systems and for

164 We further show that click-ExM is compatible with signal-amplification techni

165 Using 18 clickable labels, we demonstrate click-ExM on lipids, glycans, proteins, DNA, RNA and sma

166 Click-ExM thus provides a convenient and versatile metho

167 Here we develop click-ExM, which integrates click labeling into ExM to e

168 tly simplified user experience through a one-click Express Analysis interface to generate interpretab

169 Using 27000 clicks from 102 dives of 23 tagged pilot whales (Globice

170 After coating with click-functional multidentate polymers, the VIR-QD spect

171 y introduced in chemical biology probes as a click handle to identify molecular targets and to assess

172 itors that contain a trans-cyclooctene (TCO) click handle, we are able to enrich and characterize the

173 linking in a sequential manner, as well as a click-handle for subsequent functionalization.

174 Posted December 8, 2017.Click HERE to access Teaching Tool Components.

175 ctions themselves.(Posted September xx, 2019)Click HERE to access Teaching Tool ComponentsRECOMMENDED

176 ls for 2030 is proposed.(Posted July 6, 2020)Click HERE to access Teaching Tool ComponentsRECOMMENDED

177 of plant proteins.(Posted December 10, 2019)Click HERE to access Teaching Tools ComponentsRECOMMENDE

178 The ASSR paradigm (1 ms, 85 dB clicks in 250-0.5 s trains at a frequency of 40 Hz; 0.5

179 flex, and the auditory-brainstem response to clicks in various levels of background noise.

180 Here we test this hypothesis by analysing click-induced acoustic resonances in the nasal air sacs,

181 rge MinION datasets via a friendly point-and-click interface using commodity hardware.

182 heir collaborators can execute via point and click interfaces.

183 ck characteristics (spectral shape and inter-click interval distributions) to distinguish within-type

184 opargyl-puromycin and L-homopropargylglycine Click-iT technologies, and determined that these cells s

185 Here we develop click-ExM, which integrates click labeling into ExM to enable a 'one-stop-shop' meth

186 Because click labeling with 5-ethynyl-2'-deoxyuridine is hampere

187 By click labeling with biotin and staining with fluorescent

188 e and accumulate more TCO-nanoaggregates for click labeling.

189 poles and cyclic dienes, we report a diverse click-library of 173 unique functional molecules in mini

190 Click ligation of the two components generates an artifi

191 ndard-deviation increase in "likes clicked" (clicking "like" on someone else's content), "links click

192 reports the use of an isothiocyanate-amine "click"-like reaction between isothiocyanate-containing s

193 The resulting click-linked iLOV gene contains eight triazoles at the s

194 We report a double-click macrocyclization approach for the design of constr

195 demonstrating the application of the double-click macrocyclization approach to non-helical, extended

196 In addition, ultrasonic clicks may objectively represent mouse pain status and c

197 ability; this engine allows quick point-and-click modification of almost every graphic feature.

198 oaches, including site-directed mutagenesis, Click O-GlcNAc labeling, immunoblotting, and immunofluor

199 to 100 could be given by an equally low-cost click on the screen), scores correlated only weakly with

200 screen functionality on their smart phone to click on VAS scores (ranging from 0 to 100) for overall

201 iologists with interactive decision support (clicking on a breast region yields a local cancer likeli

202 The tool also provides a one-click option for adding articles manually via digital ob

203 l-, aryl-, and H-tetrazines, irrespective of click orientation.

204 jects (322 +/- 143 compared with 246 +/- 149 clicks; P = 0.04) but not controls (248 +/- 119 compared

205 (ES: 980 +/- 371 compared with 1700 +/- 584 clicks; P = 0.16; controls: 1056 +/- 274 compared with 1

206 ols: 1056 +/- 274 compared with 1124 +/- 273 clicks; P = 0.81).

207 trols (248 +/- 119 compared with 247 +/- 120 clicks; P = 0.97).

208 ying Yponomeuta produce bursts of ultrasonic clicks perpetually; a striated patch in their hind wing

209 Echolocating toothed whales produce powerful clicks pneumatically to detect prey in the deep sea wher

210 ed with the use of a fluorogenic azide-based click probe led to the discovery and characterization of

211 of this platform further enables a cascade "click" process where the "unmasked" Cp can rapidly react

212 tocatalyzed cycle was suggested in which the click product acts as a catalyst.

213 accomplished by monitoring formation of the click product.

214 s (Globicephala macrorhynchus), we show that click production requires only 50 uL of air/click at 500

215 lyl deprotection in situ to give the ynamine click products.

216 We used click proteomics and click sequencing to explore the gen

217 nes, leading to 3 orders of magnitude higher click rates compared to the parent reaction, and 4 to 6

218 acted as a catalytic machinery catalyzing a click reaction (= signal amplification).

219 f boronic ester formation as a bioorthogonal click reaction between abiotic boronic acids and diols.

220 Here, we use the click reaction between alkynes and azides as an example

221 catalyzed azide-alkyne dipolar cycloaddition click reaction between either a library peptide and a kn

222 permeable SCNP can efficiently catalyze the click reaction extracellularly, thereby enabling in situ

223 conjugates using an ultrafast and reversible click reaction in a post-polymerization functionalizatio

224 T) process, after which the deprotection and click reaction is triggered by UV light.

225 the same Cu(I)-SCNP perform a more efficient click reaction on modified protein surfaces and cell sur

226 The copper(I)-catalyzed click reaction on the tripropargylamino nucleoside was s

227 c acid) into redox enzymes, followed by an S-click reaction to wire the enzyme to the electrode, faci

228 reptavidin-conjugated UCNPs were prepared by click reaction using an alkyne-PEG-neridronate linker.

229 hesized using highly robust copper-catalyzed click reaction with high purity.

230 coupling, Huisgen 1,3-dipolar cycloaddition (click reaction), hydroheteroarylation, hydrosilylation r

231 cluding terminal alkyne, heterocycle through click reaction, and others.

232 , by sequential combination of TMA and CuAAC click reaction, as an easy and quick way to build comple

233 Using an orthogonal Click reaction, Green Fluorescent Protein (GFP) was engi

234 alyzed alkyne-azide cycloaddition (CuAAC), a click reaction, is one of the most powerful catalytic re

235 ON/OFF a catalytic conjugate addition and a click reaction.

236 gs (PFBHA and PFBHA- d(2)) through the oxime click reaction.

237 ular capsules by taking advantage of the TMA click reaction.

238 to functional molecules via an azide-alkyne click reaction.

239 ved by solid phase synthesis with the global click reaction.

240 nt polymer with a tetrazine/transcyclooctene click reaction.

241 zed, followed by a step-growth azide-alkyne "click" reaction between the 4th-generation diazido dendr

242 ore stable than unsupported cluster 1 under "Click" reaction conditions.

243 n, this cycloaddition is considered to be a "click" reaction with many applications in chemical biolo

244 ddition of azides and alkynes (the CuAAC or "click" reaction) as the protocol for the final macrocycl

245 target through azide-alkyne cycloaddition ("click" reaction).

246 nyl groups with azido containing SWCNTs via "Click" reaction.

247 Cu(I)-catalysed azide-alkyne cycloaddition 'click' reaction(18).

248 These light-triggered click reactions allow the synthesis of diverse organic s

249 These click reactions fulfilled key criteria (broad scope, qua

250 , Sonogashira couplings or Huisgen-Sharpless click reactions have been used for late-stage diversific

251 Although a number of click reactions were developed for this purpose, many ar

252 Click reactions were performed with 1-azidomethylpyrene

253 "Click reactions" proceeded between the azide and proparg

254 es has led to the creation of a new class of click reactions, collectively known as photoclick chemis

255 nge) is a modular, next generation family of click reactions, geared towards the rapid and reliable a

256 alysed azide-alkyne cycloaddition (SP-CuAAC) click reactions.

257 mploying copper-catalyzed or strain-promoted click reactions.

258 or, 1-azido-3-iodobicyclo[1.1.1]pentane, by "click" reactions and integrated cycloaddition-Sonogashir

259 Thiol-Michael "click" reactions are essential synthetic tools in the pr

260 The described Suzuki, Sonogashira, and "Click" reactions demonstrate the ease at which these por

261 high-yielding, and selective bioorthogonal "click" reactions employing nontoxic reagents are in high

262 reactions between alkynes and azides (i.e., "Click" reactions) at room temperature.

263 used powerful DCBs formed by simple, often "click" reactions, and highlights the powerful materials

264 These adducts are the products of so-called 'click' reactions, widely valued for providing simple, re

265 y bileaflet myxomatous disease, mid-systolic click, repolarization abnormalities in the inferior lead

266 be accessed directly via a URL, allowing one-click reproduction of published results.

267 The successful application of CNNs to clicks reveals the potential of future studies to train

268 e Sharpless and Finn groups in which in situ click screens were used to develop potent, divalent enzy

269 Through the use of Poly(A)-Click-Seq to characterize APA, we define the mRNAs subje

270 We used click proteomics and click sequencing to explore the gene regulatory function

271 addition (TMA) is a powerful methodology to click several fragments together, despite having been un

272 evised an innovative technology called sgRNA-Click (sgR-CLK) that harnesses the power of bioorthogona

273 Overall, MitoZ provides a one-click solution to construct the annotated mitogenome fro

274 Hums are often interspersed with irregular click sounds with an amplitude that is ten times greater

275 sign, optimization, and validation of double-click stapled peptides encoding the Ctf4-interacting pep

276 By developing new substrates for CB6 click that do not contain any cross-reactive functional

277 ousettus aegyptiacus, which produce sound by clicking their tongue, can dramatically change beam dire

278 omprehensive expression analyses with simple clicking through GEPIA greatly facilitate data mining in

279 use very small air volumes per echolocation click to facilitate continuous sensory flow in foraging

280 this new reaction may allow markedly reduced click-to-release reagent doses in vitro and in vivo and

281 The high rate of the 'click-to-release' reaction between an allylic substitute

282 Poly(diketoenamine)s 'click' together from a wide variety of triketones and ar

283 Click train detections increased toward the south, sugge

284 and auditory steady state response (ASSR) to click trains of stimuli at a frequency of 10-80 Hz.

285 A total of 53,823 echolocation click trains were recorded and analyzed to understand th

286 es through application of the wide family of click transformations.

287 It features arylation of a click triazole with a diaryliodonium salt in the presenc

288 Automatically-identified click types from autonomous seafloor recorders without v

289 ification across large datasets in which the click types may not be known a priori.

290 Once click types were established, an algorithm for classifyi

291 variation, and identify distinct, persistent click types.

292 for the animals producing some echolocation click types.

293 roach a human analyst uses when categorizing click types: Clusters of similar clicks were identified

294 ounters are single-pixel binary devices that click upon the absorption of a photon but obscure its sp

295 arning that extends convenient 2D 'point-and-click' user training to 3D detection of cells in challen

296 -Acute Care-Inpatient Mobility Short Form "6 clicks" was only collected during the initial physical t

297 ategorizing click types: Clusters of similar clicks were identified by incorporating multiple click c

298 rs of short duration, broadband echolocation clicks which may be useful for species classification in

299 The O-glycan derivatives can be clicked with a fluorescent bifunctional tag that allows

300 Yponomeuta's perpetual clicking would however also attract bat predators.